KR100266500B1 - Novel oxazolidine derivatives and process for preparing the same - Google Patents

Novel oxazolidine derivatives and process for preparing the same

Info

Publication number
KR100266500B1
KR100266500B1 KR1019990018054A KR19990018054A KR100266500B1 KR 100266500 B1 KR100266500 B1 KR 100266500B1 KR 1019990018054 A KR1019990018054 A KR 1019990018054A KR 19990018054 A KR19990018054 A KR 19990018054A KR 100266500 B1 KR100266500 B1 KR 100266500B1
Authority
KR
South Korea
Prior art keywords
formula
paclitaxel
manufacturing
preparing
same
Prior art date
Application number
KR1019990018054A
Other languages
Korean (ko)
Inventor
Kyoung Soo Kim
Ki Byung Chai
Young Ho Moon
Kwang Ok Lee
Nam Du Kim
Tae Hee Ha
Jung Ae Shin
Gwan Sun Lee
Wan Joo Kim
Original Assignee
Han Mi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019970039557A external-priority patent/KR100225535B1/en
Application filed by Han Mi Pharm Ind Co Ltd filed Critical Han Mi Pharm Ind Co Ltd
Priority to KR1019990018054A priority Critical patent/KR100266500B1/en
Application granted granted Critical
Publication of KR100266500B1 publication Critical patent/KR100266500B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PURPOSE: Provided is a manufacturing method of paclitaxel of the formula (1). Further, novel intermediates used for manufacturing paclitaxel and their manufacturing methods are provided. CONSTITUTION: Paclitaxel is represented by the formula (1) wherein, Ph is phenyl, Ac is acetyl, and Bz is benzoyl. The intermediate used for manufacturing paclitaxel is provided by reacting a novel oxazoline derivative of the formula (2a) or its salt, and (2R,3S)-phenylisoserine derivative of the formula (10) with a compound of the formula (11), in the solvent, in the presence of acid catalyst. In the formulae, X is halogen; R is hydrogen or C1-C3 of alkyl; and R5, R6, and R7 represent individually C1-C4 of alkyl or phenylalkyl, or R5 and R6 form 4-7 membered ring of cyclic chain together.
KR1019990018054A 1997-08-20 1999-05-19 Novel oxazolidine derivatives and process for preparing the same KR100266500B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019990018054A KR100266500B1 (en) 1997-08-20 1999-05-19 Novel oxazolidine derivatives and process for preparing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019970039557A KR100225535B1 (en) 1996-08-27 1997-08-20 Process for preparing paclitaxel
KR1019990018054A KR100266500B1 (en) 1997-08-20 1999-05-19 Novel oxazolidine derivatives and process for preparing the same

Publications (1)

Publication Number Publication Date
KR100266500B1 true KR100266500B1 (en) 2000-09-15

Family

ID=19517874

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019990018054A KR100266500B1 (en) 1997-08-20 1999-05-19 Novel oxazolidine derivatives and process for preparing the same

Country Status (1)

Country Link
KR (1) KR100266500B1 (en)

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