KR100258581B1 - 3-hydroxy-3-methylglutaryl coa reductase inhibitorycomposition comprising vitamin c and citrus peelextract - Google Patents

3-hydroxy-3-methylglutaryl coa reductase inhibitorycomposition comprising vitamin c and citrus peelextract Download PDF

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Publication number
KR100258581B1
KR100258581B1 KR1019990045735A KR19990045735A KR100258581B1 KR 100258581 B1 KR100258581 B1 KR 100258581B1 KR 1019990045735 A KR1019990045735 A KR 1019990045735A KR 19990045735 A KR19990045735 A KR 19990045735A KR 100258581 B1 KR100258581 B1 KR 100258581B1
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KR
South Korea
Prior art keywords
extract
hydroxy
vitamin
coa
methylglutaryl coa
Prior art date
Application number
KR1019990045735A
Other languages
Korean (ko)
Inventor
Song Hae Bok
Kwang Hee Son
Tae Sook Jeong
Byoung Mog Kwon
Young Kook Kim
Doil Choi
Sun Guk Kim
Ki Hwan Bae
Yong Bok Park
Myung Sook Choi
In Gyu Hwang
Surk Sik Moon
Yong Kook Kwon
Jung Ah Ahn
Eun Sook Lee
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Korea Res Inst Of Bioscience
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Application filed by Korea Res Inst Of Bioscience filed Critical Korea Res Inst Of Bioscience
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Publication of KR100258581B1 publication Critical patent/KR100258581B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

PURPOSE: Composites for inhibiting 3-Hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity are provided to drop blood cholesterol for the prevention and the treatment of high cholesterol by containing vitamin C and orange peel extract, vitamin C, hesperidin and naringin. CONSTITUTION: Orange peels are washed with water and dried at room temperature in the shade. Water or 95% ethanol is added to the dried orange peels to extract active substances at 5-140deg.C. The extract is injected to a blood cholesterol patient as much as 1-5g/1kg/day. The extract is added to foods or beverages for to impeding 3-Hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity, and drops blood cholesterol. The composites of the extract are varied by reaction time, reaction temperature, alcohol concentration, orange type and ripe rate.
KR1019990045735A 1997-10-28 1999-10-21 3-hydroxy-3-methylglutaryl coa reductase inhibitorycomposition comprising vitamin c and citrus peelextract KR100258581B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019970055581A KR100254908B1 (en) 1997-10-28 1997-10-28 3-hydroxy-3-methylglutaryl coa reductase inhibitory composition comprising vitamin c and citrus peel extract

Publications (1)

Publication Number Publication Date
KR100258581B1 true KR100258581B1 (en) 2000-05-15

Family

ID=19523581

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019970055581A KR100254908B1 (en) 1997-10-28 1997-10-28 3-hydroxy-3-methylglutaryl coa reductase inhibitory composition comprising vitamin c and citrus peel extract
KR1019990045735A KR100258581B1 (en) 1997-10-28 1999-10-21 3-hydroxy-3-methylglutaryl coa reductase inhibitorycomposition comprising vitamin c and citrus peelextract

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019970055581A KR100254908B1 (en) 1997-10-28 1997-10-28 3-hydroxy-3-methylglutaryl coa reductase inhibitory composition comprising vitamin c and citrus peel extract

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KR (2) KR100254908B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030002214A (en) * 2001-06-30 2003-01-08 알앤엘생명과학주식회사 Compositions for preventing and treating brain diseases
KR100702567B1 (en) * 2004-06-09 2007-04-02 퓨리메드 주식회사 Poncirus trifoliata extract for recovering after myocardial infraction shock and pharmaceutical composition and health food containing the same
KR20100133133A (en) * 2009-06-11 2010-12-21 (주)바이오뉴트리젠 A composition containing the extract of citrus peel, persimmon, lycium chinense and buckwheat leaf for preventing or improving hyperlipidemia and manufacturing method thereof
CN114149390B (en) * 2021-12-14 2023-10-27 梅州市珍宝金柚实业有限公司 Vitamin C extraction method

Also Published As

Publication number Publication date
KR100254908B1 (en) 2000-05-01
KR19990034092A (en) 1999-05-15

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