KR0127113B1 - 3-비닐세펨 유도체의 제조방법 - Google Patents
3-비닐세펨 유도체의 제조방법Info
- Publication number
- KR0127113B1 KR0127113B1 KR1019940001603A KR19940001603A KR0127113B1 KR 0127113 B1 KR0127113 B1 KR 0127113B1 KR 1019940001603 A KR1019940001603 A KR 1019940001603A KR 19940001603 A KR19940001603 A KR 19940001603A KR 0127113 B1 KR0127113 B1 KR 0127113B1
- Authority
- KR
- South Korea
- Prior art keywords
- vinyl
- carboxylic acid
- derivative
- cephem
- structural formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
본 발명은 세펨계 항생제로 유용한 3-비닐세펨 유도체의 제조방법에 관한 것으로서, 더욱 상세하게는 다음 구조식(Ⅰ)로 표시되는 7-[2-(2-아미노티아졸-4-일)-2-syn-(카르복시메톡시이미노)] 아세트아미도]-3-비닐-3-세펨-4-카르복실산 유도체와 그의 허용 가능한 염 및 수화물의 신규한 제조방법에 관한 것이다.
상기식에서, R 및R1은 서로 같거나 다른 것으로서 수소 C1~3의 알킬, t-부틸, 디페닐메틸, 트리페닐메틸, 벤질, p-니트로벤질 또는 p-메톡시벤질이다.
Description
[발명의 상세한 설명]
본 발명은 세펨계 항생제로 유용한 3-비닐세펨 유도체의 제조방법에 관한 것으로서, 더욱 상세하게는 다음 구조식(Ⅰ)로 표시되는 7-[2-(2-아미노티아졸-4-일)-2-syn-(카르복시메톡시이미노)] 아세트아미도]-3-비닐-3-세펨-4-카르복실산 유도체와 그의 허용 가능한 염 및 수화물의 신규한 제조방법에 관한 것이다.
1
1
3
2
3
4
1
제조예1
1
3
18
18
4
4
3
제조예 2
1
제조예 3
1
2
3
실시예
1
1
3
6
20
23
5
7
2
실시예 2
1
6
16
15
5
7
2
2
실시예 3
1
6
16
15
5
7
2
2
Claims (3)
- 다음 구조식(I)로 표시되는 3-비닐세펨 유도체를 제조하는데 있어서, 다음 구조식(Ⅱ)로 표시되는 벤조티아졸릴 티오에스테르와 다음 구조식(Ⅲ)으로 표시되는 7-아미노-3-비닐-3-세펨-4-카르복실산 유도체를 유기용매 중에서 유기아민의 존재 또는 비존재하에서 축합 반응시켜 제조되는 것을 특징으로 하는 3-비닐세펨 유도체의 제조방법.상기식에서, R 및 R1은 서로 같거나 다른 것으로 수소, C1∼3의 알킬, t-부틸, 디페닐메틸, 트리페닐메틸, 벤질, p-니트로벤질 또는 p-메톡시벤질이다.
- 제 1 항에 있어서, 상기 유기용매로는 톨루엔-메탄올 또는 메틸렌 클로라이드-메탄올 혼합용매를 사용하는 것을 특징으로 하는 3-비닐세펨 유도체의 제조방법.
- 제 1 항에 있어서, 상기 유기아민으로는 디에틸아민, 트리에틸아민, 트리프로필아민 또는 피리딘을 사용하는 것을 특징으로 하는 3-비닐세펨 유도체의 제조방법.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940001603A KR0127113B1 (ko) | 1994-01-28 | 1994-01-28 | 3-비닐세펨 유도체의 제조방법 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940001603A KR0127113B1 (ko) | 1994-01-28 | 1994-01-28 | 3-비닐세펨 유도체의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR950023645A KR950023645A (ko) | 1995-08-18 |
KR0127113B1 true KR0127113B1 (ko) | 1998-04-01 |
Family
ID=19376423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940001603A KR0127113B1 (ko) | 1994-01-28 | 1994-01-28 | 3-비닐세펨 유도체의 제조방법 |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR0127113B1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6384212B1 (en) | 2000-03-20 | 2002-05-07 | Hanmi Fine Chemicals Co., Ltd. | Process for preparing cephalosporin antibiotics using new thiazole compound |
-
1994
- 1994-01-28 KR KR1019940001603A patent/KR0127113B1/ko not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6384212B1 (en) | 2000-03-20 | 2002-05-07 | Hanmi Fine Chemicals Co., Ltd. | Process for preparing cephalosporin antibiotics using new thiazole compound |
Also Published As
Publication number | Publication date |
---|---|
KR950023645A (ko) | 1995-08-18 |
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Legal Events
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E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20040115 Year of fee payment: 9 |
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LAPS | Lapse due to unpaid annual fee |