ZA794723B
(en)
*
|
1978-09-11 |
1980-08-27 |
Univ Miami |
Anti-hypertensive agents
|
US4595675A
(en)
*
|
1979-09-19 |
1986-06-17 |
Hoechst Aktiengesellschaft |
Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
|
FR2487829A2
(fr)
*
|
1979-12-07 |
1982-02-05 |
Science Union & Cie |
Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
|
FR2503155A2
(fr)
*
|
1980-10-02 |
1982-10-08 |
Science Union & Cie |
Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
|
US4644008A
(en)
*
|
1979-12-07 |
1987-02-17 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4565819A
(en)
*
|
1979-12-07 |
1986-01-21 |
Adir |
Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
|
US4616031A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4616030A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4508729A
(en)
*
|
1979-12-07 |
1985-04-02 |
Adir |
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
|
US4599357A
(en)
*
|
1979-12-17 |
1986-07-08 |
Ciba-Geigy Corporation |
1-mercaptoalkanoylindoline-2-carboxylic acids
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IE50839B1
(en)
*
|
1980-02-26 |
1986-07-23 |
Wyeth John & Brother Ltd |
Novel processes for preparing proline derivatives and analogous compounds
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IE52663B1
(en)
*
|
1980-04-02 |
1988-01-20 |
Warner Lambert Co |
Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
|
US4766210A
(en)
*
|
1980-04-23 |
1988-08-23 |
Suh John T |
Antihypertensive lactams
|
US4287203A
(en)
*
|
1980-04-23 |
1981-09-01 |
Usv Pharmaceutical Corporation |
Antihypertensive 1,4-thiazepine-ones, 1,4-thiazonine-ones, and method of use thereof
|
US4352753A
(en)
*
|
1980-08-11 |
1982-10-05 |
American Home Products Corporation |
3-[[(2,3-Dihydro-1H-indol-2-yl)carbonyl]thio]propanoic (and acetic) acids as intermediates
|
EP0278530A3
(fr)
*
|
1980-08-30 |
1989-08-02 |
Hoechst Aktiengesellschaft |
Dérivés amino-acides, leur procédé de préparation, les agents les contenant et leur emploi
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US5162362A
(en)
*
|
1980-08-30 |
1992-11-10 |
Hoechst Aktiengesellschaft |
Octahydroindole-2-carboxylic acids
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ATE48415T1
(de)
*
|
1980-08-30 |
1989-12-15 |
Hoechst Ag |
Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
|
US4344949A
(en)
*
|
1980-10-03 |
1982-08-17 |
Warner-Lambert Company |
Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
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US4374847A
(en)
*
|
1980-10-27 |
1983-02-22 |
Ciba-Geigy Corporation |
1-Carboxyalkanoylindoline-2-carboxylic acids
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GB2086390B
(en)
*
|
1980-11-03 |
1984-06-06 |
Ciba Geigy Ag |
1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
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US4425355A
(en)
|
1981-02-17 |
1984-01-10 |
Warner-Lambert Company |
Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
|
US4479963A
(en)
*
|
1981-02-17 |
1984-10-30 |
Ciba-Geigy Corporation |
1-Carboxyalkanoylindoline-2-carboxylic acids
|
US4532342A
(en)
*
|
1981-02-20 |
1985-07-30 |
Warner-Lambert Company |
N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
US4374246A
(en)
*
|
1981-06-18 |
1983-02-15 |
Norwich Eaton Pharmaceuticals, Inc. |
1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
|
US4555502A
(en)
*
|
1982-09-30 |
1985-11-26 |
Merck & Co., Inc. |
Aminoacyl-containing dipeptide derivatives useful as antihypertensives
|
IE54551B1
(en)
*
|
1982-01-22 |
1989-11-22 |
Ici Plc |
Amide derivatives
|
US4665087A
(en)
*
|
1982-02-22 |
1987-05-12 |
Ciba-Geigy Corporation |
1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
|
US4452791A
(en)
*
|
1982-03-15 |
1984-06-05 |
E. R. Squibb & Sons, Inc. |
Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
|
US4560680A
(en)
*
|
1982-03-15 |
1985-12-24 |
E. R. Squibb & Sons, Inc. |
Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
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US4448772A
(en)
*
|
1982-04-22 |
1984-05-15 |
E. R. Squibb & Sons, Inc. |
Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
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US4560681A
(en)
*
|
1982-04-22 |
1985-12-24 |
E. R. Squibb & Sons, Inc. |
Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
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US4483850A
(en)
*
|
1982-05-10 |
1984-11-20 |
Merck & Co., Inc. |
N-Terminal substituted oligopeptide converting enzyme inhibitors
|
US4617291A
(en)
*
|
1982-05-14 |
1986-10-14 |
Mead Johnson & Company |
Angiotensin-converting enzyme inhibiting dipeptide derivatives
|
US4427665A
(en)
|
1982-05-19 |
1984-01-24 |
E. R. Squibb & Sons, Inc. |
Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions
|
US4452790A
(en)
*
|
1982-06-23 |
1984-06-05 |
E. R. Squibb & Sons, Inc. |
Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
|
US4703043A
(en)
*
|
1982-06-23 |
1987-10-27 |
E. R. Squibb & Sons, Inc. |
Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
|
US4616005A
(en)
*
|
1982-06-23 |
1986-10-07 |
E. R. Squibb & Sons, Inc. |
Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
|
US4444765A
(en)
*
|
1982-07-14 |
1984-04-24 |
E. R. Squibb & Sons, Inc. |
Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
|
US4567166A
(en)
*
|
1982-07-14 |
1986-01-28 |
E. R. Squibb & Sons, Inc. |
Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
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AU560285B2
(en)
*
|
1982-07-19 |
1987-04-02 |
Imperial Chemical Industries Plc |
Heterocyclyl carbonyl sulphonamides
|
US4659711A
(en)
*
|
1983-01-31 |
1987-04-21 |
Usv Pharmaceutical Corporation |
1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension
|
DE3303345A1
(de)
*
|
1983-02-02 |
1984-08-02 |
Hoechst Ag, 6230 Frankfurt |
Cyclische peptide mit somatostatin-wirkung
|
FR2620703B1
(fr)
*
|
1987-09-17 |
1991-10-04 |
Adir |
Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
|
BR0101088A
(pt)
*
|
2001-03-19 |
2003-03-18 |
Biolab Sanus Farmaceutica Ltda |
Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
|