JPWO2024242150A1 - - Google Patents

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Publication number
JPWO2024242150A1
JPWO2024242150A1 JP2025522440A JP2025522440A JPWO2024242150A1 JP WO2024242150 A1 JPWO2024242150 A1 JP WO2024242150A1 JP 2025522440 A JP2025522440 A JP 2025522440A JP 2025522440 A JP2025522440 A JP 2025522440A JP WO2024242150 A1 JPWO2024242150 A1 JP WO2024242150A1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025522440A
Other languages
Japanese (ja)
Other versions
JPWO2024242150A5 (https=
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed filed Critical
Publication of JPWO2024242150A1 publication Critical patent/JPWO2024242150A1/ja
Publication of JPWO2024242150A5 publication Critical patent/JPWO2024242150A5/ja
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2025522440A 2023-05-23 2024-05-22 Pending JPWO2024242150A1 (https=)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2023084423 2023-05-23
JP2024007357 2024-01-22
JP2024007358 2024-01-22
JP2024063328 2024-04-10
PCT/JP2024/018896 WO2024242150A1 (ja) 2023-05-23 2024-05-22 改変された組換えアデノ随伴ウイルス(aav)結合性タンパク質およびaavの精製方法

Publications (2)

Publication Number Publication Date
JPWO2024242150A1 true JPWO2024242150A1 (https=) 2024-11-28
JPWO2024242150A5 JPWO2024242150A5 (https=) 2026-02-10

Family

ID=93589449

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2025522440A Pending JPWO2024242150A1 (https=) 2023-05-23 2024-05-22

Country Status (4)

Country Link
EP (1) EP4717706A1 (https=)
JP (1) JPWO2024242150A1 (https=)
CN (1) CN121358762A (https=)
WO (1) WO2024242150A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021106882A1 (ja) * 2019-11-25 2021-06-03 東ソー株式会社 改良アデノ随伴ウイルス結合性タンパク質、当該タンパク質の製造方法および当該タンパク質を用いたアデノ随伴ウイルス吸着剤
JP2021526829A (ja) * 2018-06-14 2021-10-11 リジェネクスバイオ インコーポレイテッド 組換えaav生成のためのアニオン交換クロマトグラフィー
JP2022138144A (ja) * 2021-03-09 2022-09-22 Jcrファーマ株式会社 組換えaav9ビリオンの製造方法
WO2023023541A1 (en) * 2021-08-17 2023-02-23 Ultragenyx Pharmaceutical Inc. Anion-exchange chromatography methods for purification of recombinant adeno-associated viruses
WO2023140197A1 (ja) * 2022-01-21 2023-07-27 東ソー株式会社 改変された組換えアデノ随伴ウイルス(aav)結合性タンパク質及び感染能に基づくaavの分析方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011097898A (ja) 2009-11-09 2011-05-19 Sagami Chemical Research Institute 組換えFc受容体およびそれの製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021526829A (ja) * 2018-06-14 2021-10-11 リジェネクスバイオ インコーポレイテッド 組換えaav生成のためのアニオン交換クロマトグラフィー
WO2021106882A1 (ja) * 2019-11-25 2021-06-03 東ソー株式会社 改良アデノ随伴ウイルス結合性タンパク質、当該タンパク質の製造方法および当該タンパク質を用いたアデノ随伴ウイルス吸着剤
JP2022138144A (ja) * 2021-03-09 2022-09-22 Jcrファーマ株式会社 組換えaav9ビリオンの製造方法
WO2023023541A1 (en) * 2021-08-17 2023-02-23 Ultragenyx Pharmaceutical Inc. Anion-exchange chromatography methods for purification of recombinant adeno-associated viruses
WO2023140197A1 (ja) * 2022-01-21 2023-07-27 東ソー株式会社 改変された組換えアデノ随伴ウイルス(aav)結合性タンパク質及び感染能に基づくaavの分析方法

Also Published As

Publication number Publication date
EP4717706A1 (en) 2026-04-01
CN121358762A (zh) 2026-01-16
WO2024242150A1 (ja) 2024-11-28

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