JPWO2023022055A1 - - Google Patents
Info
- Publication number
- JPWO2023022055A1 JPWO2023022055A1 JP2023542355A JP2023542355A JPWO2023022055A1 JP WO2023022055 A1 JPWO2023022055 A1 JP WO2023022055A1 JP 2023542355 A JP2023542355 A JP 2023542355A JP 2023542355 A JP2023542355 A JP 2023542355A JP WO2023022055 A1 JPWO2023022055 A1 JP WO2023022055A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021132705 | 2021-08-17 | ||
| PCT/JP2022/030352 WO2023022055A1 (ja) | 2021-08-17 | 2022-08-09 | 修飾ポリヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023022055A1 true JPWO2023022055A1 (https=) | 2023-02-23 |
| JPWO2023022055A5 JPWO2023022055A5 (https=) | 2024-05-14 |
Family
ID=85240689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023542355A Pending JPWO2023022055A1 (https=) | 2021-08-17 | 2022-08-09 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPWO2023022055A1 (https=) |
| WO (1) | WO2023022055A1 (https=) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004550A1 (en) * | 1992-08-21 | 1994-03-03 | Triplex Pharmaceutical Corporation | Cholesteryl-modified triple-helix forming oligonucleotides and uses thereof |
| WO2019039403A1 (ja) * | 2017-08-22 | 2019-02-28 | 国立大学法人名古屋大学 | 修飾ポリヌクレオチド |
| JP2020514299A (ja) * | 2017-01-09 | 2020-05-21 | アポセンス リミテッドＡｐｏｓｅｎｓｅ Ｌｔｄ． | 分子を経膜送達するための化合物及び方法 |
| JP2020525502A (ja) * | 2017-07-04 | 2020-08-27 | アポセンス リミテッドＡｐｏｓｅｎｓｅ Ｌｔｄ． | 分子を経膜送達するための化合物及び方法 |
-
2022
- 2022-08-09 WO PCT/JP2022/030352 patent/WO2023022055A1/ja not_active Ceased
- 2022-08-09 JP JP2023542355A patent/JPWO2023022055A1/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004550A1 (en) * | 1992-08-21 | 1994-03-03 | Triplex Pharmaceutical Corporation | Cholesteryl-modified triple-helix forming oligonucleotides and uses thereof |
| JP2020514299A (ja) * | 2017-01-09 | 2020-05-21 | アポセンス リミテッドＡｐｏｓｅｎｓｅ Ｌｔｄ． | 分子を経膜送達するための化合物及び方法 |
| JP2020525502A (ja) * | 2017-07-04 | 2020-08-27 | アポセンス リミテッドＡｐｏｓｅｎｓｅ Ｌｔｄ． | 分子を経膜送達するための化合物及び方法 |
| WO2019039403A1 (ja) * | 2017-08-22 | 2019-02-28 | 国立大学法人名古屋大学 | 修飾ポリヌクレオチド |
Non-Patent Citations (3)
| Title |
|---|
| PEREZ-RENTERO,S. ET AL: "Synthesis of oligonucleotides carrying thiol groups using a simple reagent derived from threoninol", MOLECULES, JPN6022042455, 2012, pages 10026 - 10045, ISSN: 0005834440 * |
| PEREZ-RENTERO,S. ET AL: "Thioctic acid derivatives as building blocks to incorporate DNA oligonucleotides onto gold nanoparti", MOLECULES, vol. 19, no. 7, JPN6022042456, 2014, pages 10495 - 10523, ISSN: 0005834441 * |
| SHU,Z. ET AL: "Disulfide-unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 58, no. 20, JPN6022042457, 2019, pages 6611 - 6615, ISSN: 0005834442 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023022055A1 (ja) | 2023-02-23 |
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