JPWO2022229458A5 - - Google Patents
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- JPWO2022229458A5 JPWO2022229458A5 JP2023566500A JP2023566500A JPWO2022229458A5 JP WO2022229458 A5 JPWO2022229458 A5 JP WO2022229458A5 JP 2023566500 A JP2023566500 A JP 2023566500A JP 2023566500 A JP2023566500 A JP 2023566500A JP WO2022229458 A5 JPWO2022229458 A5 JP WO2022229458A5
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- JP
- Japan
- Prior art keywords
- alkyl
- nrarc
- heterocyclyl
- orc
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000623 heterocyclic group Chemical group 0.000 claims 114
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 101
- 125000001424 substituent group Chemical group 0.000 claims 85
- 125000003118 aryl group Chemical group 0.000 claims 67
- 229910052757 nitrogen Inorganic materials 0.000 claims 61
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 60
- 229910003827 NRaRb Inorganic materials 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000002950 monocyclic group Chemical group 0.000 claims 37
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 claims 28
- 229920006395 saturated elastomer Polymers 0.000 claims 23
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 21
- 125000002619 bicyclic group Chemical group 0.000 claims 19
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 15
- -1 5-bromo-4-methylpyrid-3-yl Chemical group 0.000 claims 14
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 125000001153 fluoro group Chemical group F* 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 4
- YKGOQXICHYEMJW-UHFFFAOYSA-N 2-cyclobutyl-7-isoquinolin-4-yl-5,7-diazaspiro[3.4]octane-6,8-dione Chemical compound O=C(C(C1)(CC1C1CCC1)NC1=O)N1C1=CN=CC2=CC=CC=C12 YKGOQXICHYEMJW-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- MFAGBOFQNNFTHG-UHFFFAOYSA-N CC(C)(C)C(C1)CC1(C(N1C2=CN=CC3=CC=CC=C23)=O)NC1=O Chemical compound CC(C)(C)C(C1)CC1(C(N1C2=CN=CC3=CC=CC=C23)=O)NC1=O MFAGBOFQNNFTHG-UHFFFAOYSA-N 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- FOZLXSUKKDDCIZ-UHFFFAOYSA-N 2-cyclobutyl-7-(5-fluoropyridin-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione Chemical compound O=C(C(C1)(CC1C1CCC1)NC1=O)N1C1=CC(F)=CN=C1 FOZLXSUKKDDCIZ-UHFFFAOYSA-N 0.000 claims 2
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- 208000025721 COVID-19 Diseases 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
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- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- QVMVVSYGYGQBLV-UHFFFAOYSA-N O=C(C(C1)(CC1C(C=CC=C1)=C1Cl)NC1=O)N1C1=C2N=CC=CC2=CN=C1 Chemical compound O=C(C(C1)(CC1C(C=CC=C1)=C1Cl)NC1=O)N1C1=C2N=CC=CC2=CN=C1 QVMVVSYGYGQBLV-UHFFFAOYSA-N 0.000 claims 2
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- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
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- XQFMLNUPNCXPRN-UHFFFAOYSA-N 2-(2-chlorophenyl)-7-isoquinolin-4-yl-5,7-diazaspiro[3.4]octane-6,8-dione Chemical compound O=C(C(C1)(CC1C(C=CC=C1)=C1Cl)NC1=O)N1C1=CN=CC2=CC=CC=C12 XQFMLNUPNCXPRN-UHFFFAOYSA-N 0.000 claims 1
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- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
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| CN115894443B (zh) * | 2022-11-17 | 2024-03-29 | 上海市重大传染病和生物安全研究院 | 一种化合物艾奎斯韦及其应用 |
| WO2025196284A1 (en) | 2024-03-22 | 2025-09-25 | Carlsson Jens | Substituted hydantoin compounds, methods for preparation thereof and use thereof in the treatment and/or prevention of a coronavirus disease |
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| WO2017047146A1 (ja) | 2015-09-17 | 2017-03-23 | オリンパス株式会社 | 内視鏡用処置具 |
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