JPWO2022204358A5 - - Google Patents
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- JPWO2022204358A5 JPWO2022204358A5 JP2023559736A JP2023559736A JPWO2022204358A5 JP WO2022204358 A5 JPWO2022204358 A5 JP WO2022204358A5 JP 2023559736 A JP2023559736 A JP 2023559736A JP 2023559736 A JP2023559736 A JP 2023559736A JP WO2022204358 A5 JPWO2022204358 A5 JP WO2022204358A5
- Authority
- JP
- Japan
- Prior art keywords
- genomic regions
- nucleic acid
- group
- methylated genomic
- tables
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 230000011987 methylation Effects 0.000 claims 12
- 238000007069 methylation reaction Methods 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 230000002062 proliferating effect Effects 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 208000007660 Residual Neoplasm Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000010801 machine learning Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims 1
- 238000006911 enzymatic reaction Methods 0.000 claims 1
- 210000003608 fece Anatomy 0.000 claims 1
- 229940079826 hydrogen sulfite Drugs 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163166641P | 2021-03-26 | 2021-03-26 | |
| US63/166,641 | 2021-03-26 | ||
| PCT/US2022/021662 WO2022204358A1 (en) | 2021-03-26 | 2022-03-24 | Methods and systems for detecting cancer via nucleic acid methylation analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024512627A JP2024512627A (ja) | 2024-03-19 |
| JP2024512627A5 JP2024512627A5 (https=) | 2025-03-17 |
| JPWO2022204358A5 true JPWO2022204358A5 (https=) | 2025-03-17 |
Family
ID=83396062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023559736A Pending JP2024512627A (ja) | 2021-03-26 | 2022-03-24 | 核酸メチル化分析を介して癌を検出するための方法およびシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20230178181A1 (https=) |
| EP (1) | EP4314322A4 (https=) |
| JP (1) | JP2024512627A (https=) |
| KR (1) | KR20230162662A (https=) |
| CN (1) | CN117413072A (https=) |
| AU (1) | AU2022245306A1 (https=) |
| CA (1) | CA3213101A1 (https=) |
| WO (1) | WO2022204358A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019060716A1 (en) | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | SAMPLE EXTRACTION METHODS AND SYSTEMS |
| AU2020283042B2 (en) | 2019-05-31 | 2026-02-19 | Freenome Holdings, Inc. | Methods and systems for high-depth sequencing of methylated nucleic acid |
| CA3178302A1 (en) | 2020-03-31 | 2021-10-07 | Freenome Holdings, Inc. | Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis |
| WO2021228418A1 (en) | 2020-05-15 | 2021-11-18 | Universal Diagnostics, S.L. | Methods and systems for identifying methylation biomarkers |
| WO2022076237A1 (en) | 2020-10-05 | 2022-04-14 | Freenome Holdings, Inc. | Markers for the early detection of colon cell proliferative disorders |
| AU2021409465A1 (en) | 2020-12-21 | 2023-08-03 | Freenome Holdings, Inc. | Markers for the early detection of colon cell proliferative disorders |
| WO2024096536A1 (ko) * | 2022-10-31 | 2024-05-10 | 주식회사 지씨지놈 | 폐암 진단용 dna 메틸화 마커 및 이의 용도 |
| JP2025539719A (ja) * | 2022-10-31 | 2025-12-09 | ジーシー ゲノム コーポレーション | 肝癌診断用ｄｎａメチル化マーカー及びその用途 |
| JP2025539741A (ja) * | 2022-11-16 | 2025-12-09 | グレイル インコーポレイテッド | モデルベースの特徴化及び分類の最適化 |
| US12606872B2 (en) | 2022-11-16 | 2026-04-21 | Universal Diagnostics, S.A. | Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers |
| WO2025128926A1 (en) * | 2023-12-13 | 2025-06-19 | Amazon Technologies, Inc. | Methods of identifying and treating individuals with elevated cancer risk |
| US20250223652A1 (en) * | 2024-01-05 | 2025-07-10 | Harbinger Health, Inc. | Tiered testing for high risk populations |
| CN117904313B (zh) * | 2024-01-18 | 2024-12-24 | 四川大学 | 一种基于酶转化法从精液或精斑中推断年龄的方法及复合体系和引物组合 |
| CN117935909B (zh) * | 2024-01-26 | 2024-10-01 | 哈尔滨工业大学 | 基于电信号与序列融合的第三代测序dna甲基化检测方法 |
| WO2025207830A1 (en) * | 2024-03-27 | 2025-10-02 | Freenome Holdings, Inc. | Methods and systems for inferring gene expression using cell-free dna fragments |
| US20250372202A1 (en) * | 2024-05-28 | 2025-12-04 | Nec Laboratories America, Inc. | Learning interdependent biomarkers of disease progression for medical decision making |
| WO2025251032A1 (en) * | 2024-05-31 | 2025-12-04 | Helio Health Inc. | Liver cancer methylation markers and machine models |
| CN118588172B (zh) * | 2024-06-07 | 2025-01-17 | 首都医科大学附属北京积水潭医院 | 用于监测多发性骨髓瘤微小残留病的计算机装置 |
| CN118888009B (zh) * | 2024-09-27 | 2024-12-20 | 安徽安龙基因科技有限公司 | 一种肝癌检测系统、试剂盒及其应用 |
| CN120148626A (zh) * | 2025-02-21 | 2025-06-13 | 上海小荷医学检验实验室有限公司 | 用于肿瘤检测的方法、装置、设备和程序产品 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018057888A1 (en) * | 2016-09-23 | 2018-03-29 | Driver, Inc. | Integrated systems and methods for automated processing and analysis of biological samples, clinical information processing and clinical trial matching |
| CN119753091A (zh) * | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| CN112888459B (zh) * | 2018-06-01 | 2023-05-23 | 格里尔公司 | 卷积神经网络系统及数据分类方法 |
-
2022
- 2022-03-24 WO PCT/US2022/021662 patent/WO2022204358A1/en not_active Ceased
- 2022-03-24 CN CN202280038299.2A patent/CN117413072A/zh active Pending
- 2022-03-24 JP JP2023559736A patent/JP2024512627A/ja active Pending
- 2022-03-24 CA CA3213101A patent/CA3213101A1/en active Pending
- 2022-03-24 KR KR1020237036681A patent/KR20230162662A/ko active Pending
- 2022-03-24 AU AU2022245306A patent/AU2022245306A1/en active Pending
- 2022-03-24 EP EP22776625.0A patent/EP4314322A4/en active Pending
-
2023
- 2023-02-01 US US18/163,174 patent/US20230178181A1/en active Pending
- 2023-09-22 US US18/472,529 patent/US20240084397A1/en active Pending
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