JPWO2022151851A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022151851A5 JPWO2022151851A5 JP2023542493A JP2023542493A JPWO2022151851A5 JP WO2022151851 A5 JPWO2022151851 A5 JP WO2022151851A5 JP 2023542493 A JP2023542493 A JP 2023542493A JP 2023542493 A JP2023542493 A JP 2023542493A JP WO2022151851 A5 JPWO2022151851 A5 JP WO2022151851A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- sequence
- seq
- immune cell
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 36
- 230000000903 blocking effect Effects 0.000 claims 18
- 210000002865 immune cell Anatomy 0.000 claims 17
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 16
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 230000003834 intracellular effect Effects 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 230000032258 transport Effects 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 2
- 206010066476 Haematological malignancy Diseases 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 238000004873 anchoring Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000005516 engineering process Methods 0.000 claims 2
- 238000003209 gene knockout Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 102100030886 Complement receptor type 1 Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims 1
- 101000727061 Homo sapiens Complement receptor type 1 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110036169.2 | 2021-01-12 | ||
| CN202110036169.2A CN113234682B (zh) | 2021-01-12 | 2021-01-12 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
| PCT/CN2021/133817 WO2022151851A1 (zh) | 2021-01-12 | 2021-11-29 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502632A JP2024502632A (ja) | 2024-01-22 |
| JPWO2022151851A5 true JPWO2022151851A5 (enrdf_load_stackoverflow) | 2024-10-02 |
Family
ID=77130068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023542493A Pending JP2024502632A (ja) | 2021-01-12 | 2021-11-29 | Ｃｄ７を標的とする改変免疫細胞、キメラ抗原受容体、ｃｄ７ブロッキング分子およびその応用 |
Country Status (8)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115947852A (zh) * | 2021-01-12 | 2023-04-11 | 上海雅科生物科技有限公司 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
| CN114716564B (zh) * | 2021-12-20 | 2023-02-28 | 四川大学华西医院 | 基于sectm1构建的嵌合抗原受体免疫细胞制备及其应用 |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| CN114560943B (zh) * | 2022-02-28 | 2022-12-16 | 先进生物(苏州)有限公司 | Cd7-car-t细胞及其制备方法和应用 |
| CN120005024A (zh) * | 2022-03-30 | 2025-05-16 | 河北森朗生物科技有限公司 | 抗cd7的纳米抗体及其相关产品和应用 |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN116003631B (zh) * | 2022-11-15 | 2024-01-26 | 江苏元晟生物科技有限公司 | 靶向cd7的人源化抗体及其应用 |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| WO2024243340A1 (en) | 2023-05-23 | 2024-11-28 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025179294A2 (en) | 2024-02-22 | 2025-08-28 | Capstan Therapeutics, Inc. | Immune engineering amplification |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000073333A2 (en) * | 1999-05-28 | 2000-12-07 | Immunex Corporation | Ligand for cd7, and methods for use thereof |
| US20040202675A1 (en) * | 2002-12-09 | 2004-10-14 | Duke University | Vaccine adjuvant |
| DK3253865T3 (da) * | 2015-02-06 | 2022-08-15 | Nat Univ Singapore | Fremgangsmåder til forbedring af virkningen af terapeutiske immunceller |
| SG11201706774WA (en) * | 2015-02-27 | 2017-09-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| WO2017213979A1 (en) * | 2016-06-06 | 2017-12-14 | St. Jude Children's Research Hospital | Anti-cd7 chimeric antigen receptor and method of use thereof |
| JP7114490B2 (ja) * | 2016-06-24 | 2022-08-08 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法 |
| SG11201903830TA (en) * | 2016-11-22 | 2019-05-30 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| GB201622044D0 (en) * | 2016-12-22 | 2017-02-08 | Ucl Business Plc | T cell-targeted T cells |
| CA3067244A1 (en) * | 2017-06-12 | 2018-12-20 | Emory University | T-cell antigen targeted chimeric antigen receptor (car) and uses in cell therapies |
| WO2020102589A1 (en) * | 2018-11-14 | 2020-05-22 | Medisix Therapeutics Pte Ltd. | Two-gene vectors for generating car-t cells and uses thereof |
| CN110760007B (zh) * | 2019-11-21 | 2022-08-26 | 博生吉医药科技(苏州)有限公司 | Cd7-car-t细胞及其制备和应用 |
| CN115947852A (zh) * | 2021-01-12 | 2023-04-11 | 上海雅科生物科技有限公司 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
-
2021
- 2021-01-12 CN CN202211663129.1A patent/CN115947852A/zh active Pending
- 2021-01-12 CN CN202211632999.2A patent/CN115786271B/zh active Active
- 2021-01-12 CN CN202110036169.2A patent/CN113234682B/zh active Active
- 2021-11-29 WO PCT/CN2021/133817 patent/WO2022151851A1/zh active Application Filing
- 2021-11-29 AU AU2021418636A patent/AU2021418636A1/en active Pending
- 2021-11-29 JP JP2023542493A patent/JP2024502632A/ja active Pending
- 2021-11-29 CA CA3204370A patent/CA3204370A1/en active Pending
- 2021-11-29 KR KR1020237027583A patent/KR20230134133A/ko active Pending
- 2021-11-29 EP EP21919042.8A patent/EP4279585A4/en active Pending
-
2023
- 2023-07-12 US US18/351,466 patent/US20240075143A1/en active Pending