JPWO2022019336A1 - - Google Patents

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Publication number
JPWO2022019336A1
JPWO2022019336A1 JP2022538046A JP2022538046A JPWO2022019336A1 JP WO2022019336 A1 JPWO2022019336 A1 JP WO2022019336A1 JP 2022538046 A JP2022538046 A JP 2022538046A JP 2022538046 A JP2022538046 A JP 2022538046A JP WO2022019336 A1 JPWO2022019336 A1 JP WO2022019336A1
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JP
Japan
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JP2022538046A
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Japanese (ja)
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JP7441475B2 (ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C07C57/12—Straight chain carboxylic acids containing eighteen carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/18—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group
    • C07C67/20—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group from amides or lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/24—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022538046A 2020-07-21 2021-07-21 重水素化標識化合物およびその製造方法 Active JP7441475B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020124674 2020-07-21
JP2020124674 2020-07-21
PCT/JP2021/027395 WO2022019336A1 (ja) 2020-07-21 2021-07-21 重水素化標識化合物およびその製造方法

Publications (2)

Publication Number Publication Date
JPWO2022019336A1 true JPWO2022019336A1 (zh) 2022-01-27
JP7441475B2 JP7441475B2 (ja) 2024-03-01

Family

ID=79729162

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022538046A Active JP7441475B2 (ja) 2020-07-21 2021-07-21 重水素化標識化合物およびその製造方法

Country Status (2)

Country Link
JP (1) JP7441475B2 (zh)
WO (1) WO2022019336A1 (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006505777A (ja) * 2002-11-04 2006-02-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
JP2016522677A (ja) * 2013-03-15 2016-08-04 パーキンエルマー・ヘルス・サイエンシーズ・インコーポレイテッドＰｅｒｋｉｎｅｌｍｅｒ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． ライソゾーム病の検査に関する化合物および方法
CN106008639A (zh) * 2016-03-11 2016-10-12 深圳市塔吉瑞生物医药有限公司 用于预防或治疗fxr-介导疾病的胆烷酸化合物
CN108276269A (zh) * 2017-12-11 2018-07-13 浙江大学 β-氘代丙戊酸的制备方法
WO2019183564A1 (en) * 2018-03-23 2019-09-26 Concert Pharmaceuticals, Inc. DEUTERATED ANALOGS OF D-β-HYDROXYBUTYRIC ACID AND USES THEREOF

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006505777A (ja) * 2002-11-04 2006-02-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
JP2016522677A (ja) * 2013-03-15 2016-08-04 パーキンエルマー・ヘルス・サイエンシーズ・インコーポレイテッドＰｅｒｋｉｎｅｌｍｅｒ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． ライソゾーム病の検査に関する化合物および方法
CN106008639A (zh) * 2016-03-11 2016-10-12 深圳市塔吉瑞生物医药有限公司 用于预防或治疗fxr-介导疾病的胆烷酸化合物
CN108276269A (zh) * 2017-12-11 2018-07-13 浙江大学 β-氘代丙戊酸的制备方法
WO2019183564A1 (en) * 2018-03-23 2019-09-26 Concert Pharmaceuticals, Inc. DEUTERATED ANALOGS OF D-β-HYDROXYBUTYRIC ACID AND USES THEREOF

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
CRANDALL,J.K.: "Methyl(trifluoromethyl)dioxirane", E-EROS ENCYCLOPEDIA OF REAGENTS FOR ORGANIC SYNTHESIS, JPN6021041215, 2016, pages 1 - 11, XP055889602, ISSN: 0005167316 *
GOSALBO,L. ET AL: "Synthesis of deuterated cyclopropene fatty esters structurally related to palmitic and myristic acid", LIPIDS, vol. 28, no. 12, JPN6021041220, 1993, pages 1125 - 30, XP035177752, ISSN: 0005167313, DOI: 10.1007/BF02537081 *
HISLOP,J. ET AL: "Synthesis of deuterated γ-lactones for use in stable isotope dilution assays", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 52, no. 23, JPN6021041216, 2004, pages 7075 - 7083, XP055214937, ISSN: 0005167315, DOI: 10.1021/jf048885b *
HUTCHINS,R.O. ET AL.: "Selective reductions of conjugated acetylenes with magnesium in methanol and methanol-d", TETRAHEDRON LETTERS, vol. 30, no. 1, JPN6021041223, 1989, pages 55 - 6, XP055889630, ISSN: 0005167311 *
LIU,W. ET AL: "Site-Selective and Metal-Free Aliphatic C-H Oxidation Enabled Synthesis of [5,24,25-D3]-(25S)-Δ7-Da", CHEMISTRY - A EUROPEAN JOURNAL, vol. 21, no. 14, JPN6021041214, 2015, pages 5345 - 5349, XP055889582, ISSN: 0005167317, DOI: 10.1002/chem.201500324 *
LUO,F. ET AL: "Palladium catalyzed arylation of C(sp3)-H bonds of carbonyl β-position in water", HUAXUE XUEBAO, vol. 74, no. 10, JPN6021041208, 2016, pages 805 - 810, XP055889562, ISSN: 0005167321, DOI: 10.6023/A16060316 *
MENDELSOHN,R. ET AL: "CD2 rocking modes as quantitative infrared probes of one-, two-, and three-bond conformational disor", BIOCHEMISTRY, vol. 30, no. 35, JPN6021041211, 1991, pages 8558 - 63, XP055889569, ISSN: 0005167319, DOI: 10.1021/bi00099a010 *
NAVARRO,I. ET AL: "Stereospecificity of the (E)- and (Z)-11 Myristoyl CoA Desaturases in the Biosynthesis of Spodoptera", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 119, no. 46, JPN6021041218, 1997, pages 11335 - 11336, ISSN: 0005167314 *
OLDFIELD,E. ET AL: "Spectroscopic studies of specifically deuterium labeled membrane systems. Nuclear magnetic resonance", BIOCHEMISTRY, vol. 17, no. 14, JPN6021041212, 1978, pages 2727 - 40, XP055889572, ISSN: 0005167318, DOI: 10.1021/bi00607a006 *
ONO,A. ET AL: "Biosynthetic pathway for production of a conjugated dienyl sex pheromone of a Plusiinae moth, Thysan", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 32, no. 6, JPN6021041222, 2002, pages 701 - 708, XP055889620, ISSN: 0005167312, DOI: 10.1016/S0965-1748(01)00154-0 *
RODRIGUEZ,S. ET AL: "Synthesis of gem-dideuterated tetradecanoic acids and their use in investigating the enzymatic trans", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 24, JPN6021041221, 2001, pages 8052 - 8058, XP055889638, ISSN: 0005167310, DOI: 10.1021/jo010560w *
ZHAO,D. ET AL: "Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to or", JOURNAL OF ORGANIC CHEMISTRY, vol. 83, no. 15, JPN6021041210, 2018, pages 7860 - 7866, XP055889568, ISSN: 0005167320, DOI: 10.1021/acs.joc.8b00734 *
佐治木弘尚: "重水素標識化反応〜「炭素−水素」結合を「炭素−重水素」に変換する〜", 化学と教育, vol. 61巻,８号, JPN6021041207, 2013, pages 404 - 407, ISSN: 0005167322 *

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WO2022019336A1 (ja) 2022-01-27

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