JPWO2021217002A5 - - Google Patents
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- JPWO2021217002A5 JPWO2021217002A5 JP2022564464A JP2022564464A JPWO2021217002A5 JP WO2021217002 A5 JPWO2021217002 A5 JP WO2021217002A5 JP 2022564464 A JP2022564464 A JP 2022564464A JP 2022564464 A JP2022564464 A JP 2022564464A JP WO2021217002 A5 JPWO2021217002 A5 JP WO2021217002A5
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- 229920001184 polypeptide Polymers 0.000 claims 102
- 108090000765 processed proteins & peptides Proteins 0.000 claims 102
- 102000004196 processed proteins & peptides Human genes 0.000 claims 102
- 150000001413 amino acids Chemical group 0.000 claims 62
- 108020005004 Guide RNA Proteins 0.000 claims 43
- 108091033409 CRISPR Proteins 0.000 claims 41
- 238000010354 CRISPR gene editing Methods 0.000 claims 41
- 108091028113 Trans-activating crRNA Proteins 0.000 claims 40
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 32
- 108091079001 CRISPR RNA Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 12
- 101710163270 Nuclease Proteins 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 108020004414 DNA Proteins 0.000 claims 7
- 102000053602 DNA Human genes 0.000 claims 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 6
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 6
- 239000012636 effector Substances 0.000 claims 6
- 239000004474 valine Substances 0.000 claims 6
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 4
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 208000009869 Neu-Laxova syndrome Diseases 0.000 claims 3
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 230000004049 epigenetic modification Effects 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims 3
- 230000037426 transcriptional repression Effects 0.000 claims 3
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063014970P | 2020-04-24 | 2020-04-24 | |
| US63/014,970 | 2020-04-24 | ||
| US202063077211P | 2020-09-11 | 2020-09-11 | |
| US63/077,211 | 2020-09-11 | ||
| PCT/US2021/028843 WO2021217002A1 (en) | 2020-04-24 | 2021-04-23 | Rna-guided nucleases and active fragments and variants thereof and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023516226A JP2023516226A (ja) | 2023-04-18 |
| JPWO2021217002A5 true JPWO2021217002A5 (de) | 2024-05-02 |
Family
ID=75919401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022564464A Pending JP2023516226A (ja) | 2020-04-24 | 2021-04-23 | Ｒｎａ誘導型ヌクレアーゼとその活性な断片およびバリアント、ならびに利用の方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20230175018A1 (de) |
| EP (2) | EP4118198A1 (de) |
| JP (1) | JP2023516226A (de) |
| KR (1) | KR20230014700A (de) |
| CN (1) | CN116096879A (de) |
| AU (1) | AU2021258273A1 (de) |
| BR (1) | BR112022021459A2 (de) |
| CA (1) | CA3174124A1 (de) |
| IL (1) | IL297500A (de) |
| MX (1) | MX2022013187A (de) |
| TW (1) | TW202208626A (de) |
| WO (1) | WO2021217002A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117295817A (zh) | 2021-03-22 | 2023-12-26 | 生命编辑制药股份有限公司 | Dna修饰酶及其活性片段和变体以及使用方法 |
| CA3173953A1 (en) | 2021-06-11 | 2023-12-10 | Tyson D. BOWEN | Rna polymerase iii promoters and methods of use |
| WO2024033901A1 (en) | 2022-08-12 | 2024-02-15 | LifeEDIT Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| WO2024042489A1 (en) | 2022-08-25 | 2024-02-29 | LifeEDIT Therapeutics, Inc. | Chemical modification of guide rnas with locked nucleic acid for rna guided nuclease-mediated gene editing |
| WO2024095245A2 (en) | 2022-11-04 | 2024-05-10 | LifeEDIT Therapeutics, Inc. | Evolved adenine deaminases and rna-guided nuclease fusion proteins with internal insertion sites and methods of use |
| WO2024127369A1 (en) | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| WO2024127370A1 (en) | 2022-12-16 | 2024-06-20 | LifeEDIT Therapeutics, Inc. | Guide rnas that target trac gene and methods of use |
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| JP2021506251A (ja) * | 2017-12-14 | 2021-02-22 | クリスパー セラピューティクス アーゲー | 新規ｒｎａプログラム可能エンドヌクレアーゼ系、ならびにゲノム編集および他の適用におけるその使用 |
| US20190264232A1 (en) * | 2018-02-23 | 2019-08-29 | Pioneer Hi-Bred International, Inc. | Novel cas9 orthologs |
| US20210172008A1 (en) * | 2018-04-04 | 2021-06-10 | Lifeedit, Inc. | Methods and compositions to identify novel crispr systems |
| SG11202011975WA (en) * | 2018-06-05 | 2020-12-30 | Lifeedit Inc | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| WO2020139873A1 (en) | 2018-12-24 | 2020-07-02 | Virginia Polytechnic Institute And State University | Tollip deficient neutrophils and uses thereof |
| KR20210149686A (ko) * | 2018-12-27 | 2021-12-09 | 라이프에디트 테라퓨틱스, 인크. | 유전자 편집에 유용한 폴리펩티드 및 사용 방법 |
| CN110551762B (zh) * | 2019-08-08 | 2023-03-10 | 复旦大学 | CRISPR/ShaCas9基因编辑系统及其应用 |
| TW202120688A (zh) * | 2019-08-12 | 2021-06-01 | 美商生命編輯公司 | Rna導引之核酸酶及其活性片段及變體以及使用方法 |
-
2021
- 2021-04-19 TW TW110113939A patent/TW202208626A/zh unknown
- 2021-04-23 EP EP21725880.5A patent/EP4118198A1/de active Pending
- 2021-04-23 JP JP2022564464A patent/JP2023516226A/ja active Pending
- 2021-04-23 EP EP23152451.3A patent/EP4242306A3/de active Pending
- 2021-04-23 MX MX2022013187A patent/MX2022013187A/es unknown
- 2021-04-23 BR BR112022021459A patent/BR112022021459A2/pt unknown
- 2021-04-23 IL IL297500A patent/IL297500A/en unknown
- 2021-04-23 AU AU2021258273A patent/AU2021258273A1/en active Pending
- 2021-04-23 CA CA3174124A patent/CA3174124A1/en active Pending
- 2021-04-23 WO PCT/US2021/028843 patent/WO2021217002A1/en active Application Filing
- 2021-04-23 KR KR1020227040633A patent/KR20230014700A/ko active Search and Examination
- 2021-04-23 CN CN202180044771.9A patent/CN116096879A/zh active Pending
-
2022
- 2022-06-28 US US17/851,887 patent/US20230175018A1/en active Pending
- 2022-08-31 US US17/823,897 patent/US11859181B2/en active Active
- 2022-09-01 US US17/929,165 patent/US11981916B2/en active Active
-
2023
- 2023-08-10 US US18/447,947 patent/US20240026384A1/en active Pending
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