JPWO2021186397A5 - - Google Patents
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- JPWO2021186397A5 JPWO2021186397A5 JP2022555955A JP2022555955A JPWO2021186397A5 JP WO2021186397 A5 JPWO2021186397 A5 JP WO2021186397A5 JP 2022555955 A JP2022555955 A JP 2022555955A JP 2022555955 A JP2022555955 A JP 2022555955A JP WO2021186397 A5 JPWO2021186397 A5 JP WO2021186397A5
- Authority
- JP
- Japan
- Prior art keywords
- immune cell
- seq
- receptor
- nucleic acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000002865 immune cell Anatomy 0.000 claims description 78
- -1 CD19a Proteins 0.000 claims description 41
- 102000039446 nucleic acids Human genes 0.000 claims description 40
- 108020004707 nucleic acids Proteins 0.000 claims description 40
- 150000007523 nucleic acids Chemical class 0.000 claims description 40
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 102100038078 CD276 antigen Human genes 0.000 claims description 24
- 102100032816 Integrin alpha-6 Human genes 0.000 claims description 24
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 24
- 102000008115 Signaling Lymphocytic Activation Molecule Family Member 1 Human genes 0.000 claims description 24
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 21
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims description 20
- 102100029197 SLAM family member 6 Human genes 0.000 claims description 20
- 102000010956 Glypican Human genes 0.000 claims description 19
- 108050001154 Glypican Proteins 0.000 claims description 19
- 108050007237 Glypican-3 Proteins 0.000 claims description 19
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims description 17
- 102100024263 CD160 antigen Human genes 0.000 claims description 16
- 101710185679 CD276 antigen Proteins 0.000 claims description 16
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims description 16
- 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 claims description 16
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 16
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims description 16
- 101001035237 Homo sapiens Integrin alpha-D Proteins 0.000 claims description 16
- 101001046687 Homo sapiens Integrin alpha-E Proteins 0.000 claims description 16
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 16
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims description 16
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims description 16
- 101000633782 Homo sapiens SLAM family member 8 Proteins 0.000 claims description 16
- 102100025323 Integrin alpha-1 Human genes 0.000 claims description 16
- 102100032818 Integrin alpha-4 Human genes 0.000 claims description 16
- 102100039904 Integrin alpha-D Human genes 0.000 claims description 16
- 102100022341 Integrin alpha-E Human genes 0.000 claims description 16
- 102100022338 Integrin alpha-M Human genes 0.000 claims description 16
- 102100022297 Integrin alpha-X Human genes 0.000 claims description 16
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 16
- 102100025390 Integrin beta-2 Human genes 0.000 claims description 16
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims description 16
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims description 16
- 108010025832 RANK Ligand Proteins 0.000 claims description 16
- 102000014128 RANK Ligand Human genes 0.000 claims description 16
- 102100029214 SLAM family member 8 Human genes 0.000 claims description 16
- 102100027744 Semaphorin-4D Human genes 0.000 claims description 16
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims description 16
- 239000003446 ligand Substances 0.000 claims description 16
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims description 15
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 15
- 239000013598 vector Substances 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 13
- 102100022339 Integrin alpha-L Human genes 0.000 claims description 12
- 230000004068 intracellular signaling Effects 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- 210000004698 lymphocyte Anatomy 0.000 claims description 11
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 9
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 8
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims description 8
- 101710095183 B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims description 8
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 8
- 108010056102 CD100 antigen Proteins 0.000 claims description 8
- 108010017009 CD11b Antigen Proteins 0.000 claims description 8
- 102100038077 CD226 antigen Human genes 0.000 claims description 8
- 102100027207 CD27 antigen Human genes 0.000 claims description 8
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 8
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 8
- 101150013553 CD40 gene Proteins 0.000 claims description 8
- 108010062802 CD66 antigens Proteins 0.000 claims description 8
- 102100027217 CD82 antigen Human genes 0.000 claims description 8
- 101710139831 CD82 antigen Proteins 0.000 claims description 8
- 102100035793 CD83 antigen Human genes 0.000 claims description 8
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 8
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims description 8
- 102100022086 GRB2-related adapter protein 2 Human genes 0.000 claims description 8
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 8
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 8
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims description 8
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 8
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 8
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims description 8
- 101000900690 Homo sapiens GRB2-related adapter protein 2 Proteins 0.000 claims description 8
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 claims description 8
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims description 8
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims description 8
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 claims description 8
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 claims description 8
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims description 8
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 8
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims description 8
- 101000873418 Homo sapiens P-selectin glycoprotein ligand 1 Proteins 0.000 claims description 8
- 101000633778 Homo sapiens SLAM family member 5 Proteins 0.000 claims description 8
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims description 8
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims description 8
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 8
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims description 8
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 8
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims description 8
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 8
- 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 claims description 8
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 8
- 102000009490 IgG Receptors Human genes 0.000 claims description 8
- 108010073807 IgG Receptors Proteins 0.000 claims description 8
- 108060003951 Immunoglobulin Proteins 0.000 claims description 8
- 108010041100 Integrin alpha6 Proteins 0.000 claims description 8
- 108010030465 Integrin alpha6beta1 Proteins 0.000 claims description 8
- 102100033016 Integrin beta-7 Human genes 0.000 claims description 8
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims description 8
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 8
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 claims description 8
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 8
- 102000027581 NK cell receptors Human genes 0.000 claims description 8
- 108091008877 NK cell receptors Proteins 0.000 claims description 8
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims description 8
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 8
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims description 8
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims description 8
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims description 8
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims description 8
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims description 8
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims description 8
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 claims description 8
- 102100029216 SLAM family member 5 Human genes 0.000 claims description 8
- 102100029198 SLAM family member 7 Human genes 0.000 claims description 8
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims description 8
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 8
- 102100037906 T-cell surface glycoprotein CD3 zeta chain Human genes 0.000 claims description 8
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 8
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims description 8
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 8
- 108010065158 Tumor Necrosis Factor Ligand Superfamily Member 14 Proteins 0.000 claims description 8
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 8
- 102100024586 Tumor necrosis factor ligand superfamily member 14 Human genes 0.000 claims description 8
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims description 8
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 8
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 8
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 8
- 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 claims description 8
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 8
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 8
- 230000004913 activation Effects 0.000 claims description 8
- 102000003675 cytokine receptors Human genes 0.000 claims description 8
- 108010057085 cytokine receptors Proteins 0.000 claims description 8
- 102000018358 immunoglobulin Human genes 0.000 claims description 8
- 102000006495 integrins Human genes 0.000 claims description 8
- 108010044426 integrins Proteins 0.000 claims description 8
- 229920001184 polypeptide Polymers 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 102000005962 receptors Human genes 0.000 claims description 8
- 108020003175 receptors Proteins 0.000 claims description 8
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 8
- 230000000139 costimulatory effect Effects 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 6
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 6
- 230000005865 ionizing radiation Effects 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 5
- 229940124650 anti-cancer therapies Drugs 0.000 claims description 5
- 238000011319 anticancer therapy Methods 0.000 claims description 5
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims description 4
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000031146 intracellular signal transduction Effects 0.000 claims description 4
- 210000000822 natural killer cell Anatomy 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 101710145634 Antigen 1 Proteins 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 208000014018 liver neoplasm Diseases 0.000 claims description 3
- 230000008054 signal transmission Effects 0.000 claims description 3
- 230000002463 transducing effect Effects 0.000 claims description 3
- 230000000735 allogeneic effect Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 102100021317 Inducible T-cell costimulator Human genes 0.000 claims 4
- 101710205775 Inducible T-cell costimulator Proteins 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062991493P | 2020-03-18 | 2020-03-18 | |
| US62/991,493 | 2020-03-18 | ||
| US202063004827P | 2020-04-03 | 2020-04-03 | |
| US63/004,827 | 2020-04-03 | ||
| US202063043237P | 2020-06-24 | 2020-06-24 | |
| US63/043,237 | 2020-06-24 | ||
| PCT/IB2021/052294 WO2021186397A1 (fr) | 2020-03-18 | 2021-03-18 | Compositions de cellules car t gpc3 et leurs procédés de fabrication et d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023518930A JP2023518930A (ja) | 2023-05-09 |
| JPWO2021186397A5 true JPWO2021186397A5 (fr) | 2024-03-29 |
Family
ID=77768047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022555955A Pending JP2023518930A (ja) | 2020-03-18 | 2021-03-18 | Ｇｐｃ３ ｃａｒ－ｔ細胞組成物、並びにそれを作製する方法及び使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230146706A1 (fr) |
| EP (1) | EP4121516A4 (fr) |
| JP (1) | JP2023518930A (fr) |
| KR (1) | KR20220155588A (fr) |
| CN (1) | CN115667500A (fr) |
| WO (1) | WO2021186397A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023518931A (ja) * | 2020-03-18 | 2023-05-09 | ユーティレックス カンパニー リミテッド | Ｉｌ－１８を分泌するｇｐｃ３ ｃａｒ－ｔ細胞、並びにそれを作製する方法及び使用する方法 |
| WO2022197949A2 (fr) | 2021-03-17 | 2022-09-22 | Myeloid Therapeutics, Inc. | Compositions de protéines de fusion chimériques modifiées et leurs méthodes d'utilisation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
| CN104140974B (zh) * | 2013-05-08 | 2017-09-29 | 科济生物医药（上海）有限公司 | 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞 |
| US20170281683A1 (en) * | 2014-09-26 | 2017-10-05 | Baylor College Of Medicine | Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy |
| CN105713881B (zh) * | 2014-12-04 | 2019-12-06 | 科济生物医药（上海）有限公司 | 双靶向gpc3和asgpr1的转基因免疫效应细胞及其应用 |
| JP2019530431A (ja) * | 2016-07-26 | 2019-10-24 | テッサ・セラピューティクス・プライベート・リミテッド | キメラ抗原受容体 |
| TWI780102B (zh) * | 2017-01-10 | 2022-10-11 | 國立大學法人山口大學 | 抗gpc3抗體 |
| CN112469829B (zh) * | 2018-07-17 | 2023-07-07 | 诺伊尔免疫生物科技株式会社 | 包含抗gpc3单链抗体的car |
-
2021
- 2021-03-18 EP EP21771035.9A patent/EP4121516A4/fr active Pending
- 2021-03-18 CN CN202180029132.5A patent/CN115667500A/zh active Pending
- 2021-03-18 WO PCT/IB2021/052294 patent/WO2021186397A1/fr unknown
- 2021-03-18 KR KR1020227035620A patent/KR20220155588A/ko unknown
- 2021-03-18 JP JP2022555955A patent/JP2023518930A/ja active Pending
- 2021-03-18 US US17/906,718 patent/US20230146706A1/en active Pending
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