JPWO2021163186A5 - - Google Patents

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JPWO2021163186A5
JPWO2021163186A5 JP2022548977A JP2022548977A JPWO2021163186A5 JP WO2021163186 A5 JPWO2021163186 A5 JP WO2021163186A5 JP 2022548977 A JP2022548977 A JP 2022548977A JP 2022548977 A JP2022548977 A JP 2022548977A JP WO2021163186 A5 JPWO2021163186 A5 JP WO2021163186A5
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JP
Japan
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composition
ester
deuterated
polyunsaturated fatty
acid
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Pending
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JP2022548977A
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Japanese (ja)
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JP2023513759A (en
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Priority claimed from PCT/US2021/017449 external-priority patent/WO2021163186A1/en
Publication of JP2023513759A publication Critical patent/JP2023513759A/en
Publication of JPWO2021163186A5 publication Critical patent/JPWO2021163186A5/ja
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Claims (17)

有効量の１つ以上の重水素化多価不飽和脂肪酸又はそのエステルを含む局所適用に適した組成物であって、前記重水素化多価不飽和脂肪酸の量は脂質自己酸化を阻害し、それによって皮膚損傷を低減するのに十分である、組成物。 A composition suitable for topical application comprising an effective amount of one or more deuterated polyunsaturated fatty acids or esters thereof, wherein the amount of deuterated polyunsaturated fatty acids inhibits lipid autooxidation; A composition that is sufficient to thereby reduce skin damage. 前記組成物は、化粧品組成物である、請求項１に記載の組成物。 2. The composition of claim 1, wherein the composition is a cosmetic composition. 前記組成物は、スキンケア又は医薬組成物である、請求項１に記載の組成物。 2. A composition according to claim 1, wherein the composition is a skin care or pharmaceutical composition. 前記重水素化多価不飽和脂肪酸又はそのエステルは、重水素化リノール酸又はそのエステルである、請求項１に記載の組成物。 2. The composition according to claim 1, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linoleic acid or ester thereof. 前記重水素化多価不飽和脂肪酸又はそのエステルは、重水素化リノレン酸又はそのエステルである、請求項１に記載の組成物。 The composition according to claim 1, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linolenic acid or an ester thereof. 前記重水素化多価不飽和脂肪酸又はそのエステルは、重水素化リノール酸又はそのエステルと重水素化リノレン酸又はそのエステルとの混合物である、請求項１に記載の組成物。 2. The composition according to claim 1, wherein the deuterated polyunsaturated fatty acid or ester thereof is a mixture of deuterated linoleic acid or ester thereof and deuterated linolenic acid or ester thereof. 前記組成物は、クリーム、軟膏、ローション、ペースト、エモリレント、ペースト、スプレー、又はエマルジョンである、請求項１に記載の組成物。 2. The composition of claim 1, wherein the composition is a cream, ointment, lotion, paste, emollient, paste, spray, or emulsion. 前記多価不飽和脂肪酸又はそのエステルは、約０．１％ｗ／ｗ～約２５％ｗ／ｗの量で存在する、請求項１に記載の組成物。 2. The composition of claim 1, wherein the polyunsaturated fatty acid or ester thereof is present in an amount of about 0.1% w/w to about 25% w/w. ＵＶ吸収剤、保湿剤、酸化防止剤、構造化剤、増粘剤、乳化剤、シリコーン剤、防腐剤、及びさらなる活性医薬成分／活性剤からなる群より選択される１つ以上の成分をさらに含む、請求項１に記載の組成物。 further comprising one or more ingredients selected from the group consisting of UV absorbers, humectants, antioxidants, structurants, thickeners, emulsifiers, silicones, preservatives, and further active pharmaceutical ingredients/active agents. , the composition of claim 1. 患者の皮膚の皮膚分解を低減するための組成物であって、脂質自己酸化及びその後の皮膚の真皮への損傷を阻害するのに有効な量の１種以上の重水素化多価不飽和脂肪酸又はそのエステルを有効な量で含む化粧品又はスキンケア組成物を皮膚に適用することを含む、組成物。 A composition for reducing skin breakdown of the skin of a patient, the composition comprising: an amount of one or more deuterated polyunsaturated fatty acids effective to inhibit lipid autooxidation and subsequent damage to the dermis of the skin; or an ester thereof in an effective amount. 前記組成物は、老化した皮膚の匂いを減衰させる、請求項１０に記載の組成物。 11. The composition of claim 10, wherein the composition attenuates aging skin odor. 前記組成物は、化粧品組成物である、請求項１０に記載の組成物。 11. The composition of claim 10, wherein the composition is a cosmetic composition. 前記組成物は、スキンケア組成物である、請求項１０に記載の組成物。 11. The composition of claim 10, wherein the composition is a skin care composition. 前記重水素化多価不飽和脂肪酸又はそのエステルは、重水素化リノール酸又はそのエステルである、請求項１０に記載の組成物。 11. The composition according to claim 10, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linoleic acid or ester thereof. 前記重水素化多価不飽和脂肪酸又はそのエステルは、重水素化リノレン酸又はそのエステルである、請求項１０に記載の組成物。 11. The composition according to claim 10, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linolenic acid or an ester thereof. 前記重水素化多価不飽和脂肪酸又はそのエステルは、重水素化リノール酸又はそのエステルと重水素化リノレン酸又はそのエステルとの混合物である、請求項１０に記載の組成物。 11. The composition according to claim 10, wherein the deuterated polyunsaturated fatty acid or ester thereof is a mixture of deuterated linoleic acid or ester thereof and deuterated linolenic acid or ester thereof. 前記組成物は、クリーム、軟膏、ローション、ペースト、エモリレント、スプレー、ペースト、又はエマルジョンである、請求項１０に記載の組成物。 11. The composition of claim 10, wherein the composition is a cream, ointment, lotion, paste, emollient, spray, paste, or emulsion.
JP2022548977A 2020-02-12 2021-02-10 Deuterated polyunsaturated fatty acids or esters thereof for cosmetic applications Pending JP2023513759A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062975543P 2020-02-12 2020-02-12
US62/975,543 2020-02-12
PCT/US2021/017449 WO2021163186A1 (en) 2020-02-12 2021-02-10 Deuterated polyunsaturated fatty acids or esters thereof for cosmetic applications

Publications (2)

Publication Number Publication Date
JP2023513759A JP2023513759A (en) 2023-04-03
JPWO2021163186A5 true JPWO2021163186A5 (en) 2024-02-13

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JP2022548977A Pending JP2023513759A (en) 2020-02-12 2021-02-10 Deuterated polyunsaturated fatty acids or esters thereof for cosmetic applications

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US (1) US20210244637A1 (en)
EP (1) EP4103145A1 (en)
JP (1) JP2023513759A (en)
CN (1) CN116472023A (en)
WO (1) WO2021163186A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11510889B2 (en) 2021-02-05 2022-11-29 Retrotope, Inc. Methods for inhibiting the progression of neurodegenerative diseases
US11491130B2 (en) 2021-02-05 2022-11-08 Retrotope, Inc. Methods of treating amyotrophic lateral sclerosis
US20230301956A1 (en) * 2021-12-21 2023-09-28 Biojiva Llc Methods and compositions for treatment of inflammatory disease

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US10052299B2 (en) * 2009-10-30 2018-08-21 Retrotope, Inc. Alleviating oxidative stress disorders with PUFA derivatives
ITMI20130354A1 (en) * 2013-03-08 2014-09-09 Again Life Italia Srl MIXTURE OF FATTY ACIDS (F.A.G. FATTY ACIDS GROUP) FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES.

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