JPWO2021122923A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021122923A5 JPWO2021122923A5 JP2022537353A JP2022537353A JPWO2021122923A5 JP WO2021122923 A5 JPWO2021122923 A5 JP WO2021122923A5 JP 2022537353 A JP2022537353 A JP 2022537353A JP 2022537353 A JP2022537353 A JP 2022537353A JP WO2021122923 A5 JPWO2021122923 A5 JP WO2021122923A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- medicament according
- selenium
- ppm
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000243 solution Substances 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 26
- 229940065287 selenium compound Drugs 0.000 claims 12
- 150000003343 selenium compounds Chemical class 0.000 claims 12
- 239000011669 selenium Substances 0.000 claims 10
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 229940127557 pharmaceutical product Drugs 0.000 claims 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims 4
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 claims 4
- 229960001471 sodium selenite Drugs 0.000 claims 4
- 235000015921 sodium selenite Nutrition 0.000 claims 4
- 239000011781 sodium selenite Substances 0.000 claims 4
- 239000008174 sterile solution Substances 0.000 claims 4
- 230000001954 sterilising effect Effects 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 3
- 206010039921 Selenium deficiency Diseases 0.000 claims 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 3
- 239000001630 malic acid Substances 0.000 claims 3
- 235000011090 malic acid Nutrition 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 150000007524 organic acids Chemical class 0.000 claims 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 229910052804 chromium Inorganic materials 0.000 claims 2
- 239000011651 chromium Substances 0.000 claims 2
- 235000015165 citric acid Nutrition 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000001530 fumaric acid Substances 0.000 claims 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 239000011976 maleic acid Substances 0.000 claims 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 2
- 229910052750 molybdenum Inorganic materials 0.000 claims 2
- 239000011733 molybdenum Substances 0.000 claims 2
- 229940082569 selenite Drugs 0.000 claims 2
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 claims 2
- 229910052711 selenium Inorganic materials 0.000 claims 2
- 229940091258 selenium supplement Drugs 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 239000011975 tartaric acid Substances 0.000 claims 2
- 235000002906 tartaric acid Nutrition 0.000 claims 2
- 239000011573 trace mineral Substances 0.000 claims 2
- 235000013619 trace mineral Nutrition 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 239000004469 amino acid formulation Substances 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000021073 macronutrients Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Claims (30)
a.Se(IV)の形態の少なくとも1種のセレン化合物を液体媒体に溶解して、0.28~28mg/Lのセレン濃度を有する溶液を製造するステップ;
b.場合により、単独でまたはSe(IV)の形態のセレン化合物と一緒に、リンゴ酸、酒石酸、クエン酸、マレイン酸およびフマル酸からなる群から選択される有機酸、および/または亜鉛、鉄、銅、マンガン、クロム、ヨウ素、フッ化物およびモリブデンからなる群から選択される少なくとも1種の追加の微量元素をさらに溶解するステップ;
c.溶液を0.5ppm~8ppmの溶存酸素濃度に調整するステップ;及び
d.溶液を滅菌するステップ
によって調製される、請求項1又は2に記載の患者におけるセレン欠乏症を予防又は是正するための医薬品を調製する方法。 The solution is as follows:
a . dissolving at least one selenium compound in the form of Se(IV) in a liquid medium to produce a solution having a selenium concentration of 0.28 to 28 mg/L;
b. an organic acid selected from the group consisting of malic acid, tartaric acid, citric acid, maleic acid and fumaric acid, and/or zinc, iron, copper, optionally alone or together with selenium compounds in the form of Se(IV); , further dissolving at least one additional trace element selected from the group consisting of , manganese, chromium, iodine, fluoride and molybdenum;
c. adjusting the solution to a dissolved oxygen concentration of 0.5 ppm to 8 ppm; and
d. A method for preparing a medicament for preventing or correcting selenium deficiency in a patient according to claim 1 or 2, which is prepared by the step of sterilizing the solution .
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19217162.7A EP3838278A1 (en) | 2019-12-17 | 2019-12-17 | Stabilization of selenite in a nutritional solution by dissolved oxygen |
EP19217162.7 | 2019-12-17 | ||
PCT/EP2020/086678 WO2021122923A1 (en) | 2019-12-17 | 2020-12-17 | Stabilization of selenite in a nutritional solution by dissolved oxygen |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023507427A JP2023507427A (en) | 2023-02-22 |
JPWO2021122923A5 true JPWO2021122923A5 (en) | 2023-12-26 |
Family
ID=68944315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022537353A Pending JP2023507427A (en) | 2019-12-17 | 2020-12-17 | Stabilization of selenate in nutrient solutions by dissolved oxygen |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230068577A1 (en) |
EP (2) | EP3838278A1 (en) |
JP (1) | JP2023507427A (en) |
CN (1) | CN114845724A (en) |
AU (1) | AU2020406658A1 (en) |
CA (1) | CA3164096A1 (en) |
IL (1) | IL293901B2 (en) |
WO (1) | WO2021122923A1 (en) |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6688081B2 (en) | 2001-12-18 | 2004-02-10 | Schmalbach-Lubeca Ag | Method for reducing headspace gas |
EP1621178A1 (en) * | 2004-07-29 | 2006-02-01 | Fresenius Kabi Deutschland GmbH | Flexible multi-chamber container for the preparation of medical mixed solutions |
US8485727B2 (en) | 2005-08-02 | 2013-07-16 | Baxter International Inc. | Multiple chamber container |
ES2893761T3 (en) * | 2008-12-09 | 2022-02-10 | Warburton Technology Ltd | trace elements |
US20100247935A1 (en) | 2009-03-24 | 2010-09-30 | Baxter International Inc. | Non-pvc films having barrier layer |
CN102511815A (en) * | 2012-01-04 | 2012-06-27 | 江西东荣实业集团有限公司 | Selenium-enriched oral solution and preparation method thereof |
CN103479667B (en) * | 2013-08-23 | 2016-05-11 | 辽宁海思科制药有限公司 | One kind of multiple micro-element injections (II) pharmaceutical composition and preparation method thereof |
CA2971786A1 (en) | 2015-03-31 | 2016-10-06 | Fresenius Kabi Deutschland Gmbh | Emulsions for parenteral administration |
KR20190105737A (en) | 2018-03-06 | 2019-09-18 | 숙명여자대학교산학협력단 | A infusion solution containing fat-soluble vitamins and trace elements |
DE102018205493A1 (en) | 2018-04-11 | 2019-10-17 | B. Braun Melsungen Ag | Process for the preparation of an O / W emulsion, O / W emulsion and apparatus for the production of an O / W emulsion |
CN108498541A (en) * | 2018-06-05 | 2018-09-07 | 百正药业股份有限公司 | The preparation method of one kind of multiple micro-element injections |
-
2019
- 2019-12-17 EP EP19217162.7A patent/EP3838278A1/en not_active Withdrawn
-
2020
- 2020-12-17 AU AU2020406658A patent/AU2020406658A1/en active Pending
- 2020-12-17 WO PCT/EP2020/086678 patent/WO2021122923A1/en active Application Filing
- 2020-12-17 CN CN202080087835.9A patent/CN114845724A/en active Pending
- 2020-12-17 US US17/784,325 patent/US20230068577A1/en active Pending
- 2020-12-17 IL IL293901A patent/IL293901B2/en unknown
- 2020-12-17 JP JP2022537353A patent/JP2023507427A/en active Pending
- 2020-12-17 CA CA3164096A patent/CA3164096A1/en active Pending
- 2020-12-17 EP EP20830178.8A patent/EP4076477A1/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6674364B2 (en) | Method for stabilizing vitamin C after mixing sugar solution and amino acid solution in autoclaved nutrient infusion for peripheral venous administration | |
ES2890523T3 (en) | Stabilized pemetrexed preparation | |
EP2925325B1 (en) | A stabilized pemetrexed formulation | |
JP5828019B2 (en) | Total nutritional fluid | |
EP0253662B1 (en) | Pharmaceutical compositions | |
JP2009507018A5 (en) | ||
CN101081301A (en) | Medicinal composition containing pemetrexed | |
US20220378077A1 (en) | Ready-To-Use Parenteral Nutrition Formulation | |
KR20020081293A (en) | Pharmaceutical Composition Comprising Pemetrexed Together With Monothioglycerol L-Cystein or Thioglycolic Acid | |
WO2015145911A1 (en) | Injection preparation and method for producing same | |
JPWO2021122923A5 (en) | ||
JPS6089428A (en) | Heat treatment of plasma protein | |
JP2019019075A (en) | Liquid pharmaceutical composition containing pemetrexed | |
JPWO2021122925A5 (en) | ||
JP4178563B2 (en) | Two-chamber Vitamin B1 combination nutritional infusion | |
JPH02145523A (en) | Liquid bismuth-containing drug and its manufacture and use | |
KR20240015484A (en) | Injectable formulation with enhanced stability containing dexibuprofen and arginin and their medicine vessel for injection | |
JP7512762B2 (en) | Liquid preparations containing sugammadex | |
CN116251057B (en) | Isosorbide dinitrate injection and preparation method thereof | |
JP2020522564A (en) | Method of making a composition with low dissolved oxygen content, containing acetaminophen and optionally one or more NSAIDs, and composition obtained thereby | |
JP2003055195A (en) | Vitamin b1-formulated comprehensive transfusion for peripheral intravenous administration | |
US20230172806A1 (en) | Multi-chamber bag for parenteral nutrition solutions | |
CN113018443B (en) | Pharmaceutical composition for treating respiratory system diseases and preparation method thereof | |
JP2022035087A (en) | Sugammadex-containing liquid formulation | |
CN116350578A (en) | Stable isoniazid injection and preparation method thereof |