CN108498541A - The preparation method of one kind of multiple micro-element injections - Google Patents
The preparation method of one kind of multiple micro-element injections Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
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- A61K33/18—Iodine; Compounds thereof
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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Abstract
The preparation method of one kind of multiple micro-element injections, prepare saturated solution of the various trace elements in 25 DEG C of water for injection, utilize the characteristic that saturated solution solute concentration is constant, the various trace elements saturated solution of different volumes is measured respectively and is mixed to form micro- mother liquor, activated carbon impurity elimination decoloration and filtration treatment are formed to mother liquor, then complete the operations such as dilution constant volume, filling and sealing, sterilizing.Various trace elements saturated solution is quantitatively formed mother liquor by the present invention, is decolourized to mother liquor, filtration treatment, then dilutes constant volume into injection by mother liquor again.The invention carries out activated carbon adsorption decolorization for mother liquor, and be different from conventional method carries out decolorization for complete soln, and activated carbon usage amount is only the 2 5% of conventional method, and efficiency and benefit greatly improve.
Description
Technical field
The invention belongs to field of medicine preparing technology, and in particular to the preparation method of one kind of multiple micro-element injections.
Background technology
Trace element keeps body eubolism to meeting human nutrition needs and human body biochemical reaction being maintained to be normally carried out
And physiological function plays an important roll.When micro- insufficient, the activity of enzyme can be made to reduce or completely lose, hormone,
Obstacle will occur for the synthesis and metabolism of protein, vitamin etc., and organism metabolism is caused to be lacked of proper care, and severe patient can threat to life.Cause
This, trace element is clinically widely used.
Invention content
Present invention aims at the preparation methods for providing one kind of multiple micro-element injections.
To achieve the above object, technical solution provided by the invention is：The preparation side of one kind of multiple micro-element injections
Method includes the following steps：
The first step：Environment temperature be 25 DEG C under the conditions of, and water for injection temperature be 25 DEG C under the conditions of, prepare chlorination respectively
The saturated solution of zinc, copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide；
Second step：Under the conditions of environment temperature is 25 DEG C, measure respectively zinc chloride saturated solution, copper chloride saturated solution,
Manganese chloride saturated solution, sodium fluoride saturated solution, sodium selenite saturated solution, saturated solution of potassium iodide, then in environment temperature
Under the conditions of 25 DEG C, by zinc chloride saturated solution, copper chloride saturated solution, manganese chloride saturated solution, sodium fluoride saturated solution, Asia
Sodium selenate saturated solution, saturated solution of potassium iodide mixing, form micro- mother liquor；
Third walks：Activated carbon is added in the micro- mother liquor, absorption 10-20min is sufficiently stirred；
4th step：Activated carbon adsorption is handled by the way of three-stage filtration processing treated micro- mother liquor；
The first order filters, and processing is filtered to micro- mother liquor using the apertures 100-120mm filter paper；
The second level is filtered, and processing is filtered to the micro- mother liquor after by-pass filtration using the apertures 1-3mm filter paper；
The third level is filtered, and place is filtered to the micro- mother liquor after secondary filtration using 0.22-0.3 μm of aperture filter membrane
Reason；
5th step：The filtered micro- mother liquor of the third level, addition water for injection and constant volume are collected to 500L, mixing is equal
It is even；
6th step：Up to multi-microelement injecta after filling and sealing and sterilizing.
Preferably technical solution is：When filling and sealing in freestanding environment region, environment temperature is 24~26 DEG C, relatively wet
Degree is 45%~65%.
Preferably technical solution is：There is the pressure difference more than or equal to 10Pa between freestanding environment region and external environment.
Preferably technical solution is：Injection after filling and sealing sterilizes 12-15min using 121 DEG C of steam insulations.
Since above-mentioned technical proposal is used, the present invention this have the advantage that compared with prior art：
1, the present invention utilizes the characteristics of saturated solution constant concentration, and the constant volume of micro-element injection is more quick, precisely
Spend higher.
2, various trace elements saturated solution is quantitatively formed mother liquor by the present invention, is decolourized to mother liquor, filtration treatment, so
Constant volume is diluted into injection by mother liquor again afterwards.The invention carries out activated carbon adsorption decolorization for mother liquor, is different from routine side
Method carries out decolorization for complete soln, and activated carbon usage amount is only the 2-5% of conventional method, and efficiency and benefit carry significantly
It is high.
3, the present invention is filtered processing for mother liquor, and place is filtered for complete soln different from conventional method
Reason, efficiency greatly improve.
Specific implementation mode
Illustrate that embodiments of the present invention, those skilled in the art can be by this explanations by particular specific embodiment below
Content disclosed by book understands other advantages and effect of the present invention easily.
Embodiment one：The preparation method of one kind of multiple micro-element injections
The preparation method of one kind of multiple micro-element injections, which is characterized in that prepare various trace elements and noted at 25 DEG C
It penetrates and measures the lot of trace of different volumes respectively using the characteristic that saturated solution solute concentration is constant with the saturated solution in water
Element saturated solution is simultaneously mixed to form micro- mother liquor (abbreviation mother liquor), is formed at activated carbon impurity elimination decoloration and filtering to mother liquor
Then reason completes the operations such as dilution constant volume, filling and sealing, sterilizing.
The preparation method of one kind of multiple micro-element injections, which is characterized in that the various trace elements are chlorination
Zinc, copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide.
The preparation method of one kind of multiple micro-element injections, which is characterized in that the preparation method includes following step
Suddenly：Micro- saturated solution is prepared, saturated solution measures, be mixed to form mother liquor, impurity elimination decoloration, three-stage filtration, dilution constant volume,
Filling and sealing and sterilizing.The specific method is as follows.
(1) micro- saturated solution is prepared
Under the conditions of 25 DEG C of environment temperature, 25 DEG C of water for injection temperature, zinc chloride, copper chloride, manganese chloride, fluorine are prepared respectively
Change the saturated solution of sodium, sodium selenite, potassium iodide；The saturated solution of each trace element, to there is a small amount of insoluble crystal settling
It is to prepare the discrimination standard completed in solution bottom.
(2) saturated solution measures
Precision is measured with 0.1ml, measures zinc chloride saturated solution 60.0ml, copper chloride saturated solution 35.5ml, fluorine respectively
Change sodium saturated solution 1465.0ml；Precision is got with 0.01ml, it is full to measure manganese chloride saturated solution 2.50ml, sodium selenite respectively
With solution 3.50ml, saturated solution of potassium iodide 0.50ml；It is spare.
(3) it is mixed to form mother liquor
The saturation of the zinc chloride measured in second step, copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide is molten
Liquid, ingredient mixes under 25 DEG C of environment temperatures, forms the micro- mother liquor (abbreviation mother liquor) that volume is 1567ml.
(4) impurity elimination is decolourized
With 0.01g weighing accuracies, 1.50g medicinal carbons are weighed, are added in mother liquor, is sufficiently stirred absorption 10-
20min。
(5) three-stage filtration
Activated carbon adsorption treated mother liquor is handled by three-stage filtration.
By-pass filtration is filtered processing using the apertures 100-120mm filter paper to mother liquor.
Secondary filtration is filtered processing using the apertures 1-3mm filter paper to the mother liquor after by-pass filtration.
Three-stage filtration is filtered processing using 0.22-0.3 μm of aperture filter membrane to the mother liquor after secondary filtration.
(6) constant volume is diluted
The mother liquor after three-stage filtration is collected, simultaneously constant volume is sufficiently mixed, shakes up to 500L addition water for injection, spare.
(7) filling and sealing and sterilizing
Filling and sealing is freestanding environment region, it is desirable that temperature is 25 ± 1 DEG C, and relative humidity is 45%~65%, relative to
Other environmental areas are remained above the pressure difference equal to 10Pa.The container filling of injection uses ampere bottle, every bottle of filling amount control
In 10.0~10.5ml.Using electronic filling and sealing machine is filling and sealing, sealing answer it is smooth, it is non-carbonized, begin to crop up, flat head, gas leakage etc. it is existing
As.
Injection after filling and sealing sterilizes 12-15min using 121 DEG C of steam insulations.
Remarks：
Zinc chloride (ZnCl2), solubility 432g/100mL (25 DEG C, water)
Copper chloride (CuCl2·2H2O), solubility 75.7g/100mL (25 DEG C)
Manganese chloride (MnCl2·4H2O), solubility is 77.2g (25 DEG C)
Sodium fluoride (NaF), solubility are 4.3g (25 DEG C)
Sodium selenite (Na2SeO3·5H2O), solubility is 95.0g (25 DEG C)
Potassium iodide (KI), solubility 127.6g (25.0 DEG C)
Trace element volume when 500L injections are prepared：Zinc chloride saturated solution 60.0ml；Copper chloride saturated solution
35.5ml；Manganese chloride saturated solution 2.5ml；Sodium fluoride saturated solution 1465.0m；Sodium selenite saturated solution 3.5ml；Potassium iodide
Saturated solution 0.5ml；Remaining supplies volume with medical grade purified water.
Embodiment two：The preparation method of one kind of multiple micro-element injections
The preparation method of one kind of multiple micro-element injections, includes the following steps：
The first step：Environment temperature be 25 DEG C under the conditions of, and water for injection temperature be 25 DEG C under the conditions of, prepare chlorination respectively
The saturated solution of zinc, copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide；
Second step：Under the conditions of environment temperature is 25 DEG C, measure respectively zinc chloride saturated solution, copper chloride saturated solution,
Manganese chloride saturated solution, sodium fluoride saturated solution, sodium selenite saturated solution, saturated solution of potassium iodide, then in environment temperature
Under the conditions of 25 DEG C, by zinc chloride saturated solution, copper chloride saturated solution, manganese chloride saturated solution, sodium fluoride saturated solution, Asia
Sodium selenate saturated solution, saturated solution of potassium iodide mixing, form micro- mother liquor；
Third walks：Activated carbon is added in the micro- mother liquor, absorption 10min is sufficiently stirred；
4th step：Activated carbon adsorption is handled by the way of three-stage filtration processing treated micro- mother liquor；
The first order filters, and processing is filtered to micro- mother liquor using the apertures 100mm filter paper；
The second level is filtered, and processing is filtered to the micro- mother liquor after by-pass filtration using the apertures 1mm filter paper；
The third level is filtered, and processing is filtered to the micro- mother liquor after secondary filtration using 0.22 μm of aperture filter membrane；
5th step：The filtered micro- mother liquor of the third level, addition water for injection and constant volume are collected to 500L, mixing is equal
It is even；
6th step：Up to multi-microelement injecta after filling and sealing and sterilizing.
Preferably technical solution is：When filling and sealing in freestanding environment region, environment temperature is 24 DEG C, and relative humidity is
45%.
Preferably technical solution is：There is the pressure difference more than or equal to 10Pa between freestanding environment region and external environment, just
To pressure difference, i.e. freestanding environment region is more than external environment 10Pa.
Preferably technical solution is：Injection after filling and sealing sterilizes 12min using 121 DEG C of steam insulations.
Embodiment three：The preparation method of one kind of multiple micro-element injections
The preparation method of one kind of multiple micro-element injections, includes the following steps：
The first step：Environment temperature be 25 DEG C under the conditions of, and water for injection temperature be 25 DEG C under the conditions of, prepare chlorination respectively
The saturated solution of zinc, copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide；
Second step：Under the conditions of environment temperature is 25 DEG C, measure respectively zinc chloride saturated solution, copper chloride saturated solution,
Manganese chloride saturated solution, sodium fluoride saturated solution, sodium selenite saturated solution, saturated solution of potassium iodide, then in environment temperature
Under the conditions of 25 DEG C, by zinc chloride saturated solution, copper chloride saturated solution, manganese chloride saturated solution, sodium fluoride saturated solution, Asia
Sodium selenate saturated solution, saturated solution of potassium iodide mixing, form micro- mother liquor；
Third walks：Activated carbon is added in the micro- mother liquor, absorption 20min is sufficiently stirred；
4th step：Activated carbon adsorption is handled by the way of three-stage filtration processing treated micro- mother liquor；
The first order filters, and processing is filtered to micro- mother liquor using the apertures 120mm filter paper；
The second level is filtered, and processing is filtered to the micro- mother liquor after by-pass filtration using the apertures 3mm filter paper；
The third level is filtered, and processing is filtered to the micro- mother liquor after secondary filtration using 0.3 μm of aperture filter membrane；
5th step：The filtered micro- mother liquor of the third level, addition water for injection and constant volume are collected to 500L, mixing is equal
It is even；
6th step：Up to multi-microelement injecta after filling and sealing and sterilizing.
Preferably technical solution is：When filling and sealing in freestanding environment region, environment temperature is 26 DEG C, and relative humidity is
65%.
Preferably technical solution is：There is the pressure difference more than or equal to 10Pa between freestanding environment region and external environment.
Preferably technical solution is：Injection after filling and sealing sterilizes 15min using 121 DEG C of steam insulations.
Example IV：The preparation method of one kind of multiple micro-element injections
The preparation method of one kind of multiple micro-element injections, includes the following steps：
The first step：Environment temperature be 25 DEG C under the conditions of, and water for injection temperature be 25 DEG C under the conditions of, prepare chlorination respectively
The saturated solution of zinc, copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide；
Second step：Under the conditions of environment temperature is 25 DEG C, measure respectively zinc chloride saturated solution, copper chloride saturated solution,
Manganese chloride saturated solution, sodium fluoride saturated solution, sodium selenite saturated solution, saturated solution of potassium iodide, then in environment temperature
Under the conditions of 25 DEG C, by zinc chloride saturated solution, copper chloride saturated solution, manganese chloride saturated solution, sodium fluoride saturated solution, Asia
Sodium selenate saturated solution, saturated solution of potassium iodide mixing, form micro- mother liquor；
Third walks：Activated carbon is added in the micro- mother liquor, absorption 15min is sufficiently stirred；
4th step：Activated carbon adsorption is handled by the way of three-stage filtration processing treated micro- mother liquor；
The first order filters, and processing is filtered to micro- mother liquor using the apertures 110mm filter paper；
The second level is filtered, and processing is filtered to the micro- mother liquor after by-pass filtration using the apertures 2mm filter paper；
The third level is filtered, and processing is filtered to the micro- mother liquor after secondary filtration using 0.26 μm of aperture filter membrane；
5th step：The filtered micro- mother liquor of the third level, addition water for injection and constant volume are collected to 500L, mixing is equal
It is even；
6th step：Up to multi-microelement injecta after filling and sealing and sterilizing.
Preferably technical solution is：When filling and sealing in freestanding environment region, environment temperature is 25 DEG C, and relative humidity is
55%.
Preferably technical solution is：There is the pressure difference more than or equal to 10Pa between freestanding environment region and external environment.
Preferably technical solution is：Injection after filling and sealing sterilizes 14min using 121 DEG C of steam insulations.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should by the present invention claim be covered.
Claims (4)
1. the preparation method of one kind of multiple micro-element injections, it is characterised in that：Include the following steps：
The first step：Environment temperature be 25 DEG C under the conditions of, and water for injection temperature be 25 DEG C under the conditions of, respectively prepare zinc chloride,
The saturated solution of copper chloride, manganese chloride, sodium fluoride, sodium selenite, potassium iodide；
Second step：Under the conditions of environment temperature is 25 DEG C, zinc chloride saturated solution, copper chloride saturated solution, chlorination are measured respectively
Then manganese saturated solution, sodium fluoride saturated solution, sodium selenite saturated solution, saturated solution of potassium iodide are 25 in environment temperature
Under the conditions of DEG C, by zinc chloride saturated solution, copper chloride saturated solution, manganese chloride saturated solution, sodium fluoride saturated solution, selenous acid
Sodium saturated solution, saturated solution of potassium iodide mixing, form micro- mother liquor；
Third walks：Activated carbon is added in the micro- mother liquor, absorption 10-20min is sufficiently stirred；
4th step：Activated carbon adsorption is handled by the way of three-stage filtration processing treated micro- mother liquor；
The first order filters, and processing is filtered to micro- mother liquor using the apertures 100-120mm filter paper；
The second level is filtered, and processing is filtered to the micro- mother liquor after by-pass filtration using the apertures 1-3mm filter paper；
The third level is filtered, and processing is filtered to the micro- mother liquor after secondary filtration using 0.22-0.3 μm of aperture filter membrane；
5th step：The filtered micro- mother liquor of the third level is collected, simultaneously constant volume is uniformly mixed addition water for injection to 500L；
6th step：Up to multi-microelement injecta after filling and sealing and sterilizing.
2. the preparation method of multi-microelement injecta according to claim 1, it is characterised in that：When filling and sealing
In freestanding environment region, environment temperature is 24 ~ 26 DEG C, and relative humidity is 45%~65%.
3. the preparation method of multi-microelement injecta according to claim 2, it is characterised in that：Freestanding environment region
There is the pressure difference more than or equal to 10Pa between external environment.
4. the preparation method of multi-microelement injecta according to claim 1, it is characterised in that：After filling and sealing
Injection sterilizes 12-15min using 121 DEG C of steam insulations.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114845724A (en) * | 2019-12-17 | 2022-08-02 | 巴克斯特国际公司 | Stabilization of selenite in nutrient solution by dissolved oxygen |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1517085A (en) * | 2003-01-15 | 2004-08-04 | 华瑞制药有限公司 | Multi-microelement injecta and its preparation method and application |
| CN1682760A (en) * | 2004-04-13 | 2005-10-19 | 魏秀华 | Multiple micro element for injection and preparing method |
| CN1685902A (en) * | 2005-05-08 | 2005-10-26 | 颜怀玮 | Liposoluble composite vitamin micro element and essential fatty acid and nutritive type edible oil and manufacturing method |
| CN102526103A (en) * | 2010-12-07 | 2012-07-04 | 西藏海思科药业集团股份有限公司 | Multi-trace element injection and preparation method thereof |
| CN104027305A (en) * | 2014-06-04 | 2014-09-10 | 回音必集团(江西)东亚制药有限公司 | Mannitol injection |
-
2018
- 2018-06-05 CN CN201810568503.7A patent/CN108498541A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1517085A (en) * | 2003-01-15 | 2004-08-04 | 华瑞制药有限公司 | Multi-microelement injecta and its preparation method and application |
| CN1682760A (en) * | 2004-04-13 | 2005-10-19 | 魏秀华 | Multiple micro element for injection and preparing method |
| CN1685902A (en) * | 2005-05-08 | 2005-10-26 | 颜怀玮 | Liposoluble composite vitamin micro element and essential fatty acid and nutritive type edible oil and manufacturing method |
| CN102526103A (en) * | 2010-12-07 | 2012-07-04 | 西藏海思科药业集团股份有限公司 | Multi-trace element injection and preparation method thereof |
| CN104027305A (en) * | 2014-06-04 | 2014-09-10 | 回音必集团(江西)东亚制药有限公司 | Mannitol injection |
Non-Patent Citations (2)
| Title |
|---|
| 周小雅主编: "《制剂工艺与艺术》", 31 August 2006, 中国医药科技出版社 * |
| 广西卫生学校药学教研组编: "《药剂学》", 29 April 1975 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114845724A (en) * | 2019-12-17 | 2022-08-02 | 巴克斯特国际公司 | Stabilization of selenite in nutrient solution by dissolved oxygen |
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