JPWO2021064072A5 - - Google Patents
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- JPWO2021064072A5 JPWO2021064072A5 JP2022520171A JP2022520171A JPWO2021064072A5 JP WO2021064072 A5 JPWO2021064072 A5 JP WO2021064072A5 JP 2022520171 A JP2022520171 A JP 2022520171A JP 2022520171 A JP2022520171 A JP 2022520171A JP WO2021064072 A5 JPWO2021064072 A5 JP WO2021064072A5
- Authority
- JP
- Japan
- Prior art keywords
- valve
- pharmaceutical composition
- agonist
- composition according
- biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Claims (12)
- それを必要とする患者において大動脈弁の石灰化を後退、予防、又は遅延させるための、治療有効量のレチノイン酸受容体（ＲＡＲ）アゴニストを含む医薬組成物。
- 弁が病的大動脈弁である、請求項１記載の医薬組成物。
- 患者が、石灰化大動脈弁疾患を患う、請求項２記載の医薬組成物。
- 弁が生体弁である、請求項１記載の医薬組成物。
- インプラントされた生体弁の変性を予防するための、請求項４記載の医薬組成物。
- 外科的弁置換術後又は経カテーテル大動脈弁留置術（ＴＡＶＩ）後のいずれかに、生体弁の石灰化を遅延させる又は予防するための、請求項４記載の医薬組成物。
- ＲＡＲアゴニストがＲＡＲαアゴニストである、請求項１記載の医薬組成物。
- ＲＡＲαアゴニストが、ＴＴＮＰＢ、タミバロテン、９－cis－レチノイン酸、trans－レチノイン酸、ＡＧＮ１９３８３６、Ｒｏ ４０－６０５５、ＣＤ６６６、及び４－［［（５，６，７，８－テトラヒドロ－５，５，８，８－テトラメチル－２－ナフタレニル）アミノ］カルボニル］安息香酸（ＡＭ８０）からなる群より選択される、請求項７記載の医薬組成物。
- 生体弁の調製のための、ＲＡＲアゴニストを含む医薬組成物。
- ＲＡＲアゴニストを含む、生体弁。
- ＲＡＲアゴニストが、弁尖に封入されている、請求項１０記載の生体弁。
- 大動脈弁狭窄症の処置のための、請求項１０記載の生体弁。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19306256 | 2019-10-02 | ||
| EP19306256.9 | 2019-10-02 | ||
| PCT/EP2020/077456 WO2021064072A1 (en) | 2019-10-02 | 2020-10-01 | Use of retinoic acid receptor (rar) agonists for reversing, preventing, or delaying calcification of aortic valve |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022550432A JP2022550432A (ja) | 2022-12-01 |
| JPWO2021064072A5 true JPWO2021064072A5 (ja) | 2023-10-02 |
Family
ID=68296410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520171A Pending JP2022550432A (ja) | 2019-10-02 | 2020-10-01 | 大動脈弁の石灰化を後退、予防、又は遅延させるためのレチノイン酸受容体（ｒａｒ）アゴニストの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220339322A1 (ja) |
| EP (1) | EP4037672A1 (ja) |
| JP (1) | JP2022550432A (ja) |
| WO (1) | WO2021064072A1 (ja) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807900A (en) | 1995-03-31 | 1998-09-15 | Hoffmann-La Roche, Inc. | Method for identifying compounds having increased activity for the repair of skin photodamage |
| US6218128B1 (en) | 1997-09-12 | 2001-04-17 | Allergan Sales, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
| FR2741878B1 (fr) | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en ortho, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| FR2741876B1 (fr) | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| FR2750426B1 (fr) | 1996-06-28 | 1998-08-07 | Cird Galderma | Nouveaux composes biaryles heterocycliques et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique |
| FR2757852B1 (fr) | 1996-12-31 | 1999-02-19 | Cird Galderma | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
| FR2763588B1 (fr) | 1997-05-23 | 1999-07-09 | Cird Galderma | Composes triaromatiques, compositions les contenant et utilisations |
| FR2764604B1 (fr) | 1997-06-13 | 1999-09-10 | Cird Galderma | Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant |
| FR2767525B1 (fr) | 1997-08-21 | 1999-11-12 | Cird Galderma | Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant |
| FR2863266B1 (fr) | 2003-12-08 | 2006-01-27 | Galderma Res & Dev | NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINES HUMAINE AINSI QU'EN COSMETIQUE |
| PL1831149T3 (pl) | 2004-12-23 | 2012-06-29 | Galderma Res & Dev | Nowe ligandy, które modulują receptory RAR, i ich zastosowanie w medycynie i kosmetyce |
-
2020
- 2020-10-01 WO PCT/EP2020/077456 patent/WO2021064072A1/en unknown
- 2020-10-01 JP JP2022520171A patent/JP2022550432A/ja active Pending
- 2020-10-01 EP EP20780717.3A patent/EP4037672A1/en active Pending
- 2020-10-01 US US17/760,568 patent/US20220339322A1/en active Pending
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