JPWO2021026247A5 - - Google Patents
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- Publication number
- JPWO2021026247A5 JPWO2021026247A5 JP2022507561A JP2022507561A JPWO2021026247A5 JP WO2021026247 A5 JPWO2021026247 A5 JP WO2021026247A5 JP 2022507561 A JP2022507561 A JP 2022507561A JP 2022507561 A JP2022507561 A JP 2022507561A JP WO2021026247 A5 JPWO2021026247 A5 JP WO2021026247A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mir
- subject
- administering
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005855 radiation Effects 0.000 claims 4
- 206010073306 Exposure to radiation Diseases 0.000 claims 2
- VPVOXUSPXFPWBN-UHFFFAOYSA-N L-sepiapterin Natural products N1=C(N)NC(=O)C2=C1NCC(C(=O)C(O)C)=N2 VPVOXUSPXFPWBN-UHFFFAOYSA-N 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 108091028606 miR-1 stem-loop Proteins 0.000 claims 2
- 108091045790 miR-106b stem-loop Proteins 0.000 claims 2
- -1 miR-335-3p Proteins 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- VPVOXUSPXFPWBN-VKHMYHEASA-N sepiapterin Chemical compound N1C(N)=NC(=O)C2=C1NCC(C(=O)[C@@H](O)C)=N2 VPVOXUSPXFPWBN-VKHMYHEASA-N 0.000 claims 2
- 229940126478 sepiapterin Drugs 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000001395 Acute radiation syndrome Diseases 0.000 claims 1
- 206010048610 Cardiotoxicity Diseases 0.000 claims 1
- 102100030393 G-patch domain and KOW motifs-containing protein Human genes 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- FEMXZDUTFRTWPE-DZSWIPIPSA-N L-erythro-7,8-dihydrobiopterin Chemical compound N1C(N)=NC(=O)C2=C1NCC([C@@H](O)[C@@H](O)C)=N2 FEMXZDUTFRTWPE-DZSWIPIPSA-N 0.000 claims 1
- 206010061924 Pulmonary toxicity Diseases 0.000 claims 1
- 206010068142 Radiation sickness syndrome Diseases 0.000 claims 1
- 101710168938 Sphingosine-1-phosphate phosphatase 2 Proteins 0.000 claims 1
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 1
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 231100000259 cardiotoxicity Toxicity 0.000 claims 1
- 230000007681 cardiovascular toxicity Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 108091045440 let-7a-1 stem-loop Proteins 0.000 claims 1
- 108091047626 let-7a-2 stem-loop Proteins 0.000 claims 1
- 108091047557 let-7a-3 stem-loop Proteins 0.000 claims 1
- 108091073704 let-7c stem-loop Proteins 0.000 claims 1
- 108091081439 let-7c-1 stem-loop Proteins 0.000 claims 1
- 108091062190 let-7c-2 stem-loop Proteins 0.000 claims 1
- 108091064407 let-7c-3 stem-loop Proteins 0.000 claims 1
- 108091033753 let-7d stem-loop Proteins 0.000 claims 1
- 108091079176 let-7d-1 stem-loop Proteins 0.000 claims 1
- 108091036331 let-7d-2 stem-loop Proteins 0.000 claims 1
- 108091043994 let-7g stem-loop Proteins 0.000 claims 1
- 108091042844 let-7i stem-loop Proteins 0.000 claims 1
- 108091043251 let-7i-1 stem-loop Proteins 0.000 claims 1
- 108091078001 let-7i-2 stem-loop Proteins 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 108091064157 miR-106a stem-loop Proteins 0.000 claims 1
- 108091041195 miR-106a-1 stem-loop Proteins 0.000 claims 1
- 108091051053 miR-106a-2 stem-loop Proteins 0.000 claims 1
- 108091023084 miR-126 stem-loop Proteins 0.000 claims 1
- 108091065272 miR-126-1 stem-loop Proteins 0.000 claims 1
- 108091081187 miR-126-2 stem-loop Proteins 0.000 claims 1
- 108091030790 miR-126-3 stem-loop Proteins 0.000 claims 1
- 108091092317 miR-126-4 stem-loop Proteins 0.000 claims 1
- 108091079016 miR-133b Proteins 0.000 claims 1
- 108091043162 miR-133b stem-loop Proteins 0.000 claims 1
- 108091047467 miR-136 stem-loop Proteins 0.000 claims 1
- 108091031326 miR-15b stem-loop Proteins 0.000 claims 1
- 108091027943 miR-16 stem-loop Proteins 0.000 claims 1
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims 1
- 108091056204 miR-16-2 stem-loop Proteins 0.000 claims 1
- 108091027698 miR-18-1 stem-loop Proteins 0.000 claims 1
- 108091090961 miR-18-2 stem-loop Proteins 0.000 claims 1
- 108091049641 miR-181-1 stem-loop Proteins 0.000 claims 1
- 108091053227 miR-181a-1 stem-loop Proteins 0.000 claims 1
- 108091092591 miR-181a-2 stem-loop Proteins 0.000 claims 1
- 108091085286 miR-181a-3 stem-loop Proteins 0.000 claims 1
- 108091032770 miR-451 stem-loop Proteins 0.000 claims 1
- 108091030646 miR-451a stem-loop Proteins 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 231100000374 pneumotoxicity Toxicity 0.000 claims 1
- 230000007047 pulmonary toxicity Effects 0.000 claims 1
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 claims 1
- 229960004617 sapropterin Drugs 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025029508A JP2025098011A (ja) | 2019-08-05 | 2025-02-26 | 放射線曝露を処置するためのセピアプテリン及びその代謝産物の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962882937P | 2019-08-05 | 2019-08-05 | |
| US62/882,937 | 2019-08-05 | ||
| PCT/US2020/045026 WO2021026247A1 (en) | 2019-08-05 | 2020-08-05 | Use of sepiapterin and metabolites thereof to treat radiation exposure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025029508A Division JP2025098011A (ja) | 2019-08-05 | 2025-02-26 | 放射線曝露を処置するためのセピアプテリン及びその代謝産物の使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022543655A JP2022543655A (ja) | 2022-10-13 |
| JP2022543655A5 JP2022543655A5 (https=) | 2023-08-15 |
| JPWO2021026247A5 true JPWO2021026247A5 (https=) | 2023-08-15 |
| JP7642611B2 JP7642611B2 (ja) | 2025-03-10 |
Family
ID=72148243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022507561A Active JP7642611B2 (ja) | 2019-08-05 | 2020-08-05 | 放射線曝露を処置するためのセピアプテリン及びその代謝産物の使用 |
| JP2025029508A Pending JP2025098011A (ja) | 2019-08-05 | 2025-02-26 | 放射線曝露を処置するためのセピアプテリン及びその代謝産物の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025029508A Pending JP2025098011A (ja) | 2019-08-05 | 2025-02-26 | 放射線曝露を処置するためのセピアプテリン及びその代謝産物の使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20220273661A1 (https=) |
| EP (2) | EP4454712A3 (https=) |
| JP (2) | JP7642611B2 (https=) |
| CN (2) | CN119837879A (https=) |
| AU (1) | AU2020324435B2 (https=) |
| BR (1) | BR112022002029A2 (https=) |
| CA (1) | CA3146477A1 (https=) |
| DK (1) | DK4009978T3 (https=) |
| ES (1) | ES2994060T3 (https=) |
| FI (1) | FI4009978T3 (https=) |
| HR (1) | HRP20241653T1 (https=) |
| HU (1) | HUE069012T2 (https=) |
| IL (1) | IL290321B1 (https=) |
| LT (1) | LT4009978T (https=) |
| MX (1) | MX2022001535A (https=) |
| PL (1) | PL4009978T3 (https=) |
| PT (1) | PT4009978T (https=) |
| RS (1) | RS66096B1 (https=) |
| SI (1) | SI4009978T1 (https=) |
| SM (1) | SMT202500089T1 (https=) |
| WO (1) | WO2021026247A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11072614B2 (en) | 2016-11-29 | 2021-07-27 | Ptc Therapeutics Mp, Inc. | Polymorphs of sepiapterin and salts thereof |
| US11130760B2 (en) | 2016-11-29 | 2021-09-28 | Ptc Therapeutics Mp, Inc. | Polymorphic form of sepiapterin |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| EP3801536B1 (en) | 2018-05-30 | 2024-07-17 | PTC Therapeutics MP, Inc. | Administration of sepiapterin without food for use in a method for increasing sepiapterin plasma exposure |
| CN112654356A (zh) | 2018-05-30 | 2021-04-13 | Ptc医疗Mp公司 | 增加四氢生物蝶呤血浆暴露的组合物和方法 |
| IL290321B1 (en) * | 2019-08-05 | 2026-04-01 | Ptc Therapeutics Inc | Use of spiapterin and its metabolites for radiation exposure treatment |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910304A (en) | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| US6036949A (en) | 1998-03-05 | 2000-03-14 | Amarillo Biosciences, Inc. | Treatment of fibromyalgia with low doses of interferon |
| EP1696877A4 (en) | 2003-11-13 | 2010-06-09 | Gen Hospital Corp | PROCESS FOR PAIN TREATMENT |
| WO2006055511A2 (en) | 2004-11-17 | 2006-05-26 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
| TWI359019B (en) * | 2006-08-14 | 2012-03-01 | Merck Eprova Ag | Use of folates for the prevention and treatment of |
| KR20160068776A (ko) | 2013-09-13 | 2016-06-15 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 방사선 효과의 완화 및 예방을 위한 조성물의 제조 및 용도 |
| WO2016054458A1 (en) | 2014-10-02 | 2016-04-07 | Cytosorbents Corporation | Use of gastroinstestinally administered porous enteron sorbent polymers to prevent or treat radiation induced mucositis, esophagitis, enteritis, colitis, and gastrointestinal acute radiation syndrome |
| US11130760B2 (en) | 2016-11-29 | 2021-09-28 | Ptc Therapeutics Mp, Inc. | Polymorphic form of sepiapterin |
| US11072614B2 (en) | 2016-11-29 | 2021-07-27 | Ptc Therapeutics Mp, Inc. | Polymorphs of sepiapterin and salts thereof |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| AU2019277372B2 (en) | 2018-05-30 | 2024-12-19 | Ptc Therapeutics Mp, Inc. | Pharmaceutically acceptable salts of sepiapterin |
| IL290321B1 (en) * | 2019-08-05 | 2026-04-01 | Ptc Therapeutics Inc | Use of spiapterin and its metabolites for radiation exposure treatment |
| CN110354133A (zh) * | 2019-08-26 | 2019-10-22 | 鞍山市肿瘤医院 | 四氢生物蝶呤的应用及药物 |
-
2020
- 2020-08-04 IL IL290321A patent/IL290321B1/en unknown
- 2020-08-05 CA CA3146477A patent/CA3146477A1/en active Pending
- 2020-08-05 EP EP24187395.9A patent/EP4454712A3/en active Pending
- 2020-08-05 CN CN202411691224.1A patent/CN119837879A/zh active Pending
- 2020-08-05 FI FIEP20758407.9T patent/FI4009978T3/fi active
- 2020-08-05 PL PL20758407.9T patent/PL4009978T3/pl unknown
- 2020-08-05 CN CN202080069308.5A patent/CN114555090B/zh active Active
- 2020-08-05 EP EP20758407.9A patent/EP4009978B1/en active Active
- 2020-08-05 HR HRP20241653TT patent/HRP20241653T1/hr unknown
- 2020-08-05 AU AU2020324435A patent/AU2020324435B2/en active Active
- 2020-08-05 HU HUE20758407A patent/HUE069012T2/hu unknown
- 2020-08-05 WO PCT/US2020/045026 patent/WO2021026247A1/en not_active Ceased
- 2020-08-05 ES ES20758407T patent/ES2994060T3/es active Active
- 2020-08-05 PT PT207584079T patent/PT4009978T/pt unknown
- 2020-08-05 SI SI202030521T patent/SI4009978T1/sl unknown
- 2020-08-05 RS RS20241189A patent/RS66096B1/sr unknown
- 2020-08-05 LT LTEPPCT/US2020/045026T patent/LT4009978T/lt unknown
- 2020-08-05 SM SM20250089T patent/SMT202500089T1/it unknown
- 2020-08-05 US US17/631,995 patent/US20220273661A1/en active Pending
- 2020-08-05 MX MX2022001535A patent/MX2022001535A/es unknown
- 2020-08-05 BR BR112022002029A patent/BR112022002029A2/pt unknown
- 2020-08-05 JP JP2022507561A patent/JP7642611B2/ja active Active
- 2020-08-05 DK DK20758407.9T patent/DK4009978T3/da active
-
2025
- 2025-02-26 JP JP2025029508A patent/JP2025098011A/ja active Pending
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