MX2022001535A - Uso de sepiapterina y metabolitos de los mismos para tratar la exposicion a radiacion. - Google Patents

Uso de sepiapterina y metabolitos de los mismos para tratar la exposicion a radiacion.

Info

Publication number
MX2022001535A
MX2022001535A MX2022001535A MX2022001535A MX2022001535A MX 2022001535 A MX2022001535 A MX 2022001535A MX 2022001535 A MX2022001535 A MX 2022001535A MX 2022001535 A MX2022001535 A MX 2022001535A MX 2022001535 A MX2022001535 A MX 2022001535A
Authority
MX
Mexico
Prior art keywords
sepiapterin
radiation exposure
metabolites
treat radiation
treat
Prior art date
Application number
MX2022001535A
Other languages
English (en)
Inventor
Neil Smith
Eleonora Mezzaroma
Christopher Rabender
Ross Mikkelsen
Vasily Yakovlev
Original Assignee
Ptc Therapeutics Mp Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Mp Inc filed Critical Ptc Therapeutics Mp Inc
Publication of MX2022001535A publication Critical patent/MX2022001535A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La invención proporciona métodos para tratar la exposición a radiación en un sujeto por administrar sepiapterina, tetrahidrobiopterina o dihidrobiopterina.
MX2022001535A 2019-08-05 2020-08-05 Uso de sepiapterina y metabolitos de los mismos para tratar la exposicion a radiacion. MX2022001535A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962882937P 2019-08-05 2019-08-05
PCT/US2020/045026 WO2021026247A1 (en) 2019-08-05 2020-08-05 Use of sepiapterin and metabolites thereof to treat radiation exposure

Publications (1)

Publication Number Publication Date
MX2022001535A true MX2022001535A (es) 2022-03-04

Family

ID=72148243

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001535A MX2022001535A (es) 2019-08-05 2020-08-05 Uso de sepiapterina y metabolitos de los mismos para tratar la exposicion a radiacion.

Country Status (10)

Country Link
US (1) US20220273661A1 (es)
EP (1) EP4009978A1 (es)
JP (1) JP2022543655A (es)
CN (1) CN114555090A (es)
AU (1) AU2020324435A1 (es)
BR (1) BR112022002029A2 (es)
CA (1) CA3146477A1 (es)
IL (1) IL290321A (es)
MX (1) MX2022001535A (es)
WO (1) WO2021026247A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122021026889A8 (pt) 2016-11-29 2022-11-22 Censa Pharmaceuticals Inc Formas cristalinas de base livre de sepiapterina e de sais dos mesmos, seu método de preparação, composições que as compreendem, uso dos mesmos e método de preparação de uma formulação líquida
WO2019046849A1 (en) 2017-09-01 2019-03-07 Censa Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING SEPAPTERINE AND USES THEREOF
US11617752B2 (en) 2018-05-30 2023-04-04 Ptc Therapeutics Mp, Inc. Methods for increasing sepiapterin plasma exposure

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910304A (en) 1982-12-13 1999-06-08 Texas A&M University System Low-dose oral administration of interferons
CA1320905C (en) 1986-11-06 1993-08-03 Joseph M. Cummins Treatment of immuno-resistant disease
US6036949A (en) 1998-03-05 2000-03-14 Amarillo Biosciences, Inc. Treatment of fibromyalgia with low doses of interferon
TWI359019B (en) * 2006-08-14 2012-03-01 Merck Eprova Ag Use of folates for the prevention and treatment of
MX2019006207A (es) 2016-11-29 2019-11-18 Censa Pharmaceuticals Inc Forma polimorfica de sepiapterina.
BR122021026889A8 (pt) 2016-11-29 2022-11-22 Censa Pharmaceuticals Inc Formas cristalinas de base livre de sepiapterina e de sais dos mesmos, seu método de preparação, composições que as compreendem, uso dos mesmos e método de preparação de uma formulação líquida
WO2019046849A1 (en) 2017-09-01 2019-03-07 Censa Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING SEPAPTERINE AND USES THEREOF
JP2021527031A (ja) 2018-05-30 2021-10-11 ピーティーシー セラピューティクス エムピー，インコーポレイテッド セピアプテリンの薬学的に許容される塩
CN110354133A (zh) * 2019-08-26 2019-10-22 鞍山市肿瘤医院 四氢生物蝶呤的应用及药物

Also Published As

Publication number Publication date
BR112022002029A2 (pt) 2022-06-07
US20220273661A1 (en) 2022-09-01
AU2020324435A1 (en) 2022-02-24
WO2021026247A1 (en) 2021-02-11
EP4009978A1 (en) 2022-06-15
IL290321A (en) 2022-04-01
CA3146477A1 (en) 2021-02-11
JP2022543655A (ja) 2022-10-13
CN114555090A (zh) 2022-05-27

Similar Documents

Publication Publication Date Title
PH12020551923A1 (en) Methods and compositions for treating cancer
MX2022001535A (es) Uso de sepiapterina y metabolitos de los mismos para tratar la exposicion a radiacion.
MX2020012797A (es) Anticuerpos biespecificos anti-pvrig/anti-tigit y métodos de uso.
MX2019013072A (es) Formulaciones de anticuerpos anti-lag3 y coformulaciones de anticuerpos anti-lag3 y anticuerpos anti-pd-1.
PH12019501575A1 (en) ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFá1 INHIBITORS AND USE THEREOF
WO2018022668A3 (en) NEUROMODULATORY COMPOSITIONS AND ASSOCIATED METHODS OF TREATING CANCER
MX2021004828A (es) Uso de antagonistas contra muerte programada 1 (pd-1) y ligando de muerte programada 1 (pd-l1) en combinacion con radioterapia.
MX2019002750A (es) Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer.
MX2019007276A (es) Composiciones y métodos para mejora o aumento de la producción de ifn tipo i.
MX2023001527A (es) Compuestos con actividad inductora de ferroptosis y metodos de uso de estos.
MX2017000408A (es) Compuestos antiproliferativos y métodos de uso de los mismos.
MX2019012464A (es) Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl.
GEP20237519B (en) Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer
WO2019040106A3 (en) COMPOUNDS, RELATED SALTS AND METHODS FOR THE TREATMENT OF DISEASES
CR20200334A (es) Compuestos, composiciones y métodos para tratar enfermedades que involucren tejidos con enfermedades ácidas o hipóxicas
MX2022007994A (es) Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.
MX2019003134A (es) Terapia de combinacion.
BR112017026061A2 (pt) composto, uso de um composto, e, método de tratamento de uma infecção viral
MX2019012465A (es) Terapia combinada con un conjugado de anticuerpo y farmaco anti-cd25.
MY201580A (en) Use of ezh2 inhibitor combined with btk inhibitor in preparing drug for treating tumor
MX2020012979A (es) Métodos para aumentar la exposición al plasma de sepiapterina.
PH12020552059A1 (en) Dosing regimen for the treatment of pi3k related disorders
MY186475A (en) Pyridazine derivatives for use in the prevention or treatment of an ataxic disorder
MX2021001612A (es) Compuestos utiles en terapia del vih.
MX2021014905A (es) Células seguras e invisibles para el sistema inmunitario.