JPWO2021022173A5 - - Google Patents
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- Publication number
- JPWO2021022173A5 JPWO2021022173A5 JP2022506331A JP2022506331A JPWO2021022173A5 JP WO2021022173 A5 JPWO2021022173 A5 JP WO2021022173A5 JP 2022506331 A JP2022506331 A JP 2022506331A JP 2022506331 A JP2022506331 A JP 2022506331A JP WO2021022173 A5 JPWO2021022173 A5 JP WO2021022173A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- lipids
- immune cell
- sterols
- ionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Claims (1)
- 免疫細胞送達脂質ナノ粒子であって、
（ｉ）イオン性脂質と、
（ｉｉ）ステロールまたは他の構造的脂質と、
（ｉｉｉ）非カチオン性ヘルパー脂質またはリン脂質と、
（ｉｖ）ＲＮＡ干渉剤と、
（ｖ）所望により、ＰＥＧ脂質と、を含み、
（ｉ）前記イオン性脂質、または（ｉｉ）前記ステロールもしくは他の構造的脂質のうちの１つ以上が、免疫細胞への前記脂質ナノ粒子の送達を増強するのに有効な量の免疫細胞送達強化脂質を含む、前記免疫細胞送達脂質ナノ粒子。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962881279P | 2019-07-31 | 2019-07-31 | |
| US62/881,279 | 2019-07-31 | ||
| PCT/US2020/044535 WO2021022173A1 (en) | 2019-07-31 | 2020-07-31 | Compositions and methods for delivery of rna interference agents to immune cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022543773A JP2022543773A (ja) | 2022-10-14 |
| JPWO2021022173A5 true JPWO2021022173A5 (ja) | 2023-08-08 |
Family
ID=72088399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506331A Pending JP2022543773A (ja) | 2019-07-31 | 2020-07-31 | 免疫細胞へのｒｎａ干渉剤の送達のための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220280639A1 (ja) |
| EP (1) | EP4003296A1 (ja) |
| JP (1) | JP2022543773A (ja) |
| AU (1) | AU2020319876A1 (ja) |
| CA (1) | CA3149386A1 (ja) |
| WO (1) | WO2021022173A1 (ja) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3112941A1 (en) * | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Sterol analogs and uses thereof |
| CA3114699A1 (en) | 2018-10-09 | 2020-04-16 | The University Of British Columbia | Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto |
| AU2021385572A1 (en) | 2020-11-25 | 2023-06-22 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| IL309505A (en) | 2021-09-03 | 2024-02-01 | CureVac SE | Lipid nanoparticles for nucleic acid delivery |
| WO2023064469A1 (en) * | 2021-10-13 | 2023-04-20 | Modernatx, Inc. | Compositions of mrna-encoded il15 fusion proteins and methods of use thereof |
| WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| WO2023144330A1 (en) | 2022-01-28 | 2023-08-03 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| WO2023148303A1 (de) * | 2022-02-02 | 2023-08-10 | Mslsolutions Gmbh | Verfahren zur medikament- und impfstoffherstellung |
| WO2023227608A1 (en) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| CN115286674A (zh) * | 2022-06-13 | 2022-11-04 | 湖北英纳氏生物科技有限公司 | 一种阳离子脂质体及其制备方法 |
| WO2023245177A2 (en) * | 2022-06-17 | 2023-12-21 | The University Of Chicago | Targeted nanomedicine for treating lung disorders |
| WO2023246218A1 (zh) * | 2022-06-20 | 2023-12-28 | 成都威斯津生物医药科技有限公司 | 用于核酸递送的可电离脂质及其组合物 |
| WO2024026475A1 (en) * | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
| WO2024064206A1 (en) * | 2022-09-20 | 2024-03-28 | Emory University | Lipid nanoparticles comprising nucleic acids encoding therapeutic genes and uses in medical methods |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| CN116143707B (zh) * | 2023-02-24 | 2024-04-19 | 山东大学 | 一种碱基可电离脂质及其制备方法与应用 |
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| AU2010259984B2 (en) | 2009-06-10 | 2017-03-09 | Arbutus Biopharma Corporation | Improved lipid formulation |
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| US8691750B2 (en) * | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| US10821175B2 (en) | 2014-02-25 | 2020-11-03 | Merck Sharp & Dohme Corp. | Lipid nanoparticle vaccine adjuvants and antigen delivery systems |
| RS63848B1 (sr) * | 2014-06-25 | 2023-01-31 | Acuitas Therapeutics Inc | Novi lipidi i formulacije lipidnih nanočestica za isporuku nukleinskih kiselina |
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| JP7030690B2 (ja) | 2015-10-28 | 2022-03-07 | アキィタス・セラピューティクス・インコーポレイテッド | 核酸のデリバリーのための新規脂質および脂質ナノ粒子製剤 |
| AU2016366978B2 (en) | 2015-12-10 | 2022-07-28 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
| CA3089117A1 (en) * | 2018-01-30 | 2019-08-08 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| AU2019338535A1 (en) * | 2018-09-14 | 2021-04-15 | Modernatx, Inc. | Methods and compositions for treating cancer using mRNA therapeutics |
-
2020
- 2020-07-31 US US17/631,216 patent/US20220280639A1/en active Pending
- 2020-07-31 CA CA3149386A patent/CA3149386A1/en active Pending
- 2020-07-31 EP EP20757469.0A patent/EP4003296A1/en active Pending
- 2020-07-31 AU AU2020319876A patent/AU2020319876A1/en active Pending
- 2020-07-31 JP JP2022506331A patent/JP2022543773A/ja active Pending
- 2020-07-31 WO PCT/US2020/044535 patent/WO2021022173A1/en unknown
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