FR2692265B1
(fr)
|
1992-05-25 |
1996-11-08 |
Centre Nat Rech Scient |
Composes biologiquement actifs de type phosphotriesters.
|
FR2705099B1
(fr)
|
1993-05-12 |
1995-08-04 |
Centre Nat Rech Scient |
Oligonucléotides phosphorothioates triesters et procédé de préparation.
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
IL135000A0
(en)
|
1997-09-12 |
2001-05-20 |
Exiqon As |
Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues
|
DE60044241D1
(de)
|
1999-03-18 |
2010-06-02 |
Exiqon As |
Xylo-lna analoge
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
JP4383176B2
(ja)
|
2002-02-13 |
2009-12-16 |
武 今西 |
ヌクレオシド類縁体およびそのヌクレオチド類縁体を含むオリゴヌクレオチド誘導体
|
MXPA05001837A
(es)
|
2002-08-14 |
2005-04-19 |
Pharmacia Corp |
Modulacion de polaridad opuesta de la expresion de la acil-coa sintetasa 1.
|
PT2284266E
(pt)
|
2002-11-14 |
2013-12-17 |
Thermo Fisher Scient Biosciences Inc |
Siarn contra tp53
|
US20070141009A1
(en)
|
2003-01-03 |
2007-06-21 |
Shaharyar Khan |
Sirna mediated post-transriptional gene silencing of genes involved in alopecia
|
DK1661905T3
(da)
|
2003-08-28 |
2012-07-23 |
Takeshi Imanishi |
Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype
|
FR2894582B1
(fr)
*
|
2005-12-12 |
2008-02-22 |
Fabre Pierre Dermo Cosmetique |
Sirna anti myosine va et depigmentation de la peau
|
EP2019692B1
(en)
|
2006-05-05 |
2014-06-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of gccr
|
ES2611924T3
(es)
|
2006-10-03 |
2017-05-11 |
Arbutus Biopharma Corporation |
Formulaciones que contienen lípidos
|
JP5429884B2
(ja)
|
2007-11-28 |
2014-02-26 |
国立大学法人 東京医科歯科大学 |
内因性カイロミクロンを利用した、標的遺伝子の発現を抑制する核酸のデリバリーシステム
|
JP2011505798A
(ja)
|
2007-12-07 |
2011-03-03 |
サンタリス ファーマ アー/エス |
Mcl−1を調節するためのRNAアンタゴニスト化合物
|
ES2605618T3
(es)
|
2008-03-31 |
2017-03-15 |
National Institute Of Advanced Industrial Science And Technology |
ARN de doble cadena, modificado con lípidos con elevado efecto de interferencia por ARN
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
DK2279254T3
(en)
|
2008-04-15 |
2017-09-18 |
Protiva Biotherapeutics Inc |
PRESENT UNKNOWN LIPID FORMS FOR NUCLEIC ACID ADMINISTRATION
|
JP2010184879A
(ja)
|
2009-02-10 |
2010-08-26 |
Univ Of Tokyo |
抗筋萎縮剤
|
WO2011052436A1
(ja)
|
2009-10-29 |
2011-05-05 |
国立大学法人大阪大学 |
架橋型人工ヌクレオシドおよびヌクレオチド
|
EP2327783A1
(en)
|
2009-11-27 |
2011-06-01 |
Universitätsklinikum Freiburg |
Pharmaceutical composition comprising miRNA-100 and its use in the modulation of blood vessel growth
|
ES2893199T3
(es)
|
2010-03-29 |
2022-02-08 |
Alnylam Pharmaceuticals Inc |
Terapia de ARNbc para amiloidosis ocular relacionada con transtiretina (TTR)
|
CA2801342A1
(en)
|
2010-06-04 |
2011-12-08 |
Eric N. Olson |
Regulation of metabolism by mir-378
|
AU2011302152B2
(en)
|
2010-09-15 |
2015-06-11 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
SG10201912170WA
(en)
|
2011-11-18 |
2020-02-27 |
Alnylam Pharmaceuticals Inc |
Rnai Agents, Compositions And Methods Of Use Thereof For Treating Transthyretin (TTR) Associated Diseases
|
CA2856289A1
(en)
|
2011-11-18 |
2013-05-23 |
Alnylam Pharmaceuticals, Inc. |
Modified rnai agents
|
JP2015502365A
(ja)
*
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
EP2791335B1
(en)
|
2011-12-16 |
2018-11-14 |
National University Corporation Tokyo Medical and Dental University |
Chimeric double-stranded nucleic acid
|
KR20220028183A
(ko)
|
2012-04-25 |
2022-03-08 |
사노피 |
마이크로rna 화합물 및 mir-21 활성 조절 방법
|
US9163235B2
(en)
|
2012-06-21 |
2015-10-20 |
MiRagen Therapeutics, Inc. |
Inhibitors of the miR-15 family of micro-RNAs
|
US20150337002A1
(en)
|
2013-01-15 |
2015-11-26 |
Shionogi & Co., Ltd. |
Nucleoside and nucleotide having sulfonamide structure
|
EP2957567B1
(en)
|
2013-02-18 |
2019-06-05 |
Shionogi & Co., Ltd. |
Nucleoside and nucleotide, having nitrogen-containing hetercycle structure
|
WO2015105083A1
(ja)
|
2014-01-07 |
2015-07-16 |
塩野義製薬株式会社 |
アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド
|
EP3137606A4
(en)
|
2014-05-01 |
2018-04-25 |
Larry J. Smith |
METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
|
US10264976B2
(en)
*
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
EP3603648A4
(en)
|
2017-03-29 |
2020-12-30 |
Shionogi & Co., Ltd |
COMPLEX OF NUCLEIC ACID MEDICINAL AND MULTI-BRANCHED LIPID
|