JPWO2021012018A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021012018A5 JPWO2021012018A5 JP2022505207A JP2022505207A JPWO2021012018A5 JP WO2021012018 A5 JPWO2021012018 A5 JP WO2021012018A5 JP 2022505207 A JP2022505207 A JP 2022505207A JP 2022505207 A JP2022505207 A JP 2022505207A JP WO2021012018 A5 JPWO2021012018 A5 JP WO2021012018A5
- Authority
- JP
- Japan
- Prior art keywords
- tautomer
- alkyl
- pharmaceutically acceptable
- solvate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 25
- 239000012453 solvate Substances 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 101150027068 DEGS1 gene Proteins 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 102100037416 Sphingolipid delta(4)-desaturase DES1 Human genes 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005347 halocycloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025100363A JP2025134819A (ja) | 2019-07-24 | 2025-06-16 | 阻害剤化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2019902614 | 2019-07-24 | ||
| AU2019902614A AU2019902614A0 (en) | 2019-07-24 | Inhibitor compounds | |
| PCT/AU2020/050763 WO2021012018A1 (en) | 2019-07-24 | 2020-07-24 | Inhibitor compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025100363A Division JP2025134819A (ja) | 2019-07-24 | 2025-06-16 | 阻害剤化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022542140A JP2022542140A (ja) | 2022-09-29 |
| JP2022542140A5 JP2022542140A5 (https=) | 2023-07-31 |
| JPWO2021012018A5 true JPWO2021012018A5 (https=) | 2023-07-31 |
Family
ID=74192564
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022505207A Pending JP2022542140A (ja) | 2019-07-24 | 2020-07-24 | 阻害剤化合物 |
| JP2025100363A Pending JP2025134819A (ja) | 2019-07-24 | 2025-06-16 | 阻害剤化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025100363A Pending JP2025134819A (ja) | 2019-07-24 | 2025-06-16 | 阻害剤化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12448371B2 (https=) |
| EP (1) | EP4003986A4 (https=) |
| JP (2) | JP2022542140A (https=) |
| KR (1) | KR20220041843A (https=) |
| CN (1) | CN114450281B (https=) |
| AU (1) | AU2020316243A1 (https=) |
| BR (1) | BR112022001270A2 (https=) |
| CA (1) | CA3144506A1 (https=) |
| IL (1) | IL290087B1 (https=) |
| MX (1) | MX2022000845A (https=) |
| WO (1) | WO2021012018A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202213792D0 (en) * | 2022-09-21 | 2022-11-02 | Benevolentai Bio Ltd | New compounds and method |
| US11912675B1 (en) | 2023-10-11 | 2024-02-27 | King Faisal University | N'-(2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio)acetoxy)-3,4-dimethoxybenzimidamide as an antimicrobial compound |
| US11919872B1 (en) | 2023-10-11 | 2024-03-05 | King Faisal University | N′-(2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio)acetoxy)benzimidamide as an antimicrobial compound |
| US11891366B1 (en) | 2023-10-12 | 2024-02-06 | King Faisal University | 4-methoxy-n′-(2-(5-phenyl-1,3,4-oxadiazol-2-ylthio)acetoxy)benzimidamide as an antimicrobial compound |
| US11999706B1 (en) | 2023-10-13 | 2024-06-04 | King Faisal University | 4-chloro-N′-(2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio)acetoxy)benzimidamide as an antimicrobial compound |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2923661A (en) | 1957-03-22 | 1960-02-02 | Irwin Neisler And Co | N-[2-(1-phenyl-propyl)]-2, 2, 2-trichloroethylidenimine |
| US5684018A (en) | 1994-12-13 | 1997-11-04 | Merck & Co., Inc. | Acyloxyisopropyl carbamates as prodrugs for amine drugs |
| FI982268L (fi) | 1998-10-20 | 2000-04-21 | Tomi Jaervinen | Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen uudet pro drugit, niiden valmistus ja käyttö |
| EP2162427A1 (en) * | 2007-05-22 | 2010-03-17 | Novartis Ag | Benzamides useful as s1p receptor modulators |
| WO2012164103A2 (en) | 2011-06-03 | 2012-12-06 | Universität Zürich | Blockers of the nogo-a s1pr pathway for the treatment of diseases characterized by neuronal damage and lack of subsequent repair |
| US20170165230A1 (en) * | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| AU2015281799B2 (en) * | 2014-06-26 | 2019-11-28 | Central Adelaide Local Health Network Incorporated | Enzyme interacting agents |
| US11135207B2 (en) * | 2016-12-13 | 2021-10-05 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
| CN108079303A (zh) | 2017-12-14 | 2018-05-29 | 广东药科大学 | 鞘氨醇激酶抑制剂在制备治疗肝纤维化药物中的应用 |
-
2020
- 2020-07-24 CA CA3144506A patent/CA3144506A1/en active Pending
- 2020-07-24 AU AU2020316243A patent/AU2020316243A1/en active Pending
- 2020-07-24 WO PCT/AU2020/050763 patent/WO2021012018A1/en not_active Ceased
- 2020-07-24 BR BR112022001270A patent/BR112022001270A2/pt unknown
- 2020-07-24 MX MX2022000845A patent/MX2022000845A/es unknown
- 2020-07-24 US US17/629,218 patent/US12448371B2/en active Active
- 2020-07-24 CN CN202080066385.5A patent/CN114450281B/zh active Active
- 2020-07-24 JP JP2022505207A patent/JP2022542140A/ja active Pending
- 2020-07-24 KR KR1020227003262A patent/KR20220041843A/ko active Pending
- 2020-07-24 EP EP20843975.2A patent/EP4003986A4/en active Pending
-
2022
- 2022-01-24 IL IL290087A patent/IL290087B1/en unknown
-
2025
- 2025-06-16 JP JP2025100363A patent/JP2025134819A/ja active Pending
- 2025-09-08 US US19/322,461 patent/US20260001870A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2019100164A (ru) | Гетероциклическое соединение, используемое как ингибитор fgfr | |
| JP2010523653A5 (https=) | ||
| RU2004117887A (ru) | Ариланилиновые агонисты бета2 адренергических рецепторов | |
| JP2017504642A5 (https=) | ||
| JPWO2020061101A5 (https=) | ||
| JPWO2023099623A5 (https=) | ||
| JP2014532716A5 (https=) | ||
| JP2020122016A5 (https=) | ||
| JP2022137237A5 (https=) | ||
| JP2021510733A5 (https=) | ||
| CN111601797A (zh) | 苯并哌啶或杂芳基并哌啶类衍生物、其制备方法及其在医药上的应用 | |
| JPWO2020131674A5 (https=) | ||
| JPWO2020061255A5 (https=) | ||
| JP2006516626A5 (https=) | ||
| JPWO2021012018A5 (https=) | ||
| JP2024112835A5 (https=) | ||
| JP2017137323A (ja) | 新規抗がん剤 | |
| JPWO2020033520A5 (https=) | ||
| JPWO2021129653A5 (https=) | ||
| JPWO2021071821A5 (https=) | ||
| JPWO2020033514A5 (https=) | ||
| JP2017532299A5 (https=) | ||
| JP2021521179A5 (https=) | ||
| JPWO2020252383A5 (https=) | ||
| JPWO2022122988A5 (https=) |