JPWO2021003152A5 - - Google Patents

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Publication number
JPWO2021003152A5
JPWO2021003152A5 JP2021577914A JP2021577914A JPWO2021003152A5 JP WO2021003152 A5 JPWO2021003152 A5 JP WO2021003152A5 JP 2021577914 A JP2021577914 A JP 2021577914A JP 2021577914 A JP2021577914 A JP 2021577914A JP WO2021003152 A5 JPWO2021003152 A5 JP WO2021003152A5
Authority
JP
Japan
Prior art keywords
rodent
immunoglobulin
sequences
bovine
transgenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021577914A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022538885A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/040290 external-priority patent/WO2021003152A1/fr
Publication of JP2022538885A publication Critical patent/JP2022538885A/ja
Publication of JPWO2021003152A5 publication Critical patent/JPWO2021003152A5/ja
Pending legal-status Critical Current

Links

JP2021577914A 2019-07-01 2020-06-30 トランスジェニック哺乳動物およびその使用法 Pending JP2022538885A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962869415P 2019-07-01 2019-07-01
US62/869,415 2019-07-01
PCT/US2020/040290 WO2021003152A1 (fr) 2019-07-01 2020-06-30 Mammifères transgéniques et leurs procédés d'utilisation

Publications (2)

Publication Number Publication Date
JP2022538885A JP2022538885A (ja) 2022-09-06
JPWO2021003152A5 true JPWO2021003152A5 (fr) 2023-07-07

Family

ID=71846497

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021577914A Pending JP2022538885A (ja) 2019-07-01 2020-06-30 トランスジェニック哺乳動物およびその使用法

Country Status (9)

Country Link
US (1) US20220369609A1 (fr)
EP (1) EP3993623A1 (fr)
JP (1) JP2022538885A (fr)
KR (1) KR20220025839A (fr)
CN (1) CN114554841B (fr)
AU (1) AU2020298458A1 (fr)
CA (1) CA3144958A1 (fr)
IL (1) IL289469A (fr)
WO (1) WO2021003152A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3476942T3 (da) 2017-10-27 2022-04-19 Trianni Inc Lange kimlinje-dh-gener og antistoffer med lang hcdr3
CA3216988A1 (fr) * 2021-05-05 2022-11-10 Werner Mueller Rongeurs transgeniques exprimant des anticorps chimeriques de rongeurs-equins et leurs methodes d'utilisation
CN118056006A (zh) 2021-10-01 2024-05-17 雅伯希勒拉生物公司 用于细胞系鉴定和富集的转基因啮齿动物
CN118265449A (zh) * 2021-11-10 2024-06-28 特里安尼公司 转基因哺乳动物及其使用方法
WO2023090361A1 (fr) * 2021-11-16 2023-05-25 国立大学法人鳥取大学 Vecteur chromosomique artificiel de mammifère ayant un locus de chaîne lourde d'immunoglobuline humaine contenant une région d modifiée, et cellule ou animal non humain contenant ledit vecteur

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293460C (fr) 1985-10-07 1991-12-24 Brian Lee Sauer Recombinaison a des sites specifiques de l'adn dans les levures
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
GB8904009D0 (en) 1989-02-22 1989-04-05 Celltech Ltd Vector
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6689610B1 (en) 1989-08-22 2004-02-10 University Of Utah Research Foundation Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5612205A (en) 1990-08-29 1997-03-18 Genpharm International, Incorporated Homologous recombination in mammalian cells
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
WO1992015694A1 (fr) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Modification de genes induite par recombinase dans des cellules de mammifere, compositions et cellules utiles a cet effet
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
US5593598A (en) 1994-04-20 1997-01-14 Mcginness; Michael P. Method and apparatus for closed loop recycling of contaminated cleaning solution
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
CA2273194C (fr) 1996-12-03 2011-02-01 Abgenix, Inc. Mammiferes transgeniques possedant des loci de genes d'immunoglobuline dorigine humaine, dotes de regions vh et vk, et anticorps produits a partir de tels mammiferes
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CA2584814A1 (fr) * 2004-10-22 2006-05-04 Therapeutic Human Polyclonals, Inc. Suppression de l'expression d'immunoglobulines endogenes
US7422889B2 (en) 2004-10-29 2008-09-09 Stowers Institute For Medical Research Dre recombinase and recombinase systems employing Dre recombinase
JP5827127B2 (ja) * 2008-12-18 2015-12-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
BR112012032991B1 (pt) * 2010-06-22 2021-08-10 Regeneron Pharmaceuticals, Inc Método para preparar um anticorpo que se liga a um antígeno de interesse
US10793829B2 (en) * 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
MX356429B (es) * 2011-12-20 2018-05-29 Regeneron Pharma Ratones con cadena ligera humanizada.
US9788534B2 (en) * 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
RU2021129958A (ru) * 2016-11-04 2021-11-02 Регенерон Фармасьютикалс, Инк. Отличные от человека животные со сконструированным локусом легкой лямбда-цепи иммуноглобулина
BR112020011184A2 (pt) * 2017-12-05 2020-11-17 Regeneron Pharmaceuticals, Inc. roedor geneticamente modificado, células de roedor isolada, célula imortalizada, embrião de roedor, uso de um roedor, célula b isolada, anticorpo preparado por um método, métodos para produzir um roedor geneticamente modificado, um anticorpo, uma cadeia pesada totalmente humana ou uma cadeia leve totalmente humana, uma sequência nucleotídica, para gerar uma ¿ sequência de domínio variável de cadeia pesada ou leve humana e gerar uma ¿ sequência da região variável de cadeia pesada ou leve humana, célula-tronco embrionária, célula es de roedor, e, célula es isolada de roedor.

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