JPWO2020252002A5

JPWO2020252002A5 -

Info

Publication number: JPWO2020252002A5
Application number: JP2021573872A
Authority: JP
Publication date: 2023-06-19
Anticipated expiration: 2040-06-10

Claims

an ionization source,
A multipole rod assembly configured to provide each of a magnetic field and a radio frequency field from said multipole rod assembly within an ion volume formed by a substantially parallel arrangement of rods of said multipole rod assembly. a multi-pole rod assembly;
an electron source configured to provide electrons within the ion volume of the multipole rod assembly to ionize an analyte introduced within the ion volume;
an electron reflector positioned collinearly with the electron source and configured to receive electrons from the electron source.

an enclosure surrounding the multipole rod assembly or internal to the multipole rod assembly, the enclosure fluidly coupled to the electron source at an inlet such that the electrons from the electron source pass through the inlet; 2. The ionization source of claim 1, comprising an opening that allows for entry into said ion volume.

further comprising an ionization block comprising an entrance opening and an exit opening, wherein a longitudinal axis of each rod of said multipole rod assembly is substantially parallel to a longitudinal axis of said ionization block, said entrance opening comprising: fluidly coupled to the ionization volume to allow introduction of electrons into the ionization volume through the entrance opening to ionize an analyte within the ionization volume, the exit opening being connected to the ionization block; 2. The ionization source of claim 1, configured to allow ionized analytes to exit from.

2. The ionization source of claim 1, further comprising an electron repeller collinear with said electron source.

2. The ionization source of Claim 1, wherein the multipole rod assembly comprises at least four rods.

2. The ionization source of claim 1, wherein the multipole rod assembly comprises one of a quadrupole rod assembly, a hexapole rod assembly, an octapole rod assembly, a decapole rod assembly or a dodecole rod assembly.

2. The ionization source of claim 1, wherein each rod of the multipole rod assembly comprises magnetizable material, each rod being magnetized to provide equivalent field strength.

When each rod of the multipole rod assembly comprises a magnetizable material and at least one rod of the multipole assembly is magnetized with the at least one rod and another rod of the multipole rod assembly 2. The ionization source of claim 1, providing a different field strength to said another rod.

the multipole rod assembly comprising a plurality of rods, the multipole rod assembly configured to operate in a quadrupole mode using four of the plurality of rods, the multipole rod assembly comprising: configured to operate in a sextupole mode using six of the plurality of rods, wherein the multipole rod assembly operates in an octapole mode using eight of the plurality of rods 2. The ionization source of claim 1, configured to:

2. The multipole assembly of claim 1, wherein at least one rod of the multipole assembly has a different length than another rod of the multipole assembly or is non-parallel to another rod of the multipole rod assembly. ionization source.

2. The ionization source of claim 1, wherein the cross-sectional width of at least one rod of said multipole rod assembly varies along the length of said at least one rod.

4. The shape of each rod of said multipole rod assembly is independently conical, round, tapered, square, rectangular, triangular, trapezoidal, parabolic, hyperbolic or other geometric shape. 2. The ionization source according to 1.

13. The ionization source of claim 12, wherein at least two rods of said multipole rod assembly comprise different shapes.

A mass spectrometer,
an ionization source,
A multipole rod assembly configured to provide each of a magnetic field and a radio frequency field from said multipole rod assembly within an ion volume formed by a substantially parallel arrangement of rods of said multipole rod assembly. a multi-pole rod assembly;
an electron source fluidly coupled to the ion volume of the multipole rod assembly for providing electrons from the electron source into the ion volume to ionize an analyte introduced into the ion volume; source and
an ionization source comprising an electron reflector positioned collinearly with the electron source and configured to receive electrons from the electron source;
a mass analyzer fluidly coupled to the ion volume and configured to receive ionized analytes exiting the ion volume.

further comprising a processor electrically coupled to a power source, the processor configured to provide a radio frequency voltage from the power source to rods of the multi-pole rod assembly to provide the radio frequency field; 15. A mass spectrometer as claimed in claim 14.

16. The mass spectrometer of claim 15, wherein the processor is further configured to provide a DC voltage to rods of the multipole rod assembly.

The processor applies the radio frequency voltage to the four rods of the multipole assembly in quadrupole mode, to the six rods of the multipole assembly in sextupole mode, and to the eight rods of the multipole assembly in octapole mode. 16. A mass spectrometer system according to claim 15, wherein the mass spectrometer system is provided on a book rod.

an ionization source,
A multipole rod assembly configured to provide each of a magnetic field and a radio frequency field from said multipole rod assembly within an ion volume formed by a substantially parallel arrangement of rods of said multipole rod assembly. each rod of said multipole rod assembly comprising magnetizable material, each rod being magnetized to provide an equal field strength, said ionization source further comprising:
An ionization source comprising an electron source configured to provide electrons within the ion volume of the multipole rod assembly to ionize an analyte introduced within the ion volume.

an enclosure surrounding the multipole rod assembly or internal to the multipole rod assembly, the enclosure fluidly coupled to the electron source at an inlet such that the electrons from the electron source pass through the inlet; 19. An ionization source according to claim 18, comprising an opening that allows for entry into said ion volume.

further comprising an ionization block comprising an entrance opening and an exit opening, wherein a longitudinal axis of each rod of said multipole rod assembly is substantially parallel to a longitudinal axis of said ionization block, said entrance opening comprising: fluidly coupled to the ionization volume to allow introduction of electrons into the ionization volume through the entrance opening to ionize an analyte within the ionization volume, the exit opening being connected to the ionization block; 19. The ionization source of claim 18, configured to allow ionized analytes to exit from.

19. The ionization source of Claim 18, further comprising an electron repeller positioned collinear with said electron source.

19. The ionization source of claim 18, wherein the multipole rod assembly comprises one of a quadrupole rod assembly, a sextupole rod assembly, an octapole rod assembly, a decapole rod assembly or a dodecole rod assembly.

the multipole rod assembly comprising a plurality of rods, the multipole rod assembly configured to operate in a quadrupole mode using four of the plurality of rods, the multipole rod assembly comprising: configured to operate in a sextupole mode using six of the plurality of rods, wherein the multipole rod assembly operates in an octapole mode using eight of the plurality of rods 19. The ionization source of claim 18, configured to:

19. The method of claim 18, wherein at least one rod of said multipole assembly has a different length than another rod of said multipole assembly or is non-parallel with another rod of said multipole rod assembly. ionization source.

19. The ionization source of claim 18, wherein the cross-sectional width of at least one rod of said multipole rod assembly varies along the length of said at least one rod.

4. The shape of each rod of said multipole rod assembly is independently conical, round, tapered, square, rectangular, triangular, trapezoidal, parabolic, hyperbolic or other geometric shape. 19. The ionization source according to 18.

an ionization source,
A multipole rod assembly configured to provide each of a magnetic field and a radio frequency field from said multipole rod assembly within an ion volume formed by a substantially parallel arrangement of rods of said multipole rod assembly. wherein each rod of said multipole rod assembly comprises a magnetizable material, and at least one rod of said multipole assembly comprises said at least one rod and said multipole rod assembly; provides a field strength different from said another rod when another rod of is magnetized, said ionization source further comprising:
An ionization source comprising an electron source configured to provide electrons within the ion volume of the multipole rod assembly to ionize an analyte introduced within the ion volume.

an enclosure surrounding the multipole rod assembly or internal to the multipole rod assembly, the enclosure fluidly coupled to the electron source at an inlet such that the electrons from the electron source pass through the inlet; 28. The ionization source of claim 27, comprising an opening that allows for entry into said ion volume.

further comprising an ionization block comprising an entrance opening and an exit opening, wherein a longitudinal axis of each rod of said multipole rod assembly is substantially parallel to a longitudinal axis of said ionization block, said entrance opening comprising: fluidly coupled to the ionization volume to allow introduction of electrons into the ionization volume through the entrance opening to ionize an analyte within the ionization volume, the exit opening being connected to the ionization block; 28. The ionization source of claim 27, configured to allow ionized analytes to exit from.

28. The ionization source of Claim 27, further comprising an electron repeller positioned collinear with said electron source.

28. The ionization source of claim 27, wherein the multipole rod assembly comprises one of a quadrupole rod assembly, a hexapole rod assembly, an octapole rod assembly, a decapole rod assembly or a dodecole rod assembly.

the multipole rod assembly comprising a plurality of rods, the multipole rod assembly configured to operate in a quadrupole mode using four of the plurality of rods, the multipole rod assembly comprising: configured to operate in a sextupole mode using six of the plurality of rods, wherein the multipole rod assembly operates in an octapole mode using eight of the plurality of rods 28. The ionization source of claim 27, configured to:

28. The method of claim 27, wherein at least one rod of said multipole assembly has a different length than another rod of said multipole assembly or is non-parallel to another rod of said multipole rod assembly. ionization source.

28. The ionization source of claim 27, wherein the cross-sectional width of at least one rod of said multipole rod assembly varies along the length of said at least one rod.

4. The shape of each rod of said multipole rod assembly is independently conical, round, tapered, square, rectangular, triangular, trapezoidal, parabolic, hyperbolic or other geometric shape. 28. The ionization source according to 27.