CN104681392A - Linear ion trap with fold-line-shaped electrodes - Google Patents
Linear ion trap with fold-line-shaped electrodes Download PDFInfo
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- CN104681392A CN104681392A CN201510011121.0A CN201510011121A CN104681392A CN 104681392 A CN104681392 A CN 104681392A CN 201510011121 A CN201510011121 A CN 201510011121A CN 104681392 A CN104681392 A CN 104681392A
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/4245—Electrostatic ion traps
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Abstract
The invention belongs to the technical field of quantity analyzers and particularly provides a linear ion trap with fold-line-shaped electrodes. The linear ion trap is formed by encircling four rod-shaped electrodes around a central symmetric axis in a manner of being parallel in pairs, wherein the cross sections, facing to the central symmetric axis, of at least one pair of rod-shaped electrodes are fold-line-shaped; the fold-line-shaped surfaces of the rod-shaped electrodes serve as working surfaces of ion storage and analysis areas and face to the central symmetric axis. When different working voltages are loaded on each fold-line-shaped electrode, the distribution of electric fields with a four-electrode electric field serving as a main component is generated in an inner space; ions entering the space are stored and quality of the ions is analyzed in the action of the generated electric fields; the distribution of the electric fields in the inner space is changed by selecting geometric structures and the working voltage of the four fold-line-shaped electrodes, thereby obtaining high ion storage and ion quality analysis performance. The linear ion trap can be applied to quality analysis or ion storage.
Description
Technical field
The invention belongs to mass spectrometer and analysis technical field, be specifically related to a kind of experimental system analyzed for ion storage and mass of ion.
Background technology
Mass spectral analysis is a kind of analytical method measuring ion mass-to-charge ratio (mass-charge ratio), its general principle is that each component in testing sample is ionized in an ion source, generate the charged ion of different mass-to-charge ratio, through the effect of accelerating field or ion guides, form ion beam, enter mass analyzer.In the mass analyser, utilize electric field or magnetic field difficulty action accomplishment analytic process, obtain mass spectrogram, thus determine its mass number.The mass spectrometer that mass spectral analysis uses is a kind of for chemical composition various in amalyzing substances sample, the scientific instrument of content and molecular structure, it has very high sensitivity and the specificity in analyte qualification, is therefore widely used in the every field such as scientific research, medical hygiene, environmental science, food security, biomedicine.Mass spectrometric structure has generally comprised vacuum system, sampling device and separator, ion source, ion-optic system, mass spectral analysis assembly, ion detection and data handling system.Conventional mass spectrometer comprises a variety of at present, according to the difference of adopted mass analyzer, mainly contains magnetic mass spectrometer, quadrupole mass spectrometer, ion trap mass spectrometer, ion cyclotron resonance mass spectrometer (ICR), time-of-flight mass spectrometer, orbit ion trap mass spectrometer etc.In these instruments, ion strap mass analyzer has the advantage of its uniqueness: volume is little, structure is simple, can work under higher air pressure and analyzer completes the ability of collision induced dissociation and tandem mass spectrometry.
Ion trap be the earliest the fifties in last century the people such as Paul of Univ Bonn Germany propose, be also referred to as Paul trap.This device is made up of 3 electrodes, comprises 2 endcap electrodes and 1 ring electrode, and the working face of electrode is all hyperboloid, owing to its structure existing the rotational symmetry of z axle, so be also referred to as three-dimensional ion trap.In a three-dimensional ion trap, ion introduces ion trap by the sample introduction aperture of endcap electrode, enter in this process of ion trap the quadripolar electric field needed by a concussion through aperture at ion, the existence of this quadripolar electric field result also in the reduction that ion introduces efficiency.The memory module of three-dimensional ion trap intermediate ion is the some position concentrating on center, under the effect of quadripolar electric field, all ions entering three-dimensional ion trap all can be drawn close towards central point, ion is caused to be assembled at center, the huge Coulomb force between ion is caused to interact, and in the three-dimensional ion trap course of work, if want to obtain a high-resolution spectrogram, must ensure that the total number of electrons before carrying out mass scanning in ion trap is less than hundreds of, these factors all result in the low ionic charge capacity of three-dimensional ion trap and low ion storage efficiency.In order to solve these problems of three-dimensional ion trap, there has been proposed the concept of linear ion hydrazine.Linear ion hydrazine is a kind of two-dimensional ion trap, and the applying mode of its voltage, for apply radio-frequency voltage on radial electrode, realizes the radio frequency constraint that two dimension is radial, axially applies direct voltage, forms direct current constraint potential well.The radio frequency of this two dimension applies mode and has fettered Particles Moving diametrically, improve the reservoir volume of electron cloud significantly, the point arrangement of ion at Jing Neicong center is made to become axial line arrangement, improve ion storage amount and storage efficiency significantly, reduce space charge effect greatly.For linear ion hydrazine, in the both sides of electrode, it has an open sample introduction entrance, and as a rule this sample introduction entrance is positioned at the center at trap electrode two ends, this position is the most weak position of ion trap inner quadripolar electric field intensity, this just makes ion not be affected completely in the process entering trap, and ion enters the efficiency of trap from outside can close to 100%.
Modern day ion trap theory sets up on the basis of the pure quadripolar electric field of ideal, and the realization of desirable quadripolar electric field needs to produce in the central task interval of the unlimited a pair hyperboloid electrode extended, but all can not complete the distribution of pure quadripolar electric field in the ion trap of any actual application (comprising the linear ion hydrazine of hyperboloid three-dimensional ion trap and hyperboloid electrode) and quadrupole mass filter, because there is the end cap aperture that ion is introduced, or due to the problem of this body length of electrode, the distortion of a shape will inevitably be produced at marginal position, thus except quadrupole field, wherein must contain the high-order field of a small amount of composition, in order to solve the impact that these high-order field compositions bring quality analysis, the geometry of adjustment ion trap and quadrupole mass filter and size become a feasible way, such as, just there is the field distortion that stretching structure brings to make up end cap aperture in the three-dimensional ion trap that Thermo Finnigan releases.Geometry and size at present by studying optimization ion trap and quadrupole mass filter improve the focus that analytical performance is current four-electrode spectrum field.
The hyperboloid three-dimensional ion trap of current commercialization and hyperboloid electrode linear ion hydrazine require higher, so developing electrode structure ion trap that is simple, that be convenient to assemble is the emphasis of a lot of research due to the processing of its hyperboloid electrode structure and assembly precision.The analytical performance of ion strap mass analyzer is determined by the electric field of ion trap inside, and the Electric Field Distribution of ion trap inside then direct geometry by ion trap and size determines, the simplification of electrode structure will inevitably bring the introducing of a large amount of high-order field composition.Professor Cooks of Purdue University develops the rectangle linear ion hydrazine (RIT) that a kind of plate electrode instead of hyperboloid electrode.Comparatively speaking, the plate electrode of this RIT is made up of 6 plate electrodes, and structure is simple, is easy to processing assembling.Experiment also demonstrates RIT and effectively can inherit the high charge capacity of linear ion hydrazine and the advantage of high storage efficiency, but due to the use of plate electrode, introduce a large amount of high-order field compositions in trap, this resolution that result also in RIT is lower.These electrode structures simplified all can bring the distortion of internal electric field structure, and bring the introducing of high-order field composition, these all can cause the decline of the quality analysis performance of ion trap thereupon.
The fold-line-shaped rod-shaped electrode ion trap that the present invention provides is to simplify electrode structure, while reducing ion trap difficulty of processing, the better ion strap mass analyzer of performance and ion storage device can be obtained, its advantage is, owing to employing four fold-line-shaped rod-shaped electrode composition ion trap spaces, its ion storage space is under the effect of operating voltage, generation is comprised quadripolar electric field, sextupole electric field, ends of the earth electric field, 12 pole electric fields are in interior multiple Electric Field Distribution.The ratio of various electric field component by using the fold-line-shaped rod-shaped electrode of various geometric, and can change the relative distance realization between electrode.Because the performance of ion trap determined by Electric Field Distribution wherein, therefore can by the performance regulating the Electric Field Distribution in ion trap to optimize ion trap.
Summary of the invention
The object of the invention is to design the ion trap that a kind of electrode structure is simple, difficulty of processing is low and performance is good.
The ion trap that the present invention proposes, built with fold-line-shaped rod-shaped electrode, is referred to as fold-line-shaped rod-shaped electrode linear ion hydrazine, and its main target is improving simplification electrode structure while that ion trap mass being differentiated, and reduces processing and assembling difficulty.It by four rod-shaped electrodes between two parallel peripheral to surround around a central symmetry axis and form, wherein have at least pair of electrodes to be fold-line-shaped towards the cross section of central symmetry axis.Here so-called fold-line-shaped, refers to that the cross section of rod-shaped electrode is fold-line-shaped, the face of the fold-line-shaped of rod-shaped electrode as the working face of ion storage analyzed area towards central symmetry axis.Its structure as shown in Figure 1.
Fold-line-shaped rod-shaped electrode ion trap given by the present invention, the shape of its multiple fold-line-shaped rod-shaped electrode can be identical, also can be not identical.
In the present invention, because the performance of ion trap determined by Electric Field Distribution wherein, therefore can by the performance regulating the Electric Field Distribution in ion trap to optimize ion trap, but in actual application, the angle not between coplanar of this fold-line-shaped needs to select suitable value, to obtain best mass resolving power, being respectively drift angle scope is 110 °≤drift angle < 180 °, and the scope of two side angles that drift angle is adjacent is (180 °-drift angle)/2≤side angle < 180 °.
In the present invention, preferred rod-shaped electrode is four faces in fold-line-shaped towards the working face of symmetry axis.
The fold-line-shaped rod-shaped electrode ion trap that the present invention provides, may be used for quality analysis, or ion storage.
The present invention is when be used for used time of quality analysis, and have at least pair of electrodes to have slit for Ion Extraction, described slit is positioned at the plane of electrode symmetry.
The present invention, when the used time being used for ion storage, electrode does not open Ion Extraction groove.
In the present invention, fold-line-shaped rod-shaped electrode is processed by any electric conducting material.
Fold-line-shaped rod-shaped electrode ion trap given by the present invention, so-called fold-line-shaped rod-shaped electrode, refer to that the cross section of rod-shaped electrode is fold-line-shaped, and one of the fold-line-shaped of four electrodes facing to central symmetry axis, as working face, four fold-line-shaped electrodes surround and form a space as ion storage and quality analysis.
Because the electric field in ion storage and quality analysis region is determined by electrode shape, in this broken line type electrode structural designs, the area of each is variable, angle between each is also unfixed, therefore Electric Field Distribution can be regulated by regulating the relative distance between these electrode parameter and electrodes, to realize the object of better mass of ion analysis or ion storage performance.Its advantage is that electrode is planar structure, be compared to hyperboloid structure more easily to process, simultaneously owing to employing four fold-line-shaped rod-shaped electrode composition ion trap spaces, its ion storage space is under the effect of operating voltage, generation is comprised quadripolar electric field, sextupole electric field, ends of the earth electric field, 12 pole electric fields are in interior multiple Electric Field Distribution.The ratio of various electric field component by using the fold-line-shaped rod-shaped electrode of various geometric, and can change the relative distance realization between electrode.
Ion trap systems of the present invention, can be used alone, also can with other experimental systems, as the mass spectrometer of other types, as four-electrode spectrum, flight time mass spectrum etc. join together use.
Accompanying drawing explanation
Fig. 1: the ion trap structure schematic diagram be made up of four fold-line-shaped rod-shaped electrodes.
Fig. 2: the cross section structure schematic diagram with four identical fold-line-shaped rod-shaped electrode ion traps.
Fig. 3: the cross section structure schematic diagram of the ion trap be made up of a pair fold-line-shaped rod-shaped electrode and plane electrode.
Fig. 4: the ion trap mass spectrometer operation principle schematic diagram be made up of fold-line-shaped rod-shaped electrode.
Embodiment
Below in conjunction with drawings and Examples, the present invention is described in further detail.
Fig. 1 is a linear ion trap structure schematic diagram be made up of four fold-line-shaped rod-shaped electrodes.In FIG, 101,102,103 and 104 is 4 rod-shaped electrodes with fold-line-shaped cross section, and in every pair of electrodes, electrode is positioned on relative position, and the plane of symmetry of electrode pair is vertical each other.Four electrode runs parallel ground distribute round a central symmetry axis and are fixed together.Each electrode cross-section at least one pair of electrode has the fold-line-shaped shape of top towards the longitudinal axis (i.e. Z-direction) of trap.Rod-shaped electrode 101 is identical with 103, and rod-shaped electrode 102 is identical with 104.109,110 is the fold-line-shaped working face of 103 and 104 electrodes, respectively by four independently working face form.105,106,107 and 108 is processing through holes at electrode 101,102,103 and 104 center.Their effect be allow store ion in an ion trap can from wherein evicting from.In actual applications, the pair of electrodes only on x or y any direction can process the aperture passed through for ion, on four electrodes, also all can process the aperture passed through for ion.Aperture can be any shape, and what show in Fig. 1 is form of slits.
Fig. 2 is the cross section structure schematic diagram of an ion trap be made up of the identical fold-line-shaped rod-shaped electrode of size.Electrode 201,202,203 is identical with the cross section of 204, and each electrode respectively has an Ion Extraction groove, can be aperture or slit, be respectively 205,206,207 and 208, can be used for Ion Extraction, and aperture or slit can be any shapes.The position at the Ion Extraction Cao Dao center of two pairs of electrodes is respectively a and b, and they can be identical value or different values.Every pair of electrodes has two angle [alpha] and β, wherein a is the angle in adjacent two faces of fold-line-shaped working face, Ion Extraction groove both sides, and β is two side angles adjacent with drift angle.A, b and α, these four parameter values of β determine electrode surround Electric Field Distribution in region i.e. quality analysis region, changing them can effectively regulate internal electric field structure, but needs to select suitable value just can obtain good quality analysis effect.Be d as figure shows slit width, when d value is zero, namely electrode does not have Ion Extraction groove, under these conditions, ion cannot eject and be caught by detector, disappears on electrode.Although now ion trap cannot be used as mass analyzer, still can as ion storage device, for the mass spectrometric further analysis in downstream is prepared.Can allow the ion annihilation of not Water demand on electrode by resonant excitation mode in this ion trap, allow the ion of Water demand retain in an ion trap.
The cross section structure schematic diagram of ion trap of Fig. 3 for being made up of a pair fold-line-shaped rod-shaped electrode and pair of planar electrode.Wherein, electrode 301 and 303 is a pair fold-line-shaped rod-shaped electrode, and electrode 302 and 304 cross section is two pieces of plane electrodes.Each electrode shown in figure all there is an Ion Extraction groove, can be aperture or slit, be respectively 305,306,307 and 308, also only any pair electrode can open Ion Extraction groove wherein.
The ion trap mass spectrometer operation principle schematic diagram that Fig. 4 forms for fold-line-shaped rod-shaped electrode.Wherein 401 is the ion sources that can produce sample ions 402.Ion beam 402, after the focusing and transmission of Multipole ion guiding bar 403, enters into fold-line-shaped rod-shaped electrode linear ion hydrazine 406 from the ion introduction hole ion trap inlet electrode 404.After ion is dissociated by enrichment, storage and possible collision in an ion trap, the ion 408 in ion trap is optionally evicted from ion trap from the aperture a fold-line-shaped electrode, and detect by detector 407.405 is another termination electrode of ion trap.409 for providing the pump housing of vacuum needed for working region.
Claims (6)
1. the linear ion trap of fold-line-shaped rod-shaped electrode, it is characterized in that by four rod-shaped electrodes between two parallel peripheral to surround around a central symmetry axis and form, wherein have at least a pair bar electrode to be fold-line-shaped towards the cross section of central symmetry axis; The face of the fold-line-shaped of rod-shaped electrode as the working face of ion storage analyzed area towards central symmetry axis.
2. the linear ion trap of fold-line-shaped rod-shaped electrode according to claim 1, is characterized in that the shape of multiple fold-line-shaped rod-shaped electrode is identical, or not identical.
3. the linear ion trap of fold-line-shaped rod-shaped electrode according to claim 1, it is characterized in that the angle of the fold-line-shaped of described fold-line-shaped rod-shaped electrode is respectively: drift angle scope: 110 °≤drift angle < 180 °, two side angle scopes that drift angle is adjacent: (180 °-drift angle)/2≤side angle < 180 °.
4. the linear ion trap of fold-line-shaped rod-shaped electrode according to claim 1, is characterized in that, rod-shaped electrode is four faces in fold-line-shaped towards the working face of symmetry axis.
5. according to the linear ion trap of fold-line-shaped rod-shaped electrode one of claim 1-4 Suo Shu, it is characterized in that, when for quality analysis, have at least pair of electrodes to have slit for Ion Extraction, described slit is positioned at the plane of electrode symmetry.
6. according to the linear ion trap of fold-line-shaped rod-shaped electrode one of claim 1-4 Suo Shu, it is characterized in that, when for ion storage, electrode does not open Ion Extraction groove.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106736310A (en) * | 2017-02-27 | 2017-05-31 | 尹智勇 | The preparation method of linear ion hydrazine analyzer |
| CN107104032A (en) * | 2017-06-07 | 2017-08-29 | 苏州大学 | Linear ion hydrazine, mass spectrograph and method based on asymmetric triangular-shaped electrodes |
| CN108183061A (en) * | 2017-11-20 | 2018-06-19 | 上海裕达实业有限公司 | Eight electrode linear ion trap mass analyzers |
| CN109360782A (en) * | 2018-09-21 | 2019-02-19 | 上海卫星装备研究所 | Six electrode linear ion trap mass analyzers and radio frequency applying method |
| CN110164749A (en) * | 2019-04-30 | 2019-08-23 | 宁波大学 | A kind of asymmetric triangular-shaped electrodes structure ion trap |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN203607367U (en) * | 2013-11-19 | 2014-05-21 | 苏州美实特质谱仪器有限公司 | Level four ion trap |
| CN104011828A (en) * | 2011-12-21 | 2014-08-27 | 塞莫费雪科学（不来梅）有限公司 | Collision cell multipole |
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2015
- 2015-01-11 CN CN201510011121.0A patent/CN104681392A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104011828A (en) * | 2011-12-21 | 2014-08-27 | 塞莫费雪科学（不来梅）有限公司 | Collision cell multipole |
| CN203607367U (en) * | 2013-11-19 | 2014-05-21 | 苏州美实特质谱仪器有限公司 | Level four ion trap |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106736310A (en) * | 2017-02-27 | 2017-05-31 | 尹智勇 | The preparation method of linear ion hydrazine analyzer |
| CN106736310B (en) * | 2017-02-27 | 2019-01-11 | 尹智勇 | The preparation method of linear ion hydrazine analyzer |
| CN107104032A (en) * | 2017-06-07 | 2017-08-29 | 苏州大学 | Linear ion hydrazine, mass spectrograph and method based on asymmetric triangular-shaped electrodes |
| CN108183061A (en) * | 2017-11-20 | 2018-06-19 | 上海裕达实业有限公司 | Eight electrode linear ion trap mass analyzers |
| US11075069B2 (en) | 2017-11-20 | 2021-07-27 | Shanghai Yuda Industrial Co., Ltd. | OCTA-electrode linear ion trap mass analyzer |
| CN109360782A (en) * | 2018-09-21 | 2019-02-19 | 上海卫星装备研究所 | Six electrode linear ion trap mass analyzers and radio frequency applying method |
| CN110164749A (en) * | 2019-04-30 | 2019-08-23 | 宁波大学 | A kind of asymmetric triangular-shaped electrodes structure ion trap |
| CN110164749B (en) * | 2019-04-30 | 2024-06-07 | 宁波大学 | Asymmetric triangular electrode structure ion trap |
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Application publication date: 20150603 |