CN110164749B - Asymmetric triangular electrode structure ion trap - Google Patents
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- CN110164749B CN110164749B CN201910361576.3A CN201910361576A CN110164749B CN 110164749 B CN110164749 B CN 110164749B CN 201910361576 A CN201910361576 A CN 201910361576A CN 110164749 B CN110164749 B CN 110164749B
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Classifications
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/4255—Device types with particular constructional features
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- Chemical & Material Sciences (AREA)
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- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
The invention discloses an asymmetric triangular electrode structure ion trap, which comprises a pair of X electrodes with equal angles, a pair of Y electrodes with equal angles and at least two end cover electrodes, wherein the X electrodes, the Y electrodes and the end cover electrodes enclose a space three-dimensional structure similar to a cuboid, the X electrodes and the Y electrodes are triangular columnar electrodes, each X electrode and each Y electrode are parallel to each other, the angle of the X electrodes is a, the angle of the Y electrodes is b, wherein a=b+/-delta alpha, 10 degrees is more than or equal to delta alpha >0 degrees; ion extraction grooves are formed in the X electrode and the Y electrode, and the X electrode is arranged in the ion emergent direction; the method has the advantages that the method can effectively generate the component potential distribution of the eight-pole field and the sixteen-pole field which mainly take the quadrupole electric field and introduce a certain amount in the ion trap, and improves the ion extraction efficiency, thereby improving the sensitivity of the ion trap and the analysis performance of the invention; the ion trap has the advantages of simple structure and easy processing without changing a working circuit of the ion trap.
Description
Technical Field
The invention relates to the technical field of mass spectrometers, in particular to an ion trap with an asymmetric triangular electrode structure.
Background
The mass spectrometer is a modern analysis instrument based on the development of electromagnetic theory, has the advantages of high sensitivity and high specificity, and can effectively analyze the components and the structure of chemical substances. Mass analyzers are core components of mass spectrometers, which can be classified into magnetic mass spectrometry, time-of-flight mass spectrometry, quadrupole mass spectrometry, ion trap mass spectrometry, fourier transform ion cyclotron resonance mass spectrometry, and orbitrap mass spectrometry, depending on the mass analyzer. The ion trap mass spectrum has the advantages of small volume, low vacuum requirement, cascade mass spectrum capability and the like, and can be widely studied, in particular to the study of mass spectrum miniaturization.
In 1953, paul first proposed to verify a hyperboloid ion trap, consisting of a pair of ring electrodes and two hyperboloid end cap electrodes, as a three-dimensional ion trap, ions were stored in the center of the ion trap, and space charge effects limited its mass analysis performance. US6797950 proposes a linear ion trap mass analyser consisting of two pairs of hyperbolic cylindrical electrodes and two end cap electrodes placed symmetrically, during mass analysis ions being stored on the linear ion trap axis. Compared with a three-dimensional ion trap, the linear ion trap has a larger ion storage space, so that more ions can be stored, the analysis sensitivity is improved, the space charge effect is weakened, and the mass resolution is ensured to meet the analysis requirement.
However, the ion traps are all of hyperboloid structures, so that the mechanical processing difficulty is high, the manufacturing cost of the ion trap mass spectrometer is increased, and the ion trap mass spectrometer is not beneficial to further popularization. In recent years, ion traps with simplified structures have become a popular research direction in the mass spectrometry field. The use of rectangular ion traps formed with plate electrodes is proposed in US 6838666 to greatly simplify the structure of hyperboloid linear ion traps and reduce the cost of manufacturing ion trap mass analyzers. However, the rectangular ion trap introduces too much higher order field component into the electric field inside the ion trap due to the change in the shape of the electrodes, resulting in a decrease in mass resolution of the rectangular ion trap. After that, xiao et al developed a novel triangular electrode structure linear ion trap consisting of four triangular columnar electrodes and two planar electrodes, all of which were planar electrodes with good ion storage and mass analysis capabilities. At a scan speed of 1307 Th/s, the mass resolution can reach 1500 when testing reserpine solutions (m/z=609).
It has been found in recent years that the introduction of a suitable amount of higher order field components into an ion trap is beneficial to improving the sensitivity of the ion trap mass analyser. However, the existing method for introducing the high-order field is complex and difficult to quantitatively introduce. There is therefore a need to develop an ion trap that can conveniently and quantitatively introduce high order fields.
Disclosure of Invention
The invention aims to solve the technical problem of providing an asymmetric triangular electrode structure ion trap with simple structure, low manufacturing cost and high sensitivity.
The technical scheme adopted for solving the technical problems is as follows: an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes with equal angles, a pair of Y electrodes with equal angles and at least two end cover electrodes, wherein the X electrodes, the Y electrodes and the end cover electrodes enclose a space three-dimensional structure similar to a cuboid, the X electrodes and the Y electrodes are triangular columnar electrodes, each X electrode and each Y electrode are parallel to each other in pairs, the angle of each X electrode is a, the angle of each Y electrode is b, and a = b +/-delta alpha, and 10 degrees or more delta alpha >0 degrees;
The X electrode and the Y electrode are respectively provided with an ion extraction groove, and the X electrode is arranged in the ion emitting direction.
Further, the angle of the X electrode is a=b-delta alpha, and 10 degrees is more than or equal to delta alpha >0 degrees.
Further, the value range of b is 120-160 degrees.
Further, the value of b is 140 degrees.
Further, ion extraction grooves are formed in the centers of each X electrode and each Y electrode.
Further, adjacent X electrodes and Y electrodes are separated by an insulating material to maintain the insulation between the electrodes.
Further, a small hole for introducing ions is formed in the center of the end cover electrode.
Further, the electrode materials of the X electrode and the Y electrode are conductive materials or insulating materials plated with conductive coatings.
Further, the conductive metal material comprises stainless steel, gold, silver or copper; the insulating material comprises ceramic, PCB or polymer material.
Compared with the prior art, the invention has the advantages that the ion trap with the asymmetric triangular electrode structure is disclosed, and by changing the electrode angles of two triangular columnar electrodes, a certain amount of eight-pole field and sixteen-pole field component potential distribution which is mainly a quadrupole electric field can be effectively generated in the ion trap, so that the ion extraction efficiency is improved, the sensitivity of the ion trap is improved, and the analysis performance of the ion trap is improved; the ion trap has the advantages of simple structure and easy processing without changing a working circuit of the ion trap;
The ion trap provided by the invention can be used alone or in combination with other experimental systems, such as other types of mass spectrometers, such as quadrupole mass spectrometry, time-of-flight mass spectrometry, and the like.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic diagram of a triangular columnar electrode of the present invention;
FIG. 3 is a front view of the triangular columnar electrode of the present invention surrounded by a frame;
FIG. 4 is a diagram of a voltage application mode according to the present invention;
FIG. 5 is a graph showing the higher order field content as a function of the ratio of the fourth order field at different electrode angles in accordance with the present invention;
FIG. 6 is a graph showing simulated mass spectrum peaks of the present invention at different electrode angles.
Detailed Description
The invention is described in further detail below with reference to the embodiments of the drawings.
In order that those skilled in the art will better understand the present invention, a technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in which it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.
Embodiment one: as shown in fig. 1-3, an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes 11 with equal angles, a pair of Y electrodes 12 with equal angles and at least two end cover electrodes 13 arranged in the Z direction, wherein the X electrodes 11, the Y electrodes 12 and the end cover electrodes 13 enclose a space three-dimensional structure similar to a cuboid, the X electrodes 11 and the Y electrodes 12 are triangular columnar electrodes, each X electrode 11 and each Y electrode 12 are parallel to each other, the angle of the X electrodes 11 is a, the angle of the Y electrodes 12 is 120 degrees, a=120° ±Δα, and 10 degrees or more than Δα >0 degrees; ion extraction grooves 14 are provided on both the X electrode 11 and the Y electrode 12, and the X electrode 11 is arranged in the ion emission direction. An ion extraction groove 14 is provided in the center of each X electrode 11 and each Y electrode 12. The adjacent X electrodes 11 and Y electrodes 12 are separated from each other by an insulating material to maintain the insulation between the electrodes. The center of the end cap electrode 13 is provided with a small hole 15 for ion introduction. The electrode materials of the X electrode 11 and the Y electrode 12 are conductive materials or insulating materials plated with conductive coatings. The conductive metal material may be one of stainless steel, gold, silver, or copper; the insulating material may be one of ceramic, PCB or polymer material.
Embodiment two: as shown in fig. 1-3, an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes 11 with equal angles, a pair of Y electrodes 12 with equal angles and at least two end cover electrodes 13 arranged in the Z direction, wherein the X electrodes 11, the Y electrodes 12 and the end cover electrodes 13 enclose a space three-dimensional structure similar to a cuboid, the X electrodes 11 and the Y electrodes 12 are triangular columnar electrodes, each X electrode 11 and each Y electrode 12 are parallel to each other, the angle of the X electrodes 11 is a, the angle of the Y electrodes 12 is 140 degrees, a=140 degrees±Δα, and 10 degrees or more Δα >0 degrees; ion extraction grooves 14 are provided on both the X electrode 11 and the Y electrode 12, and the X electrode 11 is arranged in the ion emission direction. An ion extraction groove 14 is provided in the center of each X electrode 11 and each Y electrode 12. The adjacent X electrodes 11 and Y electrodes 12 are separated from each other by an insulating material to maintain the insulation between the electrodes. The center of the end cap electrode 13 is provided with a small hole 15 for ion introduction. The electrode materials of the X electrode 11 and the Y electrode 12 are conductive materials or insulating materials plated with conductive coatings. The conductive metal material may be one of stainless steel, gold, silver, or copper; the insulating material may be one of ceramic, PCB or polymer material.
Embodiment III: as shown in fig. 1-3, an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes 11 with equal angles, a pair of Y electrodes 12 with equal angles and at least two end cover electrodes 13 arranged in the Z direction, wherein the X electrodes 11, the Y electrodes 12 and the end cover electrodes 13 enclose a space three-dimensional structure similar to a cuboid, the X electrodes 11 and the Y electrodes 12 are triangular columnar electrodes, each X electrode 11 and each Y electrode 12 are parallel to each other, the angle of the X electrodes 11 is a, the angle of the Y electrodes 12 is 160 °, wherein a=160° ±Δα, and 10 ° or more than Δα >0 °; ion extraction grooves 14 are provided on both the X electrode 11 and the Y electrode 12, and the X electrode 11 is arranged in the ion emission direction. An ion extraction groove 14 is provided in the center of each X electrode 11 and each Y electrode 12. The adjacent X electrodes 11 and Y electrodes 12 are separated from each other by an insulating material to maintain the insulation between the electrodes. The center of the end cap electrode 13 is provided with a small hole 15 for ion introduction. The electrode materials of the X electrode 11 and the Y electrode 12 are conductive materials or insulating materials plated with conductive coatings. The conductive metal material may be one of stainless steel, gold, silver, or copper; the insulating material may be one of ceramic, PCB or polymer material.
Embodiment four: as shown in fig. 1-3, an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes 11 with equal angles, a pair of Y electrodes 12 with equal angles, and two end cover electrodes 13 arranged in the Z direction, wherein the X electrodes 11, the Y electrodes 12 and the end cover electrodes 13 enclose a space three-dimensional structure similar to a cuboid, the X electrodes 11 and the Y electrodes 12 are triangular columnar electrodes, each X electrode 11 and each Y electrode 12 are parallel to each other, the angle of the X electrodes 11 is a, the angle of the Y electrodes 12 is 120 °, wherein a=120 ° - Δα, and 10 ° - Δα >0 °; ion extraction grooves 14 are provided on both the X electrode 11 and the Y electrode 12, and the X electrode 11 is arranged in the ion emission direction. An ion extraction groove 14 is provided in the center of each X electrode 11 and each Y electrode 12. The adjacent X electrodes 11 and Y electrodes 12 are separated from each other by an insulating material to maintain the insulation between the electrodes. The center of the end cap electrode 13 is provided with a small hole 15 for ion introduction. The electrode materials of the X electrode 11 and the Y electrode 12 are conductive materials or insulating materials plated with conductive coatings. The conductive metal material may be one of stainless steel, gold, silver, or copper; the insulating material may be one of ceramic, PCB or polymer material.
Fifth embodiment: as shown in fig. 1-3, an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes 11 with equal angles, a pair of Y electrodes 12 with equal angles, and two end cover electrodes 13 arranged in the Z direction, wherein the X electrodes 11, the Y electrodes 12 and the end cover electrodes 13 enclose a space three-dimensional structure similar to a cuboid, the X electrodes 11 and the Y electrodes 12 are triangular columnar electrodes, each X electrode 11 and each Y electrode 12 are parallel to each other, the angle of the X electrodes 11 is a, the angle of the Y electrodes 12 is 120 °, wherein a=140 ° - Δα, and 10 ° - Δα >0 °; ion extraction grooves 14 are provided on both the X electrode 11 and the Y electrode 12, and the X electrode 11 is arranged in the ion emission direction. An ion extraction groove 14 is provided in the center of each X electrode 11 and each Y electrode 12. The adjacent X electrodes 11 and Y electrodes 12 are separated from each other by an insulating material to maintain the insulation between the electrodes. The center of the end cap electrode 13 is provided with a small hole 15 for ion introduction. The electrode materials of the X electrode 11 and the Y electrode 12 are conductive materials or insulating materials plated with conductive coatings. The conductive metal material may be one of stainless steel, gold, silver, or copper; the insulating material may be one of ceramic, PCB or polymer material.
Example six: as shown in fig. 1-3, an asymmetric triangular electrode structure ion trap comprises a pair of X electrodes 11 with equal angles, a pair of Y electrodes 12 with equal angles, and two end cover electrodes 13 arranged in the Z direction, wherein the X electrodes 11, the Y electrodes 12 and the end cover electrodes 13 enclose a space three-dimensional structure similar to a cuboid, the X electrodes 11 and the Y electrodes 12 are triangular columnar electrodes, each X electrode 11 and each Y electrode 12 are parallel to each other, the angle of the X electrodes 11 is a, the angle of the Y electrodes 12 is 120 °, wherein a=160 ° - Δα, and 10 ° - Δα >0 °; ion extraction grooves 14 are provided on both the X electrode 11 and the Y electrode 12, and the X electrode 11 is arranged in the ion emission direction. An ion extraction groove 14 is provided in the center of each X electrode 11 and each Y electrode 12. The adjacent X electrodes 11 and Y electrodes 12 are separated from each other by an insulating material to maintain the insulation between the electrodes. The center of the end cap electrode 13 is provided with a small hole 15 for ion introduction. The electrode materials of the X electrode 11 and the Y electrode 12 are conductive materials or insulating materials coated with conductive coatings. The conductive metal material may be one of stainless steel, gold, silver, or copper; the insulating material may be one of ceramic, PCB or polymer material.
The invention is simulated by a computer, the electrode angle of the Y electrode 12 is kept to be 140 degrees, the electrode angle of the X electrode 11 is changed, 135 degrees, 136 degrees, 137 degrees, 138 degrees, 139 degrees and 140 degrees are respectively taken, so that high-order field components are introduced, the multi-pole fields such as quadrupole field A 2, octapole field A 4, hexadecpole field A 8 and the like are distributed in the electric field in the whole ion trap system, the optimization of ion trap analysis performance is achieved, and the sensitivity is verified.
1000 Ions with positive monovalent charges with mass numbers of 609Da, 610Da and 611Da are selected as test ions. The initial position of the ion is set as the center position of the ion trap model, the distribution state is set as gaussian distribution, the initial energy of the ion is set as 0, and the distribution state is set as gaussian distribution. Helium is selected as buffer gas and cooling gas in the ion trap model, the air pressure of the inner space is 7×10 -3 Pa, and the temperature is 300K. Only the motion track of the ions on the x-y plane is observed in the simulation process.
The voltage application mode in the simulation experiment is an analog radio frequency scanning mode. As shown in fig. 4, radio frequency voltages with equal and opposite phases are applied to the two pairs of electrodes in the x-direction and the y-direction, respectively, and the frequency of the radio frequency voltage signal is set to be 1MHz. Meanwhile, alternating voltages with equal magnitudes and opposite phases are applied to the two electrodes in the x direction in a coupling mode, the frequency of the alternating voltage signal is near the frequency division of the radio frequency voltage signal, and the amplitude of the alternating voltage signal needs to be further optimized for triangular electrode ion traps with different structures. When the long-term frequency of the ions is equal to the frequency of the alternating voltage signal, the ions generate resonance motion, the motion amplitude in the ion trap is obviously increased, and the ions are ejected out between the electrode slits in the x direction. The scanning speed of the ion trap can be adjusted by adjusting the amplitude of the scanning voltage, and the scanning speed of the ion trap in the experiment is about 1900 Da/s.
And recording the motion trail of the ions, and processing the motion trail of the ions by using software to obtain a mass spectrogram of the simulation.
FIG. 5 is a graph showing the higher order field content as a function of the ratio of the fourth order field at different electrode angles, wherein the higher order field content increases gradually and is introduced in a good linear relationship as the angle decreases; wherein:
In the high-order field component distribution, the content of the octupole field A 4 is between-1.5% and 1.5% of the quadrupole field A 2;
In the high-order field component distribution, the content of the sixteen-pole field A 8 is between-3% and 3% of the quadrupole field A 2.
Through mass spectrum peak simulation, as shown in fig. 6, when the angles of the four triangular electrodes are 140 degrees, the tailing phenomenon appears in the mass spectrum peak waveform diagram, when the angles of the two X electrodes 11 are changed (139 degrees, 138 degrees, 137 degrees or 136 degrees), the tailing phenomenon in the four mass spectrum peak waveform diagrams is improved, especially no tailing phenomenon appears when 139 degrees, which shows that when the angles of the two electrodes in the emergent direction of the triangular electrode linear ion trap are changed at the same time, a certain amount of even high-order field components (such as an octapole field A 4, a hexadecpole field A 8 and the like) can be introduced, the ion extraction efficiency is improved, the sensitivity of the ion trap is improved, and the analysis performance of the ion trap is improved.
Claims (7)
1. The ion trap with the asymmetric triangular electrode structure comprises a pair of X electrodes with equal angles, a pair of Y electrodes with equal angles and at least two end cover electrodes arranged in the Z direction, wherein the X electrodes, the Y electrodes and the end cover electrodes enclose a space three-dimensional structure similar to a cuboid;
the X electrode and the Y electrode are respectively provided with an ion extraction groove, the X electrode is arranged in the ion emitting direction, and the center of the end cover electrode is provided with a small hole for introducing ions.
2. An ion trap with an asymmetric triangular electrode structure according to claim 1, wherein the angle of the X-electrode is a = b- Δα,10 ° > Δα >0 °.
3. An ion trap according to claim 1 or claim 2, wherein b has a value of 140 °.
4. An asymmetric triangular electrode structure ion trap as claimed in claim 1, wherein an ion extraction slot is provided in the center of each of said X-electrodes and each of said Y-electrodes.
5. An asymmetric triangular electrode structure ion trap as claimed in claim 1 in which adjacent said X electrodes are separated from said Y electrodes by insulating material to maintain the insulation between the electrodes.
6. The ion trap with asymmetric triangular electrode structure according to claim 1, wherein the electrode materials of the X electrode and the Y electrode are conductive materials or insulating materials coated with conductive coatings.
7. An ion trap with an asymmetric triangular electrode structure according to claim 6, wherein said conductive material comprises stainless steel, gold, silver or copper; the insulating material comprises ceramic, PCB or polymer material.
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|---|---|---|---|---|
| CN103903954A (en) * | 2014-03-13 | 2014-07-02 | 复旦大学 | Linear ion trap |
| CN104681392A (en) * | 2015-01-11 | 2015-06-03 | 复旦大学 | Linear ion trap with fold-line-shaped electrodes |
| CN105869986A (en) * | 2016-05-04 | 2016-08-17 | 苏州大学 | Mass spectrometry system capable of improving ion detection efficiency |
| CN107104032A (en) * | 2017-06-07 | 2017-08-29 | 苏州大学 | Linear ion hydrazine, mass spectrograph and method based on asymmetric triangular-shaped electrodes |
| CN108183061A (en) * | 2017-11-20 | 2018-06-19 | 上海裕达实业有限公司 | Eight electrode linear ion trap mass analyzers |
| CN108428612A (en) * | 2017-12-31 | 2018-08-21 | 宁波大学 | A kind of ion Transmission system and its working method |
| CN209981165U (en) * | 2019-04-30 | 2020-01-21 | 宁波大学 | Asymmetric triangular electrode structure ion trap |
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