JPWO2020221485A5

JPWO2020221485A5 -

Info

Publication number: JPWO2020221485A5
Application number: JP2021559610A
Authority: JP
Publication date: 2023-02-02
Anticipated expiration: 2040-02-14

Claims

an electrosurgical generator configured to supply microwave energy and an electroporation signal;
An electrosurgical instrument for insertion into a treatment area of living tissue, comprising:
a coaxial cable connected to the electrosurgical generator for receiving the microwave energy and the electroporation signal;
a rod-shaped radiating tip coupled to the distal end of the coaxial cable for receiving the microwave energy and the electroporation signal, the distal end radiating the microwave energy to the treatment area; and said radiating tip portion for establishing an electric field at its distal end using said electroporation signal for electroporating biological tissue in said treatment region;
a conduit for carrying biological tissue away from the treatment area;
the electrosurgical instrument comprising:
a cytometer in fluid communication with the conduit for receiving biological tissue, the cytometer for detecting the presence of a first predetermined cell type in the received biological tissue;
An electrosurgical system, comprising:

The radiating tip portion comprises:
A proximal coaxial transmission line for receiving and transmitting said microwave energy, said proximal coaxial transmission line comprising an inner conductor, an outer conductor, and a dielectric material separating said inner conductor from said outer conductor. and,
a distal needle tip attached to the distal end of the proximal coaxial transmission line, the distal needle tip including a rigid dielectric sleeve extending longitudinally from the distal end of the proximal coaxial transmission line; and including
the rod-shaped radiating tip portion has a diameter smaller than the diameter of the coaxial cable;
The rigid dielectric sleeve surrounds an elongated conductive element electrically connected to the inner conductor of the proximal coaxial transmission line and extending beyond a distal end of the outer conductor of the proximal coaxial transmission line; an elongated conductive element acting as a half-wave transformer of the microwave energy to radiate the microwave energy from the distal needle tip into biological tissue;
the elongated conductive element terminates in an active electrode exposed at the distal end of the distal needle tip;
The active electrode is axially spaced from a return electrode electrically connected to the distal end of the outer conductor of the proximal coaxial transmission line, the active electrode and the return electrode being connected to the distal needle. configured to establish the electric field for electroporation of biological tissue at the tip;
The electrosurgical system of claim 1.

An electrosurgical system according to claim 2, wherein the dielectric material of the proximal coaxial transmission line is more flexible than the rigid dielectric sleeve.

4. An electrosurgical system according to claim 2 or 3, wherein the active electrode is a conductive ring concentrically disposed with the elongated conductive element.

An electrosurgical system according to claim 4, wherein the conductive ring has a channel extending longitudinally therethrough, and a portion of the elongated conductive element is contained within the channel.

An electrosurgical system according to claim 5, wherein the distal needle tip includes a tip element attached to the distal end of the conductive ring.

An electrosurgical system according to claim 6, wherein the distal end of the tip element is pointed.

An electrosurgical system according to any of claims 2-7, wherein a distal portion of the outer conductor overlaps a proximal portion of the rigid dielectric sleeve.

The electrosurgical system of any of claims 2-8, wherein the conduit includes the inner conductor and the elongated conductive element bore.

An electrosurgical system according to claim 9, wherein the bore has a maximum diameter of 0.4 mm.

11. An electrosurgical system according to claim 9 or 10, wherein the conduit includes at least one pipe connected to the inner conductor for carrying the body tissue away from the bore.

The conduit includes an outlet on the axis of the proximal coaxial transmission line, and the microwave energy and the electroporation signal are directed toward the radiating tip portion at an angle to the axis of the proximal coaxial transmission line. 12. The electrosurgical system of claim 11, connected to a.

The microwave energy and the electroporation signal are delivered to the radiating tip portion along the axis of the proximal coaxial transmission line, and the biological tissue is oriented at an angle to the axis of the proximal coaxial transmission line. 12. The electrosurgical system of claim 11, extracted using the at least one pipe labeled with .

An electrosurgical system according to any of claims 1-13, wherein the conduit is integral with the radiating tip portion.

An electrosurgical system according to any of claims 1-14, wherein the radiating tip portion has a maximum outer diameter of 1.067 mm or less.

a surgical scope device having a flexible insertion cord for insertion into a patient's body, said flexible insertion cord having an instrument channel extending along a length thereof, said electrosurgical instrument comprising: 16. An electrosurgical system according to any preceding claim , dimensioned to fit within the instrument channel.

a detector for detecting microwave power reflected back from the treatment area;
and a controller for detecting a second predetermined cell type in biological tissue in the treatment area based on changes in the detected reflected microwave power . The electrosurgical system of any preceding paragraph .

An electrosurgical system according to any one of the preceding claims , further comprising an impedance matching mechanism configured to match impedance of the electrosurgical generator with the radiating tip portion.

the cytometer;
a suction pump in fluid communication with the conduit to extract biological tissue therefrom;
a sample generator for generating a sample by suspending cells of the extracted biological tissue in a fluid;
further comprising a cell identification assembly;
the cytometer uses the sample to detect the presence of the first predetermined cell type;
19. An electrosurgical system according to any one of claims 1-18 .

An electrosurgical system according to any one of the preceding claims , further comprising a fluid injection mechanism in fluid communication with the conduit for injecting fluid into the treatment region.