JPWO2020172686A5 - - Google Patents

Info

Publication number

JPWO2020172686A5

JPWO2020172686A5 JP2021549163A JP2021549163A JPWO2020172686A5 JP WO2020172686 A5 JPWO2020172686 A5 JP WO2020172686A5 JP 2021549163 A JP2021549163 A JP 2021549163A JP 2021549163 A JP2021549163 A JP 2021549163A JP WO2020172686 A5 JPWO2020172686 A5 JP WO2020172686A5

Authority

JP

Japan

Prior art keywords

seq

nos

iapp peptide

iapp

group

Prior art date

2022-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• PLOPBXQQPZYQFA-AXPWDRQUSA-N Amlintide Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)CSSC1)[C@@H](C)O)C(C)C)C1=CC=CC=C1 PLOPBXQQPZYQFA-AXPWDRQUSA-N 0.000 claims 18
• 102000036849 Islet amyloid polypeptide Human genes 0.000 claims 18
• 108010041872 Islet amyloid polypeptide Proteins 0.000 claims 18
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 206010002022 Amyloidosis Diseases 0.000 claims 3
• 206010012601 Diabetes mellitus Diseases 0.000 claims 1
• 230000002776 aggregation Effects 0.000 claims 1
• 238000004220 aggregation Methods 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 239000000546 pharmaceutic aid Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1