JPWO2020163805A5 - - Google Patents

Claims (43)

A composite scaffold,
a three-dimensional support structure defined by first and second outer layers having a length dimension defined by first and second ends thereof and separated by an interior space;
a plurality of spacer elements extending through the interior space and connecting the first outer layer and the second outer layer;
a microporous matrix having a plurality of interconnected pores disposed in the interior space and collectively defining a void between a first end and a second end of the support structure. ,
Said scaffold. 2. The composite scaffold of claim 1 , wherein at least about 60% of the voids include pores having a diameter dimension of at least 10 [mu]m or greater. 2. The composite scaffold of claim 1 , wherein the void volume is between about 3.0 cm ^<3> /gram and 9.0 cm ^<3> /gram. 2. The composite scaffold of claim 1 , having a cross-sectional area on the order of 3 mm ^<2> to 250 mm ^<2> , wherein at a strain rate of 13%, the cross-sectional area changes by less than about 17%. 2. The composite scaffold of claim 1 , wherein the surface area of the composite scaffold is between about 0.3 m ^<2> /gram and 1.5 m ^<2> /gram. The composite scaffold according to claim 1 , having an ultimate stress of the order of 2.5 MPa to 30 MPa. The composite scaffold according to claim 1 , having a yield stress of the order of 2.5 MPa to 30 MPa. The composite scaffold according to claim 1 , wherein the composite scaffold has an elastic modulus of about 2.5 MPa to 70 MPa, and the elastic modulus is determined using the cross-sectional area of the composite scaffold and the material containing the void. The scaffold is calculated as follows. 2. A composite scaffold according to claim 1 , wherein the composite scaffold has an elastic modulus of the order of 150 MPa to 600 MPa, the elastic modulus being calculated using the cross-sectional area of only the material comprising the composite scaffold. , said scaffold. 2. The composite scaffold of claim 1 , wherein the three-dimensional support structure comprises a three-dimensional woven structure. 2. The composite scaffold of claim 1 , wherein the microporous matrix comprises any of sponge, foam, or processed fibers or yarns, or any combination thereof. 2. The composite scaffold of claim 1 , wherein the microporous matrix comprises any of a freeze-dried sponge, an open cell extruded foam, a particle-infused sponge, or any combination thereof. The microporous matrix is a sponge, foam, or fabricated in which the microporous matrix is placed within a three-dimensional support structure by knitting, weaving, freeze drying, particle leaching, open cell extrusion, solution casting, solid foaming, and crosslinking. 2. The composite scaffold of claim 1 , comprising either fibers or textured yarns, or any combination thereof. 2. The composite scaffold of claim 1 , wherein the microporous matrix comprises one of collagen and hydrogel. 2. The composite scaffold of claim 1 , wherein the three-dimensional support structure comprises monofilaments, multifilaments, or textured yarns, or any combination thereof, organized into a three-dimensional structure. 2. The composite scaffold of claim 1 , wherein the three-dimensional support structure comprises any combination of synthetic bioabsorbable polymers, natural polymers, and/or additives. The three-dimensional support structure is a homopolymer, copolymer, or the following: polylactic acid, polyglycolic acid, polycaprolactone, polydioxanone, polyhydroxyalkanoic acid, polyanhydride, poly(orthoester), polyphosphazene, poly(amino acid), any of the following polymer blends: polyalkylcyanoacrylate, poly(propylene fumaric acid, trimethylene carbonate), poly(glycerol sebacic acid), poly(glyconate), poly(ethylene glycol), poly(vinyl alcohol) and polyurethane; or any combination thereof . A composite scaffold,
a support structure comprising first and second outer layers separated by an interior space and a plurality of spacer elements extending through the interior space and connecting the first and second outer layers; the structure has an external profile;
a microporous matrix having a plurality of interconnected pores opening to the exterior of the support structure and disposed within the interior space;
a plurality of interconnected pores are oriented relative to the dimensional characteristics of the support structure;
Said scaffold. 19. The composite scaffold of claim 18 , wherein the plurality of interconnected pores are oriented radially inward from an outer surface of the outer profile toward the inner space. 19. The composite scaffold of claim 18 , wherein the plurality of interconnected pores are oriented toward a longitudinal dimension of the support structure. 19. The composite scaffold of claim 18 , wherein the support structure has a cross-sectional external profile that is substantially rectangular in shape. 19. The composite scaffold of claim 18 , wherein the support structure has a cross-sectional external profile that is substantially circular in shape. A scaffold structure ,
a longitudinal dimension perpendicular to said longitudinal dimension defined by first and second ends thereof and further defined by first and second outer layers separated at least in part by an interior space therebetween; a support structure having a thickness dimension; and a plurality of spacer elements extending through the interior space and connecting the first outer layer and the second outer layer ;
a microporous matrix disposed within the interior space between the first and second outer layers;
the thickness dimension of the support structure changes by less than about 10% when stretched by about 5% of the length dimension;
Said scaffold. 24. The scaffold structure of claim 23 , wherein the plurality of spacer elements comprises spacer yarns. 24. The scaffold structure of claim 23 , wherein the plurality of spacer elements have a length extending between about 100 [mu]m and 5000 [mu]m between the first and second outer layers. 24. The scaffold structure of claim 23 , wherein the scaffold structure has an elongation at tensile failure of between about 20% and 125%. 24. The scaffold structure of claim 23 , wherein the scaffold structure has an elongation at yield between about 5% and 50%. 24. The scaffold structure of claim 23 , wherein the scaffold structure has a stiffness on the order of 2.5 N/mm to 25 N/mm. 24. The scaffold structure of claim 23 , wherein the scaffold structure has an ultimate strain on the order of 20% to 70%. 24. A scaffold structure according to claim 23 , wherein the scaffold structure has an ultimate stress of the order of 2.5 MPa to 30 MPa. 24. A scaffold structure according to claim 23 , wherein the scaffold structure has a yield stress of the order of 2.5 MPa to 30 MPa. 24. The scaffold structure has an elastic modulus of about 2.5 MPa to 70 MPa, and the elastic modulus is defined as stress divided by strain in the cross - sectional area of the scaffold including the voids. Scaffold structure as described . 23. The scaffold structure has an elastic modulus of about 150 MPa to 600 MPa, and the elastic modulus is defined as stress divided by strain of the bulk material constituting the scaffold excluding the voids. Scaffold structure as described in . 24. The scaffold structure of claim 23 , wherein the scaffold structure has a stiffness of the order of 2.5 N/mm to 250 N/mm. 24. The scaffold structure of claim 23 , wherein the scaffold structure has a tensile strength on the order of 0.07 grams-force/denier to 1.10 grams-force/denier. 24. The scaffold structure of claim 23 , wherein the scaffold structure has a tensile strength at failure on the order of 0.3 gram-force/denier to 2 gram-force/denier. body . 24. The scaffold structure of claim 23 , wherein at least a portion of the scaffold structure is coated with a hydrophilic solution. 24. The scaffold structure of claim 23 , wherein the hydrophilic solution comprises polyethylene glycol (PEG). 24. The scaffold structure of claim 23 , comprising any of monofilaments, multifilaments, or engineered yarns, or any combination thereof, organized into a three-dimensional structure. 24. The scaffold structure of claim 23 , wherein the scaffold structure comprises any combination of bioabsorbable polymers, natural polymers, and/or additives. The scaffold structure may be a homopolymer, copolymer, or the following: polylactic acid, polyglycolic acid, polycaprolactone, polydioxanone, polyhydroxyalkanoic acid, polyanhydride, poly(orthoester), polyphosphazene, poly(amino acid), poly any of the following polymer blends: alkyl cyanoacrylates, poly(propylene fumaric acid, trimethylene carbonate), poly(glycerol sebacic acid), poly(glyconate), poly(ethylene glycol), poly(vinyl alcohol) and polyurethane; or 24. A scaffold structure according to claim 23 , comprising any combination thereof. The scaffold structure has a cross-sectional area of about 3 mm ² to 3000 mm ² , and the cross-sectional area is the two-dimensional shape of the scaffold structure at a point perpendicular to the length of the scaffold structure. 24. The scaffold structure of claim 23 , wherein at a 5% stretch, the cross-sectional area changes by less than about 10%. 24. The scaffold structure of claim 23, wherein the microporous matrix defines a number of interconnected pores that collectively open to the outer surface of the microporous matrix.