JPWO2020162596A1 - Chemical injection device and chemical injection system - Google Patents

Abstract

This chemical injection device includes an injection head and a control unit, and is a chemical injection device that sucks the first chemical solution from the chemical solution container into the first syringe with respect to at least the first chemical solution, and the control unit is a chemical solution injection device. A process for displaying information on the concentration of the contrast agent which is the first chemical solution and information on the mixing conditions of the first and second chemical solutions, a process for accepting a change in the concentration of the contrast agent, and a process after the change. It is configured to change the mixing conditions of the first and second chemical solutions according to the concentration of the contrasting agent and to display information on the changed mixing conditions.

Description

The present invention relates to a drug solution injection device for delivering a drug solution such as a contrast medium to a subject and a system provided with the drug solution injection device, and in particular, even in a method of sucking a contrast medium from a drug solution container and injecting the contrast medium, the concentration is high. The present invention relates to a drug solution injection device capable of injecting a drug solution having various contrast medium concentrations without preparing a plurality of different types of contrast medium in advance and capable of changing the concentration with ease of operation, and a drug solution injection system equipped with the drug solution injection device. ..

As a medical diagnostic imaging apparatus, a CT (Computed Tomography) scanner, an MRI (Magnetic Response Imaging) apparatus, a PET (Positron Emission Tomography) apparatus, an ultrasonic diagnostic apparatus, an angiography (angiography) imaging apparatus and the like are known. .. When using such an imaging device, a contrast medium, physiological saline, or the like (hereinafter, these are also simply referred to as “drugs”) may be injected into the patient.

The drug solution is generally filled in a syringe having a cylinder and a piston. A drug solution injection device is commonly used to inject the drug solution filled in the syringe. The chemical injection device has a syringe holding mechanism and a piston driving mechanism, and the subject is charged with the chemical liquid filled in the syringe by advancing the piston by the piston driving mechanism while the syringe is held by the syringe holding mechanism. Can be injected into. As another aspect, a device for injecting a drug solution contained in a container such as a drug solution bag or a drug solution bottle into a subject instead of a syringe is also known conventionally.

As the contrast medium, different types are used depending on the type such as CT examination and MRI examination. For example, in the case of CT examination, an iodine contrast agent containing iodine is used. Further, even if the same iodine contrast medium is used, a plurality of types having different iodine contents are commercially available (for example, 240 mgI / mL, 300 mgI / mL, 320 mgI / mL, 350 mgI / mL, 370 mgI / mL, etc.).

As a chemical injection device, there is also known as a device that holds a syringe filled with a contrast medium and a syringe filled with physiological saline, and injects them at the same time to dilute the contrast medium and inject (injection). For example, Patent Document 1).

WO2011 / 125987

As the diluted injection of the contrast medium and physiological saline, for example, the injection conditions are such that a contrast medium of 350 mgI / mL is used, the mixing ratio is set to 50%, and the drug solution is injected at a predetermined injection rate and injection amount. Set. On the other hand, depending on the hospital facility and procedure, for example, it may be desirable to set the injection protocol with a contrast medium of 300 mgI / mL instead of a contrast medium of 350 mgI / mL. When trying to cope with it by changing the miscibility condition without replacing the attached contrast medium, for example, by changing the miscibility ratio from 50% to 40% (one example), the contrast medium equivalent to 300 mgI / mL is taken. It is possible to set the injection conditions so that the agent is attached.

However, with the above setting method, it is difficult to intuitively change the concentration of the contrast medium. This problem can be avoided by changing the syringe or contrast medium bottle attached to the drug solution injection device from 350 mgI / mL to 300 mgI / mL, but in this case, prepare multiple types of syringes in advance. Problems such as having to do it and the labor of work may be complicated.

Therefore, an object of the present invention is to inject a contrast medium having various concentrations without preparing a plurality of types of contrast media having different concentrations in advance, even in a method of sucking a contrast medium from a chemical solution container and injecting the contrast medium. It is an object of the present invention to provide a chemical solution injection device or the like capable of changing the concentration thereof with good operability.

In order to achieve the above problems, one embodiment of the present invention is as follows:
An injection head that holds a first syringe filled with a first drug solution and a second syringe filled with a second drug solution, and can mix and inject the first and second drug solutions.
A control unit that provides a graphical user interface for configuring the infusion protocol,
Equipped with
At least with respect to the first chemical solution, it is a chemical solution injection device that sucks the first chemical solution from the chemical solution container into the first syringe.
The control unit is
A process of displaying information on the concentration of the contrast medium which is the first chemical solution and information on the miscibility condition of the first and second chemical solutions.
The process of accepting changes in the concentration of the contrast medium and
A process of changing the mixing conditions of the first and second chemical solutions according to the changed contrast medium concentration and displaying information on the changed mixing conditions.
A chemical infusion device that is configured to do.

(Explanation of terms)
The "drug solution" means, for example, a contrast medium, a physiological saline solution, or a mixture thereof.
Specific examples of the "contrast medium" include a contrast medium having an iodine concentration of 240 mgI / mL (for example, a viscosity of 3.3 Pa · s at 37 ° C. and a specific density of 1.268 to 1.296) and a contrast medium having an iodine concentration of 300 mgI / mL (for example). For example, a contrast medium having a viscosity of 6.1 mPa · s and a specific density of 1.335 to 1.371 at 37 ° C. and an iodine concentration of 350 mgI / mL (for example, a viscosity of 10.6 mPa · s at 37 ° C. and a specific gravity of 1.392 to 1. 433) and the like.
Specific examples of the "physiological saline solution" include physiological saline solution containing 180 mg of sodium chloride in 20 ml of physiological saline solution (for example, viscosity 0.9595 mPa · s at 20 ° C., specific density 1.004 to 1.006). be.
The "injection protocol" indicates what kind of drug solution is infused at what amount, at what infusion rate and infusion time. The injection protocol may include pressure conditions such as how much pressure to inject.
The “IC tag” refers to a small non-contact type electronic device having an IC chip, an antenna, or the like and working by receiving radio waves, and may be synonymous with an RFID tag in the context of the present specification.
A "control unit" is a unit that has a CPU, memory, etc. and performs arithmetic processing, or includes the CPU, a "controller", a "controller unit", a "controller circuit (control circuit)", and a "controller module (control)". Module) ”,“ processor unit ”,“ processor unit ”,“ processor module ”and the like. The "control unit" can be configured to include a microcomputer, a microcontroller, a programmable logic controller, an integrated circuit for a specific application, other programmable circuits, and the like. In the present specification, the "control unit" may be physically one configuration, but two or three or more control units functionally cooperate to form one "control unit". May be.

The "computer program" may be one that reads out a storage medium that stores it by a predetermined device, device, mechanism, or the like, and operates those computers with a predetermined function. In this case, the storage medium that stores the computer program constitutes one form of the present invention. Further, the computer program may be provided via a communication network (for example, the Internet). The computer program may be a so-called difference program that can be realized in combination with a program already recorded in the computer.

"Part (also expressed as" element "or" module "etc.)"-For example, what is represented by "(name of function)" + "part" in this specification can be realized as a function realized by a computer. It is a thing. Such "parts (elements), modules, etc." may be provided in any device in the system. Further, it is not always necessary to be provided in one device, and the corresponding functions may be distributed and provided in two or more devices. Further, only a predetermined one or a plurality of predetermined "parts" may be provided in an external server or the like via a communication network (for example, the Internet).

It should be noted that the various components (devices, devices, parts, modules, etc.) referred to in the present specification do not have to be individually independent, and a plurality of components are configured as one member. One component is composed of multiple members, one component is part of another, and some of one component overlaps with some of another. , Etc. may be used. The various components may be configured to realize the function, and may be realized by hardware or by a computer program. For example, a certain component can be realized as dedicated hardware that exerts a predetermined function, a setting device in which a predetermined function is realized by a computer program, a combination thereof, and the like.

A "graphical user interface" (GUI) is defined by, for example, visualizing one or more of an icon, image button, pull-down menu, or numerical input window on the screen by touching it with a cursor or in the case of a touch panel. An interface that can be operated in a targeted manner.

The "icon" is configured so that (i) a predetermined information can be displayed and selected by an operator, and (ii) a simple information can be displayed and can be selected. It may include both those that do not and those that do not. All or part of the icons displayed on the screen can be selected by touching each display location with a touch pen, an operator's finger, or the like, or by using a cursor on the screen.

According to the present invention, even in a method of sucking a contrast medium from a chemical solution container and injecting the contrast medium, it is possible to inject a chemical solution having various contrast medium concentrations without preparing a plurality of types of contrast media having different concentrations in advance. Moreover, it is possible to provide a chemical solution injection device or the like capable of changing the concentration with good operability.

It is a perspective view which shows the structural example of the chemical liquid injection apparatus. It is a perspective view which shows the injection head and the drug solution syringe attached to it. It is a block diagram of a chemical solution injection device and an image pickup device. It is a figure which shows schematically the chemical solution circuit corresponding to multi-use. This is an example of a graphical user interface screen (drug information display). This is an example of a graphical user interface screen (displayed after suction). This is an example (condition setting) of the graphical user interface screen. This is an example (condition change) of the graphical user interface screen. Another example of a graphical user interface screen (condition change).

Hereinafter, the chemical solution injection device according to the embodiment of the present invention will be described with reference to the drawings.

As shown in FIGS. 1 to 3, the chemical injection device 100 according to one embodiment of the present invention is connected to the injection head 110 held on the upper part of the movable stand 111 and the injection head 110 by a cable 102, as shown in FIGS. It is equipped with a console 150. In this example, two syringes 200A and 200B are detachably attached to the injection head 110 in parallel. The injection head 110 and the console 150 may be wirelessly connected to each other.

In the following description, the syringes 200A and 200B may be simply referred to as "syringe 200" without distinction. Further, in the following description, the description will be made based on one specific form shown in the drawings, but the chemical solution injection device, the syringe and the like can be variously changed other than those described below.

[Syringe and chemical circuit]
Examples of the chemical solution filled in the syringes 200A and 200B (see FIG. 2) include a contrast medium and a physiological saline solution. For example, one syringe 200A may be filled with a contrast medium and the other syringe 200B may be filled with physiological saline. Instead of the physiological saline solution, another contrast medium or the like different from the contrast medium of the syringe A may be filled.

The syringe 200 has a hollow cylindrical cylinder member 221 and a piston member 222 slidably inserted into the cylinder member 221. The cylinder member 221 may have a cylinder flange 221a formed at its base end and a conduit portion 221b formed at its tip. By pushing the piston member 222 into the cylinder member 221, the chemical solution in the syringe is pushed out through the conduit portion 221b.

As shown in FIG. 3, with respect to at least one syringe 200, a data holding medium 225 may be attached to a part of the cylinder member 221. The data holding medium 225 contains information about the syringe (syringe identification information, pressure resistance of the syringe, inner diameter of the cylinder member, stroke of the piston member, etc.) and information on the chemical solution filled in the syringe (name (for example, product name)). , Component information such as iodine amount, expiration date, chemical volume, etc.) may be stored. The data holding medium may have a unique ID unique to the tag. The data retention medium may have at least one piece of information selected from the syringe size, syringe serial number, and drug standardization code. As the data holding medium, for example, a medium called an RFID (Radio frequency identification) tag or an IC tag, which can read information by wireless communication, can be used. As another example, it may read code information printed, engraved or displayed on a display, such as a barcode. As an example, the position where the data holding medium is attached may be the outer peripheral surface of the cylinder member, or specifically, the outer peripheral surface near the cylinder flange 211a.

The syringe may be a prefilled type filled with a chemical solution in advance, or may be a suction type syringe used by sucking the chemical solution into an empty syringe. In the case of the suction type, information such as a data holding medium may be read from a chemical solution container (bottle in one example) containing a chemical solution such as a contrast medium (details below).

In the case of the suction type, for example, a chemical solution circuit 880 as shown in FIG. 4 may be used, although it is not limited. The chemical solution circuit 880 has a first flow path 881a through which the chemical solution from one syringe 200A flows, and a second flow path 881b through which the chemical solution from the other syringe 200B flows. These channels meet at connector 883. The connector 883 may be, for example, a mixing device having a function of generating a swirling flow inside and mixing the two chemical solutions. The chemical solution from the connector 883 is sent via the third flow path 881c, and is sent out into the blood vessel of the subject through the indwelling needle 885 connected to the end thereof.

The chemical solution circuit 880 may include a multi-use portion 880M that is commonly used for a plurality of subjects a plurality of times, and a single-use portion 880S that is detachably connected to the multi-use portion 880M. The single-use portion 880S is a portion that is removed and discarded after being used for one subject.

In the middle of the first flow path 881a, a flow path 882a through which the chemical solution from the first chemical solution container 890A flows during suction is connected. Similarly, a flow path 882b through which the chemical solution from the second chemical solution container 890B flows during suction is connected to the middle of the second flow path 881b. In addition to these flow paths, some predetermined one-sided valves (not shown) are provided, so that when the piston members of the syringes 200A and 200B are pulled, the chemical liquid containers 890A and 890B (hereinafter, referred to as each) are provided. These may be referred to as a chemical solution container 890 without distinguishing between them), and a predetermined amount of the chemical solution is sucked into the syringe as needed. On the other hand, when the drug solution is pushed out from the syringes 200A and 200B to the subject side, the backflow to the flow paths 882a and 882b is prevented. The specific configuration of the chemical solution circuit 880 is not particularly limited, but for example, a detection means such as an air sensor is provided in one or both of the flow paths 882a and 882b connected to the chemical solution containers 890A and 890B, and the chemical solution in the chemical solution container is provided. It is also preferable to have a configuration that can detect when there is no more.

[Injection head]
As shown in FIG. 2, the injection head 110 has a housing extending long in the front-rear direction as an example, and two recesses on which syringes 200A and 200B are placed, respectively, on the front end side of the upper surface of the housing. 120a is formed. The recess 120a is a portion that functions as a syringe holding portion.

The syringe 200 may be directly attached to the recess 120a, or may be attached via a predetermined syringe adapter. In FIG. 2, the syringe adapters 121 and 122 that hold the cylinder flange 221a of each syringe 200 and its vicinity thereof are shown as an example. The shape and function of the syringe adapter is not limited to a specific one, and may be anything. The housing of the injection head 110 is also provided with a plurality of physical buttons for causing the injection head 110 to perform various operations.

The injection head 110 also has a piston drive mechanism 130 having at least a function of pushing the piston member 222 of the syringe 200, as shown in FIGS. 2 and 3. Two piston drive mechanisms 130 are provided, and each mechanism 130 operates independently. The piston drive mechanism 130 may have a function of retracting the piston member 222, for example, for sucking a chemical solution into a syringe. The two piston drive mechanisms 130 may be driven at the same time or at different timings.

Although detailed illustration is omitted, the piston drive mechanism 130 is connected to a drive motor (not shown), a motion conversion mechanism (not shown) that converts the rotational output of the drive motor into linear motion, and the motion conversion mechanism. , It may have a syringe presser (ram member) that advances and / or retracts the piston member 222. As such a piston drive mechanism, a known mechanism generally used in a chemical injection device can be used. An actuator other than the motor may be used as the drive source.

Typical piston drive mechanism operations include: chemical injection (forwarding of the ram member) and suction of chemicals (backward of the ram member). In "chemical injection", the motor is operated according to a predetermined motor control signal to advance the ram member, whereby the chemical injection according to the set injection protocol (injection condition) is performed. In "chemical liquid suction", the chemical liquid is sucked into the syringe by operating the motor according to a predetermined control signal and retracting the piston member. As a mechanism for delivering the chemical solution in the chemical solution bag or the chemical solution bottle toward the subject, a drive mechanism such as a tube pump that crushes the tube and sends the chemical solution may be used instead of the piston drive mechanism.

The piston drive mechanism 130 may have a load cell (not shown) for detecting the force with which the ram member presses the piston member 220. Using the detection result of the load cell, for example, an estimated value of the pressure of the drug solution when the drug solution is being injected can be obtained. This estimated value is calculated in consideration of the needle size, the concentration of the drug solution, the injection conditions, and the like. In addition, instead of using a load cell (not shown), the pressure may be calculated based on the motor current of the drive motor (not shown).

When the syringe is attached with a data holding medium 225, the injection head 110 reads information on the data holding medium 225 and / or writes information to the data holding medium 225, as shown in FIG. It may have a writer 145. The reader / writer 145 may be provided in the recess 120a in which the syringe 200 is mounted. The reader / writer 145 may have only a function of reading the information of the data holding medium 225.

As shown in FIG. 3, the injection head 110 may have a control unit 144 for controlling the operation of the piston drive mechanism 130 and the reader / writer 145. Further, for example, it may have a storage unit 146 for storing information read from the data holding medium 225. The control unit 144 can be configured as a control circuit having a processor, a memory, and the like.

Although the syringe 200 (200A, 200B) is used in the example of FIG. 3, the drug solution may be stored in a drug solution container (not shown) other than the syringe. The chemical solution container may be, for example, a chemical solution bag, a chemical solution bottle, or the like.

(Data reading means for chemical container)
As shown in FIG. 3, the data holding medium 892 may be provided in either or both of the chemical liquid containers 890A and 890B. As the data holding medium 892, for example, an RFID tag or an IC tag may be used, or a barcode or the like may be used. The information stored in the data holding medium may be one or a combination of a chemical solution type, a product name, a manufacturing company name, an expiration date, a volume, a concentration, a manufacturing number, a manufacturing date, and the like. Examples of the chemical solution container 890 include a chemical solution bottle, a chemical solution bag, and the like, and any specific outer shape may be used. The data holding medium 892 may be provided, for example, on a part of the peripheral wall surface of the chemical solution bottle.

In order to hold the chemical liquid container 890, the chemical liquid injection device 100 may be provided with holders 181A and 181B, as schematically shown in FIG. In this example, the holder 181A and the holder 181B are configured separately and each holds the chemical liquid container 890, but the holders 181A and 181B are integrally configured as one component and the two chemical liquid containers are used. It may be configured to hold 890A and 890B.

A data reading device 183 may be provided to read the information in the chemical container 890. The data reading device 183 may be, for example, a barcode reader, an IC tag reader, or the like, depending on the type of the data holding medium 892 attached to the chemical solution container 890. Of course, other data holding media and data reading devices 183 may be used. The positional relationship between the data holding medium 892 and the data reading device 183 is not limited, but the data reading device 183 faces the data holding medium 892 with the chemical solution container 890 set in a predetermined position. May be. The information read by the data reading device 183 is referenced by at least one of the injection head 110 and the console 150 of the drug solution injection device 100.

〔console〕
The console 150 may be used by being placed in an operation room adjacent to the examination room as an example. The console 150 includes a display device (display) 151 for displaying a predetermined image, an operation panel 159 provided on the front surface of the housing, and a control circuit (details below) arranged in the housing. The operation panel 159 is a portion where one or a plurality of physical buttons are arranged, and is operated by an operator. The display device 151 may be a touch panel type display device or a display having only a display function. The console 150 may have a speaker or the like (not shown) for outputting sound and / or sound. Further, another display device may be provided in the injection head.

In the block diagram of FIG. 3, the console 150 is connected to a control unit 155 that controls the operation of each connected unit, an injection processing unit 153, a storage unit 154 that stores various data, and a predetermined external device. It is depicted as having an interface for doing so. The console 150 may have an input device 157 operated by an operator.

The injection processing unit 153 is a part that controls the creation of an injection protocol, the execution of injection, and the like, and includes, for example, a setting screen display function, an injection protocol creation function, an injection control function, a history generation function, and a history output function. It may be a thing. Although the injection processing unit 153 is shown separately from the control unit 155 in FIG. 3, the function of the injection processing unit 153 may be provided as a part of the control unit 154.

The setting screen display function may correspond to a function of displaying information for setting the injection protocol, specifically, a GUI for setting the injection protocol on the display device 151. The GUI for setting the injection protocol may be stored in a drug solution injection device, an image pickup device, or any other storage device of the computer.

The protocol creation function may correspond to, for example, a function of accepting an input operation on the touch panel or the like of the display device 151 by the operator and creating an injection protocol in which the content thereof is reflected. The conditions input by the operator in this way are, for example, at least selected from the type of the drug solution, the injection rate of the drug solution, the injection amount of the drug solution, the physical information of the patient, the body classification of the patient to be imaged, the imaging site, and the like. There may be one.

The injection control function may correspond to a function of controlling the operation of the piston drive mechanism 130 according to the created injection protocol. The injection control function may operate only one of the piston drive mechanisms 130 and may operate both at the same time.

The history generation function may correspond to a function of generating injection history data and suction history data. The "injection history data" includes, for example, the injection work ID which is unique identification information for each injection work, the date and time of the injection start and end, the identification information of the drug solution injection device, and the identification of the drug solution and the imaging site which are the above-mentioned injection conditions. It may be information or the like. These may be text data. Further, one of the horizontal axis and the vertical axis may be the elapsed time and the other may be the image data of the time-lapse graph of the injection rate. The injection history data may be information on a drug solution acquired from a data holding medium of a syringe, manually input by an operator, or input from an external network or the like, or information on a syringe. The "suction history data" may include, for example, an injection work ID which is unique identification information for each injection work as described above, a date and time when suction was performed, information on suction conditions, information on a chemical solution container, and a chemical solution. Information, identification information of the drug solution injection device, and the like may be included.

The history output function may correspond to a function of transmitting injection history data or the like to the outside. Specifically, the data may be transmitted to a predetermined external device and / or network. The drug solution information and syringe information acquired from a data holding medium such as a syringe, obtained from a data holding medium of a drug solution container, manually input by an operator, or input from an external network, etc., are the drug solution injection device. May be sent to the medical information system in the hospital.

The storage unit 154 may store, for example, an image displayed on the display device 151, GUI data, or the like. Further, an algorithm including an injection condition and / or a calculation formula for setting a suction condition, and data of the injection protocol may be stored. The injection rate may be constant or may change over time. Information about such an injection protocol may be input from an external device connected via an interface. Further, the console 150 may have a slot (not shown) and input may be performed through an external storage medium inserted therein.

[Image pickup device]
The image pickup apparatus 300 (FIG. 3) is, for example, an X-ray CT scanner, an MRI apparatus, an angiography apparatus, a PET apparatus, an ultrasonic diagnostic apparatus, or the like, and has an imaging unit 303b for capturing a fluoroscopic image of a patient and a bed on which the patient is placed. It may have 304 and a control unit 303a for controlling their operation. The chemical injection device shown in FIGS. 1 and 2 is for CT examination in this example, but the chemical injection device corresponding to the type of the imaging device is appropriately used.

〔motion〕
An operation example of the chemical solution injection system of the present embodiment configured as described above will be described below. In the following, only the suction of the contrast medium from the drug solution container 890A will be mentioned, but of course, in the present invention, it is also possible to suck the physiological saline solution into the syringe 200B from the drug solution container 890B.

First, the chemical liquid containers 890A and 890B are set in the holders 181A and 181B, respectively, and the flow paths 882a and 882b of the chemical liquid circuit 880 are connected to the chemical liquid containers 890A and 890B, respectively. Syringes 200A and 200B are set in the injection head 110. Although not particularly limited, it is assumed that the syringe 200B is already filled with physiological saline and the syringe 200A is empty.

With the chemical solution container 890A set in the holder 181A, the data reading device 183 reads the information of the data holding medium 892 of the chemical solution container 890A. Note that this reading operation may be automatically performed, for example, when the chemical solution container 890A is set in the holder 181A.

The console 150 displays the read information on the display device 151 on a screen as shown in FIG. 5, for example. In this example, the chemical solution information 520 in the chemical solution container is displayed. Specifically, one or more of the product name of the contrast medium, the concentration of the contrast medium, and the capacity (remaining amount) of the contrast medium are displayed. According to the configuration in which the chemical solution information of the chemical solution container 890A is read by the device and displayed in this way, the operator looks at the displayed contents and the set chemical solution container 890A is correct. It is possible to confirm whether or not.

FIG. 6 is an example of a screen displayed when suction is performed from the chemical solution container 890A to the syringe 200A. In this example, the product name of the contrast medium and the information of the concentration information 513 of the contrast medium are displayed on the screen, and the velocity information 521 and the suction amount information 523 are also displayed. Although not limited, the suction may be started by pressing the icon 531 on the screen. It is preferable that the remaining amount of the chemical solution container 890A is displayed on the screen after the suction is completed, and in FIG. 6, the remaining amount display unit 525 displayed in the shape of a bottle is drawn as an example. .. In this example, 60 ml is sucked from the volume that was initially 500 ml, so that the remaining amount is 440 ml. In this way, according to the configuration in which the remaining amount after suction is displayed, for example, when the chemical solution container 890A is arranged at a position where it is difficult to see, or when it is set in the holder 181A, the remaining amount of the container can be confirmed. Even in the case of a structure that makes it difficult to perform, it is preferable because the remaining amount can be confirmed satisfactorily.

The display device for displaying information about the drug solution container and / or the drug solution contained therein may be any other device (for example, an injection head) other than the console. As a specific example, in a configuration in which the chemical solution bottle is set in the bottle keeper (holder), it is assumed that the contents such as the label attached to the chemical solution bottle cannot be visually recognized when the chemical solution bottle is set. On the other hand, according to the configuration as in the present embodiment, it is possible to surely confirm the information about the chemical solution container and / or the chemical solution contained therein.

By displaying information about the drug solution container and / or the drug solution contained therein on the display device, the remaining capacity can be constantly monitored and the next test can be performed manually and / or automatically. It is possible to count the number of times of suction, replenish (suck) when the required amount is insufficient, read the set amount, and suck the appropriate capacity. When the remaining amount of the chemical solution container becomes less than a predetermined value, a message such as "Please replace the chemical solution bottle" may be displayed.

Various condition settings (for example, setting of injection conditions) may be performed using the information read from the data holding medium of the chemical solution container. With such a configuration, it is possible to set conditions and the like more accurately than when an operator looks at the label of a chemical solution bottle and manually inputs the information read from the label into the device. Become.

FIG. 7A is an example of a graphical user interface for configuring the injection protocol. Various types of interfaces have been conventionally proposed, and any method may be used, so detailed description thereof will be omitted. However, in FIG. 7A, a human body image 540 imitating a human body is displayed. The human body image 540 includes a plurality of body classification icons 540a to 540d, and each body classification icon can be selected. For example, when the chest icon 540b is selected, the preset drug solution conditions are read and displayed correspondingly. As an example, in FIG. 7A, the injection protocol display unit 542 displays a condition image 541 containing information on the injection rate (5.0 mL / sec) and the injection amount (20 mL).

On the screen of FIG. 7A, the syringe remaining amount information 533, the pressure limit information 534, the contrast medium concentration information 535, and the dilution rate information 536 are further displayed.

In the syringe remaining amount information 533, it is displayed that the remaining amount of the syringe A is 150 mL and the remaining amount of the syringe B is 150 mL. The pressure limit information 534 indicates that the withstand voltage of the syringe is 300 psi. The contrast medium concentration information 535 indicates that the iodine amount of the contrast medium is 350 mgI / mL (note that the numerical value of the relevant portion is a value that serves as a reference concentration when setting the conditions, and is actually in the syringe. The value may be different from the concentration of the contrast medium contained in it). Dilution rate information 536 shows that the mixing ratio of the contrast medium and the saline solution is 1: 1 and the dilution rate is 50.

On the screen of FIG. 7A, the portion of the contrast medium concentration information 535 is a selectable icon, and the iodine amount of the contrast medium can be changed by touching this icon. For example, there may be a toggle display in which several concentrations are sequentially switched, such as 350 mgI / mL → 300 mgI / mL → 240 mgI / mL. As a matter of course, the number of concentrations to be displayed as candidates is not necessarily limited to three, and may be increased or decreased as appropriate. Instead of the selection method as described above, a numeric keypad (not shown) may be displayed and a numerical value of concentration may be input via the numeric keypad. Further, a pull-down menu including a plurality of candidates is displayed on the screen, and one of them may be selected.

When, for example, 350 mgI / mL is changed to 300 mgI / mL by the above function, in the configuration of this embodiment, the dilution ratio of the drug solution is automatically changed accordingly as if a contrast medium of 300 mgI / mL is used. (In this case, the dilution ratio is changed from 50% to 40%). On the screen after the change, for example, as shown in FIG. 7B, the numerical value of the contrast medium concentration information 535 is changed to "300", and the numerical value of the dilution rate information 536'is changed to "40%".

According to the above configuration, although the contrast medium actually contained in the syringe 200A is 350 mgI / mL, the contrast medium concentration (see reference numeral 535) is directly changed and the dilution ratio (reference numeral 536') is changed. ) Can be used like that of 300 mgI / mL. Such an embodiment is particularly useful for a multi-use method such as injecting into a plurality of patients without changing the drug solution container 890A.

Even when the contrast medium concentration is changed as in the state of the screen of FIG. 7B, the concentration information 513 of the contrast medium actually filled in the syringe continues to be displayed on the screen. In morphology, it is preferred. By doing so, both the actual contrast medium concentration (350 mgI / mL in this example) and the changed contrast medium concentration (300 mgI / mL in this example) can be confirmed on one screen.

After the injection protocol setting is completed, the drug solution injection is started when the operator receives one or more predetermined inputs. Various conventionally known methods can be used for the procedure up to the start of the chemical solution injection, the operation of the piston drive mechanism 130 during the chemical solution injection, and the like.

As described above, according to the chemical solution injection device of the present embodiment, the contrast medium or the like is sucked into the syringe 200 from the chemical solution container 890 to inject the chemical solution, but the contrast medium concentration is changed on the graphical user interface. It is possible, and the dilution rate is automatically changed accordingly, and the drug solution having a desired concentration is injected. Therefore, it is not necessary to prepare a plurality of types of contrast media having different concentrations in advance.

In the configuration in which the drug solution is sucked from the drug solution bottle (example) as in the above-described embodiment, the drug solution bottle containing 500 mL of the contrast medium of 350 mgI / mL is removed after using, for example, only 100 mL, and the 350 mgI / mL drug solution bottle is removed. When it comes to resetting, such work is not preferable from the viewpoint of labor and maintenance of the chemical solution. In particular, in the case of a device for heating a chemical solution bottle, it may be necessary to reheat the bottle. On the other hand, according to the configuration of the present embodiment, it is possible to inject the contrast medium at a desired concentration without replacing the chemical solution container 890, which is preferable.

In the above, the present invention has been described by showing specific examples, but the present invention can be appropriately modified without departing from the spirit of the present invention:
-For example, with respect to the screen shown as an example of the graphical user interface, not all the display elements on the screen are indispensable, and the number may be increased or decreased as appropriate.
-The contents of the graphical user interface are not necessarily limited to those displayed in one unit or one place, and may be configured to be displayed in a plurality of units or a plurality of places as needed.

In the above embodiment, an example in which a plurality of syringes are held by the injection head has been described, but as one embodiment of the present invention, a first chemical solution (for example, a contrast medium) and a second chemical solution are contained in one syringe from the chemical solution container. The chemical solution of the above (for example, physiological saline) may be drawn in by a predetermined amount to prepare a chemical solution having a desired concentration. The injection head may be a single-cylinder type or a multi-cylinder type.

(A concrete example of GUI)
Although various changes can be made to the graphical user interface, for example, the conditional image 541 shown in FIG. 7A or the like may be more specifically as shown in FIG. In the example of FIG. 8, the injection rate (5.0 mL / sec) and the injection amount (80 mL) of the mixed drug solution are displayed, and the injection condition indications 547a and 547b of the contrast medium and the physiological saline are shown, respectively. ing. For example, the injection condition display 547a is displayed as 3.0 mL / sec, 50 mL, and the injection condition display 547b is displayed as 2.0 mL / sec, 30 mL (the displayed numerical values are merely examples).

The condition image 541 may not only display the setting condition but also function as a user interface for receiving an input for starting a predetermined operation. For example, the image portion 543 showing the injection amount of the contrast medium is an icon, and when it is touched (or accompanied by a predetermined input from the operator accompanying it), the suction operation into the syringe is performed. It may be started. Of course, the same user interface may be used with saline.

(Example of display mode related to contrast agent concentration information)
7A and 7B show an example in which two information, that is, the concentration information 513 of the contrast medium in the actual chemical solution container and the contrast medium concentration information 535 that can be used for setting the conditions, are displayed on the screen. In this regard, the drug infusion device may be configured as follows:
As described above, a plurality of options (for example, 350 mgI / mL, 300 mgI / mL, 240 mgI / mL) can be displayed as the contrast medium concentration information 535, but with respect to this display, the actual contrast medium concentration (reference numeral 513) is used. The high concentration option may be configured so that it is not displayed. For example, if 300 mgI / mL is used, the 350 mgI / mL option will not be displayed. With such a display mode, it becomes more convenient to use. Similarly, an option (value) having a concentration higher than the actual contrast medium concentration may not be input, and if such an option (value) is input, a notification is given to that effect. The operation of recording information and / or transmitting data to a predetermined external device may be performed.

Further, even if the chemical solution injection device is configured to compare the actual contrast medium concentration (reference numeral 513) with the contrast medium concentration for setting conditions (reference numeral 535) and perform predetermined control according to the result. good. For example, the predetermined light emitting device of the chemical solution injection device or the predetermined display on the screen may be different depending on whether the two are the same or different. Specifically, when both are the same, the display on the screen in the first color, the first emission pattern, and / or the first shape (in one example, contrast agent concentration information 535 and dilution rate information 536) is displayed. If they are different, they may be represented by a second color, a second emission pattern, and / or a second shape.

(Additional note)
This application discloses the following inventions:
1. 1. A first syringe (200A) filled with a first drug solution and a second syringe (200B) filled with a second drug solution are held, and the first and second drug solutions are mixed and injected. With the head (110),
A control unit (150, 155) that provides a graphical user interface for configuring the drug infusion protocol.
Equipped with
At least for the first chemical solution, it is a chemical solution injection device that sucks the first chemical solution from the chemical solution container (890) into the first syringe (200).
The control unit (150, 155) is
A process for displaying information on the concentration of the contrast medium as the first chemical solution (513) and information on the miscibility condition of the first and second chemical solutions (536).
The process of accepting the change in the concentration of the contrast medium (350 mgI → 300 mgI) and
A process of changing the mixing conditions of the first and second chemical solutions according to the changed contrast medium concentration and displaying information (536') regarding the changed mixing conditions.
A chemical infusion device that is configured to do.

2. 2. The drug solution injection device according to the above, wherein the information regarding the miscibility condition is the dilution ratio.

3. 3. Moreover,
The drug solution injection device according to the above description, comprising a data reading unit (183) for reading information on a data holding medium attached to the drug solution container (890). This unit may write data.

4. The drug solution injection device according to the above description, wherein the data holding medium is an IC tag.

5. The control unit performs a process of displaying at least one information of the suction amount (523) and the remaining amount of the chemical solution (525) in the chemical solution container when the chemical solution is sucked from the chemical solution container (890). The above-mentioned chemical injection device to be performed.

6. A drug solution injection system comprising the above-mentioned chemical solution injection device and a chemical solution circuit (880) connected to the first and second syringes.

7. The chemical solution circuit is
A multi-use portion (880M) comprising at least a flow path connected to the first syringe and a flow path connected to the second syringe and used multiple times for examination of a plurality of subjects.
A single-use part (880S) that is detachably connected to the multi-use part and exchanged for each subject,
Is included,
The drug solution injection system described above.

7. Further, the chemical solution injection system according to the above description, which comprises a chemical solution bottle as the chemical solution container.

A1. With an injection head that holds the first drug solution container filled with the first drug solution and the second drug solution container filled with the second drug solution, and can mix and inject the first and second drug solutions. ,
A control unit that provides a graphical user interface for configuring the infusion protocol,
Equipped with
At least with respect to the first chemical solution, it is a chemical solution injection device that sucks the first chemical solution from the chemical solution container into the first syringe.
The control unit is
A process of displaying information on the concentration of the contrast medium which is the first chemical solution and information on the miscibility condition of the first and second chemical solutions.
The process of accepting changes in the concentration of the contrast medium and
A process of changing the mixing conditions of the first and second chemical solutions according to the changed contrast medium concentration and displaying information on the changed mixing conditions.
A chemical infusion device that is configured to do.

The present application also discloses a representation of the technical idea of the above invention as an invention of a control method and an invention of a computer program. The reference numerals in parentheses described above do not limit the present invention in any way.

100 Chemical injection device 110 Injection head 130 Piston drive mechanism 150 Console 151 Display device 200 (200A, 200B) Syringe 221 Cylinder member 222 Piston member 225 Data retention medium 300 Imaging device 880 Chemical liquid circuit 880M Multi-use unit 880S Single-use unit 881a, 881b , 881c Flow path 883 Connector 885 Indwelling needle 890 (890A, 890B) Chemical solution container 892 Data retention medium

Claims (10)

An injection head that holds a first syringe filled with a first drug solution and a second syringe filled with a second drug solution, and can mix and inject the first and second drug solutions.
A control unit that provides a graphical user interface for configuring the infusion protocol,
Equipped with
At least with respect to the first chemical solution, it is a chemical solution injection device that sucks the first chemical solution from the chemical solution container into the first syringe.
The control unit is
A process of displaying information on the concentration of the contrast medium which is the first chemical solution and information on the miscibility condition of the first and second chemical solutions.
The process of accepting changes in the concentration of the contrast medium and
A process of changing the mixing conditions of the first and second chemical solutions according to the changed contrast medium concentration and displaying information on the changed mixing conditions.
A chemical infusion device that is configured to do. The chemical injection device according to claim 1, wherein the information regarding the miscibility condition is a dilution rate. Moreover,
A data reading unit for reading information on a data holding medium attached to the chemical solution container is provided.
The drug solution injection device according to claim 1 or 2. The drug solution injection device according to any one of claims 1 to 3, wherein the data holding medium is an IC tag. The control unit is
When the chemical solution is sucked from the chemical solution container,
Performs a process of displaying information on at least one of the suction amount and the remaining amount of the chemical solution in the chemical solution container.
The drug solution injection device according to any one of claims 1 to 4. The drug solution injection device according to any one of claims 1 to 5.
The drug solution circuit connected to the first and second syringes,
A chemical injection system equipped with. The chemical solution circuit is
A multi-use portion that includes at least a flow path connected to the first syringe and a flow path connected to the second syringe and is used multiple times for examination of a plurality of subjects.
A single-use part that is detachably connected to the multi-use part and exchanged for each subject, and a single-use part.
Is included,
The drug solution injection system according to claim 6. Moreover,
A chemical solution bottle is provided as the chemical solution container.
The drug solution injection system according to claim 6 or 7. To a computer that provides a graphical user interface for configuring the drug infusion protocol,
A process of displaying information on the concentration of the contrast medium, which is the first chemical solution, and information on the miscibility conditions of the first and second chemical solutions on the display.
The process of accepting changes in the concentration of the contrast medium and
A process of changing the mixing conditions of the first and second chemical solutions according to the changed contrast medium concentration and displaying information on the changed mixing conditions.
A computer program that runs. A computer control method that provides a graphical user interface for configuring a drug infusion protocol.
A step in which the computer displays information on the concentration of the contrast medium, which is the first drug solution, and information on the miscibility conditions of the first and second drug solutions on the display.
The step in which the computer accepts the change in the concentration of the contrast medium,
A step in which the computer changes the mixing conditions of the first and second chemical solutions according to the changed contrast medium concentration and displays information on the changed mixing conditions.
Control methods, including.

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