JPWO2020146752A5

JPWO2020146752A5 -

Info

Publication number: JPWO2020146752A5
Application number: JP2021540141A
Authority: JP
Publication date: 2023-04-25

Claims

To treat or prevent oral lesions in a subject, or damaged tissue or compromised skin such as mucositis, ulcers (such as diabetic podiatric ulcers), wounds, burns, and (herpes virus type 1 ( A composition for treating peripheral nerve injury due to infection with HSV-1) or tissue damage due to viral infection, such as blisters due to infection with herpes virus type 2 (HSV-2). ,
(i) a drug delivery system comprising a carbonate buffer, at least two different biosurfactants, at least one hygroscopic agent, and at least one antioxidant;
(ii) at least one bioactive agent , 7.5-9 . A composition having a pH in the range of 5.

The composition has the following characteristics:
said carbonate buffer comprises one of the following ions: sodium, potassium, calcium and magnesium, optionally said carbonate buffer is a sodium bicarbonate buffer;
each of the at least two biosurfactants is selected from glycolipids, lipopeptides, and polymeric biosurfactants;
the hygroscopic agent comprises an agent selected from glycol polymers, glycosaminoglycans, mucopolysaccharides, and cellulose polymers;
said at least one antioxidant comprises a lipophilic antioxidant; and
said at least one bioactive agent is a small molecule, protein, nucleic acid, or bioactive extract;
2. The composition of claim 1, having one or more of

The composition has the following characteristics:
said glycolipid is selected from rhamnolipids, sophorolipids, trehalolipids, cellobiolipids, mannosylerythritol lipids, and any combination thereof , in particular a combination of rhamnolipiro and sophorolipids ;
said lipopeptide is selected from surfactin, privastatin, basilomycin, fengycin, subtilisin, gramicidin, polymyxin, and any combination thereof;
said polymeric biosurfactant is selected from emulsan, biodispersan, liposan, mannan-lipid-protein complexes, carbohydrate-lipid-protein complexes, and any combination thereof;
wherein the glycol polymer comprises a polyethylene glycol polymer;
The glycosaminoglycan is hyaluronic acid or chondroitin sulfate and dermatan sulfate,
the cellulose polymer comprises carboxymethylcellulose, hydroxyethylcellulose, or hydroxyethylcellulose; and
said lipophilic antioxidant is butylhydroxytoluene (BHT), butylhydroxyanisole (BHA) and/or tocopherol, optionally said tocopherol is α-tocopherol;
3. The composition of claim 2, having one or more of

The total amount of said biosurfactant in said composition is: 1 . 5% (w/w) to 10 % ( w/w) and/or the amount of the moisture absorbent in the composition is 1% (w/w) to 10% (w/w). w) .

4. The composition according to claim 3 , wherein the rhamnolipid to sophorolipid ratio ranges from 1 :9 to 9 :1 , or the ratio is 1 :1 or 7 :3.

Said bioactive extract is obtained from one or more types of propolis , optionally said propolis is green propolis (Baccharis dracunculifolia propolis) , brown propolis, red propolis (Dalbergia ecastophyllum propolis) , or any of the foregoing. including any combination, optionally wherein the ratio of said green propolis to brown propolis ranges from 1:9 to 9:1, and optionally a bioactive propolis extract. is in the range of 5% (w/w) to 20% (w / w) .

7. The bioactive extract of claim 6 , wherein the bioactive extract is a natural bioactive extract comprising one or more of the following : flavonols, flavanones , artepillin C, triterpenoids, isoflavonides, chalcones, pterocarpanes, and aromatic acids. composition.

Said bioactive extract is a naturally occurring bioactive extract obtained from one or more species of seaweed, optionally wherein said one or more species of seaweed is Enteromorpha, Ulva selected from the genera Ulva, Monostroma, Codium, Caulerpa, Bryopsis, Porphyra and Laminaria , optionally 3. The composition of claim 2 , wherein the total amount of bioactive extract ranges from 5% (w/w) to 20% (w/w) .

wherein said natural bioactive extract comprises one or more sulfated polysaccharides, optionally each of said one or more sulfated polysaccharides is selected from carrageenan, urban, galactan, and fucoidan 9. The composition of claim 8 .

A composition according to any one of claims 6 to 9 , wherein said bioactive extract further comprises one or more of Aloe vera, baicalin , andrographolide and thymol.

The composition has the following characteristics:
said bioactive extract is a natural bioactive extract comprising one or more carotenoids and/or vitamin A, optionally said carotenoids and/or vitamin A are obtained from carrot oil;
said natural bioactive extract comprises one or more B vitamin complexes, optionally said one or more B vitamin complexes is pantothenic acid or a derivative or analogue thereof; optionally the B vitamin complex comprises dexpanthenol, and
wherein the total amount of said natural bioactive extract ranges from 1% (w/w) to 5% (w/w);
3. The composition of claim 2, having one or more of

12. The composition of claim 11 , wherein said composition further comprises one or more proteins, optionally said proteins comprising collagen and/or albumin.

Said bioactive extract is a natural bioactive extract obtained from lemon balm (Melissa officinalis), optionally comprising one or more vitamin B complex, optionally said one wherein said B vitamin complex comprises methylcobalamin and/or cyanocobalamin , or is pantothenic acid or a derivative or analogue thereof; optionally said B vitamin complex comprises dexpanthenol ; is in the range of 1 % ( w/w) to 5 % (w/ w ).

The composition is formulated as a solid, liquid, gel, or foam, including a powder or lyophilized powder , optionally
the liquid is a mouthwash;
wherein the gel or foam is formulated as an aerosolized spray or hydrogel;
2. The composition of claim 1 , wherein said composition is present on or in a solid substrate , said solid substrate optionally comprising cotton fibers and optionally being a bandage or cotton mask. The described composition.

A solid substrate comprising a composition according to any one of claims 1-14 .

(i) a composition according to any one of claims 1-14 ;
(ii) a non-adhesive wound dressing;

17. A kit according to claim 16 , wherein the non-adhesive wound dressing comprises cotton fibers and optionally one or more elastic bandages.

(i) a composition according to any one of claims 1-14 ;
(ii) one or more antiviral agents effective to treat herpes simplex virus and genital herpes virus (HSV2) ;

Said kit has the following features:
the one or more antiviral agents are selected from acyclovir, valacyclovir, and famciclovir ; and
wherein the herpes simplex virus is herpes simplex labialis (HSL or HSV-1) and genital herpes is HSV-2;
19. The kit of claim 18, comprising one or more of

A method for treating oral lesions in a subject comprising administering a composition according to any one of claims 1 to 14 to a subject having one or more oral lesions. The composition according to any one of claims 1 to 14, wherein

the subject is
have or are suspected of having mucositis,
have previously received chemotherapy, radiation therapy, or a combination of chemotherapy and radiation therapy; and/or
21. The composition according to claim 20 , undergoing mandibular facial surgery , in particular dental implant surgery .

The composition has the following characteristics:
wherein said composition is administered directly to said subject's oral cavity, optionally said administration is by oral spray or mouthwash;
The subject is administered the composition more than once a day, including 2, 3, 4, or more times a day, optionally before meals, after meals, or both before and after meals. and _
administration of the composition inhibits bacterial biofilm formation and/or growth;
21. The composition of claim 20, having one or more of

A composition according to any one of claims 1 to 14 , for use in a method comprising administering a composition according to any one of claims 1 to 14 to the skin of a subject in need thereof. composition .

said skin has undergone a cosmetic treatment, optionally said cosmetic treatment is a laser skin peel, optionally said skin of said subject is compromised, optionally 24. The composition of Claim 23 , wherein the compromised skin is a wound, ulcer, or blister.

Said administering comprises contacting said subject's skin with a solid substrate comprising said composition, optionally said solid substrate being a non-adhesive bandage or a cotton face mask. 24. The composition of claim 23 .

24. The method of claim 23, wherein said administration is topical administration, optionally at least 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 times per day or per week . composition .

the subject is
have or are suspected of having chronic wounds as a result of diabetes or compromised skin with inadequate blood flow , including varicose veins and pressure ulcers ;
having herpes simplex virus or genital herpes (HSV-2) or suspected of being infected with herpes simplex virus or genital herpes (HSV-2) , optionally wherein said herpes simplex virus is herpes labialis 24. The composition of claim 23 , wherein a

A composition for use in a method of regenerating peripheral nerve endings in a subject in need thereof, comprising:
(i) a first composition comprising a bioactive lemon balm (Melissa officinalis) extract;
(ii) a second composition comprising methylcobalamin and/or cyanocobalamin ;
A combination composition, wherein said method comprises administering said combination composition to said subject.

The first composition and the second composition are administered as a composition according to claim 13 , optionally wherein the first composition and/or the second composition are topically 29. The combination composition of claim 28 , administered.

The skin of the subject is compromised, optionally the compromised skin is a wound, ulcer, or blister, optionally the subject is infected with herpes simplex virus or genital herpes (HSV). -2) or suspected of being infected with herpes simplex virus or genital herpes (HSV-2) , optionally wherein said herpes simplex virus is herpes labialis . Mixed composition .