JPWO2020120801A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020120801A5 JPWO2020120801A5 JP2021555890A JP2021555890A JPWO2020120801A5 JP WO2020120801 A5 JPWO2020120801 A5 JP WO2020120801A5 JP 2021555890 A JP2021555890 A JP 2021555890A JP 2021555890 A JP2021555890 A JP 2021555890A JP WO2020120801 A5 JPWO2020120801 A5 JP WO2020120801A5
- Authority
- JP
- Japan
- Prior art keywords
- endotoxin
- solid phase
- phase material
- contain
- suspected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002158 endotoxin Substances 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 20
- 239000007790 solid phase Substances 0.000 claims description 13
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims description 7
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 6
- 241001515965 unidentified phage Species 0.000 claims description 6
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 238000005571 anion exchange chromatography Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 230000009920 chelation Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000000975 co-precipitation Methods 0.000 claims description 2
- 238000002270 exclusion chromatography Methods 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000002458 infectious effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000011236 particulate material Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- 238000011013 endotoxin removal Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 2
- 102000052508 Lipopolysaccharide-binding protein Human genes 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000010364 biochemical engineering Methods 0.000 description 1
- 238000011217 control strategy Methods 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000001597 immobilized metal affinity chromatography Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- DFENKTCEEGOWLB-UHFFFAOYSA-N n,n-bis(methylamino)-2-methylidenepentanamide Chemical compound CCCC(=C)C(=O)N(NC)NC DFENKTCEEGOWLB-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229960000160 recombinant therapeutic protein Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024174611A JP2025022878A (ja) | 2018-12-14 | 2024-10-03 | エンドトキシン含有供給物又はエンドトキシンを含有する可能性のある供給物からエンドトキシンを枯渇させる又は除去するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18212639.1 | 2018-12-14 | ||
| EP18212639 | 2018-12-14 | ||
| PCT/EP2019/085401 WO2020120801A1 (en) | 2018-12-14 | 2019-12-16 | A method for depletion or removal of endotoxin from an endotoxin-containing source or potentially endotoxin-containing source |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024174611A Division JP2025022878A (ja) | 2018-12-14 | 2024-10-03 | エンドトキシン含有供給物又はエンドトキシンを含有する可能性のある供給物からエンドトキシンを枯渇させる又は除去するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022528310A JP2022528310A (ja) | 2022-06-10 |
| JPWO2020120801A5 true JPWO2020120801A5 (enrdf_load_stackoverflow) | 2022-12-28 |
| JP7650811B2 JP7650811B2 (ja) | 2025-03-25 |
Family
ID=65003076
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021555890A Active JP7650811B2 (ja) | 2018-12-14 | 2019-12-16 | エンドトキシン含有供給物又はエンドトキシンを含有する可能性のある供給物からエンドトキシンを枯渇させる又は除去するための方法 |
| JP2024174611A Withdrawn JP2025022878A (ja) | 2018-12-14 | 2024-10-03 | エンドトキシン含有供給物又はエンドトキシンを含有する可能性のある供給物からエンドトキシンを枯渇させる又は除去するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024174611A Withdrawn JP2025022878A (ja) | 2018-12-14 | 2024-10-03 | エンドトキシン含有供給物又はエンドトキシンを含有する可能性のある供給物からエンドトキシンを枯渇させる又は除去するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220056421A1 (enrdf_load_stackoverflow) |
| EP (1) | EP3894579A1 (enrdf_load_stackoverflow) |
| JP (2) | JP7650811B2 (enrdf_load_stackoverflow) |
| CN (1) | CN113166792B (enrdf_load_stackoverflow) |
| WO (1) | WO2020120801A1 (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114450398A (zh) * | 2019-10-01 | 2022-05-06 | 自适应噬菌体治疗公司 | 纯化噬菌体粒子的方法 |
| EP3995196B1 (en) * | 2020-11-04 | 2023-08-09 | Sartorius BIA Separations d.o.o. | Purification process for lipid-membrane-enclosed complex assemblages |
| CN114230641B (zh) * | 2021-12-29 | 2024-03-26 | 内蒙古必威安泰生物科技有限公司 | 一种去除口蹄疫抗原液中内毒素的方法 |
| CN115161308A (zh) * | 2022-06-13 | 2022-10-11 | 江苏丰华生物制药有限公司 | 一种注射用替奈普酶上清液的纯化方法 |
| WO2025111368A1 (en) * | 2023-11-20 | 2025-05-30 | San Diego State Unversity (Sdsu) Foundation, Dba San Diego State University Research Foundation | Methods for purifying bacteriophage and products of manufacture containing purifyied bacteriophage |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0664814A1 (en) | 1993-08-18 | 1995-08-02 | MorphoSys AG | Lipopolysaccharide-binding and neutralizing peptides |
| AUPM388494A0 (en) * | 1994-02-16 | 1994-03-10 | Csl Limited | Process for removing endotoxins |
| US20020197249A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products |
| US6365147B1 (en) | 1999-10-13 | 2002-04-02 | New Jersey Institute Of Technology | Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography |
| CN1137860C (zh) * | 2000-12-20 | 2004-02-11 | 中国科学院生态环境研究中心 | 高铁氧化去除水中微藻素的方法 |
| WO2002083710A2 (en) * | 2001-04-13 | 2002-10-24 | Wyeth Holdings Corporation | Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography |
| GB0211805D0 (en) * | 2002-05-22 | 2002-07-03 | Prometic Biosciences Ltd | Endotoxin-binding ligands and their use |
| RU2344425C2 (ru) * | 2002-06-24 | 2009-01-20 | Профос АГ | Способ идентификации и экстракции эндотоксина |
| US20060030007A1 (en) * | 2003-05-30 | 2006-02-09 | Byrd Devon R | Peptides for metal ion affinity chromatography |
| US7294614B2 (en) * | 2004-10-12 | 2007-11-13 | Clontech Laboratories, Inc. | Phosphoprotein affinity resins and methods for making and using the same |
| DE102005002969A1 (de) * | 2005-01-21 | 2006-08-03 | Profos Ag | Verfahren zum Nachweis und zur Entfernung von Endotoxin |
| GB0621452D0 (en) * | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Therapy for liver disease |
| US20100004218A1 (en) * | 2008-06-20 | 2010-01-07 | Whiteford Jeffery A | Bridged polycyclic compound based compositions for renal therapy |
| US9701558B1 (en) * | 2014-02-08 | 2017-07-11 | Mansour S. Bader | Methods to treat source water for oil-fields heavy oil and other applications |
| WO2013180648A1 (en) * | 2012-05-31 | 2013-12-05 | Agency For Science, Technology And Research | Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations |
| SG11201505190VA (en) * | 2013-02-22 | 2015-08-28 | Agency Science Tech & Res | Chromatographic purification of virus preparations with negatively charged particles |
| WO2014129973A1 (en) * | 2013-02-22 | 2014-08-28 | Agency For Science, Technology And Research | Materials and methods for removing endotoxins from protein preparations |
| GB201310151D0 (en) * | 2013-06-07 | 2013-07-24 | Glaxosmithkline Biolog Sa | Novel method |
| WO2017213588A1 (en) * | 2016-06-06 | 2017-12-14 | National University Of Singapore | A method and a kit for detecting and/or quantifying endotoxin |
| CN108743616B (zh) * | 2018-05-30 | 2020-12-25 | 博瑞生物医药（苏州）股份有限公司 | 一种超顺磁氧化铁内毒素的去除方法 |
-
2019
- 2019-12-16 CN CN201980082566.4A patent/CN113166792B/zh active Active
- 2019-12-16 JP JP2021555890A patent/JP7650811B2/ja active Active
- 2019-12-16 EP EP19817377.5A patent/EP3894579A1/en not_active Withdrawn
- 2019-12-16 US US17/312,756 patent/US20220056421A1/en active Pending
- 2019-12-16 WO PCT/EP2019/085401 patent/WO2020120801A1/en not_active Application Discontinuation
-
2024
- 2024-10-03 JP JP2024174611A patent/JP2025022878A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6039550B2 (ja) | タンパク質の精製装置および方法 | |
| EP1154827B1 (en) | Purification of biological substances | |
| CN113166792B (zh) | 一种用于从含内毒素源或潜在含内毒素源中去掉或去除内毒素的方法 | |
| EP1775000A2 (en) | Method of producing universal blood plasma from blood | |
| Charlton et al. | Characterisation of a generic monoclonal antibody harvesting system for adsorption of DNA by depth filters and various membranes | |
| TW201221641A (en) | Processes for purification of proteins | |
| JP6320429B2 (ja) | 負帯電粒子を用いるウイルス調製物のクロマトグラフィー精製 | |
| JP2015503524A5 (enrdf_load_stackoverflow) | ||
| JP2018501222A (ja) | 混床イオン交換吸着剤 | |
| JP2015520026A (ja) | 溶媒抽出法で処理される低有機抽出物デプスフィルター媒体 | |
| CN116234619A (zh) | 宿主细胞dna的金属亲和提取 | |
| US20210292788A1 (en) | Method for Adenovirus Purification | |
| Pitiot et al. | A potential set up based on histidine hollow fiber membranes for the extracorporeal removal of human antibodies | |
| JPWO2020120801A5 (enrdf_load_stackoverflow) | ||
| US20150147243A1 (en) | Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations | |
| JP7512891B2 (ja) | ポリペプチドの分離方法、ポリペプチドの製造方法及びポリペプチドの精製装置 | |
| WO2020127505A1 (en) | A method for removing nucleosomal contaminants from bioprocessing solutions | |
| EP4493199A1 (en) | Methods and compositions for purifying small extracellular vesicles | |
| JP2016513245A (ja) | タンパク質製剤の凝集体含有量を減少させる混合多官能金属親和性表面 | |
| JP2023529187A (ja) | 混入ｄｎａをより効果的に除去するための、アデノ随伴ウイルスの精製の強化 | |
| JP2009042074A (ja) | 吸着担体及び吸着担体の製造方法 | |
| JP2010070490A (ja) | 抗体の精製方法 | |
| JP7344232B2 (ja) | バイオセパレーションのための複合材料 | |
| JP2005232156A (ja) | 生体成分精製溶液、生体成分分離方法および生体成分分離装置 | |
| JP2025506274A (ja) | 生物学的薬剤の精製プロセス中の夾雑物の選択的除去方法 |