JPWO2020086955A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020086955A5 JPWO2020086955A5 JP2021521511A JP2021521511A JPWO2020086955A5 JP WO2020086955 A5 JPWO2020086955 A5 JP WO2020086955A5 JP 2021521511 A JP2021521511 A JP 2021521511A JP 2021521511 A JP2021521511 A JP 2021521511A JP WO2020086955 A5 JPWO2020086955 A5 JP WO2020086955A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- ecm
- soluble
- pharmaceutical composition
- infusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 31
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 31
- 210000002744 extracellular matrix Anatomy 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 238000001802 infusion Methods 0.000 claims 9
- 239000007788 liquid Substances 0.000 claims 9
- 238000002347 injection Methods 0.000 claims 8
- 239000007924 injection Substances 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 7
- 239000000463 material Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 210000002889 endothelial cell Anatomy 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000006378 damage Effects 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 230000007717 exclusion Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 230000008439 repair process Effects 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 108091005508 Acid proteases Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 102000016611 Proteoglycans Human genes 0.000 claims 1
- 108010067787 Proteoglycans Proteins 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000005166 vasculature Anatomy 0.000 claims 1
- 230000007998 vessel formation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024129889A JP2024166198A (ja) | 2018-10-25 | 2024-08-06 | 可溶性細胞外マトリックス組成物および血管内送達のための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862750303P | 2018-10-25 | 2018-10-25 | |
| US62/750,303 | 2018-10-25 | ||
| PCT/US2019/058052 WO2020086955A1 (en) | 2018-10-25 | 2019-10-25 | Soluble extracellular matrix composition and method for intravascular delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024129889A Division JP2024166198A (ja) | 2018-10-25 | 2024-08-06 | 可溶性細胞外マトリックス組成物および血管内送達のための方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022505468A JP2022505468A (ja) | 2022-01-14 |
| JP2022505468A5 JP2022505468A5 (https=) | 2022-08-19 |
| JPWO2020086955A5 true JPWO2020086955A5 (https=) | 2022-08-19 |
| JP7536004B2 JP7536004B2 (ja) | 2024-08-19 |
Family
ID=70330739
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521511A Active JP7536004B2 (ja) | 2018-10-25 | 2019-10-25 | 可溶性細胞外マトリックス組成物および血管内送達のための方法 |
| JP2024129889A Pending JP2024166198A (ja) | 2018-10-25 | 2024-08-06 | 可溶性細胞外マトリックス組成物および血管内送達のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024129889A Pending JP2024166198A (ja) | 2018-10-25 | 2024-08-06 | 可溶性細胞外マトリックス組成物および血管内送達のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210379245A1 (https=) |
| EP (1) | EP3870192A4 (https=) |
| JP (2) | JP7536004B2 (https=) |
| CN (1) | CN112867499A (https=) |
| AU (1) | AU2019363610B2 (https=) |
| CA (1) | CA3117688A1 (https=) |
| WO (1) | WO2020086955A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230364152A1 (en) * | 2020-09-14 | 2023-11-16 | The Regents Of The University Of California | Compositions and methods of use for infusible extracellular matrix |
| CN121195059A (zh) * | 2023-04-06 | 2025-12-23 | 株式会社Medifab | 基于超临界二氧化碳工艺的水溶性脱细胞基质 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2808225C (en) * | 2010-08-24 | 2019-02-12 | The Regents Of The University Of California | Compositions and methods for cardiac therapy |
| WO2015164728A1 (en) * | 2014-04-24 | 2015-10-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Fractionating extracellular matrix to modulate bioactivity and the host response |
| KR101628821B1 (ko) * | 2015-03-02 | 2016-06-13 | 강원대학교산학협력단 | 탈세포화된 생체 조직 유래의 생체적합성 가용화 스캐폴드 추출물, 이의 제조방법 및 이의 용도 |
| US11406736B2 (en) * | 2016-01-13 | 2022-08-09 | University of Pittsburgh—Of the Commonwealth Systems of Higher Education | Vascular extracellular matrix hydrogel |
| AU2018226871B2 (en) * | 2017-03-02 | 2023-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular matrix (ECM) hydrogel and soluble fraction thereof for the treatment of cancer |
| EP3755267B1 (en) * | 2018-02-22 | 2024-06-12 | University of Pittsburgh - of the Commonwealth System of Higher Education | Extracts for the regeneration of ligaments |
-
2019
- 2019-10-25 EP EP19876046.4A patent/EP3870192A4/en active Pending
- 2019-10-25 CN CN201980067713.0A patent/CN112867499A/zh active Pending
- 2019-10-25 US US17/286,534 patent/US20210379245A1/en active Pending
- 2019-10-25 AU AU2019363610A patent/AU2019363610B2/en active Active
- 2019-10-25 WO PCT/US2019/058052 patent/WO2020086955A1/en not_active Ceased
- 2019-10-25 CA CA3117688A patent/CA3117688A1/en active Pending
- 2019-10-25 JP JP2021521511A patent/JP7536004B2/ja active Active
-
2024
- 2024-08-06 JP JP2024129889A patent/JP2024166198A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Yoon et al. | Regeneration of ischemic heart using hyaluronic acid‐based injectable hydrogel | |
| Nguyen et al. | Developing injectable nanomaterials to repair the heart | |
| US9775930B2 (en) | Composition for modifying myocardial infarction expansion | |
| EP4523713A1 (en) | Injectable anti-heart failure hydrogel having myocardial tissue repair functionality, method for preparing same, and use thereof | |
| Ravichandran et al. | Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease | |
| US10864233B2 (en) | Compositions and methods for treatment of cardiovascular disorders | |
| Qiao et al. | Synergistic effects of adipose-derived stem cells combined with decellularized myocardial matrix on the treatment of myocardial infarction in rats | |
| Joshi et al. | Nanofibers based tissue engineering and drug delivery approaches for myocardial regeneration | |
| Yoon et al. | Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel | |
| JP2025039572A (ja) | １型及び２型真性糖尿病の治療に（１）ネオ膵島の製造、及び（２）異なる臓器傷害及び疾病の治療に使用される様々な細胞型からのエクソソームの生成のための中空繊維系細胞培養技術の適応 | |
| CN101282652B (zh) | 预血管化的装置及相关方法 | |
| JP2024166198A (ja) | 可溶性細胞外マトリックス組成物および血管内送達のための方法 | |
| Haider et al. | MyoCell, a cell-based, autologous skeletal myoblast therapy for the treatment of cardiovascular diseases | |
| JP2022505468A5 (https=) | ||
| CN115725500A (zh) | 脂肪间充质干细胞外泌体、其制备方法及其应用 | |
| JPWO2020086955A5 (https=) | ||
| US20250057885A1 (en) | Platelet-derived extracellular vessicles for treatment of cardiogenic shock and sepsis | |
| KR20210057689A (ko) | 유도만능줄기세포-유래 중간엽 줄기세포 전구세포로부터 유래된 엑소좀을 포함하는 신장 질환의 예방 또는 치료용 조성물 | |
| CN111544658A (zh) | 一种调控免疫反应和促进内膜再生的心血管植入物及其制备方法 | |
| Wang et al. | Recent advances in the application of Injectable hydrogels for myocardial infarction | |
| Makkar et al. | Fine Tuning Mesenchymal Stromal Cells–Code For Mitigating Kidney Diseases | |
| Wang et al. | Hydrogels for cardiac repair | |
| CN115025287A (zh) | 一种用于子宫内膜修复的长效缓释细胞支架及其制备方法和应用 | |
| Mutsaers et al. | Future directions in mesothelial transplantation research | |
| CN116459278B (zh) | 一种抗氧化掺硒石墨烯纳米点药物及其制备方法和应用 |