JPWO2020081741A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020081741A5
JPWO2020081741A5 JP2021520923A JP2021520923A JPWO2020081741A5 JP WO2020081741 A5 JPWO2020081741 A5 JP WO2020081741A5 JP 2021520923 A JP2021520923 A JP 2021520923A JP 2021520923 A JP2021520923 A JP 2021520923A JP WO2020081741 A5 JPWO2020081741 A5 JP WO2020081741A5
Authority
JP
Japan
Prior art keywords
reduce
pharmaceutical composition
fold
agent
decrease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021520923A
Other languages
English (en)
Japanese (ja)
Other versions
JP7678748B2 (ja
JP2022504990A (ja
JP2022504990A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/056616 external-priority patent/WO2020081741A2/en
Publication of JP2022504990A publication Critical patent/JP2022504990A/ja
Publication of JPWO2020081741A5 publication Critical patent/JPWO2020081741A5/ja
Publication of JP2022504990A5 publication Critical patent/JP2022504990A5/ja
Priority to JP2024031893A priority Critical patent/JP2024063161A/ja
Priority to JP2025076487A priority patent/JP2025118759A/ja
Application granted granted Critical
Publication of JP7678748B2 publication Critical patent/JP7678748B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021520923A 2018-10-16 2019-10-16 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法 Active JP7678748B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024031893A JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862746524P 2018-10-16 2018-10-16
US62/746,524 2018-10-16
US201862747587P 2018-10-18 2018-10-18
US62/747,587 2018-10-18
US201962838049P 2019-04-24 2019-04-24
US62/838,049 2019-04-24
PCT/US2019/056616 WO2020081741A2 (en) 2018-10-16 2019-10-16 Compositions and methods for treating vascular ehlers danlos syndrome and associated disorders

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2024031893A Division JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A Division JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

Publications (4)

Publication Number Publication Date
JP2022504990A JP2022504990A (ja) 2022-01-13
JPWO2020081741A5 true JPWO2020081741A5 (https=) 2022-09-20
JP2022504990A5 JP2022504990A5 (https=) 2022-09-20
JP7678748B2 JP7678748B2 (ja) 2025-05-16

Family

ID=70284358

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021520923A Active JP7678748B2 (ja) 2018-10-16 2019-10-16 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2024031893A Pending JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A Pending JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024031893A Pending JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A Pending JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

Country Status (16)

Country Link
US (2) US11938135B2 (https=)
EP (2) EP4268822A3 (https=)
JP (3) JP7678748B2 (https=)
KR (1) KR20210094532A (https=)
CN (2) CN121197400A (https=)
AU (2) AU2019359872B2 (https=)
BR (1) BR112021007237A2 (https=)
CA (1) CA3116321A1 (https=)
DK (1) DK3866799T3 (https=)
ES (1) ES2973130T3 (https=)
FI (1) FI3866799T3 (https=)
IL (1) IL281623A (https=)
MX (1) MX2021004387A (https=)
PL (1) PL3866799T3 (https=)
PT (1) PT3866799T (https=)
WO (1) WO2020081741A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3866799T3 (pl) 2018-10-16 2024-04-29 The Johns Hopkins University Kompozycje do leczenia zespołu ehlersa-danlosa o typie naczyniowym
EP4126957A4 (en) * 2020-03-31 2024-07-24 The Regents of the University of California COMPOSITIONS AND METHODS FOR TREATING DYSREGULATED WOUND HEALING
EP4208203A4 (en) * 2020-09-04 2024-09-04 The Johns Hopkins University TREATMENT OF VASCULAR EHLERS-DANLOS SYNDROME AND ASSOCIATED SYNDROMES
US20250144095A1 (en) * 2022-02-03 2025-05-08 The Johns Hopkins University Compositions and methods for treatment of connective tissue disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
DE102004019413A1 (de) 2004-04-19 2005-11-24 Phenos Gmbh Hemmung der Proteinkinase C epsilon zur Behandlung von Krankheiten
US20150119435A1 (en) * 2012-05-11 2015-04-30 Yale University Compounds useful for promoting protein degradation and methods using same
US10730870B2 (en) * 2015-03-18 2020-08-04 Arvinas Operations, Inc. Compounds and methods for the enhanced degradation of targeted proteins
AU2016349279A1 (en) * 2015-11-03 2018-05-10 Board Of Regents, The University Of Texas System Combination of Bcl-2 inhibitor and MEK inhibitor for the treatment of cancer
US11692028B2 (en) * 2017-03-02 2023-07-04 The Johns Hopkins University Map kinase pathway targets for the treatment of Marfan syndrome
PL3866799T3 (pl) 2018-10-16 2024-04-29 The Johns Hopkins University Kompozycje do leczenia zespołu ehlersa-danlosa o typie naczyniowym

Similar Documents

Publication Publication Date Title
Li et al. CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway
JP7344337B2 (ja) ミオスタチン阻害剤の使用および併用療法
Li et al. Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways
US11852634B2 (en) Use of AKT phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
Zangerolamo et al. The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model
Chang et al. Reversing LRP 5‐Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
Chen et al. Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension
Archer et al. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies
Weger et al. Hyperhomocyst (e) inemia and MTHFR C677T genotypes in patients with central retinal vein occlusion
Jünemann et al. Agonistic autoantibodies to the β2-adrenergic receptor involved in the pathogenesis of open-angle glaucoma
JP2022504990A5 (https=)
CN104244956A (zh) 使用环糊精的方法
Kim et al. Lower uncarboxylated osteocalcin and higher sclerostin levels are significantly associated with coronary artery disease
EP2723391A2 (en) Fibroblast growth factor receptor inhibition for the treatment of disease
Zemankova et al. Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin
Barreto et al. Prognostic implication of plasma osteopontin levels in patients with chronic kidney disease
EP3089748A1 (en) Treating ocular neovascularization
Kumagai et al. Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients
Gamil et al. Increased serum levels of asymmetric dimethylarginine and symmetric dimethylarginine and decreased levels of arginine in Sudanese patients with essential hypertension
WO2021216548A1 (en) Methods and compositions for treatment of age-related macular degeneration
JPWO2020081741A5 (https=)
WO2024030909A1 (en) Biomarkers of amino acid composition treatment response in long covid
US20130302337A1 (en) Methods and compositions for treating alzheimer's disease
Yamagata et al. Bactericidal/permeability‐increasing protein's signaling pathways and its retinal trophic and anti‐angiogenic effects
JP6709493B2 (ja) 進行性骨化性線維異形成症治療剤