JP7678748B2 - 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法 - Google Patents

血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法 Download PDF

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JP7678748B2
JP7678748B2 JP2021520923A JP2021520923A JP7678748B2 JP 7678748 B2 JP7678748 B2 JP 7678748B2 JP 2021520923 A JP2021520923 A JP 2021520923A JP 2021520923 A JP2021520923 A JP 2021520923A JP 7678748 B2 JP7678748 B2 JP 7678748B2
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ハリー シー． デイツ
ケイトリン ジェイ． ボーエン
ジアドロシク フアン フランシスコ カルデロン
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ザ・ジョンズ・ホプキンス・ユニバーシティー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
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JP2021520923A 2018-10-16 2019-10-16 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法 Active JP7678748B2 (ja)

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JP2024031893A JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

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US201862746524P 2018-10-16 2018-10-16
US62/746,524 2018-10-16
US201862747587P 2018-10-18 2018-10-18
US62/747,587 2018-10-18
US201962838049P 2019-04-24 2019-04-24
US62/838,049 2019-04-24
PCT/US2019/056616 WO2020081741A2 (en) 2018-10-16 2019-10-16 Compositions and methods for treating vascular ehlers danlos syndrome and associated disorders

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JP2024031893A Division JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A Division JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

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JP2022504990A JP2022504990A (ja) 2022-01-13
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JP2024031893A Pending JP2024063161A (ja) 2018-10-16 2024-03-04 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法
JP2025076487A Pending JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

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JP2025076487A Pending JP2025118759A (ja) 2018-10-16 2025-05-02 血管型エーラース・ダンロス症候群および関連障害を処置するための組成物および方法

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EP (2) EP4268822A3 (https=)
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KR (1) KR20210094532A (https=)
CN (2) CN121197400A (https=)
AU (2) AU2019359872B2 (https=)
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PL3866799T3 (pl) 2018-10-16 2024-04-29 The Johns Hopkins University Kompozycje do leczenia zespołu ehlersa-danlosa o typie naczyniowym
EP4126957A4 (en) * 2020-03-31 2024-07-24 The Regents of the University of California COMPOSITIONS AND METHODS FOR TREATING DYSREGULATED WOUND HEALING
EP4208203A4 (en) * 2020-09-04 2024-09-04 The Johns Hopkins University TREATMENT OF VASCULAR EHLERS-DANLOS SYNDROME AND ASSOCIATED SYNDROMES
US20250144095A1 (en) * 2022-02-03 2025-05-08 The Johns Hopkins University Compositions and methods for treatment of connective tissue disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
DE102004019413A1 (de) 2004-04-19 2005-11-24 Phenos Gmbh Hemmung der Proteinkinase C epsilon zur Behandlung von Krankheiten
US20150119435A1 (en) * 2012-05-11 2015-04-30 Yale University Compounds useful for promoting protein degradation and methods using same
US10730870B2 (en) * 2015-03-18 2020-08-04 Arvinas Operations, Inc. Compounds and methods for the enhanced degradation of targeted proteins
AU2016349279A1 (en) * 2015-11-03 2018-05-10 Board Of Regents, The University Of Texas System Combination of Bcl-2 inhibitor and MEK inhibitor for the treatment of cancer
US11692028B2 (en) * 2017-03-02 2023-07-04 The Johns Hopkins University Map kinase pathway targets for the treatment of Marfan syndrome
PL3866799T3 (pl) 2018-10-16 2024-04-29 The Johns Hopkins University Kompozycje do leczenia zespołu ehlersa-danlosa o typie naczyniowym

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cardiol Rev，2012年，Vol.20 No.1，p.4-7，doi: 10.1097/CRD.0b013e3182342316
eLife，2015年，Vol.4，Article.e08648 (p.1-18)，DOI: 10.7554/eLife.08648
医学のあゆみ，2018年01月20日，Vol.264 No.3，p.211-215
医学のあゆみ，2018年01月20日，Vol.264 No.3，p.227-233

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KR20210094532A (ko) 2021-07-29
EP3866799A4 (en) 2022-07-27
BR112021007237A2 (pt) 2021-08-10
EP3866799B1 (en) 2023-12-06
WO2020081741A2 (en) 2020-04-23
US20240408091A1 (en) 2024-12-12
IL281623A (en) 2021-05-31
US20210386740A1 (en) 2021-12-16
MX2021004387A (es) 2021-08-19
CN121197400A (zh) 2025-12-26
EP4268822A2 (en) 2023-11-01
JP2024063161A (ja) 2024-05-10
EP3866799A2 (en) 2021-08-25
CN113194946B (zh) 2025-10-14
ES2973130T3 (es) 2024-06-18
US11938135B2 (en) 2024-03-26
WO2020081741A3 (en) 2020-05-22
JP2025118759A (ja) 2025-08-13
AU2019359872A1 (en) 2021-05-27
AU2025200315A1 (en) 2025-02-13
FI3866799T3 (fi) 2024-02-29
PT3866799T (pt) 2024-03-06
DK3866799T3 (da) 2024-02-05
JP2022504990A (ja) 2022-01-13
CA3116321A1 (en) 2020-04-23
EP4268822A3 (en) 2024-01-03
PL3866799T3 (pl) 2024-04-29
AU2019359872B2 (en) 2024-10-17
CN113194946A (zh) 2021-07-30

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