JPWO2020070303A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020070303A5 JPWO2020070303A5 JP2021518493A JP2021518493A JPWO2020070303A5 JP WO2020070303 A5 JPWO2020070303 A5 JP WO2020070303A5 JP 2021518493 A JP2021518493 A JP 2021518493A JP 2021518493 A JP2021518493 A JP 2021518493A JP WO2020070303 A5 JPWO2020070303 A5 JP WO2020070303A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- combination
- mva
- administered
- taa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 68
- 201000011510 cancer Diseases 0.000 claims description 53
- 201000001441 melanoma Diseases 0.000 claims description 28
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 150000007523 nucleic acids Chemical class 0.000 claims description 17
- 108010029697 CD40 Ligand Proteins 0.000 claims description 16
- 102100032937 CD40 ligand Human genes 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 206010006187 Breast cancer Diseases 0.000 claims description 15
- 208000026310 Breast neoplasm Diseases 0.000 claims description 15
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims description 14
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 14
- 239000005557 antagonist Substances 0.000 claims description 14
- 229940126546 immune checkpoint molecule Drugs 0.000 claims description 14
- 101000796203 Homo sapiens L-dopachrome tautomerase Proteins 0.000 claims description 13
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 13
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims description 13
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 230000005867 T cell response Effects 0.000 claims description 11
- 238000002648 combination therapy Methods 0.000 claims description 11
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims description 10
- 230000004083 survival effect Effects 0.000 claims description 10
- 206010009944 Colon cancer Diseases 0.000 claims description 8
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 8
- 229940124060 PD-1 antagonist Drugs 0.000 claims description 8
- 229940123751 PD-L1 antagonist Drugs 0.000 claims description 8
- 238000001990 intravenous administration Methods 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 230000001965 increasing effect Effects 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 206010005003 Bladder cancer Diseases 0.000 claims description 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 108060006580 PRAME Proteins 0.000 claims description 5
- 102000036673 PRAME Human genes 0.000 claims description 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 206010038389 Renal cancer Diseases 0.000 claims description 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 5
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 5
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 5
- 206010017758 gastric cancer Diseases 0.000 claims description 5
- 201000010982 kidney cancer Diseases 0.000 claims description 5
- 201000007270 liver cancer Diseases 0.000 claims description 5
- 208000014018 liver neoplasm Diseases 0.000 claims description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 5
- 201000002528 pancreatic cancer Diseases 0.000 claims description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 5
- 230000037452 priming Effects 0.000 claims description 5
- 201000011549 stomach cancer Diseases 0.000 claims description 5
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims description 5
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 5
- 208000007089 vaccinia Diseases 0.000 claims description 5
- 210000000822 natural killer cell Anatomy 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 230000036755 cellular response Effects 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 description 19
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 12
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 12
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 12
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 12
- 239000000556 agonist Substances 0.000 description 12
- 229940045513 CTLA4 antagonist Drugs 0.000 description 9
- 108010013709 Leukocyte Common Antigens Proteins 0.000 description 9
- 102100039373 Membrane cofactor protein Human genes 0.000 description 9
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 9
- NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 description 6
- HSFWRNGVRCDJHI-UHFFFAOYSA-N Acetylene Chemical compound C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 6
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 6
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 6
- 102100032912 CD44 antigen Human genes 0.000 description 6
- 108010009575 CD55 Antigens Proteins 0.000 description 6
- 102100022002 CD59 glycoprotein Human genes 0.000 description 6
- 102000004091 Caspase-8 Human genes 0.000 description 6
- 108090000538 Caspase-8 Proteins 0.000 description 6
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 6
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 6
- 108010023729 Complement 3d Receptors Proteins 0.000 description 6
- 102000011412 Complement 3d Receptors Human genes 0.000 description 6
- -1 Dna78 Proteins 0.000 description 6
- 108090000368 Fibroblast growth factor 8 Proteins 0.000 description 6
- 102000003956 Fibroblast growth factor 8 Human genes 0.000 description 6
- 102400000921 Gastrin Human genes 0.000 description 6
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 6
- 102000005720 Glutathione transferase Human genes 0.000 description 6
- 108010070675 Glutathione transferase Proteins 0.000 description 6
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 6
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 6
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 6
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 description 6
- 241000681881 Human mammary tumor virus Species 0.000 description 6
- 108010017511 Interleukin-13 Receptors Proteins 0.000 description 6
- 102100039078 Interleukin-4 receptor subunit alpha Human genes 0.000 description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
- 102000017578 LAG3 Human genes 0.000 description 6
- 101150030213 Lag3 gene Proteins 0.000 description 6
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 6
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 6
- 101710146216 Membrane cofactor protein Proteins 0.000 description 6
- 102100034256 Mucin-1 Human genes 0.000 description 6
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 6
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 6
- 102100035703 Prostatic acid phosphatase Human genes 0.000 description 6
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 6
- 229940123803 TIM3 antagonist Drugs 0.000 description 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 6
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 6
- 101800004564 Transforming growth factor alpha Proteins 0.000 description 6
- 102400001320 Transforming growth factor alpha Human genes 0.000 description 6
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 6
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 6
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 6
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 6
- 150000002270 gangliosides Chemical class 0.000 description 6
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 6
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 6
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 6
- 108010043671 prostatic acid phosphatase Proteins 0.000 description 6
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 6
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 6
- 210000001744 T-lymphocyte Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 description 3
- 101800000504 3C-like protease Proteins 0.000 description 3
- 102100036464 Activated RNA polymerase II transcriptional coactivator p15 Human genes 0.000 description 3
- 102100021305 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 Human genes 0.000 description 3
- 102000052587 Anaphase-Promoting Complex-Cyclosome Apc3 Subunit Human genes 0.000 description 3
- 108700004606 Anaphase-Promoting Complex-Cyclosome Apc3 Subunit Proteins 0.000 description 3
- 101710145634 Antigen 1 Proteins 0.000 description 3
- 102100035526 B melanoma antigen 1 Human genes 0.000 description 3
- 101710131520 B melanoma antigen 1 Proteins 0.000 description 3
- 101710187595 B-cell receptor CD22 Proteins 0.000 description 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 3
- 108010074708 B7-H1 Antigen Proteins 0.000 description 3
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 3
- 102000015735 Beta-catenin Human genes 0.000 description 3
- 108060000903 Beta-catenin Proteins 0.000 description 3
- 102100024217 CAMPATH-1 antigen Human genes 0.000 description 3
- 108091016585 CD44 antigen Proteins 0.000 description 3
- 108010065524 CD52 Antigen Proteins 0.000 description 3
- 108010055167 CD59 Antigens Proteins 0.000 description 3
- 101150108242 CDC27 gene Proteins 0.000 description 3
- MUJJVOYNTCTXIC-UHFFFAOYSA-N CNC(=O)c1ccc2-c3c(C)c(nn3CCOc2c1)-c1ncnn1-c1ccc(F)cc1F Chemical compound CNC(=O)c1ccc2-c3c(C)c(nn3CCOc2c1)-c1ncnn1-c1ccc(F)cc1F MUJJVOYNTCTXIC-UHFFFAOYSA-N 0.000 description 3
- 101150071146 COX2 gene Proteins 0.000 description 3
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 3
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 3
- 101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 description 3
- 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 description 3
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 3
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 description 3
- 102000005600 Cathepsins Human genes 0.000 description 3
- 108010084457 Cathepsins Proteins 0.000 description 3
- 101710163595 Chaperone protein DnaK Proteins 0.000 description 3
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 3
- 102100025680 Complement decay-accelerating factor Human genes 0.000 description 3
- 102100030886 Complement receptor type 1 Human genes 0.000 description 3
- 102100032768 Complement receptor type 2 Human genes 0.000 description 3
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 3
- 102000009508 Cyclin-Dependent Kinase Inhibitor p16 Human genes 0.000 description 3
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 3
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 3
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 3
- 101100216227 Dictyostelium discoideum anapc3 gene Proteins 0.000 description 3
- 101150049307 EEF1A2 gene Proteins 0.000 description 3
- 101150029707 ERBB2 gene Proteins 0.000 description 3
- 102400000102 Eosinophil granule major basic protein Human genes 0.000 description 3
- 102000007317 Farnesyltranstransferase Human genes 0.000 description 3
- 108010007508 Farnesyltranstransferase Proteins 0.000 description 3
- 108091072337 GAGE family Proteins 0.000 description 3
- 102000040452 GAGE family Human genes 0.000 description 3
- 101710113436 GTPase KRas Proteins 0.000 description 3
- 102100039788 GTPase NRas Human genes 0.000 description 3
- 108010052343 Gastrins Proteins 0.000 description 3
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 3
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 3
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 3
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 3
- 102100024025 Heparanase Human genes 0.000 description 3
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 3
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 description 3
- 101001042227 Homo sapiens Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 Proteins 0.000 description 3
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 3
- 101100165850 Homo sapiens CA9 gene Proteins 0.000 description 3
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 3
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 description 3
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 3
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 description 3
- 101000727061 Homo sapiens Complement receptor type 1 Proteins 0.000 description 3
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 description 3
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 3
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 3
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 description 3
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 3
- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 description 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 description 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 3
- 101000693231 Homo sapiens PDZK1-interacting protein 1 Proteins 0.000 description 3
- 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 description 3
- 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 description 3
- 101000818517 Homo sapiens Zinc-alpha-2-glycoprotein Proteins 0.000 description 3
- 108010073816 IgE Receptors Proteins 0.000 description 3
- 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 description 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 3
- 102000014429 Insulin-like growth factor Human genes 0.000 description 3
- 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 description 3
- 108010010995 MART-1 Antigen Proteins 0.000 description 3
- 102000051089 Melanotransferrin Human genes 0.000 description 3
- 108700038051 Melanotransferrin Proteins 0.000 description 3
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 3
- 102000003735 Mesothelin Human genes 0.000 description 3
- 108090000015 Mesothelin Proteins 0.000 description 3
- 102100023123 Mucin-16 Human genes 0.000 description 3
- 108010063954 Mucins Proteins 0.000 description 3
- 102000015728 Mucins Human genes 0.000 description 3
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 3
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 3
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 3
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 3
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 description 3
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 description 3
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 3
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 description 3
- 108010077077 Osteonectin Proteins 0.000 description 3
- 102000009890 Osteonectin Human genes 0.000 description 3
- 102100025648 PDZK1-interacting protein 1 Human genes 0.000 description 3
- 101150000187 PTGS2 gene Proteins 0.000 description 3
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 3
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 description 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 description 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 3
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 3
- 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 description 3
- 108091077753 SSX family Proteins 0.000 description 3
- 102000042330 SSX family Human genes 0.000 description 3
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 3
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 3
- 108010002687 Survivin Proteins 0.000 description 3
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 description 3
- 102100030306 TBC1 domain family member 9 Human genes 0.000 description 3
- 101710109927 Tail assembly protein GT Proteins 0.000 description 3
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 3
- 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 102100027244 U4/U6.U5 tri-snRNP-associated protein 1 Human genes 0.000 description 3
- 101710155955 U4/U6.U5 tri-snRNP-associated protein 1 Proteins 0.000 description 3
- LFTYTUAZOPRMMI-CFRASDGPSA-N UDP-N-acetyl-alpha-D-glucosamine Chemical compound O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-CFRASDGPSA-N 0.000 description 3
- LFTYTUAZOPRMMI-UHFFFAOYSA-N UNPD164450 Natural products O1C(CO)C(O)C(O)C(NC(=O)C)C1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-UHFFFAOYSA-N 0.000 description 3
- 102100021144 Zinc-alpha-2-glycoprotein Human genes 0.000 description 3
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 3
- 102000006834 complement receptors Human genes 0.000 description 3
- 108010047295 complement receptors Proteins 0.000 description 3
- 108010048134 estramustine-binding protein Proteins 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 102000006815 folate receptor Human genes 0.000 description 3
- 108020005243 folate receptor Proteins 0.000 description 3
- 108010066264 gastrin 17 Proteins 0.000 description 3
- GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 108010037536 heparanase Proteins 0.000 description 3
- 229940022353 herceptin Drugs 0.000 description 3
- 101800000607 p15 Proteins 0.000 description 3
- 108010042121 probasin Proteins 0.000 description 3
- 239000003488 releasing hormone Substances 0.000 description 3
- 101150050955 stn gene Proteins 0.000 description 3
- 101150047061 tag-72 gene Proteins 0.000 description 3
- 210000001550 testis Anatomy 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 102000001301 EGF receptor Human genes 0.000 description 2
- 108060006698 EGF receptor Proteins 0.000 description 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000002619 cancer immunotherapy Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 208000010543 22q11.2 deletion syndrome Diseases 0.000 description 1
- 102100024507 BMP-2-inducible protein kinase Human genes 0.000 description 1
- 206010055113 Breast cancer metastatic Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000000398 DiGeorge Syndrome Diseases 0.000 description 1
- 101100218937 Homo sapiens BMP2K gene Proteins 0.000 description 1
- 102000002227 Interferon Type I Human genes 0.000 description 1
- 108010014726 Interferon Type I Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 101100343535 Mus musculus Litaf gene Proteins 0.000 description 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000009134 cell regulation Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007705 epithelial mesenchymal transition Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 229960002087 pertuzumab Drugs 0.000 description 1
- 238000009520 phase I clinical trial Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18199002.9 | 2018-10-05 | ||
| EP18199002 | 2018-10-05 | ||
| PCT/EP2019/076947 WO2020070303A1 (fr) | 2018-10-05 | 2019-10-04 | Polythérapie pour le traitement du cancer comprenant une administration intraveineuse de mva recombiné et d'un antagoniste ou d'un agoniste d'un point de contrôle immunitaire |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512595A JP2022512595A (ja) | 2022-02-07 |
| JPWO2020070303A5 true JPWO2020070303A5 (fr) | 2022-09-26 |
| JP7555334B2 JP7555334B2 (ja) | 2024-09-24 |
Family
ID=63998486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518493A Active JP7555334B2 (ja) | 2018-10-05 | 2019-10-04 | 組み換えｍｖａ、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240269254A1 (fr) |
| EP (1) | EP3860641A1 (fr) |
| JP (1) | JP7555334B2 (fr) |
| AU (1) | AU2019354101A1 (fr) |
| CA (1) | CA3113818A1 (fr) |
| IL (1) | IL281988A (fr) |
| WO (1) | WO2020070303A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20210186A1 (ar) | 2019-01-10 | 2023-01-30 | Janssen Biotech Inc | مستضدات البروستاتا المستحدثة واستخداماتها |
| US12018289B2 (en) | 2019-11-18 | 2024-06-25 | Janssen Biotech, Inc. | Vaccines based on mutant CALR and JAK2 and their uses |
| WO2022036495A1 (fr) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Co-stimulateurs de cellules présentatrices d'antigène de lymphocytes et leurs utilisations |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
| USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (fr) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Récepteurs chimériques par liaison et expression de l'ADN |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| AU606320B2 (en) | 1985-11-01 | 1991-02-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| ATE363532T1 (de) | 1991-03-01 | 2007-06-15 | Dyax Corp | Verfahren zur herstellung bindender miniproteine |
| ES2315612T3 (es) | 1991-04-10 | 2009-04-01 | The Scripps Research Institute | Genotecas de receptores heterodimericos usando fagemidos. |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| DE69435171D1 (de) | 1993-09-14 | 2009-01-08 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
| AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
| JP2002526419A (ja) | 1998-10-05 | 2002-08-20 | ファーメクサ エイ／エス | 治療上のワクチン注射のための新規な方法 |
| CN101676389A (zh) | 2000-11-23 | 2010-03-24 | 巴法里安诺迪克有限公司 | 改良安卡拉痘苗病毒变体 |
| CA2468258C (fr) | 2001-11-30 | 2011-10-11 | Jeffrey Schlom | Peptides agonistes d'antigenes specifiques de la prostate et leurs utilisations |
| EP2345665A3 (fr) | 2001-12-04 | 2012-02-15 | Bavarian Nordic A/S | Le vaccin de sous-unité de NS1 de Flavivirus |
| EP2367944B1 (fr) | 2008-11-27 | 2019-01-09 | Bavarian Nordic A/S | Promoteurs pour expression virale recombinante |
| US8394385B2 (en) | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
| US8709417B2 (en) | 2009-09-30 | 2014-04-29 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for the treatment of cancer |
| WO2012131004A2 (fr) | 2011-03-31 | 2012-10-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps dirigés contre icos et utilisation de ceux-ci |
| DK2800762T3 (en) | 2012-01-03 | 2018-04-16 | Us Health | NATIVE AND AGONISTIC CTL EPITOPES OF THE MUC1 TUMOR ANTIGEN |
| US10111946B2 (en) | 2012-06-22 | 2018-10-30 | Bavarian Nordic A/S | Poxviral vectors for low antibody response after a first priming immunization |
| EP2892549A1 (fr) | 2012-09-04 | 2015-07-15 | Bavarian Nordic A/S | Procédés et compositions pour l'amélioration de réponses immunitaires à la vaccine |
| WO2014043535A1 (fr) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions destinées à traiter le cancer |
| CA2888367A1 (fr) | 2012-10-19 | 2014-04-24 | Bavarian Nordic, Inc. | Methodes et compositions pour le traitement du cancer |
| SG11201503200PA (en) | 2012-10-28 | 2015-05-28 | Bavarian Nordic As | Pr13.5 promoter for robust t-cell and antibody responses |
| JP6535337B2 (ja) | 2013-11-05 | 2019-06-26 | バヴァリアン・ノルディック・アクティーゼルスカブ | 腫瘍抗原を発現するポックスウイルスならびに免疫チェックポイント阻害剤のアンタゴニスト及び／またはアゴニストにより癌を治療するための組み合わせ療法 |
| KR20150135148A (ko) | 2014-05-23 | 2015-12-02 | 주식회사 제넥신 | Pd-l1 융합 단백질 및 이의 용도 |
| EP3256156A1 (fr) | 2015-02-13 | 2017-12-20 | Transgene SA | Vaccin immunothérapeutique et thérapie combinée à base d'anticorps |
| DK3329016T3 (da) | 2015-07-31 | 2022-01-10 | Bavarian Nordic As | Promotorer til forbedring af ekspression i poxvirus |
-
2019
- 2019-10-04 CA CA3113818A patent/CA3113818A1/fr active Pending
- 2019-10-04 JP JP2021518493A patent/JP7555334B2/ja active Active
- 2019-10-04 EP EP19780255.6A patent/EP3860641A1/fr active Pending
- 2019-10-04 AU AU2019354101A patent/AU2019354101A1/en active Pending
- 2019-10-04 WO PCT/EP2019/076947 patent/WO2020070303A1/fr active Application Filing
- 2019-10-04 US US17/282,774 patent/US20240269254A1/en active Pending
-
2021
- 2021-04-01 IL IL281988A patent/IL281988A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7368305B2 (ja) | 腫瘍抗原を発現するポックスウイルス及びｔｉｍ－３に対するモノクローナル抗体を用いた癌治療のための併用療法 | |
| JP2023030083A (ja) | 治療用ｒｎａ | |
| US20200085891A1 (en) | Oncolytic vaccinia virus and checkpoint inhibitor combination therapy | |
| AU2017274540B2 (en) | Compositions and methods for tumor vaccination using prostate cancer-associated antigens | |
| JP2020531524A5 (fr) | ||
| JP2019521099A (ja) | Ｈｅｒ２／ｎｅｕを含む、腫瘍ワクチン接種及び免疫療法のための組成物及び方法 | |
| US11723964B2 (en) | Combination therapy for treating cancer with an antibody and intravenous administration of a recombinant MVA | |
| JP2017515841A5 (fr) | ||
| KR20210094535A (ko) | 4-1bbl (cd137l) 및/또는 cd40l를 암호화하는 재조합 mva의 종양내 및/또는 정맥내 투여에 의한 암의 치료 방법 | |
| Radosa et al. | Clinical data on immunotherapy in breast cancer | |
| Li et al. | Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy: a comprehensive review | |
| US20240269254A1 (en) | Combination Therapy for Treating Cancer with an Intravenous Administration of a Recombinant MVA and an Immune Checkpoint Antagonist or Agonist | |
| Harrop et al. | Viral vectors for cancer immunotherapy | |
| Chang et al. | Vaccinating against cancer: getting to prime time | |
| JPWO2020070303A5 (fr) | ||
| Izzi et al. | Poxvirus-based vaccines for cancer immunotherapy: New insights from combined cytokines/co-stimulatory molecules delivery and “uncommon” strains | |
| US20230190922A1 (en) | Recombinant MVA Viruses for Intratumoral and/or Intravenous Administration for Treating Cancer | |
| WO2021150713A2 (fr) | Épitopes immunogènes humains de rétrovirus endogènes humains (herv) h, k et e | |
| US20230277592A1 (en) | Armed Dual CAR-T Compositions and Methods For Cancer Immunotherapy | |
| ES2883720T3 (es) | Desarrollo de epítopos agonistas del virus del papiloma humano | |
| US20220000997A1 (en) | Therapy for Treating Cancer with an Intratumoral or Intravenous Administration of a Recombinant MVA Encoding 4-1BBL (CD137L) and/or CD40L | |
| RU2795103C2 (ru) | Комбинированная терапия для лечения рака путем внутривенного введения рекомбинантного mva и антитела | |
| CA3240596A1 (fr) | Therapie pour moduler une reponse immunitaire au moyen d'un mva recombinant codant pour il-12 | |
| US20240325473A1 (en) | Cancer Treatments | |
| JPWO2019038388A5 (fr) |