JPWO2020061278A5 - - Google Patents
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- Publication number
- JPWO2020061278A5 JPWO2020061278A5 JP2021515067A JP2021515067A JPWO2020061278A5 JP WO2020061278 A5 JPWO2020061278 A5 JP WO2020061278A5 JP 2021515067 A JP2021515067 A JP 2021515067A JP 2021515067 A JP2021515067 A JP 2021515067A JP WO2020061278 A5 JPWO2020061278 A5 JP WO2020061278A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment zone
- treatment
- dose
- light
- photoactivating light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011282 treatment Methods 0.000 claims description 123
- 210000004087 cornea Anatomy 0.000 claims description 53
- 230000003287 optical effect Effects 0.000 claims description 23
- 239000003431 cross linking reagent Substances 0.000 claims description 22
- 238000012876 topography Methods 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004132 cross linking Methods 0.000 description 31
- 238000000034 method Methods 0.000 description 21
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 20
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 10
- 238000005286 illumination Methods 0.000 description 10
- 229960002477 riboflavin Drugs 0.000 description 10
- 235000019192 riboflavin Nutrition 0.000 description 10
- 239000002151 riboflavin Substances 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 201000002287 Keratoconus Diseases 0.000 description 6
- 230000002186 photoactivation Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 201000009310 astigmatism Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 239000004971 Cross linker Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 210000003560 epithelium corneal Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 206010020675 Hypermetropia Diseases 0.000 description 2
- 208000031816 Pathologic Dilatation Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004980 dosimetry Methods 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 201000006318 hyperopia Diseases 0.000 description 2
- 230000004305 hyperopia Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012014 optical coherence tomography Methods 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010054760 Corneal thinning Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 208000021921 corneal disease Diseases 0.000 description 1
- 201000004573 corneal ectasia Diseases 0.000 description 1
- 210000003683 corneal stroma Anatomy 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 201000000766 irregular astigmatism Diseases 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002311 multiphoton fluorescence microscopy Methods 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 201000010041 presbyopia Diseases 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000013515 script Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024094250A JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862733617P | 2018-09-19 | 2018-09-19 | |
| US62/733,617 | 2018-09-19 | ||
| PCT/US2019/051876 WO2020061278A1 (fr) | 2018-09-19 | 2019-09-19 | Systèmes et méthodes de traitement pour des troubles ectatiques cornéens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094250A Division JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022508020A JP2022508020A (ja) | 2022-01-19 |
| JPWO2020061278A5 true JPWO2020061278A5 (fr) | 2023-02-07 |
| JP7504083B2 JP7504083B2 (ja) | 2024-06-21 |
Family
ID=69772609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021515067A Active JP7504083B2 (ja) | 2018-09-19 | 2019-09-19 | 角膜拡張障害を治療するシステム及び方法 |
| JP2024094250A Pending JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094250A Pending JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200085617A1 (fr) |
| EP (1) | EP3852700A4 (fr) |
| JP (2) | JP7504083B2 (fr) |
| CN (1) | CN113329723A (fr) |
| AU (1) | AU2019345061A1 (fr) |
| CA (1) | CA3112937A1 (fr) |
| WO (1) | WO2020061278A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107205845B (zh) * | 2014-10-27 | 2020-03-31 | 艾维德洛公司 | 用于眼的交联治疗的系统和方法 |
| WO2021248100A1 (fr) * | 2020-06-05 | 2021-12-09 | Robert Epstein | Masque uv pour le traitement de réticulation du kératocône |
| CA3213111A1 (fr) * | 2021-03-08 | 2022-09-15 | Avedro, Inc. | Systemes et methodes de generation de schemas de traitement de cross linking du collagene corneen specifiques au patient |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20041625A1 (it) * | 2004-08-06 | 2004-11-06 | Roberto Pinelli | Apparato per la correzione della presbiopia |
| US20080015660A1 (en) * | 2006-07-13 | 2008-01-17 | Priavision, Inc. | Method And Apparatus For Photo-Chemical Oculoplasty/Keratoplasty |
| EP2547298B1 (fr) * | 2010-03-19 | 2019-05-08 | Avedro, Inc. | Systèmes d'application et de surveillance de thérapie oculaire |
| US20120215155A1 (en) * | 2010-03-19 | 2012-08-23 | Avedro Inc. | Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking |
| JP6030632B2 (ja) * | 2011-04-20 | 2016-11-24 | アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． | 架橋を指向させるための制御された架橋開始及び角膜トポグラフィーフィードバックシステム |
| ES2871378T3 (es) * | 2013-10-30 | 2021-10-28 | Alcon Inc | Control de reticulación |
| CN107205845B (zh) * | 2014-10-27 | 2020-03-31 | 艾维德洛公司 | 用于眼的交联治疗的系统和方法 |
| US10028657B2 (en) * | 2015-05-22 | 2018-07-24 | Avedro, Inc. | Systems and methods for monitoring cross-linking activity for corneal treatments |
-
2019
- 2019-09-19 US US16/575,428 patent/US20200085617A1/en active Pending
- 2019-09-19 CN CN201980068841.7A patent/CN113329723A/zh active Pending
- 2019-09-19 JP JP2021515067A patent/JP7504083B2/ja active Active
- 2019-09-19 CA CA3112937A patent/CA3112937A1/fr active Pending
- 2019-09-19 AU AU2019345061A patent/AU2019345061A1/en active Pending
- 2019-09-19 WO PCT/US2019/051876 patent/WO2020061278A1/fr unknown
- 2019-09-19 EP EP19861900.9A patent/EP3852700A4/fr active Pending
-
2024
- 2024-06-11 JP JP2024094250A patent/JP2024113169A/ja active Pending
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