JPWO2020061278A5 - - Google Patents
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- Publication number
- JPWO2020061278A5 JPWO2020061278A5 JP2021515067A JP2021515067A JPWO2020061278A5 JP WO2020061278 A5 JPWO2020061278 A5 JP WO2020061278A5 JP 2021515067 A JP2021515067 A JP 2021515067A JP 2021515067 A JP2021515067 A JP 2021515067A JP WO2020061278 A5 JPWO2020061278 A5 JP WO2020061278A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment zone
- treatment
- dose
- light
- photoactivating light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011282 treatment Methods 0.000 claims description 123
- 210000004087 cornea Anatomy 0.000 claims description 53
- 230000003287 optical effect Effects 0.000 claims description 23
- 239000003431 cross linking reagent Substances 0.000 claims description 22
- 238000012876 topography Methods 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004132 cross linking Methods 0.000 description 31
- 238000000034 method Methods 0.000 description 21
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 20
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 10
- 238000005286 illumination Methods 0.000 description 10
- 229960002477 riboflavin Drugs 0.000 description 10
- 235000019192 riboflavin Nutrition 0.000 description 10
- 239000002151 riboflavin Substances 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 201000002287 Keratoconus Diseases 0.000 description 6
- 230000002186 photoactivation Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 201000009310 astigmatism Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 239000004971 Cross linker Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 210000003560 epithelium corneal Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 206010020675 Hypermetropia Diseases 0.000 description 2
- 208000031816 Pathologic Dilatation Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004980 dosimetry Methods 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 201000006318 hyperopia Diseases 0.000 description 2
- 230000004305 hyperopia Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012014 optical coherence tomography Methods 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010054760 Corneal thinning Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 208000021921 corneal disease Diseases 0.000 description 1
- 201000004573 corneal ectasia Diseases 0.000 description 1
- 210000003683 corneal stroma Anatomy 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 201000000766 irregular astigmatism Diseases 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002311 multiphoton fluorescence microscopy Methods 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 201000010041 presbyopia Diseases 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000013515 script Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024094250A JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862733617P | 2018-09-19 | 2018-09-19 | |
| US62/733,617 | 2018-09-19 | ||
| PCT/US2019/051876 WO2020061278A1 (en) | 2018-09-19 | 2019-09-19 | Systems and methods treating for corneal ectatic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094250A Division JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022508020A JP2022508020A (ja) | 2022-01-19 |
| JPWO2020061278A5 true JPWO2020061278A5 (de) | 2023-02-07 |
| JP7504083B2 JP7504083B2 (ja) | 2024-06-21 |
Family
ID=69772609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021515067A Active JP7504083B2 (ja) | 2018-09-19 | 2019-09-19 | 角膜拡張障害を治療するシステム及び方法 |
| JP2024094250A Pending JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094250A Pending JP2024113169A (ja) | 2018-09-19 | 2024-06-11 | 角膜拡張障害を治療するシステム及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200085617A1 (de) |
| EP (1) | EP3852700A4 (de) |
| JP (2) | JP7504083B2 (de) |
| CN (1) | CN113329723A (de) |
| AU (1) | AU2019345061A1 (de) |
| CA (1) | CA3112937A1 (de) |
| WO (1) | WO2020061278A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3212140B1 (de) * | 2014-10-27 | 2021-12-01 | Avedro, Inc. | Systeme zur vernetzung von behandlungen trockener augen |
| WO2021248100A1 (en) * | 2020-06-05 | 2021-12-09 | Robert Epstein | Uv-mask for crosslinking treatment of keratoconus |
| AU2022232309A1 (en) * | 2021-03-08 | 2023-10-12 | Avedro, Inc. | Systems and methods for generating patient-specific corneal cross-linking treatment patterns |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20041625A1 (it) * | 2004-08-06 | 2004-11-06 | Roberto Pinelli | Apparato per la correzione della presbiopia |
| US20080015660A1 (en) * | 2006-07-13 | 2008-01-17 | Priavision, Inc. | Method And Apparatus For Photo-Chemical Oculoplasty/Keratoplasty |
| JP6377906B2 (ja) * | 2010-03-19 | 2018-08-22 | アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． | 眼治療を適用およびモニターするためのシステム |
| US20120215155A1 (en) * | 2010-03-19 | 2012-08-23 | Avedro Inc. | Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking |
| WO2012145159A1 (en) * | 2011-04-20 | 2012-10-26 | Avedro, Inc. | Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking |
| CA2924775C (en) * | 2013-10-30 | 2020-03-31 | Wavelight Gmbh | Crosslinking control |
| EP3212140B1 (de) * | 2014-10-27 | 2021-12-01 | Avedro, Inc. | Systeme zur vernetzung von behandlungen trockener augen |
| WO2016191342A1 (en) * | 2015-05-22 | 2016-12-01 | Avedro, Inc. | Systems and methods for monitoring cross-linking activity for corneal treatments |
-
2019
- 2019-09-19 US US16/575,428 patent/US20200085617A1/en active Pending
- 2019-09-19 CN CN201980068841.7A patent/CN113329723A/zh active Pending
- 2019-09-19 EP EP19861900.9A patent/EP3852700A4/de active Pending
- 2019-09-19 JP JP2021515067A patent/JP7504083B2/ja active Active
- 2019-09-19 WO PCT/US2019/051876 patent/WO2020061278A1/en unknown
- 2019-09-19 AU AU2019345061A patent/AU2019345061A1/en active Pending
- 2019-09-19 CA CA3112937A patent/CA3112937A1/en active Pending
-
2024
- 2024-06-11 JP JP2024094250A patent/JP2024113169A/ja active Pending
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