JPWO2020039088A5 - - Google Patents
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- Publication number
- JPWO2020039088A5 JPWO2020039088A5 JP2021510062A JP2021510062A JPWO2020039088A5 JP WO2020039088 A5 JPWO2020039088 A5 JP WO2020039088A5 JP 2021510062 A JP2021510062 A JP 2021510062A JP 2021510062 A JP2021510062 A JP 2021510062A JP WO2020039088 A5 JPWO2020039088 A5 JP WO2020039088A5
- Authority
- JP
- Japan
- Prior art keywords
- methyloxa
- oxa
- azaspiroheptyl
- cyclopropyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 tert-octyl Chemical group 0.000 claims 23
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 2
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 claims 2
- LLSRLLPHUVVLQJ-UHFFFAOYSA-N 1-cycloheptyldiazepane Chemical group C1CCCCCC1N1NCCCCC1 LLSRLLPHUVVLQJ-UHFFFAOYSA-N 0.000 claims 1
- LPWKGYDOGOIQBD-UHFFFAOYSA-N 1-cyclononyl-1-methylcyclononane Chemical group C1CCCCCCCC1C1(C)CCCCCCCC1 LPWKGYDOGOIQBD-UHFFFAOYSA-N 0.000 claims 1
- NFDXQGNDWIPXQL-UHFFFAOYSA-N 1-cyclooctyldiazocane Chemical group C1CCCCCCC1N1NCCCCCC1 NFDXQGNDWIPXQL-UHFFFAOYSA-N 0.000 claims 1
- GGTBELZDHKHESR-UHFFFAOYSA-N 2-cycloheptyloxazepane Chemical group C1CCCCCC1N1OCCCCC1 GGTBELZDHKHESR-UHFFFAOYSA-N 0.000 claims 1
- UBEOVNYFKACFOT-UHFFFAOYSA-N 2-cyclononyloxazonane Chemical group C1CCCCCCCC1N1OCCCCCCC1 UBEOVNYFKACFOT-UHFFFAOYSA-N 0.000 claims 1
- ULTRBDTWHYVXPE-UHFFFAOYSA-N 2-cyclooctyloxazocane Chemical group C1CCCCCCC1N1OCCCCCC1 ULTRBDTWHYVXPE-UHFFFAOYSA-N 0.000 claims 1
- 125000003725 azepanyl group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000004069 aziridinyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical group C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 claims 1
- PVKHSOLHXMOBOY-UHFFFAOYSA-N cyclohexanone Chemical group O=C1CC[CH]CC1 PVKHSOLHXMOBOY-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- WVIIMZNLDWSIRH-UHFFFAOYSA-N cyclohexylcyclohexane Chemical group C1CCCCC1C1CCCCC1 WVIIMZNLDWSIRH-UHFFFAOYSA-N 0.000 claims 1
- UVCMYJYTEVWUCV-UHFFFAOYSA-N cyclononylcyclononane Chemical group C1CCCCCCCC1C1CCCCCCCC1 UVCMYJYTEVWUCV-UHFFFAOYSA-N 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- MAWOHFOSAIXURX-UHFFFAOYSA-N cyclopentylcyclopentane Chemical group C1CCCC1C1CCCC1 MAWOHFOSAIXURX-UHFFFAOYSA-N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000006264 diethylaminomethyl group Chemical group [H]C([H])([H])C([H])([H])N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 125000005879 dioxolanyl group Chemical group 0.000 claims 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000006437 ethyl cyclopropyl group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- XOBKSJJDNFUZPF-UHFFFAOYSA-N methoxyethyl Chemical group CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000006431 methyl cyclopropyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 claims 1
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 125000000466 oxiranyl group Chemical group 0.000 claims 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 claims 1
- 125000002053 thietanyl group Chemical group 0.000 claims 1
- 125000001730 thiiranyl group Chemical group 0.000 claims 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
Claims (1)
- Ｒ１が、メチル、エチル、ｎ－プロピル、ｎ－ブチル、ｎ－ペンチル、ｎ－ヘキシル、ｉｓｏ－プロピル、ｓｅｃ－ブチル、ｔｅｒｔ－ブチル、ｔｅｒｔ－ペンチル、ｔｅｒｔ－オクチル、３－ペンチル、－ＣＦ３、－ＣＦ２ＣＦ３、－（ＣＦ２）２ＣＦ３、－ＣＨ（ＣＦ３）２、－ＣＨ２ＳＣＨ３、－ＣＨ２ＣＨ２ＳＣＨ３、－ＣＨ２ＳＣＨ２ＣＨ３、－ＣＨ２ＣＨ２ＳＣＨ２ＣＨ３、メトキシメチル、メトキシエチル、メトキシプロピル、エトキシメチル、エトキシエチル、プロポキシメチル、ジメチル－アミノメチル、ジメチル－アミノエチル、ジエチル－アミノメチル、エチル－メチル－アミノメチル、シクロプロピル、メチル－シクロプロピル、エチル－シクロプロピル、トリフルオロメチル－シクロプロピル、パーフルオロエチル－シクロプロピル、シクロブチル、シクロペンチル、シクロヘキシル、シクロヘプチル、ビシクロペンチル、ビシクロヘキシル、ビシクロヘプチル好ましくはノルボルニル、ビシクロオクチル、ビシクロオクテニル、ビシクロノニル、メチルビシクロノニル、アダマンチル、トリシクロデシル、オキシラニル、オキセタニル、テトラヒドロフラニル、メチルテトラヒドロフラニル、トリメチルテトラヒドロフラニル、テトラヒドロピラニル、アジリジニル、Ｎ－メチルアジリジニル、アゼチジニル、Ｎ－メチルアゼチジニル、ジフルオロアゼチジニル、ピロリジニル、Ｎ－メチルピロリジニル、ピペリジニル、Ｎ－メチルピペリジニル、ジフルオロピペリジニル、チイラニル、チエタニル、テトラヒドロチオフェニル、テトラヒドロチオピラニル、ジオキサニル、ピペラジニル、ジメチルピペラジニル、ジチアニル、モルホリニル、Ｎ－メチルモルホリニル、チオモルホリニル、Ｎ－メチルチオモルホリニル、オキサ－アザスピロヘプチル、Ｎ－メチルオキサ－アザスピロヘプチル、アザスピロヘプチル、Ｎ－メチルアザスピロヘプチル、チア－アザスピロヘプチル、Ｎ－メチルチア－アザスピロヘプチル、ジフルオロチア－アザスピロヘプチル、アザスピロオクチル、Ｎ－メチルアザスピロオクチル、オキサ－アザスピロオクチル、Ｎ－メチルオキサ－アザスピロオクチル、オキサ－アザスピロノニル、Ｎ－メチルオキサ－アザスピロノニル、アザスピロノニル、Ｎ－メチルアザスピロノニル、オキサ－アザスピロデシル、Ｎ－メチルオキサ－アザスピロデシル、アザスピロデシル、Ｎ－メチルアザスピロデシル、ジヒドロ－オキサジニル、Ｎ－メチルジヒドロ－オキサジニル、オキサゾリジニル、Ｎ－メチルオキサゾリジニル、ジオキソラニル、イミダゾリジニル、Ｎ－メチルイミダゾリジニル、Ｎ，Ｎ－ジメチルイミダゾリジニル、アゼパニル、Ｎ－メチルアゼパニル、アザスピロヘキシル、Ｎ－メチルアザスピロヘキシル、オキサ－アザジスピロデシル、Ｎ－メチルオキサ－アザジスピロデシル、アザジスピロデシル、Ｎ－メチルアザジスピロデシル、オキサ－アザビシクロオクチル、Ｎ－メチルオキサ－アザビシクロオクチル、アザビシクロオクチル、Ｎ－メチルアザビシクロオクチル、アザビシクロヘプチル、Ｎ－メチルアザビシクロヘプチル、アザビシクロノニル、Ｎ－メチルアザビシクロノニル、アザアダマンチル、－Ｏ（アダマンチル）、オキサ－アザビシクロノニル、Ｎ－メチルオキサ－アザビシクロノニル、オキサ－アザビシクロヘプチル、Ｎ－メチルオキサ－アザビシクロヘプチル、ジアザビシクロオクチル、Ｎ－メチルジアザビシクロオクチル、Ｎ，Ｎ－ジメチルジアザビシクロオクチル、ジアザビシクロヘプチル、Ｎ－メチルジアザビシクロヘプチル、Ｎ，Ｎ－ジメチルジアザビシクロヘプチル；４－オキソシクロヘキシル；３－オキソシクロペンチル；２－オキソシクロブチル、４－オキソビシクロ［４．１．０］ヘプタン－１－イルから選択される請求項１～５のいずれか１項の化合物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18190769 | 2018-08-24 | ||
| EP18190769.2 | 2018-08-24 | ||
| PCT/EP2019/072633 WO2020039088A2 (en) | 2018-08-24 | 2019-08-23 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021534215A JP2021534215A (ja) | 2021-12-09 |
| JPWO2020039088A5 true JPWO2020039088A5 (ja) | 2022-08-31 |
Family
ID=63405085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510062A Pending JP2021534215A (ja) | 2018-08-24 | 2019-08-23 | 病的症状の治療における使用のための芳香族分子 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220354949A1 (ja) |
| EP (1) | EP3840834A2 (ja) |
| JP (1) | JP2021534215A (ja) |
| CN (1) | CN112888479A (ja) |
| AU (1) | AU2019323712A1 (ja) |
| CA (1) | CA3109419A1 (ja) |
| IL (1) | IL280876A (ja) |
| MA (1) | MA53430A (ja) |
| SG (1) | SG11202101093QA (ja) |
| WO (1) | WO2020039088A2 (ja) |
| ZA (1) | ZA202100482B (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3429576A1 (en) * | 2016-03-17 | 2019-01-23 | Xeniopro GmbH | Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch |
| US20220209150A1 (en) * | 2019-05-09 | 2022-06-30 | Merck Patent Gmbh | Diamondoid compounds |
| JP2022550576A (ja) * | 2019-10-03 | 2022-12-02 | テナヤ セラピューティクス， インコーポレイテッド | ５－フルオロニコチンアミド誘導体およびその使用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4204686A1 (de) * | 1992-02-17 | 1993-08-19 | Gruenenthal Gmbh | Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln |
| IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| JP2001064176A (ja) * | 1999-08-25 | 2001-03-13 | Sumitomo Pharmaceut Co Ltd | アミド系化合物を有効成分とする脂肪蓄積抑制剤 |
| GB0007884D0 (en) * | 2000-03-31 | 2000-05-17 | Pfizer Ltd | Diphenyl ether compounds useful in therapy |
| DE60321207D1 (en) * | 2002-09-19 | 2008-07-03 | Lilly Co Eli | Diaryläther als opioid-rezeptor antagonisten |
| GB0223249D0 (en) * | 2002-10-08 | 2002-11-13 | Amersham Plc | Improved imaging agents |
| CA2517888C (en) * | 2003-03-14 | 2012-05-01 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
| MXPA06007198A (es) * | 2003-12-22 | 2006-09-04 | Lilly Co Eli | Antagonistas de receptor opioide. |
| EP1650183A1 (en) * | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| WO2008156644A2 (en) * | 2007-06-14 | 2008-12-24 | Frank David A | Stat modulators |
| US20100286131A1 (en) * | 2007-08-03 | 2010-11-11 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2010097373A1 (de) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
| US8877754B2 (en) * | 2010-09-06 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| CN104364240B (zh) * | 2012-06-08 | 2017-02-22 | 四川贝力克生物技术有限责任公司 | 一种用于预防或治疗分支杆菌疾病的药物 |
| AU2015295248B2 (en) * | 2014-07-31 | 2019-05-16 | Institut Pasteur Korea | 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors |
| WO2016057322A1 (en) * | 2014-10-08 | 2016-04-14 | Salk Institute For Biological Studies | Ppar agonists and methods of use thereof |
| EP3429576A1 (en) * | 2016-03-17 | 2019-01-23 | Xeniopro GmbH | Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch |
| WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
| WO2018154118A2 (en) * | 2017-02-24 | 2018-08-30 | Reinmueller Viktoria | Novel aromatic compounds |
-
2019
- 2019-08-23 AU AU2019323712A patent/AU2019323712A1/en active Pending
- 2019-08-23 EP EP19759545.7A patent/EP3840834A2/en active Pending
- 2019-08-23 US US17/270,665 patent/US20220354949A1/en active Pending
- 2019-08-23 CA CA3109419A patent/CA3109419A1/en active Pending
- 2019-08-23 JP JP2021510062A patent/JP2021534215A/ja active Pending
- 2019-08-23 MA MA053430A patent/MA53430A/fr unknown
- 2019-08-23 SG SG11202101093QA patent/SG11202101093QA/en unknown
- 2019-08-23 CN CN201980069476.1A patent/CN112888479A/zh active Pending
- 2019-08-23 WO PCT/EP2019/072633 patent/WO2020039088A2/en unknown
-
2021
- 2021-01-22 ZA ZA2021/00482A patent/ZA202100482B/en unknown
- 2021-02-15 IL IL280876A patent/IL280876A/en unknown
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