JPWO2019183448A5 - - Google Patents
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- Publication number
- JPWO2019183448A5 JPWO2019183448A5 JP2020550650A JP2020550650A JPWO2019183448A5 JP WO2019183448 A5 JPWO2019183448 A5 JP WO2019183448A5 JP 2020550650 A JP2020550650 A JP 2020550650A JP 2020550650 A JP2020550650 A JP 2020550650A JP WO2019183448 A5 JPWO2019183448 A5 JP WO2019183448A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- set forth
- concentration
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 49
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 14
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 14
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 14
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 14
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 14
- 229940127557 pharmaceutical product Drugs 0.000 claims description 14
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 14
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 14
- 229940068977 polysorbate 20 Drugs 0.000 claims description 14
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 7
- 208000023761 AL amyloidosis Diseases 0.000 claims description 7
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 7
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 7
- 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 claims description 7
- 230000008021 deposition Effects 0.000 claims description 7
- 230000003442 weekly effect Effects 0.000 claims description 7
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 6
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 30
- 238000000034 method Methods 0.000 description 14
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862647341P | 2018-03-23 | 2018-03-23 | |
| US62/647,341 | 2018-03-23 | ||
| PCT/US2019/023528 WO2019183448A1 (en) | 2018-03-23 | 2019-03-22 | Treatment and prophylaxis of amyloidosis |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021518393A JP2021518393A (ja) | 2021-08-02 |
| JPWO2019183448A5 true JPWO2019183448A5 (https=) | 2022-03-29 |
| JP2021518393A5 JP2021518393A5 (https=) | 2022-03-29 |
| JP7217287B2 JP7217287B2 (ja) | 2023-02-02 |
Family
ID=66041747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550650A Active JP7217287B2 (ja) | 2018-03-23 | 2019-03-22 | アミロイド症の処置および予防 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210017278A1 (https=) |
| EP (1) | EP3768311A1 (https=) |
| JP (1) | JP7217287B2 (https=) |
| KR (1) | KR20200143400A (https=) |
| CN (1) | CN112040983A (https=) |
| AU (2) | AU2019240413A1 (https=) |
| BR (1) | BR112020019172A2 (https=) |
| CA (1) | CA3095100A1 (https=) |
| EA (1) | EA202092264A1 (https=) |
| MX (1) | MX2020009920A (https=) |
| MY (1) | MY203432A (https=) |
| SG (1) | SG11202009295YA (https=) |
| WO (1) | WO2019183448A1 (https=) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2237803T3 (en) * | 2007-12-28 | 2015-10-05 | Prothena Biosciences Ltd | Treatment and prophylaxis of amyloidosis |
| SG10201604104PA (en) * | 2011-10-25 | 2016-07-28 | Prothena Therapeutics Ltd | Antibody formulations and methods |
| WO2018005967A1 (en) * | 2016-06-30 | 2018-01-04 | Prothena Therapeutics Limited | Compositions for treating amyloidosis |
-
2019
- 2019-03-22 MX MX2020009920A patent/MX2020009920A/es unknown
- 2019-03-22 KR KR1020207030523A patent/KR20200143400A/ko not_active Ceased
- 2019-03-22 WO PCT/US2019/023528 patent/WO2019183448A1/en not_active Ceased
- 2019-03-22 AU AU2019240413A patent/AU2019240413A1/en not_active Abandoned
- 2019-03-22 CA CA3095100A patent/CA3095100A1/en active Pending
- 2019-03-22 MY MYPI2020004912A patent/MY203432A/en unknown
- 2019-03-22 EP EP19715723.3A patent/EP3768311A1/en active Pending
- 2019-03-22 CN CN201980028739.4A patent/CN112040983A/zh active Pending
- 2019-03-22 BR BR112020019172-8A patent/BR112020019172A2/pt not_active Application Discontinuation
- 2019-03-22 US US17/040,343 patent/US20210017278A1/en not_active Abandoned
- 2019-03-22 JP JP2020550650A patent/JP7217287B2/ja active Active
- 2019-03-22 EA EA202092264A patent/EA202092264A1/ru unknown
- 2019-03-22 SG SG11202009295YA patent/SG11202009295YA/en unknown
-
2023
- 2023-04-05 AU AU2023202109A patent/AU2023202109A1/en active Pending
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