JPWO2019178342A5 - - Google Patents
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- JPWO2019178342A5 JPWO2019178342A5 JP2020573073A JP2020573073A JPWO2019178342A5 JP WO2019178342 A5 JPWO2019178342 A5 JP WO2019178342A5 JP 2020573073 A JP2020573073 A JP 2020573073A JP 2020573073 A JP2020573073 A JP 2020573073A JP WO2019178342 A5 JPWO2019178342 A5 JP WO2019178342A5
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- 206010028980 Neoplasm Diseases 0.000 description 6
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- APCLRHPWFCQIMG-UHFFFAOYSA-N 4-(5,6-dimethoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid Chemical compound C1=C(OC)C(OC)=CC2=C1SC(C(=O)CCC(O)=O)=C2 APCLRHPWFCQIMG-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 101150092365 MSA2 gene Proteins 0.000 description 1
- 101100240989 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nrd1 gene Proteins 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 206010052015 cytokine release syndrome Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Description
大きな成功にもかかわらず、ＣＡＲ Ｔ細胞システムの開発と改善の取り組みは、複数の課題によって妨げられた：（ｉ）システムの機能には、さまざまな検出器の迅速な適応性のためのプラットフォームがないため、ターゲット抗原ごとに個別の細胞開発パスが必要である（ｉｉ）ＣＡＲ Ｔ細胞系の単一抗原特異性は、腫瘍の不均一性の場合、および癌細胞がＣＡＲを標的とするマーカーの一部の発現を停止し、それによって免疫応答を回避する場合に問題となる可能性がある（ｉｉｉ）ＣＡＲ活性の無秩序な持続は、サイトカイン放出症候群および他の毒性を引き起こす可能性がある（ｉｖ）現在のシステムは、Ｔ細胞の使用に重点を置いており、その分野のごく一部が他の細胞タイプを使用しようとする。（ｖ）ほとんどのＣＡＲ Ｔ細胞は、感染症の治療にほとんどまたはまったく注意を払わずに癌治療のために開発される（ｖｉ）ＣＡＲ Ｔ細胞は、弱く発現したオフ腫瘍標的に結合して反応し、望ましくない効果（「オンターゲットオフ腫瘍」反応）を引き起こすことがある。（ｖｉｉ）操作された細胞は、シグナル伝達能力が低く、細胞増殖と持続性が低下する可能性がある。したがって、より予測可能で、効果的で、信頼性の高い別の世代のＣＡＲ Ｔ細胞、または前述の欠陥を克服する別のシステムに対する継続的な必要性が存在する。
この出願の発明に関連する先行技術文献情報としては、以下のものがある（国際出願日以降国際段階で引用された文献及び他国に国内移行した際に引用された文献を含む）。
（先行技術文献）
（特許文献）
（特許文献１） 米国特許出願公開第２０１７／０２５８８３５号明細書
（特許文献２） 国際公開第２００４／０１８５０９号
（非特許文献）
（非特許文献１） ＬＯＨＭＵＥＬＬＥＲ ａｔ ａｌ．， ｍＳＡ２ ａｆｆｉｎｉｔｙ－ｅｎｈａｎｃｅｄ ｂｉｏｔｉｎ－ｂｉｎｄｉｎｇ ＣＡＲ Ｔ ｃｅｌｌｓ ｆｏｒ ｕｎｉｖｅｒｓａｌ ｔｕｍｏｒ ｔａｒｇｅｔｉｎｇ， Ｏｎｃｏｌｍｍｕｎｏｌｏｇｙ， ｐｕｂｌｉｓｈｅｄ ｏｎｌｉｎｅ ２６ Ｏｃｔｏｂｅｒ ２０１７， Ｖｏｌ． ７， Ｎｏ．１； ｐａｇｅ ｅ１３６８６０４ （ｐｇ １－６）； ａｂｓｔｒａｃｔ； ｐｇ １， ｃｏｌ １， ｐａｒａ ３－ ｃｏｌ ２， ｐａｒａ １； ｐｇ ２， ｃｏｌ ２， ｐａｒａ １
この出願の発明に関連する先行技術文献情報としては、以下のものがある（国際出願日以降国際段階で引用された文献及び他国に国内移行した際に引用された文献を含む）。
（先行技術文献）
（特許文献）
（特許文献１） 米国特許出願公開第２０１７／０２５８８３５号明細書
（特許文献２） 国際公開第２００４／０１８５０９号
（非特許文献）
（非特許文献１） ＬＯＨＭＵＥＬＬＥＲ ａｔ ａｌ．， ｍＳＡ２ ａｆｆｉｎｉｔｙ－ｅｎｈａｎｃｅｄ ｂｉｏｔｉｎ－ｂｉｎｄｉｎｇ ＣＡＲ Ｔ ｃｅｌｌｓ ｆｏｒ ｕｎｉｖｅｒｓａｌ ｔｕｍｏｒ ｔａｒｇｅｔｉｎｇ， Ｏｎｃｏｌｍｍｕｎｏｌｏｇｙ， ｐｕｂｌｉｓｈｅｄ ｏｎｌｉｎｅ ２６ Ｏｃｔｏｂｅｒ ２０１７， Ｖｏｌ． ７， Ｎｏ．１； ｐａｇｅ ｅ１３６８６０４ （ｐｇ １－６）； ａｂｓｔｒａｃｔ； ｐｇ １， ｃｏｌ １， ｐａｒａ ３－ ｃｏｌ ２， ｐａｒａ １； ｐｇ ２， ｃｏｌ ２， ｐａｒａ １
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862643378P | 2018-03-15 | 2018-03-15 | |
| US62/643,378 | 2018-03-15 | ||
| US201862651916P | 2018-04-03 | 2018-04-03 | |
| US62/651,916 | 2018-04-03 | ||
| PCT/US2019/022245 WO2019178342A1 (en) | 2018-03-15 | 2019-03-14 | Programmable immunocyte receptor complex system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021518428A JP2021518428A (ja) | 2021-08-02 |
| JPWO2019178342A5 true JPWO2019178342A5 (ja) | 2022-03-10 |
| JP7462578B2 JP7462578B2 (ja) | 2024-04-05 |
Family
ID=67905164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573073A Active JP7462578B2 (ja) | 2018-03-15 | 2019-03-14 | プログラム可能な免疫細胞受容体複合体システム |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20190284255A1 (ja) |
| EP (1) | EP3765093A4 (ja) |
| JP (1) | JP7462578B2 (ja) |
| KR (1) | KR20210018196A (ja) |
| CN (1) | CN112955184A (ja) |
| WO (1) | WO2019178342A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11117936B2 (en) * | 2017-11-10 | 2021-09-14 | University of Pittsburg—Of the Commonwealth System of Higher Education | Affinity-enhanced monomeric streptavidin chimeric antigen receptor (CAR) |
| US20220242929A1 (en) * | 2019-08-05 | 2022-08-04 | Cartherics Pty. Ltd. | Immune cells expressing modified cell receptors and methods of making |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721075D0 (en) * | 1997-10-03 | 1997-12-03 | Cancer Res Campaign Tech | Materials and methods relating to the stimulation of cells |
| FI20021518A0 (fi) * | 2002-08-23 | 2002-08-23 | Jyvaeskylaen Yliopisto | Avidiinin lämpökestävyyden lisääminen |
| WO2013044225A1 (en) * | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| MX2015000426A (es) * | 2012-07-13 | 2015-07-14 | Univ Pennsylvania | Incremento de actividad de celulas t car mediante cointroduccion de un anticuerpo biespecifico. |
| TW201414837A (zh) * | 2012-10-01 | 2014-04-16 | Univ Pennsylvania | 標定基質細胞以治療癌症之組合物和方法 |
| CN105980402B (zh) * | 2013-12-20 | 2021-06-15 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
| WO2016070061A1 (en) * | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Methods and compositions for modified t cells |
| EP3404410B1 (en) * | 2015-03-31 | 2021-07-14 | Fundamental Solutions Corporation | Biosensor system for the rapid detection of analytes |
| US9752199B2 (en) | 2015-03-31 | 2017-09-05 | Fundamental Solutions Corporation | Biosensor system for the rapid detection of analytes |
| EP3303381A1 (en) * | 2015-05-29 | 2018-04-11 | Fred Hutchinson Cancer Research Center | Compositions for cellular immunotherapy |
| CN108350462B (zh) * | 2015-09-11 | 2022-05-27 | 生物权威（英国）有限公司 | 嵌合抗原受体及其用途 |
| EP4353750A2 (en) * | 2016-06-24 | 2024-04-17 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
-
2019
- 2019-03-14 CN CN201980032485.3A patent/CN112955184A/zh active Pending
- 2019-03-14 KR KR1020207029506A patent/KR20210018196A/ko unknown
- 2019-03-14 EP EP19767510.1A patent/EP3765093A4/en active Pending
- 2019-03-14 WO PCT/US2019/022245 patent/WO2019178342A1/en active Application Filing
- 2019-03-14 US US16/353,337 patent/US20190284255A1/en not_active Abandoned
- 2019-03-14 JP JP2020573073A patent/JP7462578B2/ja active Active
-
2020
- 2020-06-10 US US16/897,885 patent/US20200299352A1/en active Pending
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