JPWO2019175216A5 - - Google Patents
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- JPWO2019175216A5 JPWO2019175216A5 JP2020547326A JP2020547326A JPWO2019175216A5 JP WO2019175216 A5 JPWO2019175216 A5 JP WO2019175216A5 JP 2020547326 A JP2020547326 A JP 2020547326A JP 2020547326 A JP2020547326 A JP 2020547326A JP WO2019175216 A5 JPWO2019175216 A5 JP WO2019175216A5
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- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- composition
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090001123 antibodies Proteins 0.000 claims 37
- 102000004965 antibodies Human genes 0.000 claims 37
- 239000000427 antigen Substances 0.000 claims 20
- 102000038129 antigens Human genes 0.000 claims 20
- 108091007172 antigens Proteins 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 101700082799 IL2RA Proteins 0.000 claims 6
- 102100002950 ISG20 Human genes 0.000 claims 6
- 101700015336 ISG20 Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 102000000588 Interleukin-2 Human genes 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 3
- 229940121650 immune-checkpoint protein inhibitors Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000003042 antagnostic Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 230000002489 hematologic Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035800 maturation Effects 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- 108010047814 Antigen-Antibody Complex Proteins 0.000 claims 1
- 230000035693 Fab Effects 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 108010070144 Single-Chain Antibodies Proteins 0.000 claims 1
- 102000005632 Single-Chain Antibodies Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 230000000779 depleting Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642232P | 2018-03-13 | 2018-03-13 | |
| US201862642218P | 2018-03-13 | 2018-03-13 | |
| US201862642230P | 2018-03-13 | 2018-03-13 | |
| US201862642248P | 2018-03-13 | 2018-03-13 | |
| US201862642243P | 2018-03-13 | 2018-03-13 | |
| GB1804029.5 | 2018-03-13 | ||
| GBGB1804027.9A GB201804027D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| PCT/EP2018/056312 WO2018167104A1 (en) | 2017-03-17 | 2018-03-13 | Fc-optimized anti-cd25 for tumour specific cell depletion |
| GBGB1804028.7A GB201804028D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| US62/642,243 | 2018-03-13 | ||
| EPPCT/EP2018/056312 | 2018-03-13 | ||
| US62/642,230 | 2018-03-13 | ||
| GB1804028.7 | 2018-03-13 | ||
| GB1804027.9 | 2018-03-13 | ||
| US62/642,248 | 2018-03-13 | ||
| US62/642,218 | 2018-03-13 | ||
| GBGB1804029.5A GB201804029D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| US62/642,232 | 2018-03-13 | ||
| PCT/EP2019/056248 WO2019175216A1 (en) | 2018-03-13 | 2019-03-13 | Anti-cd25 for tumour specific cell depletion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021516973A JP2021516973A (ja) | 2021-07-15 |
| JPWO2019175216A5 true JPWO2019175216A5 (ru) | 2022-03-18 |
Family
ID=67903878
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体 |
| JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547399A Active JP7451415B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547326A Pending JP2021516973A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547331A Pending JP2021515565A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547332A Pending JP2021516974A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗ｃｄ２５抗体剤 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体 |
| JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547399A Active JP7451415B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547331A Pending JP2021515565A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547332A Pending JP2021516974A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗ｃｄ２５抗体剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (11) | US11919960B2 (ru) |
| EP (8) | EP3765503B1 (ru) |
| JP (7) | JP7474701B2 (ru) |
| KR (3) | KR20200131286A (ru) |
| CN (8) | CN112020514A (ru) |
| AU (3) | AU2019233576A1 (ru) |
| BR (3) | BR112020016501A2 (ru) |
| CA (3) | CA3088246A1 (ru) |
| CR (3) | CR20200465A (ru) |
| MA (1) | MA51993A (ru) |
| PE (3) | PE20210289A1 (ru) |
| SG (3) | SG11202008699WA (ru) |
| TW (3) | TW201938588A (ru) |
| WO (8) | WO2019175216A1 (ru) |
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| US11371066B2 (en) | 2015-07-13 | 2022-06-28 | Modular Genetics, Inc. | Generation of acyl alcohols |
| CN108795858A (zh) * | 2017-04-28 | 2018-11-13 | 深圳宾德生物技术有限公司 | 高抗癌活性t细胞的筛选方法和应用 |
| EP3765503B1 (en) | 2018-03-13 | 2024-05-01 | Tusk Therapeutics Ltd | Anti-cd25 for tumour specific cell depletion |
| EP3972997A1 (en) * | 2019-05-20 | 2022-03-30 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Novel anti-cd25 antibodies |
| TW202138388A (zh) | 2019-12-30 | 2021-10-16 | 美商西根公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| TW202144429A (zh) * | 2020-05-14 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｃｄ２５抗體、其抗原結合片段及其醫藥用途 |
| EP4247496A1 (en) * | 2020-11-20 | 2023-09-27 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Anti-cd25 antibodies |
| CA3199006A1 (en) * | 2020-11-20 | 2022-05-27 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-cd25 antibodies |
| EP4255929A2 (en) | 2020-12-02 | 2023-10-11 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
| WO2022182483A1 (en) | 2021-02-02 | 2022-09-01 | Rakuten Medical, Inc. | Methods for local and systemic treatment of cancers, tumors and tumor cells |
| CN116940844A (zh) | 2021-03-01 | 2023-10-24 | 豪夫迈·罗氏有限公司 | 新颖生物标志物及其用途 |
| CN115724971A (zh) | 2021-08-09 | 2023-03-03 | 南京诺艾新生物技术有限公司 | 重组抗人cd25抗体及其应用 |
| TW202319400A (zh) | 2021-09-02 | 2023-05-16 | 瑞士商赫孚孟拉羅股份公司 | 用於治療aml之抗體 |
| AU2022337286A1 (en) * | 2021-09-03 | 2024-02-29 | Novarock Biotherapeutics, Ltd. | Bispecific binding proteins that bind cd137 and a tumor associated antigen |
| WO2023208990A1 (en) | 2022-04-26 | 2023-11-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer comprising a fas axis antagonist and a t-reg cell depleting agent antagonist, |
| CN115197321B (zh) * | 2022-06-02 | 2023-08-18 | 四川大学 | 靶向cd25的抗体及其用途 |
| CN115181182B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种人源化的抗cd25的单域抗体及其应用 |
| CN115181181B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种抗cd25的单域抗体及其应用 |
| WO2024006965A1 (en) * | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd25-specific antibodies and uses thereof |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| CN116004636B (zh) * | 2023-01-10 | 2024-03-12 | 广西师范大学 | 一种不结合红细胞的差异化cd47核酸适体及其应用 |
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2019
- 2019-03-13 EP EP19709955.9A patent/EP3765503B1/en active Active
- 2019-03-13 AU AU2019233576A patent/AU2019233576A1/en not_active Abandoned
- 2019-03-13 CN CN201980019248.3A patent/CN112020514A/zh active Pending
- 2019-03-13 CN CN201980019249.8A patent/CN112020515A/zh active Pending
- 2019-03-13 EP EP19709956.7A patent/EP3765504A1/en active Pending
- 2019-03-13 EP EP19711315.2A patent/EP3765511A1/en active Pending
- 2019-03-13 CN CN201980019257.2A patent/CN112218891A/zh active Pending
- 2019-03-13 TW TW108108451A patent/TW201938588A/zh unknown
- 2019-03-13 CR CR20200465A patent/CR20200465A/es unknown
- 2019-03-13 CN CN201980019235.6A patent/CN112041345A/zh active Pending
- 2019-03-13 JP JP2020547371A patent/JP7474701B2/ja active Active
- 2019-03-13 CN CN201980019241.1A patent/CN112020512A/zh active Pending
- 2019-03-13 SG SG11202008699WA patent/SG11202008699WA/en unknown
- 2019-03-13 CN CN201980019234.1A patent/CN112074536A/zh active Pending
- 2019-03-13 TW TW108108467A patent/TW202003034A/zh unknown
- 2019-03-13 BR BR112020016501-8A patent/BR112020016501A2/pt unknown
- 2019-03-13 WO PCT/EP2019/056248 patent/WO2019175216A1/en active Application Filing
- 2019-03-13 KR KR1020207029205A patent/KR20200131286A/ko unknown
- 2019-03-13 US US16/979,933 patent/US11919960B2/en active Active
- 2019-03-13 US US16/352,717 patent/US10745485B2/en active Active
- 2019-03-13 WO PCT/EP2019/056256 patent/WO2019175222A1/en active Application Filing
- 2019-03-13 PE PE2020001320A patent/PE20210289A1/es unknown
- 2019-03-13 CR CR20200466A patent/CR20200466A/es unknown
- 2019-03-13 EP EP19709954.2A patent/EP3765502A1/en active Pending
- 2019-03-13 CN CN201980019247.9A patent/CN112020513A/zh active Pending
- 2019-03-13 AU AU2019233575A patent/AU2019233575A1/en not_active Abandoned
- 2019-03-13 JP JP2020547415A patent/JP2021515568A/ja active Pending
- 2019-03-13 EP EP19710416.9A patent/EP3765507B1/en active Active
- 2019-03-13 PE PE2020001299A patent/PE20210288A1/es unknown
- 2019-03-13 CA CA3088246A patent/CA3088246A1/en not_active Abandoned
- 2019-03-13 MA MA051993A patent/MA51993A/fr unknown
- 2019-03-13 JP JP2020547399A patent/JP7451415B2/ja active Active
- 2019-03-13 AU AU2019233581A patent/AU2019233581A1/en active Pending
- 2019-03-13 CA CA3088659A patent/CA3088659A1/en not_active Abandoned
- 2019-03-13 US US16/979,929 patent/US11802161B2/en active Active
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