JPWO2019078220A1 - Injection method for fixed-quantity injection aerosol products and fixed-quantity injection aerosol products - Google Patents

Abstract

It contains the undiluted solution and the propellant, and the mixing ratio (volume ratio) of the undiluted solution and the propellant is 1/99 to 10/90, and the injection amount per injection is 1.0 to 3.0 mL. Fixed-quantity injection aerosol products.

Description

The present invention relates to a fixed-quantity injection aerosol product and a method for injecting a fixed-quantity injection aerosol product. More specifically, the present invention relates to a quantitative injection aerosol product and a method for injecting a quantitative injection aerosol product, in which the injected aerosol composition is easily visible and the volatile compound can be diffused over a wide range.

Conventionally, as a means for diffusing an insecticide or the like into an indoor space, a smoke agent or a total amount injection type aerosol product is known. However, some smoke agents generate heat. In addition, the total amount injection type aerosol product may contaminate the indoor wall surface, floor surface, etc. with a solvent. Therefore, there are known aerosol products intended to sustain the insecticidal effect and the effect of imparting aroma in a room by injecting a small amount of a volatile compound such as an insecticide or an air freshener (see, for example, Patent Document 1).

Japanese Unexamined Patent Publication No. 2011-63576

However, in the method described in Patent Document 1, the visibility of the injected aerosol composition is not sufficient, and the volatile compound is difficult to diffuse over a wide range. Therefore, in the method described in Patent Document 1, the range in which the medicinal effect can be obtained is narrow, and it is difficult to determine the range in which the medicinal effect can be obtained. Further, even when an amount capable of imparting a sufficient medicinal effect is injected by one injection, it is difficult for the user to sufficiently visually recognize the injected aerosol composition, so that the injected aerosol composition is injected more than necessary times. , You may overuse aerosol products.

By the way, in order to improve the visibility of the injected aerosol composition, it is conceivable to increase the injection amount per injection. However, when the injection amount per injection is large, the time required for injection becomes long, it is difficult to use it properly, and the walls and floor are easily contaminated.

The present invention has been made in view of such conventional problems, and is a quantitative injection type aerosol product and a quantitative injection type aerosol product in which the injected aerosol composition is easily visible and the aerosol composition can be diffused over a wide range. It is an object of the present invention to provide a method for injecting an injection type aerosol product.

The present inventor has earnestly studied the conditions for solving the above problems and obtained the following findings. That is, the injected aerosol is injected while enhancing the visibility of the injected aerosol composition by containing the undiluted solution and the propellant so as to have a specific blending ratio and adjusting the injection amount at one time to a specific amount. They have found that the composition can be diffused over a wide area and have completed the present invention.

The quantitative injection type aerosol product of the present invention that solves the above problems contains a stock solution and a propellant, and the blending ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90. It is a fixed-quantity injection type aerosol product in which the injection amount per injection is 1.0 to 3.0 mL.

Further, in the injection method of the quantitative injection type aerosol product of the present invention which solves the above-mentioned problems, the blending ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90. This is an injection method for a quantitative injection type aerosol product, in which an aerosol composition containing the above-mentioned is injected so that the injection amount per injection is 1.0 to 3.0 mL.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide an injection method for a fixed-quantity injection aerosol product and a fixed-quantity injection aerosol product, in which the injected aerosol composition is easily visible and the aerosol composition can be diffused over a wide range. ..

FIG. 1 is a schematic diagram for explaining a method for measuring a drug diffusion rate in an example. FIG. 2 is a schematic diagram for explaining a method of measuring the drug diffusion rate in Examples. FIG. 3 is a photograph explaining the injection state of the aerosol composition of Example 4, which was evaluated as ◯ in the visibility evaluation. FIG. 4 is a photograph illustrating an injection state of the aerosol composition of Comparative Example 1 evaluated as x in the visibility evaluation.

<Quantitative injection aerosol product>
The quantitative injection type aerosol product (hereinafter, also referred to as an aerosol product) according to an embodiment of the present invention includes an aerosol container filled with an aerosol composition containing a stock solution and an propellant, and an aerosol metering valve attached to the aerosol container. , A stem mechanism attached to the aerosol metering valve and an injection button for operating the stem mechanism and the aerosol metering valve. The mixing ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90. The injection amount per injection is 1.0 to 3.0 mL. Each configuration will be described below. The aerosol product of the present embodiment is characterized in that the blending ratio of the undiluted solution and the propellant and the injection amount of the aerosol composition per injection are adjusted to be within the above-mentioned specific ranges. Therefore, other configurations (for example, the shape of the aerosol product, the components and blending amounts in the undiluted solution, various physical properties such as the pressure inside the container, etc.) are not particularly limited as long as they satisfy the above ranges. Therefore, in the following detailed description, the components in the undiluted solution, the mixing ratio of the undiluted solution and the propellant, and the injection amount of the aerosol composition at one time are adjusted to be in the above-mentioned specific types and ranges. Other than that, all are examples.

(Undiluted solution)
The stock solution may contain the desired component to be diffused. Such components are not particularly limited. As an example, the undiluted solution preferably contains a volatile compound having a vapor pressure of 1.0 × 10 ^-5 mmHg (25 ° C.) or higher.

Volatile compounds having a vapor pressure of 1.0 × 10 ^-5 mmHg (25 ° C.) or higher are not particularly limited. The vapor pressure of the volatile compound is preferably 1.0 × 10 ^-5 mmHg (25 ° C.) or higher, more preferably 1.5 × 10 ^-5 mmHg (25 ° C.) or higher, and 2.0. It is more preferably × 10 ^-5 mmHg (25 ° C.) or more. The vapor pressure of the volatile compound is preferably 5.0 × 10 ^-3 mmHg (25 ° C.) or less, and more preferably 3.0 × 10 ^-3 mmHg (25 ° C.) or less. When the vapor pressure of the volatile compound is within the above range, the volatile compound tends to spread in the space in the aerosol product.

The type of volatile compound is not particularly limited. The volatile compound is appropriately selected so that the aerosol product of the present embodiment can impart the desired medicinal effect. For example, when an aerosol product is used for pest control, the volatile compounds include insecticidal compounds such as pyrethroid compounds, carbamate compounds, oxadiazole compounds and the like. Further, when the aerosol product is used for fragrance, the volatile compound includes a fragrance compound such as menthol, citral and geraniol. When the aerosol product is used for antibacterial purposes, the volatile compound contains an antibacterial compound such as an isothiocyanate antibacterial agent and a phenolic antibacterial agent. These volatile compounds may be used in combination. That is, for example, when an aerosol product is used for pest control and for fragrance, each of the above volatile compounds can be used in combination.

Pyrethroid compounds are metoflutrin (vapor pressure: 1.5 × 10 ^-5 mmHg (25 ° C)), profluthrin (vapor pressure: 7.7 × 10 ^-5 mmHg (25 ° C)), transfluthrin (vapor pressure: 2). .7 × 10 ^-5 mmHg (25 ° C)), terraresulin (vapor pressure: 6.6 × 10 ^-4 mmHg (25 ° C)), etc. Among these, the insecticidal effect is high and the effect of the present invention can be obtained. From the viewpoint of ease, the pyrethroid compound preferably contains transfluthrin.

Carbamate compounds include propoxul (vapor pressure: 2.1 × 10 ^-5 mmHg (25 ° C.)) and carbaryl (vapor pressure: 4.1 × 10 ^-5 mmHg (23.5 ° C.)). Among these, the carbamate compound is preferably propoxul because of its high vapor pressure and high insecticidal activity. The vapor pressure of carbyl is 4.1 × 10 ^-5 mmHg or more at 25 ° C.

The oxadiazole-based compound is methoxadiazone (vapor pressure: 1.1 × 10 ^-3 mmHg (25 ° C.)) or the like.

In addition to these, insecticidal compounds include dichlorvos (vapor pressure: 1.6 × ^10-2 mmHg (25 ° C)) as an organic phosphorus agent system and hydroprene (vapor pressure: 1.9), which is a juvenile hormone-like substance. It may be × 10 ^-4 mmHg (25 ° C.)), amidoflumeth (vapor pressure: 1.1 × 10 ^-3 mmHg (20 ° C.)), or the like. The vapor pressure of amide flumeth is 1.1 × 10 ^-3 mmHg or more at 25 ° C.

By using these pesticide compounds as volatilizing compounds, for example, cockroaches such as Smokybrown cockroaches, American cockroaches, American cockroaches, American cockroaches, brown cockroaches, spiders, mukade, ants, geji, yasude, dangomushi, warajimushi, termites, chemists, ticks , Flea, brown cockroach, termites and other pests, mosquitoes, flies, moths, bees, turtles, cockroaches, cockroaches, cockroaches, cockroaches and other flying pests can be suitably controlled.

The fragrance compounds are menthol (vapor pressure: 6.3 × ^10-2 mmHg (25 ° C.)) and citral (vapor pressure: 9.1 × ^10-2 mmHg (vapor pressure: 9.1 × ^10-2 mmHg)) because of their high palatability and low threshold. 25 ° C.)), geraniol (vapor pressure: 3.0 × ^10-2 mmHg (25 ° C.)) and the like are preferable.

Examples of the isothiocyanate antibacterial agent are methyl isothiocyanate (vapor pressure: 16 mmHg (30 ° C.)), allyl isothiocyanate (vapor pressure: 3.7 mmHg (20 ° C.)) and the like. Among these, the isothiocyanate antibacterial agent is preferably allyl isothiocyanate. The vapor pressure of methyl isothiocyanate is 1.0 × 10 ^-5 mmHg or more at 25 ° C., and the vapor pressure of allyl isothiocyanate is 3.7 mmHg or more at 25 ° C.

Phenolic antibacterial agents include thymol (vapor pressure: 2.2 × 10 ^-3 mmHg (25 ° C.)), isopropylmethylphenol (vapor pressure: 2.0 × 10 ^-3 mmHg (20 ° C.)) and the like. Among these, the phenolic antibacterial agent is preferably isopropylmethylphenol from the viewpoint of achieving both safety and efficacy. The vapor pressure of isopropylmethylphenol is 2.0 × 10 ^-3 mmHg or more at 25 ° C.

The content of the volatile compound is not particularly limited. The content of the volatile compound can be appropriately adjusted depending on the type of the volatile compound. As an example, when the volatile compound is the above-mentioned insecticidal compound, the content of the insecticidal compound is preferably 0.1 w / v% or more, more preferably 10 w / v% or more in the undiluted solution. .. On the other hand, the content of the insecticidal compound may be 100 w / v% in the undiluted solution. When the content of the insecticidal compound is less than 0.1 w / v%, the aerosol product may not sufficiently exert the desired insecticidal effect or may be difficult to spread widely.

When the volatile compound is the above-mentioned fragrance compound, the content of the fragrance compound is preferably 0.05 w / v% or more, and more preferably 10 w / v% or more in the undiluted solution. On the other hand, the content of the fragrance compound may be 100 w / v% in the undiluted solution. If the content of the fragrance compound is less than 1 w / v%, the aerosol product may not be able to sufficiently impart the fragrance or may be difficult to diffuse widely.

Further, when the volatile compound is the antibacterial compound, the content of the antibacterial compound in the stock solution is preferably 1 w / v% or more, more preferably 10 w / v% or more. On the other hand, the content of the antibacterial compound may be 100 w / v% in the undiluted solution. When the content of the antibacterial compound is less than 1 w / v%, the aerosol product may not sufficiently exert the desired antibacterial effect or may not be widely diffused.

The undiluted solution may contain a solvent as appropriate. The solvent may be contained to appropriately dissolve the volatile compound to facilitate mixing with the propellant in the aerosol container or to assist the diffusion of the volatile compound into the room.

The solvent is not particularly limited. As an example, the solvent is ethanol, isopropyl alcohol (IPA), propylene glycol monomethyl ether, isopropyl myristate (IPM) and the like. Among these, the solvent is preferably ethanol or IPA from the viewpoint of easily dissolving the volatile compound, being inexpensive, and being easy to handle.

When the solvent is contained, the content of the solvent in the stock solution is preferably more than 0% by mass, more preferably 10% by mass or more. On the other hand, the content of the solvent is preferably 99% by mass or less, more preferably 90% by mass or less in the stock solution. When the content of the solvent exceeds 99% by mass, the amount of the volatile compound blended in the aerosol product is small, and the effect of blending the volatile compound may not be sufficiently obtained.

The undiluted solution may contain an optional component in addition to the above-mentioned volatile compound and solvent which are preferably blended. To give an example, optional components are non-volatile or non-volatile compounds; non-ionic, anionic or cationic surfactants; antioxidants such as butyl hydroxytoluene; stabilizers such as citric acid, ascorbic acid; Inorganic powders such as talc and citric acid, deodorants, pigments and the like.

(Injector)
The propellant is a content that is pressurized and filled in an aerosol container together with the undiluted solution. The propellant is injected together with the undiluted solution from the injection button injection port described later by operating the aerosol metering valve described later. At that time, the propellant imparts a propulsive force when injecting the undiluted solution, and at the same time, the aerosol composition is made into fine particles and diffused in the space.

The type of propellant is not particularly limited. As an example, the propellant is a liquefied gas. Examples of the liquefied gas include liquefied petroleum gas, propane, normal butane, isobutane, normal pentane, isopentane and other aliphatic hydrocarbons having 3 to 5 carbon atoms, and trans-1,3,3,3-tetrafluoropropa-1-. Examples thereof include hydrofluoroolefins such as ene, trans-2,3,3,3-tetrafluoropropa-1-ene, dimethyl ether and mixtures thereof. As the liquefied gas, a compressed gas may be used in combination. Examples of the compressed gas include nitrogen gas, carbon dioxide gas, nitrous oxide gas, and compressed air. Of these, liquefied petroleum gas is preferable as the propellant.

In the aerosol product of the present embodiment, the mixing ratio (volume ratio) of the stock solution and the propellant at 20 ° C. may be 1/99 to 10/90, preferably 1/99 to 9/91. It is more preferably .5 / 98.5-8 / 92. When the blending ratio (volume ratio) of the propellant exceeds 99% by volume, the aerosol composition may have a small amount of active ingredients and it may be difficult to exhibit the effect. On the other hand, when the blending ratio (volume ratio) of the propellant is less than 90% by volume, the aerosol composition may have reduced diffusivity after spraying.

The internal pressure of the aerosol metering valve at 25 ° C. in a state of being filled with the stock solution and the propellant is preferably 0.2 MPa or more, more preferably 0.25 MPa or more. The internal pressure of the aerosol metering valve at 25 ° C. is preferably 0.8 MPa or less, more preferably 0.7 MPa or less. If the internal pressure of the aerosol metering valve is less than 0.2 MPa, the aerosol composition may drip from the nozzle after injection. On the other hand, when the internal pressure of the aerosol metering valve exceeds 0.8 MPa, the aerosol composition may leak from the aerosol container. The internal pressure of the aerosol metering valve is, for example, at 25 ° C., the PGM-E compact pressure sensor (manufactured by Kyowa Electric Co., Ltd.) attached to the WGA-710C instrumentation conditioner (manufactured by Kyowa Electric Co., Ltd.) is used to quantify the aerosol. It can be measured by connecting to a valve.

The aerosol product containing the above-mentioned stock solution and propellant is pressure-filled in the aerosol container. The aerosol container is not particularly limited. As an example, the aerosol container is a substantially cylindrical pressure-resistant container having an opening formed at the top. The opening is a filling port for filling the aerosol composition, and is closed by an aerosol metering valve described later after the stock solution is filled.

The material of the aerosol container is not particularly limited. For example, the material of the aerosol container is a metal such as aluminum or tin, a synthetic resin such as polyethylene terephthalate, and pressure-resistant glass.

The aerosol metering valve is a mechanism for taking out the aerosol composition filled in the aerosol container, and is attached to the opening of the aerosol container and closes the opening. Further, the aerosol metering valve of the present embodiment is formed with a metering chamber for temporarily storing the aerosol composition taken out from the aerosol container. The volume of the metering chamber corresponds to the volume of the aerosol composition injected by one injection. The volume of the metering chamber of this embodiment is 1.0 to 3.0 mL.

The stem mechanism is a portion attached to the aerosol metering valve, and an internal passage for sending the undiluted solution and the propellant taken into the aerosol metering valve to the injection button described later is formed. The internal passage is appropriately opened and closed by the stem rubber of the stem mechanism.

The injection button is a member for injecting the undiluted solution taken in from the aerosol container through the stem mechanism by the aerosol metering valve together with the propellant. The injection button is formed with a nozzle for injecting the aerosol composition.

The number, dimensions and shape of the nozzles are not particularly limited. As an example, the number of nozzles may be one or two or more. The size of the nozzle (injection diameter) is preferably 0.2 mm or more, more preferably 0.3 mm or more, and further preferably 0.5 mm or more. Further, the nozzle diameter is preferably 4.5 mm or less, more preferably 3.0 mm or less, and further preferably 0.9 mm or less. The shape (cross-sectional shape) of the nozzle may be circular, elliptical, polygonal, or various irregular shapes. With respect to the total area of nozzle hole, it is preferably 0.03 mm ² or more, more preferably 0.1 mm ² or more, more preferably 0.25 mm ² or more. The total area of the nozzle is preferably 16 mm ² or less, more preferably 5 mm ² or less, and further preferably 3.5 mm ² or less.

In the aerosol product of the present embodiment, when the injection button is operated by the user, the stem mechanism and the aerosol metering valve are operated, and the inside and the outside of the aerosol container communicate with each other. As a result, a certain amount of the aerosol composition in the aerosol container is taken out from the aerosol container according to the pressure difference between the inside and the outside of the aerosol container, and is injected from the injection port of the injection member.

The aerosol product of the present embodiment is adjusted so that the injection amount per injection is 1.0 to 3.0 mL. The injection amount per injection may be 1.0 mL or more. The injection amount per injection may be 3.0 mL or less, preferably 2.5 mL or less, and more preferably 2.2 mL or less. When the injection amount per injection is less than 1.0 mL, the injected aerosol composition is difficult to see. On the other hand, when the injection amount per injection exceeds 3.0 mL, the injected aerosol composition has a large particle size, does not diffuse over a wide area, and easily falls.

The aerosol product of the present embodiment is injected by specifying the mixing ratio of the stock solution and the propellant described above and adjusting the injection amount per injection so as to be 1.0 to 3.0 mL. It has achieved widespread diffusion of the aerosol composition in the stock solution while improving the visibility of the aerosol composition. Therefore, the method for adjusting the injection amount per injection is not particularly limited. The injection amount per injection can be adjusted, for example, by appropriately adjusting the capacity of the metering chamber of the aerosol metering valve, the time for communication between the inside and the outside of the aerosol container when the injection button is operated, and the like.

In the aerosol composition injected by the aerosol product of the present embodiment, the injection load at a position 20 cm away from the injection port is preferably 5 gf or more, and more preferably 9 gf or more. Further, in the aerosol composition, the injection load at a position 20 cm away from the injection port is preferably 40 gf or less, and more preferably 30 gf or less. By adjusting the injection load so as to be within the above range, the aerosol product tends to diffuse the volatile compound over a wide range while improving the visibility of the injected aerosol composition. The injection load of the injected aerosol composition is a circular flat plate of Φ60 mm mounted on a digital force gauge (model number: DS2-2N, manufactured by Imada Co., Ltd.) from a distance of 20 cm from the injection port at room temperature of 25 ° C. It can be calculated by calculating the average with the maximum value when the aerosol composition is injected in the horizontal direction toward the center as the injection load.

The method for producing the aerosol product of the present embodiment is not particularly limited. As an example, an aerosol product is manufactured by filling an aerosol container with a stock solution, closing the opening of the aerosol container by an aerosol metering valve provided with a metering chamber, and pressurizing and filling the propellant through a stem mechanism. can do. As an example, the injection button may be a trigger button, a push-down button, or the like.

As described above, according to the aerosol product of the present embodiment, the injected aerosol composition is easily visible and the volatile compound is diffused over a wide range.

<Injection method for quantitative injection aerosol products>
In the injection method (hereinafter, also referred to as an injection method) of the quantitative injection type aerosol product according to the embodiment of the present invention, the blending ratio (volume ratio) of the stock solution and the propellant is 1/99 or more. This is a method of injecting an aerosol composition containing 10/90 so that the injection amount per injection is 1.0 to 3.0 mL.

In carrying out the injection method of the present embodiment, the aerosol composition and the aerosol product may be the same as those described in the above-described embodiment.

In the present embodiment, the number of injections may be one. According to the injection method of the present embodiment, the injection amount per injection is 1.0 to 3.0 mL, so that the user can visually recognize the injected aerosol composition even if the number of injections is one. It's easy to do. Further, even if the number of injections is one, the injected aerosol composition is easily diffused and the medicinal effect can be imparted in a wide range. According to the injection method of the present embodiment, the desired effect can be obtained even if the number of injections is one, but if necessary, the number of injections may be two or more.

As described above, according to the injection method of the present embodiment, the injected aerosol composition is easily visible and the volatile compound is diffused over a wide range.

Hereinafter, the present invention will be described in more detail with reference to Examples. The present invention is not limited to these examples.

<Aerosol products>
Details of the aerosol products used are shown below.
Aerosol 1: Button nozzle diameter φ0.6mm button, valve 0.2cc valve aerosol 2: button nozzle diameter φ0.6mm button, valve 1.0cc valve aerosol 3: button valve nozzle diameter φ1.0mm button, valve 1.0cc valve aerosol 4 : Button nozzle diameter φ2.0mm button, valve 1.0cc valve aerosol 5: Button nozzle diameter φ2.0mm button, valve 2.2cc valve aerosol 6: Button nozzle diameter φ0.5mm x 8 buttons, valve 1.0cc valve aerosol 7: Button nozzle diameter φ1.0mm x 3 buttons, valve 1.0cc valve

(Example 1)
As a volatile compound, 100 parts by mass of transfluthrin (stock solution, vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C)) is filled in an aerosol container with a capacity of 200 mL, a valve is attached, and then the raw material and injection are performed. Aerosol products are filled with a propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (25 ° C)) under pressure so that the blending ratio (volume ratio) with the agent is 1.6 / 98.4, and an injection button is attached. Was prepared in 100 mL (valves and buttons according to aerosol 4). The internal pressure of the aerosol product (internal pressure of the valve; the same applies hereinafter) (25 ° C.) was 0.45 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 19.5 gf. The internal pressure of the valve is 25 ° C. Connect the PGM-E compact pressure sensor (Kyowa Electric Co., Ltd.) attached to the WGA-710C instrumentation conditioner (Kyowa Electric Co., Ltd.) to the aerosol metering valve. Measured by. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 2)
A volume of transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) as a precursor together with 72 parts by mass of isopropyl alcohol (IPA) so that the concentration in the stock solution is 25% by weight / volume. After filling a 200 mL aerosol container and installing a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 6.4 / 93.6. (25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 4). The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 25.4 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 3)
An aerosol product was produced by the same method as in Example 2 except that the valves and buttons were in accordance with the aerosol 5. The internal pressure (25 ° C.) of the aerosol product was 0.43 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 24.8 gf. By using this aerosol product, 35 mg of the original body is injected at one time.

(Example 4)
An aerosol product was produced by the same method as in Example 2 except that the valves and buttons were in accordance with the aerosol 2. The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 9.4 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 5)
An aerosol product was produced by the same method as in Example 2 except that the valves and buttons were in accordance with the aerosol 3. The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 11.6 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 6)
Transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) was used as the raw material, and 31.6 parts by mass of isopropyl alcohol (31.6 parts by weight) so that the concentration in the stock solution was 62.5% by weight / volume%. After filling an aerosol container with a capacity of 200 mL together with IPA) and installing a valve, the propellant (liquefied petroleum gas saturated vapor pressure) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 2.6 / 97.4. : 0.49 MPa (25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 2). The internal pressure (25 ° C.) of the aerosol product was 0.45 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 9.8 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 7)
An aerosol product was produced by the same method as in Example 2 except that the valves and buttons were in accordance with the aerosol 6. The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 21.2 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 8)
100 parts by mass of phthalthrin (vapor pressure: 4.5 × 10 ^-6 mmHg (25 ° C.)) as the raw material, 46 parts by mass of isopropyl alcohol (IPA) so that the concentration in the stock solution is 50% by mass / volume%. After filling the aerosol container with a capacity of 200 mL and attaching the valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 6.4 / 93.6. .49 MPa (25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 2). The internal pressure (25 ° C.) of the aerosol product was 0.48 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 10.3 gf. By using this aerosol product, 32 mg of the original body is injected at one time.

(Example 9)
100 parts by mass of linalol (fragrance compound, vapor pressure: 0.16 mmHg (25 ° C.)) as the raw material together with 69 parts by mass of isopropyl alcohol (IPA) so that the concentration in the stock solution is 25% by weight / volume. After filling a 200 mL aerosol container and installing a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 6.4 / 93.6. (25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 6). The internal pressure (25 ° C.) of the aerosol product was 0.50 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 21.4 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 10)
Transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) as the raw material, 72.0 parts by mass of isopropyl myristate (IPM) so that the concentration in the stock solution is 25% by weight / volume%. ) And the aerosol container with a capacity of 200 mL, and after installing the valve, the propellant (liquefied petroleum gas saturated vapor pressure:) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 6.4 / 93.6. 0.49 MPa (25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 6). The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 19.5 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Example 11)
An aerosol product was produced by the same method as in Example 2 except that the valves and buttons were in accordance with the aerosol 7. The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at the horizontal position 20 cm away from the injection port was 19.6 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Comparative Example 1)
Transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) was used as the raw material, and 31.6 parts by mass of isopropyl alcohol (31.6 parts by weight) so that the concentration in the stock solution was 62.5% by weight / volume%. After filling an aerosol container with a capacity of 200 mL together with IPA) and attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 16/84. (25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 1). The internal pressure (25 ° C.) of the aerosol product was 0.43 MPa, and the injection load at a position 20 cm away from the injection port was 9.0 gf. By using this aerosol product, 20 mg of the original body is injected at one time.

(Comparative Example 2)
Transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) as the raw material, 52.4 parts by mass of isopropyl myristate (IPM) so that the concentration in the stock solution is 50% by weight / volume%. After filling an aerosol container with a capacity of 200 mL together with) and attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (liquefied petroleum gas saturated vapor pressure: 0.49 MPa) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 16/84. 25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 1). The internal pressure (25 ° C.) of the aerosol product was 0.42 MPa, and the injection load at a position 20 cm away from the injection port was 10.7 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Comparative Example 3)
Transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) as the raw material, 87.5 parts by mass of isopropyl myristate (IPM) so that the concentration in the stock solution is 10% by weight / volume%. After filling an aerosol container with a capacity of 200 mL together with) and attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (liquefied petroleum gas saturated vapor pressure: 0.49 MPa) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 16/84. 25 ° C.)) was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 4). The internal pressure (25 ° C.) of the aerosol product was 0.45 MPa, and the injection load at a position 20 cm away from the injection port was 21.9 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

(Comparative Example 4)
Volume of transfluthrin (vapor pressure: 2.7 × 10 ^-5 mmHg (25 ° C.)) as an aerosol together with 93.3 parts by mass of isopentane so that the concentration in the stock solution is 4.4% by weight / volume. After filling a 200 mL aerosol container and installing a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (25 ° C)) so that the mixing ratio (volume ratio) of the undiluted solution and the propellant is 36/64. ) Was pressurized and filled, and an injection button was attached to prepare an aerosol product (valves and buttons were in accordance with aerosol 4). The internal pressure (25 ° C.) of the aerosol product was 0.37 MPa, and the injection load at a position 20 cm away from the injection port was 14.5 gf. By using this aerosol product, 16 mg of the original body is injected at one time.

For the obtained aerosol products of Examples 1 to 11 and Comparative Examples 1 to 4, the diffusion rate of the volatile compound was measured according to the following evaluation method. The results are shown in Table 1 or Table 2. In addition, in the column of "the nozzle diameter" of Table 1 and Table 2, the number of nozzles is also shown in the example using the button which has a plurality of nozzles.

<Diffusion rate of volatile compound>
In an 8-mat chamber (ventilation condition: no ventilation), a metal petri dish having a diameter of 9 cm was installed at the positions shown in FIGS. 1 and 2. 1 and 2 are schematic views of an 8-mat chamber C for explaining a method of measuring the diffusion rate of volatile compounds, FIG. 1 is a perspective view, and FIG. 2 is a plan view. The dimensions of the 8-mat chamber C are a width l of 360 cm, a depth m of 360 cm, and a height n of 270 cm. One metal petri dish (metal petri dish S1, Φ9 cm stainless petri dish in units of 10) is placed in the center of the 8-mat chamber C (horizontal position l1 is 180 cm, depth position m1 is 180 cm), and the remaining two places (metal). Petri dishes S2 and metal petri dishes S3) were placed at both ends of the 8-mat chamber C on the entrance door D side. The aerosol product was sprayed once from the height of the entrance door D toward the center of the 8-mat chamber C. After 4 hours, the amount of the drug (primary substance) in the metal petri dishes S1 to S3 was quantified. From the obtained quantitative value (drug amount), the volatile compound diffusion rate was measured according to the following formula.
Volatile compound diffusion rate (%) = 100 × (average value of the amount of chemicals in the metal petri dish S2 and the metal petri dish S3 placed at both ends) / the amount of the chemical in the metal petri dish S1 placed in the center

<Visibility>
The aerosol product was sprayed once, and the degree of visibility was visually confirmed. FIG. 3 is a photograph explaining the injection state of the aerosol composition of Example 4, which was evaluated as ◯ in the visibility evaluation. FIG. 4 is a photograph illustrating an injection state of the aerosol composition of Comparative Example 1 evaluated as x in the visibility evaluation.
(Evaluation criteria)
◯: The aerosol composition was visually recognizable.
X: The aerosol composition was difficult to visually recognize.

As shown in Tables 1 and 2, when the aerosol products of Examples 1 to 11 are used, the diffusion rate of the volatile compound is higher than that of the cases of using the aerosol products of Comparative Examples 1 to 4, and the source is widely used. It turned out that the body could be applied. In addition, all of the aerosol products of Examples 1 to 11 could be visually visually recognized at the time of injection. Above all, in the aerosol product of Example 3, the aerosol composition injected at the time of injection could be clearly visually recognized. From this, it was found that in the aerosol product of the present invention, the injected aerosol composition can be easily visually recognized and the volatile compound can be diffused over a wide range by one injection. When the aerosol products of Comparative Examples 1 and 2 were used, it was difficult to visually visually recognize the injected aerosol composition at the time of injection.

C 8 tatami chamber D Entrance door S1, S2, S3 Metal petri dish l Width l1 Width m Depth m1 Depth position n Height

Claims (4)

Contains undiluted solution and propellant,
The blending ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90.
A fixed-quantity injection aerosol product with a single injection amount of 1.0 to 3.0 mL. The quantitative injection aerosol product according to claim 1, wherein the undiluted solution contains a volatile compound having a vapor pressure of 1.0 × 10 ^-5 mmHg (25 ° C.) or higher. The quantitative injection aerosol product according to claim 2, wherein the volatile compound is at least one selected from the group consisting of pyrethroid compounds, fragrance compounds, and antibacterial compounds. An aerosol composition containing the undiluted solution and the propellant so that the blending ratio (volume ratio) of the undiluted solution and the propellant is 1/99 to 10/90 is 1.0 to the injection amount per injection. A method for injecting a fixed-quantity injection aerosol product that injects so as to be 3.0 mL.