JP2023017810A - Fixed-quantity spray aerosol product and method for spraying the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a fixed-quantity spray aerosol product that increases the visibility of the sprayed aerosol composition and enables the aerosol composition to be diffused in a wide range and a method for spraying the fixed-quantity spray aerosol product.

SOLUTION: A fixed-quantity spray aerosol product includes a stock solution and a propellant, the blend ratio (volume ratio) of the stock solution and the propellant being 1/99 to 10/90. The amount of the aerosol product to be sprayed at one time is 1.0-3.0 mL.

SELECTED DRAWING: Figure 3

COPYRIGHT: (C)2023,JPO&INPIT

Description

TECHNICAL FIELD The present invention relates to a metered dose aerosol product and a method for spraying a metered dose aerosol product. More specifically, the present invention relates to a metered dose aerosol product and a method for spraying a metered dose aerosol product in which the sprayed aerosol composition is easily visible and the volatile compound can be diffused over a wide area.

Conventionally, fumigants and full-volume aerosol products have been known as means for diffusing insecticides and the like in indoor spaces. However, some fumigants generate heat. In addition, full-spray aerosol products may contaminate indoor walls and floors with solvents. Therefore, there are known aerosol products intended to sustain the insecticidal effect and the effect of imparting fragrance indoors by injecting a small amount of volatile compounds such as insecticides and fragrances (see, for example, Patent Document 1).

JP 2011-63576 A

However, in the method described in Patent Document 1, the visibility of the jetted aerosol composition is not sufficient, and the volatile compound is difficult to diffuse over a wide area. Therefore, the method described in Patent Literature 1 has a narrow range of efficacy, and it is difficult to determine the range of efficacy. In addition, even if the amount of the aerosol composition that can provide sufficient efficacy is injected by one injection, it is difficult for the user to see the injected aerosol composition sufficiently. , may overuse aerosol products.

By the way, in order to improve the visibility of the injected aerosol composition, it is conceivable to increase the injection amount per injection. However, when the injection amount per time is large, the injection time is long, it is difficult to use properly, and the walls and floors are likely to be contaminated.

The present invention has been made in view of such conventional problems. An object of the present invention is to provide a method for spraying a spray-type aerosol product.

The present inventors have earnestly studied the conditions for solving the above problems, and obtained the following knowledge. That is, the undiluted solution and the propellant are contained so as to have a specific blending ratio, and the amount of one injection is adjusted to a specific amount, thereby improving the visibility of the injected aerosol composition and the injected aerosol. The inventors have found that the composition can be diffused over a wide range, and completed the present invention.

The metered injection type aerosol product of the present invention that solves the above problems contains a stock solution and a propellant, and the mixing ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90, It is a metered injection type aerosol product with an injection amount of 1.0 to 3.0 mL per injection.

Further, the injection method of the fixed quantity injection type aerosol product of the present invention, which solves the above-mentioned problems, comprises a stock solution and a propellant, and a mixing ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90. This is a method of injecting a metered injection type aerosol product by injecting an aerosol composition containing such that the injection amount per injection is 1.0 to 3.0 mL.

According to the present invention, it is possible to provide a fixed quantity injection type aerosol product and a method for injecting a fixed quantity injection type aerosol product, in which the injected aerosol composition is easily visible and the aerosol composition can be diffused over a wide area. .

FIG. 1 is a schematic diagram for explaining a method for measuring drug diffusivity in Examples. FIG. 2 is a schematic diagram for explaining a method for measuring drug diffusivity in Examples. FIG. 3 is a photograph for explaining the injection state of the aerosol composition of Example 4, which was evaluated as ◯ in the visibility evaluation. FIG. 4 is a photograph for explaining the injection state of the aerosol composition of Comparative Example 1, which was evaluated as x in the visibility evaluation.

<Fixed quantity spray type aerosol product>
A metered injection type aerosol product (hereinafter also referred to as an aerosol product) of one embodiment of the present invention comprises an aerosol container filled with an aerosol composition containing a stock solution and a propellant, and an aerosol metering valve attached to the aerosol container. , a stem mechanism attached to the aerosol metering valve, and a spray button for operating the stem mechanism and the aerosol metering valve. The mixing ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90. The injection amount per injection is 1.0 to 3.0 mL. Each configuration will be described below. The aerosol product of the present embodiment is characterized in that the mixing ratio of the stock solution and the propellant and the injection amount of the aerosol composition per injection are adjusted to fall within the above specific ranges. Therefore, other constitutions (for example, the shape of the aerosol product, components and amounts in the concentrate, various physical properties such as the internal pressure of the container, etc.) are not particularly limited as long as they satisfy the above ranges. Therefore, in the following detailed description, the ingredients in the stock solution, the blending ratio of the stock solution and the propellant, and the injection amount per injection of the aerosol composition are adjusted to the above specific types and ranges. Other than that, they are all examples.

(Undiluted solution)
A stock solution may incorporate the desired components to be diffused. Such components are not particularly limited. For example, the stock solution preferably contains a volatile compound having a vapor pressure of 1.0×10 ⁻⁵ mmHg (25° C.) or higher.

Volatile compounds having a vapor pressure of 1.0×10 ⁻⁵ mmHg (25° C.) or higher are not particularly limited. The vapor pressure of the volatile compound is preferably 1.0×10 ⁻⁵ mmHg (25° C.) or higher, more preferably 1.5×10 ⁻⁵ mmHg (25° C.) or higher, and 2.0 It is more preferably at least ×10 ^-5 mmHg (25°C). Moreover, the vapor pressure of the volatile compound is preferably 5.0×10 ⁻³ mmHg (25° C.) or less, more preferably 3.0×10 ⁻³ mmHg (25° C.) or less. Since the vapor pressure of the volatile compound is within the above range, the volatile compound easily spreads in space in the aerosol product.

The type of volatile compound is not particularly limited. The volatile compound is appropriately selected so that the aerosol product of the present embodiment can impart the intended efficacy. As an example, when the aerosol product is used for pest control, volatile compounds include insecticidal compounds such as pyrethroid compounds, carbamate compounds, oxadiazole compounds, and the like. Volatile compounds also include perfume compounds such as menthol, citral, geraniol, etc. when the aerosol product is used for perfuming. In addition, when the aerosol product is used for antibacterial purposes, the volatile compound includes antibacterial compounds such as isothiocyanate antibacterial agents and phenolic antibacterial agents. These volatile compounds may be used in combination. Thus, for example, when the aerosol product is used for pest control and fragrance, each of the above volatile compounds may be used in combination.

Pyrethroid compounds include Metofluthrin (vapor pressure: 1.5×10 ⁻⁵ mmHg (25° C.), Profluthrin (vapor pressure: 7.7×10 ⁻⁵ mmHg (25° C.)), Transfluthrin (vapor pressure: 2 .7×10 ⁻⁵ mmHg (25° C.)), terarethrin (vapor pressure: 6.6×10 ⁻⁴ mmHg (25° C.)), etc. Among these, the insecticidal effect is high and the effect of the present invention can be obtained. The pyrethroid compound preferably contains transfluthrin because it is easy to use.

Carbamate compounds include propoxur (vapor pressure: 2.1×10 ⁻⁵ mmHg (25° C.)) and carbaryl (vapor pressure: 4.1×10 ⁻⁵ mmHg (23.5° C.)). Among these, the carbamate compound is preferably propoxur because of its high vapor pressure and high insecticidal activity. Carbaryl has a vapor pressure of 4.1×10 ⁻⁵ mmHg or more at 25° C.

The oxadiazole compound is methoxadiazone (vapor pressure: 1.1×10 ⁻³ mmHg (25° C.)) and the like.

Other insecticidal compounds include dichlorvos (vapor pressure: 1.6×10 ⁻² mmHg (25° C.)) as an organophosphorus agent and hydroprene (vapor pressure: 1.9 ×10 ⁻⁴ mmHg (25° C.)), amidoflumet (vapor pressure: 1.1×10 ⁻³ mmHg (20° C.)), and the like. The vapor pressure of amidoflumet is 1.1×10 ^-3 mmHg or more at 25°C.

By using these insecticidal compounds as volatile compounds, for example, cockroaches such as black cockroaches, German cockroaches, Japanese cockroaches, American cockroaches, and brown cockroaches, spiders, centipedes, ants, Japanese centipedes, millipedes, pill bugs, woodlice, termites, caterpillars and mites. Crawling pests such as fleas, bed bugs, and lice, and flying pests such as mosquitoes, flies, moths, bees, stink bugs, deer beetles, beetles, bark beetles, burrs, and carp moths can be suitably controlled.

Perfume compounds, menthol (vapor pressure: 6.3 × 10 ^-2 mmHg (25 ° C.)), citral (vapor pressure: 9.1 × 10 ^-2 mmHg ( 25° C.)), geraniol (vapor pressure: 3.0×10 ⁻² mmHg (25° C.)), and the like.

Isothiocyanate-based antibacterial agents include methyl isothiocyanate (vapor pressure: 16 mmHg (30°C)), allyl isothiocyanate (vapor pressure: 3.7 mmHg (20°C)), and the like. Among these, the isothiocyanate antibacterial agent is preferably allyl isothiocyanate. The vapor pressure of methyl isothiocyanate is 1.0×10 ^-5 mmHg or more at 25°C, and the vapor pressure of allyl isothiocyanate is 3.7 mmHg or more at 25°C.

Phenolic antibacterial agents include thymol (vapor pressure: 2.2×10 ⁻³ mmHg (25° C.)), isopropylmethylphenol (vapor pressure: 2.0×10 ⁻³ mmHg (20° C.)), and the like. Among these, the phenol-based antibacterial agent is preferably isopropylmethylphenol from the viewpoint of achieving both safety and efficacy. Incidentally, the vapor pressure of isopropylmethylphenol is 2.0×10 ⁻³ mmHg or more at 25° C.

The content of the volatile compound is not particularly limited. The content of the volatile compound can be appropriately adjusted depending on the type of volatile compound. For example, when the volatile compound is the insecticidal compound, the content of the insecticidal compound is preferably 0.1 w/v% or more, more preferably 10 w/v% or more, in the undiluted solution. . On the other hand, the content of the insecticidal compound may be 100 w/v % in the stock solution. If the content of the insecticidal compound is less than 0.1 w/v%, the aerosol product may not exhibit the desired insecticidal effect sufficiently or may be difficult to spread over a wide area.

Further, when the volatile compound is the perfume compound, the content of the perfume compound is preferably 0.05 w/v% or more, more preferably 10 w/v% or more, in the stock solution. On the other hand, the content of perfume compound may be 100 w/v % in the stock solution. If the content of the perfume compound is less than 1 w/v%, the aerosol product may not be sufficiently scented or may not diffuse widely.

Furthermore, when the volatile compound is the antibacterial compound, the content of the antibacterial compound is preferably 1 w/v% or more, more preferably 10 w/v% or more, in the stock solution. On the other hand, the content of the antimicrobial compound may be 100 w/v% in the stock solution. If the content of the antibacterial compound is less than 1 w/v%, the aerosol product may not exhibit the desired antibacterial effect sufficiently or may be difficult to spread over a wide area.

The stock solution may optionally contain a solvent. A solvent may be included to suitably dissolve the volatile compound to facilitate mixing with the propellant in the aerosol container or to aid diffusion of the volatile compound into the chamber.

A solvent is not particularly limited. Examples of solvents include ethanol, isopropyl alcohol (IPA), propylene glycol monomethyl ether, isopropyl myristate (IPM), and the like. Among these solvents, ethanol and IPA are preferred because they easily dissolve volatile compounds, are inexpensive, and are easy to handle.

When a solvent is included, the content of the solvent is preferably more than 0% by mass, more preferably 10% by mass or more, in the undiluted solution. On the other hand, the solvent content is preferably 99% by mass or less, more preferably 90% by mass or less, in the undiluted solution. If the content of the solvent exceeds 99% by mass, the amount of the volatile compound blended in the aerosol product is reduced, and the effect of blending the volatile compound may not be sufficiently obtained.

The stock solution may contain optional components in addition to the above-mentioned volatile compound and solvent that are suitably blended. By way of example, optional ingredients include non-volatile or low-volatility compounds; nonionic, anionic or cationic surfactants; antioxidants such as butylhydroxytoluene; stabilizers such as citric acid and ascorbic acid; These include inorganic powders such as talc and silicic acid, deodorants, pigments, and the like.

(propellant)
The propellant is the content that is pressurized into the aerosol container together with the stock solution. The propellant is ejected together with the undiluted solution from the injection port of the injection button, which will be described later, by operating an aerosol metering valve, which will be described later. At that time, the propellant imparts a driving force for injecting the stock solution, and at the same time, atomizes the aerosol composition and diffuses it in space.

The type of propellant is not particularly limited. In one example, the propellant is a liquefied gas. Examples of liquefied gases include liquefied petroleum gas, aliphatic hydrocarbons having 3 to 5 carbon atoms such as propane, normal butane, isobutane, normal pentane and isopentane, trans-1,3,3,3-tetrafluoroproper-1- Examples include hydrofluoroolefins such as ene, trans-2,3,3,3-tetrafluoroprop-1-ene, dimethyl ether and mixtures thereof. A compressed gas may be used together with the liquefied gas. Examples of compressed gas include nitrogen gas, carbon dioxide gas, nitrous oxide gas, and compressed air. Among these, the propellant is preferably liquefied petroleum gas.

In the aerosol product of the present embodiment, the mixing ratio (volume ratio) of the stock solution and the propellant at 20° C. may be 1/99 to 10/90, preferably 1/99 to 9/91. It is more preferably 0.5/98.5 to 8/92. If the blending ratio (volume ratio) of the propellant exceeds 99% by volume, the aerosol composition may have a small amount of active ingredients and may be less effective. On the other hand, if the blending ratio (volume ratio) of the propellant is less than 90% by volume, the aerosol composition may have reduced diffusivity after injection.

The internal pressure of the aerosol metering valve at 25° C. is preferably 0.2 MPa or higher, more preferably 0.25 MPa or higher, in a state filled with the stock solution and the propellant. Moreover, the internal pressure of the aerosol metering valve at 25° C. is preferably 0.8 MPa or less, more preferably 0.7 MPa or less. If the internal pressure of the aerosol metering valve is less than 0.2 MPa, the aerosol composition may drip from the nozzle after injection. On the other hand, if the internal pressure of the aerosol metering valve exceeds 0.8 MPa, the aerosol composition may leak from the aerosol container. The internal pressure of the aerosol metering valve can be measured by measuring the aerosol metering pressure with a PGM-E compact pressure sensor (manufactured by Kyowa Dengyo Co., Ltd.) attached to a WGA-710C instrumentation conditioner (manufactured by Kyowa Dengyo Co., Ltd.), for example, at 25°C. It can be measured by connecting to a valve.

An aerosol product containing the concentrate and propellant described above is pressurized into an aerosol container. The aerosol container is not particularly limited. For example, an aerosol container is a substantially cylindrical pressure-resistant container with an opening formed at the top. The opening is a filling port for filling the aerosol composition, and is closed by an aerosol metering valve described later after the stock solution is filled.

The material of the aerosol container is not particularly limited. For example, the material of the aerosol container is metal such as aluminum or tinplate, synthetic resin such as polyethylene terephthalate, pressure-resistant glass, or the like.

The aerosol metering valve is a mechanism for taking out the aerosol composition filled in the aerosol container, and is attached to the opening of the aerosol container to close the opening. Further, the aerosol metering valve of the present embodiment is formed with a metering chamber for temporarily storing the aerosol composition taken out from the aerosol container. The volume of the metering chamber corresponds to the volume of the aerosol composition delivered by one shot. The volume of the metering chamber of this embodiment is 1.0-3.0 mL.

The stem mechanism is a part attached to the aerosol metering valve, and an internal passage is formed for sending the undiluted solution and the propellant taken into the aerosol metering valve to the injection button, which will be described later. The internal passage is appropriately opened and closed by the stem rubber of the stem mechanism.

The injection button is a member for injecting, together with the propellant, the undiluted liquid taken in from the aerosol container via the stem mechanism by the aerosol metering valve. The injection button is formed with a nozzle hole for injecting the aerosol composition.

The number, size and shape of the orifices are not particularly limited. For example, the number of nozzle holes may be one, or two or more. Also, the dimension of the nozzle (orifice diameter) is preferably 0.2 mm or more, more preferably 0.3 mm or more, and even more preferably 0.5 mm or more. Also, the nozzle diameter is preferably 4.5 mm or less, more preferably 3.0 mm or less, and even more preferably 0.9 mm or less. The shape (cross-sectional shape) of the orifice may be circular, elliptical, square, or various irregular shapes. Also, the total area of the nozzle holes is preferably 0.03 mm ² or more, more preferably 0.1 mm ² or more, and even more preferably 0.25 mm ² or more. Also, the total area of the nozzle holes is preferably 16 mm ² or less, more preferably 5 mm ² or less, and even more preferably 3.5 mm ² or less.

In the aerosol product of the present embodiment, when the user operates the injection button, the stem mechanism and the aerosol metering valve operate, and the inside of the aerosol container communicates with the outside. As a result, a certain amount of the aerosol composition in the aerosol container is taken out from the aerosol container according to the pressure difference between the inside and the outside of the aerosol container, and is injected from the nozzle of the injection member.

The aerosol product of this embodiment is adjusted so that the injection amount per injection is 1.0 to 3.0 mL. The injection amount per injection may be 1.0 mL or more. In addition, the injection amount per injection may be 3.0 mL or less, preferably 2.5 mL or less, and more preferably 2.2 mL or less. When the injection amount per injection is less than 1.0 mL, the injected aerosol composition is hardly visible. On the other hand, when the injection amount per injection exceeds 3.0 mL, the injected aerosol composition has a large particle diameter and tends to fall without spreading over a wide range.

The aerosol product of the present embodiment is jetted by specifying the blending ratio of the stock solution and the propellant and adjusting the jetting amount per injection to be 1.0 to 3.0 mL. While improving the visibility of the aerosol composition, it is possible to diffuse the aerosol composition in the undiluted solution over a wide area. Therefore, the method for adjusting the injection amount per injection is not particularly limited. The injection amount per injection can be adjusted, for example, by appropriately adjusting the volume of the metering chamber in the aerosol metering valve, the time during which the inside of the aerosol container communicates with the outside when the injection button is operated, and the like.

The aerosol composition jetted by the aerosol product of the present embodiment preferably has a jetting load of 5 gf or more, more preferably 9 gf or more, at a position 20 cm away from the nozzle. In addition, the aerosol composition preferably has an injection load of 40 gf or less, more preferably 30 gf or less, at a position 20 cm away from the nozzle hole. By adjusting the injection load to be within the above range, the aerosol product can easily diffuse the volatile compound over a wide range while improving the visibility of the injected aerosol composition. The injection load of the injected aerosol composition was determined by measuring a circular flat plate of Φ60 mm attached to a digital force gauge (model number: DS2-2N manufactured by Imada Co., Ltd.) from a distance of 20 cm from the nozzle at a room temperature of 25°C. It can be calculated by calculating the average of the maximum value when the aerosol composition is horizontally jetted toward the center as the jetting load.

The method for producing the aerosol product of this embodiment is not particularly limited. To give an example, an aerosol product is manufactured by filling an aerosol container with an undiluted solution, closing the opening of the aerosol container with an aerosol metering valve provided with a metering chamber, and pressurizing and filling the propellant via a stem mechanism. can do. For example, the ejection button may be a trigger button, a push-down button, or the like.

As described above, according to the aerosol product of the present embodiment, the jetted aerosol composition is easily visible, and the volatile compound is widely diffused.

<Injection method of metered injection type aerosol product>
In one embodiment of the present invention, a method of injecting a metered dose aerosol product (hereinafter, also referred to as an injecting method) comprises a stock solution and a propellant at a blending ratio (volume ratio) of the stock solution and the propellant of 1/99 to 1/99. In this method, an aerosol composition containing 10/90 is injected so that the injection amount per injection is 1.0 to 3.0 mL.

In carrying out the injection method of this embodiment, the same aerosol composition and aerosol product as those described in the above embodiments can be used.

In this embodiment, the number of injections may be one. According to the injection method of the present embodiment, since the injection amount per injection is 1.0 to 3.0 mL, even if the injection is performed once, the user can visually confirm the injected aerosol composition. It's easy to do. In addition, even if the number of times of injection is one, the injected aerosol composition spreads easily, and the medicinal effect can be imparted over a wide range. According to the injection method of this embodiment, a desired effect can be obtained even if the number of times of injection is one, but if necessary, the number of times of injection may be two or more.

As described above, according to the injection method of the present embodiment, the injected aerosol composition is easily visible, and the volatile compound is widely diffused.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples. The present invention is by no means limited to these examples.

<Aerosol products>
Details of the aerosol products used are given below.
Aerosol 1: Button φ0.6mm button, valve 0.2cc valve aerosol 2: Button φ0.6mm button, valve 1.0cc valve aerosol 3: Button φ1.0mm button, valve 1.0cc valve aerosol 4 : Button nozzle diameter φ2.0mm button, valve 1.0cc valve aerosol 5: button nozzle diameter φ2.0mm button, valve 2.2cc valve aerosol 6: button nozzle diameter φ0.5mm x 8 buttons, valve 1.0cc valve aerosol 7: Button injection port diameter φ1.0mm x 3 buttons, valve 1.0cc valve

(Example 1)
As a volatile compound, 100 parts by mass of transfluthrin (undiluted solution, vapor pressure: 2.7×10 ⁻⁵ mmHg (25° C.)) is filled into an aerosol container with a capacity of 200 mL, and after attaching a valve, the active substance and the injection are injected. Propellant (liquefied petroleum gas, saturated vapor pressure: 0.49 MPa (25°C)) is pressurized so that the mixing ratio (volume ratio) with the agent is 1.6/98.4, and the injection button is attached to create an aerosol product. 100 mL was prepared (valves and buttons were in accordance with Aerosol 4). The internal pressure of the aerosol product (the internal pressure of the valve; the same applies hereinafter) (25° C.) was 0.45 MPa, and the injection load at a horizontal position 20 cm away from the nozzle port was 19.5 gf. The internal pressure of the valve was set at 25°C and a PGM-E compact pressure sensor (Kyowa Dengyo Co., Ltd.) attached to a WGA-710C instrumentation conditioner (Kyowa Dengyo Co., Ltd.) was connected to the aerosol metering valve. Measured by By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 2)
Transfluthrin (vapor pressure: 2.7×10 ⁻⁵ mmHg (25° C.)) was added as a raw material together with 72 parts by mass of isopropyl alcohol (IPA) so that the concentration in the stock solution was 25% by weight/volume. After filling a 200 mL aerosol container and attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (valve and button were in accordance with Aerosol 4). The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 25.4 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 3)
An aerosol product was produced in the same manner as in Example 2, except that the valve and button conformed to Aerosol 5. The internal pressure (25° C.) of the aerosol product was 0.43 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 24.8 gf. By using this aerosol product, 35 mg of the active ingredient is injected per time.

(Example 4)
An aerosol product was produced in the same manner as in Example 2, except that the valve and button were in accordance with Aerosol 2. The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 9.4 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 5)
An aerosol product was produced in the same manner as in Example 2, except that the valve and button were in accordance with Aerosol 3. The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 11.6 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 6)
Transfluthrin (vapor pressure: 2.7×10 ⁻⁵ mmHg (25° C.)) was used as the active ingredient, and 31.6 parts by mass of isopropyl alcohol ( IPA) into an aerosol container with a capacity of 200 mL, and after attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure : 0.49 MPa (25° C.)), and an injection button was attached to produce an aerosol product (valve and button according to Aerosol 2). The internal pressure (25° C.) of the aerosol product was 0.45 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 9.8 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 7)
An aerosol product was produced in the same manner as in Example 2, except that the valve and button were in accordance with Aerosol 6. The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 21.2 gf. By using this aerosol product, 16 mg of the active ingredient is ejected per time.

(Example 8)
100 parts by mass of phthalthrin (vapor pressure: 4.5×10 ⁻⁶ mmHg (25° C.)) as the active ingredient, and 46 parts by mass of isopropyl alcohol (IPA) so that the concentration in the stock solution is 50% by weight/volume. After filling an aerosol container with a capacity of 200 mL and attaching a valve, the propellant (liquefied petroleum gas, saturated vapor pressure: 0 .49 MPa (25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (the valve and button were in accordance with Aerosol 2). The internal pressure (25° C.) of the aerosol product was 0.48 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 10.3 gf. By using this aerosol product, 32 mg of the active ingredient is injected per time.

(Example 9)
100 parts by mass of linalool (fragrance compound, vapor pressure: 0.16 mmHg (25°C)) as the active ingredient was added to the volume with 69 parts by mass of isopropyl alcohol (IPA) so that the concentration in the stock solution was 25% by weight/volume. After filling a 200 mL aerosol container and attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (valve and button according to Aerosol 6). The internal pressure (25° C.) of the aerosol product was 0.50 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 21.4 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 10)
^72.0 parts by mass of isopropyl myristate (IPM ) in an aerosol container with a capacity of 200 mL, and after attaching a valve, the propellant (liquefied petroleum gas, saturated vapor pressure: 0.49 MPa (25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (the valve and button were in accordance with Aerosol 6). The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 19.5 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Example 11)
An aerosol product was produced in the same manner as in Example 2, except that the valve and button conformed to Aerosol 7. The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a horizontal position 20 cm away from the orifice was 19.6 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Comparative example 1)
Transfluthrin (vapor pressure: 2.7×10 ⁻⁵ mmHg (25° C.)) was used as the active ingredient, and 31.6 parts by mass of isopropyl alcohol ( IPA) into an aerosol container with a capacity of 200 mL, and after attaching a valve, the propellant (liquefied petroleum gas, saturated vapor pressure: 0.49 MPa (25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (valve and button according to Aerosol 1). The internal pressure (25° C.) of the aerosol product was 0.43 MPa, and the injection load at a position 20 cm away from the nozzle hole was 9.0 gf. By using this aerosol product, 20 mg of the active ingredient is ejected per time.

(Comparative example 2)
^52.4 parts by mass of isopropyl myristate (IPM ) together with ) into an aerosol container with a capacity of 200 mL, and after attaching a valve, the propellant (liquefied petroleum gas, saturated vapor pressure: 0.49 MPa ( 25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (the valve and button were in accordance with Aerosol 1). The internal pressure (25° C.) of the aerosol product was 0.42 MPa, and the injection load at a position 20 cm away from the nozzle hole was 10.7 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Comparative Example 3)
87.5 parts by mass of isopropyl ^myristate (IPM ) together with ) into an aerosol container with a capacity of 200 mL, and after attaching a valve, the propellant (liquefied petroleum gas, saturated vapor pressure: 0.49 MPa ( 25° C.)) was filled under pressure, and an injection button was attached to produce an aerosol product (the valve and button were in accordance with Aerosol 4). The internal pressure (25° C.) of the aerosol product was 0.45 MPa, and the injection load at a position 20 cm away from the nozzle port was 21.9 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

(Comparative Example 4)
Transfluthrin (vapor pressure: 2.7×10 ⁻⁵ mmHg (25° C.)) as the active ingredient was added to the volume together with 93.3 parts by mass of isopentane so that the concentration in the undiluted solution was 4.4% by weight/volume. After filling a 200 mL aerosol container and attaching a valve, the propellant (liquefied petroleum gas saturated vapor pressure: 0.49 MPa (25 ° C.) ) was filled under pressure, and an injection button was attached to produce an aerosol product (the valve and button were in accordance with Aerosol 4). The internal pressure (25° C.) of the aerosol product was 0.37 MPa, and the injection load at a position 20 cm away from the nozzle port was 14.5 gf. By using this aerosol product, 16 mg of the active ingredient is injected per time.

Regarding the obtained aerosol products of Examples 1 to 11 and Comparative Examples 1 to 4, the diffusivity of volatile compounds was measured according to the following evaluation method. The results are shown in Table 1 or Table 2. In addition, in the column of "nozzle diameter" in Tables 1 and 2, the number of orifices is also indicated in the example using a button having a plurality of orifices.

<Volatile compound diffusivity>
A metal petri dish with a diameter of 9 cm was placed at the position shown in FIGS. 1 and 2 in an 8 tatami mat chamber (ventilation condition: no ventilation). 1 and 2 are schematic diagrams of an 8-tatami chamber C for explaining the method of measuring the diffusivity of a volatile compound, FIG. 1 being a perspective view and FIG. 2 being a plan view. The dimensions of the 8 tatami mat chamber C are 360 cm in width l, 360 cm in depth m, and 270 cm in height n. One metal petri dish (metal petri dish S1, 10 pieces of Φ9 cm stainless petri dish) is placed in the center of the 8 tatami chamber C (horizontal position l1 is 180 cm, depth position m1 is 180 cm), and the remaining two places (metal A petri dish S2 and a metal petri dish S3) were placed at both ends of the 8-tatami chamber C on the entrance door D side. The aerosol product was sprayed once toward the center of the 8 tatami chamber C from the entrance door D at a height of 1 m. After 4 hours had passed, the amount of drug (technical substance) in the metal petri dishes S1 to S3 was quantified. From the obtained quantitative value (drug amount), the diffusivity of the volatile compound was measured according to the following formula.
Volatile compound diffusivity (%) = 100 x (average amount of drug in metal petri dish S2 and metal petri dish S3 placed at both ends)/drug amount in metal petri dish S1 placed in the center

<Visibility>
The aerosol product was injected once, and the degree of visibility was visually confirmed. FIG. 3 is a photograph for explaining the injection state of the aerosol composition of Example 4, which was evaluated as ◯ in the visibility evaluation. FIG. 4 is a photograph for explaining the injection state of the aerosol composition of Comparative Example 1, which was evaluated as x in the visibility evaluation.
(Evaluation criteria)
○: The aerosol composition was visually recognizable.
x: The aerosol composition was difficult to visually recognize.

As shown in Tables 1 and 2, when the aerosol products of Examples 1 to 11 were used, the diffusion rate of the volatile compound was higher than when the aerosol products of Comparative Examples 1 to 4 were used. It turned out that the body could be applied. Further, all of the aerosol products of Examples 1 to 11 could be visually recognized at the time of ejection. Among them, in the aerosol product of Example 3, the jetted aerosol composition could be clearly visually recognized at the time of jetting. As a result, it was found that the aerosol product of the present invention is capable of diffusing the volatile compound over a wide range, and that the aerosol composition that is jetted is easily visible by a single injection. Incidentally, when the aerosol products of Comparative Examples 1 and 2 were used, it was difficult to visually confirm the jetted aerosol composition during jetting.

C 8 tatami chamber D Entrance door S1, S2, S3 Metal petri dish l Width l1 Horizontal position m Depth m1 Depth position n Height

Claims (4)

comprising a stock solution and a propellant;
The mixing ratio (volume ratio) of the stock solution and the propellant is 1/99 to 10/90,
A metered injection type aerosol product with an injection volume of 1.0 to 3.0 mL per injection. 2. The metered dose aerosol product according to claim 1, wherein said stock solution contains a volatile compound having a vapor pressure of 1.0*10< ^-5 > mmHg (25[deg.] C.) or higher. 3. The metered dose aerosol product according to claim 2, wherein said volatile compound is at least one selected from the group consisting of pyrethroid compounds, fragrance compounds and antibacterial compounds. An aerosol composition containing an undiluted solution and a propellant at a blending ratio (volume ratio) of the undiluted solution and the propellant of 1/99 to 10/90, wherein the injection amount per injection is 1.0 to 1.0. A method of injecting a fixed quantity aerosol product, in which the volume is 3.0 mL.

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