JPWO2019016680A5 - - Google Patents
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- JPWO2019016680A5 JPWO2019016680A5 JP2020502118A JP2020502118A JPWO2019016680A5 JP WO2019016680 A5 JPWO2019016680 A5 JP WO2019016680A5 JP 2020502118 A JP2020502118 A JP 2020502118A JP 2020502118 A JP2020502118 A JP 2020502118A JP WO2019016680 A5 JPWO2019016680 A5 JP WO2019016680A5
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- JP
- Japan
- Prior art keywords
- composition
- seq
- self
- rna
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 42
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 150000007523 nucleic acids Chemical group 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 7
- 241000700605 Viruses Species 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 239000002105 nanoparticle Substances 0.000 claims description 4
- 102000003886 Glycoproteins Human genes 0.000 claims description 3
- 108090000288 Glycoproteins Proteins 0.000 claims description 3
- 229940022005 RNA vaccine Drugs 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 230000002163 immunogen Effects 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims description 2
- 108060003393 Granulin Proteins 0.000 claims description 2
- 102000007999 Nuclear Proteins Human genes 0.000 claims description 2
- 108010089610 Nuclear Proteins Proteins 0.000 claims description 2
- 102000007982 Phosphoproteins Human genes 0.000 claims description 2
- 108010089430 Phosphoproteins Proteins 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 5
- 108020004705 Codon Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 10
- 239000013598 vector Substances 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- -1 constructs Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007908 nanoemulsion Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762533312P | 2017-07-17 | 2017-07-17 | |
| US62/533,312 | 2017-07-17 | ||
| PCT/IB2018/055258 WO2019016680A1 (en) | 2017-07-17 | 2018-07-16 | ANTIGEN CONSTRUCTS OF LYSSAVIRUS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530765A JP2020530765A (ja) | 2020-10-29 |
| JPWO2019016680A5 true JPWO2019016680A5 (https=) | 2022-05-25 |
| JP2020530765A5 JP2020530765A5 (https=) | 2022-05-25 |
Family
ID=63364109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502118A Pending JP2020530765A (ja) | 2017-07-17 | 2018-07-16 | リサウイルス抗原構築物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11278613B2 (https=) |
| EP (1) | EP3655536A1 (https=) |
| JP (1) | JP2020530765A (https=) |
| CN (1) | CN111108203A (https=) |
| BR (1) | BR112020000802A2 (https=) |
| CA (1) | CA3070042A1 (https=) |
| WO (1) | WO2019016680A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110269933A (zh) * | 2019-07-17 | 2019-09-24 | 苏州世诺生物技术有限公司 | 一种狂犬病毒亚单位疫苗的制备方法及其应用 |
| CN110643632B (zh) * | 2019-09-26 | 2022-06-10 | 中国科学院武汉病毒研究所 | 一种基于甲病毒复制子载体的狂犬病毒感染性克隆及制备方法和应用 |
| WO2022077330A1 (zh) * | 2020-10-15 | 2022-04-21 | 中国科学院深圳先进技术研究院 | 一种新型g基因及其在高效逆向跨单突触中的应用 |
| WO2022152939A1 (en) | 2021-01-18 | 2022-07-21 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
| CN113993839B (zh) * | 2021-02-05 | 2024-02-09 | 嘉晨西海(杭州)生物技术有限公司 | 一种可离子化脂质分子、其制备方法及其在制备脂质纳米颗粒中的应用 |
| EP4342993A4 (en) * | 2021-05-19 | 2025-05-28 | Daiichi Sankyo Company, Limited | Hpv infectious disease vaccine |
| WO2023031858A1 (en) | 2021-09-01 | 2023-03-09 | Glaxosmithkline Biologicals Sa | Plasmid dna purification methods |
| WO2023151570A1 (en) * | 2022-02-09 | 2023-08-17 | Suzhou Abogen Biosciences Co., Ltd. | Nucleic acid vaccines for rabies |
| CN116120198B (zh) * | 2022-03-21 | 2024-03-15 | 苏州科锐迈德生物医药科技有限公司 | 具有甘油骨架的脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN116063410B (zh) * | 2022-10-20 | 2023-07-14 | 北京标驰泽惠生物科技有限公司 | 一种狂犬病毒g蛋白的突变体及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4368202A3 (en) | 2007-03-30 | 2024-08-21 | The Research Foundation for The State University of New York | Attenuated viruses useful for vaccines |
| BR112016001192A2 (pt) * | 2013-08-21 | 2017-08-29 | Curevac Ag | Vacina contra a raiva |
| EP4019506A1 (en) | 2013-12-19 | 2022-06-29 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| ES2895651T3 (es) | 2013-12-19 | 2022-02-22 | Novartis Ag | Lípidos y composiciones lipídicas para la administración de agentes activos |
| US10125092B2 (en) | 2014-09-05 | 2018-11-13 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| CA3045976A1 (en) * | 2016-12-09 | 2018-06-14 | Glaxosmithkline Biologicals Sa | Chimpanzee adenovirus constructs with lyssavirus antigens |
| GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
-
2018
- 2018-07-16 WO PCT/IB2018/055258 patent/WO2019016680A1/en not_active Ceased
- 2018-07-16 BR BR112020000802-8A patent/BR112020000802A2/pt not_active Application Discontinuation
- 2018-07-16 US US16/630,951 patent/US11278613B2/en not_active Expired - Fee Related
- 2018-07-16 CA CA3070042A patent/CA3070042A1/en active Pending
- 2018-07-16 JP JP2020502118A patent/JP2020530765A/ja active Pending
- 2018-07-16 CN CN201880060285.4A patent/CN111108203A/zh active Pending
- 2018-07-16 EP EP18759392.6A patent/EP3655536A1/en not_active Withdrawn
-
2022
- 2022-02-02 US US17/591,421 patent/US20220241398A1/en not_active Abandoned
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