JPWO2018065102A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2018065102A5 JPWO2018065102A5 JP2019518515A JP2019518515A JPWO2018065102A5 JP WO2018065102 A5 JPWO2018065102 A5 JP WO2018065102A5 JP 2019518515 A JP2019518515 A JP 2019518515A JP 2019518515 A JP2019518515 A JP 2019518515A JP WO2018065102 A5 JPWO2018065102 A5 JP WO2018065102A5
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- amplification product
- group
- sensor
- sensor device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003321 amplification Effects 0.000 claims description 219
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 218
- 238000006243 chemical reaction Methods 0.000 claims description 131
- 238000009396 hybridization Methods 0.000 claims description 100
- 239000000523 sample Substances 0.000 claims description 94
- 239000012491 analyte Substances 0.000 claims description 82
- 239000012530 fluid Substances 0.000 claims description 70
- 230000000875 corresponding Effects 0.000 claims description 35
- 238000001514 detection method Methods 0.000 claims description 28
- 150000007523 nucleic acids Chemical class 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 239000012472 biological sample Substances 0.000 claims description 8
- 239000000047 product Substances 0.000 description 202
- 238000004458 analytical method Methods 0.000 description 67
- 239000003153 chemical reaction reagent Substances 0.000 description 48
- 239000007788 liquid Substances 0.000 description 35
- 238000005259 measurement Methods 0.000 description 20
- 238000002844 melting Methods 0.000 description 20
- 238000007689 inspection Methods 0.000 description 17
- 238000003860 storage Methods 0.000 description 17
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 15
- 239000000126 substance Substances 0.000 description 15
- 229920002676 Complementary DNA Polymers 0.000 description 13
- 239000002299 complementary DNA Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 13
- 238000010438 heat treatment Methods 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- 238000005086 pumping Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 238000001035 drying Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- 238000003752 polymerase chain reaction Methods 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000011144 upstream manufacturing Methods 0.000 description 6
- 229920000160 (ribonucleotides)n+m Polymers 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 230000001717 pathogenic Effects 0.000 description 5
- 244000052769 pathogens Species 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 4
- 210000004369 Blood Anatomy 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L MgCl2 Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 229920001850 Nucleic acid sequence Polymers 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000006011 modification reaction Methods 0.000 description 4
- 239000011534 wash buffer Substances 0.000 description 4
- 108010090804 Streptavidin Proteins 0.000 description 3
- 230000036462 Unbound Effects 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000006479 redox reaction Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 210000001736 Capillaries Anatomy 0.000 description 2
- 101700011961 DPOM Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101710029649 MDV043 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 101700061424 POLB Proteins 0.000 description 2
- 101700054624 RF1 Proteins 0.000 description 2
- 210000003296 Saliva Anatomy 0.000 description 2
- 210000002700 Urine Anatomy 0.000 description 2
- 230000003213 activating Effects 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000835 electrochemical detection Methods 0.000 description 2
- 238000002848 electrochemical method Methods 0.000 description 2
- 238000003891 environmental analysis Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- FXZCCINCKDATPA-UHFFFAOYSA-L (4-aminophenyl) phosphate Chemical compound NC1=CC=C(OP([O-])([O-])=O)C=C1 FXZCCINCKDATPA-UHFFFAOYSA-L 0.000 description 1
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-Aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 1
- 210000000601 Blood Cells Anatomy 0.000 description 1
- 108010092799 EC 2.7.7.49 Proteins 0.000 description 1
- 102000033147 ERVK-25 Human genes 0.000 description 1
- 229940088597 Hormone Drugs 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 241000269800 Percidae Species 0.000 description 1
- 231100000614 Poison Toxicity 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 210000002966 Serum Anatomy 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 102000004965 antibodies Human genes 0.000 description 1
- 108090001123 antibodies Proteins 0.000 description 1
- 230000001174 ascending Effects 0.000 description 1
- 238000004638 bioanalytical method Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001419 dependent Effects 0.000 description 1
- 230000002349 favourable Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002209 hydrophobic Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 239000005445 natural product Substances 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- 230000002572 peristaltic Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000001603 reducing Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 230000003362 replicative Effects 0.000 description 1
- 230000000284 resting Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 125000003396 thiol group Chemical class [H]S* 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000001131 transforming Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 239000011778 trisodium citrate Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16020371.7 | 2016-10-07 | ||
EP16020371 | 2016-10-07 | ||
PCT/EP2017/025279 WO2018065102A1 (en) | 2016-10-07 | 2017-10-05 | Method and analysis system for testing a sample |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019537706A JP2019537706A (ja) | 2019-12-26 |
JP2019537706A5 JP2019537706A5 (pt) | 2022-01-11 |
JPWO2018065102A5 true JPWO2018065102A5 (pt) | 2022-07-20 |
Family
ID=57132952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019518515A Ceased JP2019537706A (ja) | 2016-10-07 | 2017-10-05 | サンプルを検査するための方法及び分析システム |
Country Status (8)
Country | Link |
---|---|
US (2) | US10953403B2 (pt) |
EP (1) | EP3523046B1 (pt) |
JP (1) | JP2019537706A (pt) |
KR (1) | KR20190066619A (pt) |
CN (1) | CN109789409A (pt) |
BR (1) | BR112019006655A2 (pt) |
CA (1) | CA3035141A1 (pt) |
WO (1) | WO2018065102A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201917832D0 (en) * | 2019-12-05 | 2020-01-22 | Oxford Nanopore Tech Ltd | Microfluidic device for preparing and analysing a test liquid |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5096669A (en) | 1988-09-15 | 1992-03-17 | I-Stat Corporation | Disposable sensing device for real time fluid analysis |
DE4438785C2 (de) | 1994-10-24 | 1996-11-07 | Wita Gmbh Wittmann Inst Of Tec | Mikrochemische Reaktions- und Analyseeinheit |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
CA2189907A1 (en) | 1995-11-15 | 1997-05-16 | Arkray, Inc. | Liquid detection method and device therefor |
US6054277A (en) | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system |
DE19648441A1 (de) | 1996-11-22 | 1998-05-28 | Abb Patent Gmbh | Analysegerät |
DE19648695C2 (de) | 1996-11-25 | 1999-07-22 | Abb Patent Gmbh | Vorrichtung zur automatischen und kontinuierlichen Analyse von Flüssigkeitsproben |
WO1999033559A1 (en) | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
GB9804483D0 (en) | 1998-03-02 | 1998-04-29 | Central Research Lab Ltd | Apparatus for and method of controlling the rate of flow of fluid along a pathway |
DE59905743D1 (de) | 1998-03-11 | 2003-07-03 | Steag Microparts Gmbh | Probenträger |
DE19846466A1 (de) | 1998-10-08 | 2000-04-27 | Ghs Gesundheits Service Ag | Analyseverfahren zur simultanen Bestimmung von Parametern aus unterschiedlichen Medien |
AU5646800A (en) | 1999-03-02 | 2000-09-21 | Helix Biopharma Corporation | Card-based biosensor device |
US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
AU782343B2 (en) | 1999-05-28 | 2005-07-21 | Cepheid | Apparatus and method for analyzing a fluid sample |
DE19928410C2 (de) | 1999-06-22 | 2002-11-28 | Agilent Technologies Inc | Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips |
EP1203959B1 (en) | 1999-08-11 | 2007-06-13 | Asahi Kasei Kabushiki Kaisha | Analyzing cartridge and liquid feed control device |
US6495104B1 (en) | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
DE60028819T2 (de) | 1999-12-23 | 2007-01-11 | Gyros Patent Ab | Verfahren zur behandlung einer matrixnukleinsäure unter verwendung einer integrierten mikrofluidischen platte |
FR2808089B1 (fr) | 2000-04-25 | 2002-07-05 | Sebia Sa | Dispositif perfectionne d'analyse d'echantillons par electrophorese multicapillaire a thermo-regulation solide/solide |
AU2001297830A1 (en) | 2000-10-25 | 2002-12-09 | Exiqon A/S | Closed substrate platforms suitable for analysis of biomolecules |
DE10058394C1 (de) | 2000-11-24 | 2002-07-11 | Siemens Ag | Verfahren für die biochemische Analytik und zugehörige Anordnung |
AT410444B (de) * | 2001-03-02 | 2003-04-25 | Oesterr Forsch Seibersdorf | Verfahren zur detektion von nukleinsäuremolekülen |
DE10111458B4 (de) | 2001-03-09 | 2008-09-11 | Siemens Ag | Analyseeinrichtung |
DE10111457B4 (de) | 2001-03-09 | 2006-12-14 | Siemens Ag | Diagnoseeinrichtung |
US7192557B2 (en) | 2001-03-28 | 2007-03-20 | Handylab, Inc. | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids |
US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6896778B2 (en) | 2001-06-04 | 2005-05-24 | Epocal Inc. | Electrode module |
US6845327B2 (en) | 2001-06-08 | 2005-01-18 | Epocal Inc. | Point-of-care in-vitro blood analysis system |
US20030064507A1 (en) | 2001-07-26 | 2003-04-03 | Sean Gallagher | System and methods for mixing within a microfluidic device |
US20030087292A1 (en) | 2001-10-04 | 2003-05-08 | Shiping Chen | Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays |
US7344894B2 (en) | 2001-10-16 | 2008-03-18 | Agilent Technologies, Inc. | Thermal regulation of fluidic samples within a diagnostic cartridge |
WO2003052097A1 (en) * | 2001-12-19 | 2003-06-26 | Hitachi High-Technologies Corporation | Potentiometric dna microarray, process for producing the same and method of analyzing nucleic acid |
DE10258840A1 (de) | 2002-01-28 | 2003-08-07 | Eppendorf Ag | Stapelanordnung von Reaktionsgefäßen |
US7485128B2 (en) | 2002-04-19 | 2009-02-03 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7744816B2 (en) | 2002-05-01 | 2010-06-29 | Intel Corporation | Methods and device for biomolecule characterization |
US7217542B2 (en) | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
US20040115794A1 (en) * | 2002-12-12 | 2004-06-17 | Affymetrix, Inc. | Methods for detecting transcriptional factor binding sites |
CA3171720C (en) | 2002-12-26 | 2024-01-09 | Meso Scale Technologies, Llc. | Methods for conducting electrochemiluminescence measurements |
US7122153B2 (en) | 2003-01-08 | 2006-10-17 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
US20040224339A1 (en) | 2003-03-31 | 2004-11-11 | Canon Kabushiki Kaisha | Biochemical reaction cartridge |
EP1473084B1 (en) | 2003-03-31 | 2015-07-29 | Canon Kabushiki Kaisha | Biochemical reaction cartridge |
US7914655B2 (en) | 2003-05-13 | 2011-03-29 | Siemens Aktiengesellschaft | Potentiostatic circuit arrangement on a biosensor for digitisation of the measured current |
DE10352887A1 (de) | 2003-11-10 | 2005-04-21 | Infineon Technologies Ag | Vorrichtung zur Vervielfältigung und Charakterisierung von Nukleinsäure-Proben mit flexiblem Speicherelement zur Speicherung von probenspezifischen Daten |
KR20050055349A (ko) | 2003-12-08 | 2005-06-13 | 삼성전자주식회사 | 스페이서용 감광제 및 이를 이용한 액정 표시 장치의 제조방법 |
US20050176135A1 (en) | 2004-02-06 | 2005-08-11 | Brian Jones | Cassette for isolation, amplification and identification of DNA or protein and method of use |
JP4127679B2 (ja) | 2004-03-18 | 2008-07-30 | 株式会社東芝 | 核酸検出カセット及び核酸検出装置 |
EP1796838B1 (de) | 2004-10-15 | 2014-10-08 | Boehringer Ingelheim Vetmedica GmbH | Verfahren zur durchführung einer elektrochemischen messung an einer flüssigen messprobe in einer über leitungen zugänglichen messkammer |
JP4185904B2 (ja) | 2004-10-27 | 2008-11-26 | 株式会社日立ハイテクノロジーズ | 液体搬送基板、分析システム、分析方法 |
CN101218032A (zh) | 2005-05-25 | 2008-07-09 | 西门子公司 | 综合和自动化的dna或蛋白质分析系统及其运行方法 |
EP1715348B2 (en) | 2005-07-15 | 2019-05-08 | Agilent Technologies, Inc. | Handling unit for microfluidic devices with clamping means |
DE102005059535B4 (de) | 2005-12-13 | 2010-01-14 | Siemens Ag | Vorrichtung und Verfahren zur Durchführung eines Nukleinsäure-Tests, sowie Verfahren zur Herstellung einer solchen Vorrichtung |
WO2007117346A2 (en) | 2006-01-26 | 2007-10-18 | California Institute Of Technology | Programming microfluidic devices with molecular information |
GB2436616A (en) | 2006-03-29 | 2007-10-03 | Inverness Medical Switzerland | Assay device and method |
US8900828B2 (en) | 2006-05-01 | 2014-12-02 | Cepheid | Methods and apparatus for sequential amplification reactions |
WO2008147382A1 (en) * | 2006-09-27 | 2008-12-04 | Micronics, Inc. | Integrated microfluidic assay devices and methods |
JP2009034052A (ja) * | 2007-08-02 | 2009-02-19 | Canon Inc | ハイブリダイゼーション方法および装置 |
EP1947197A1 (en) * | 2007-08-24 | 2008-07-23 | Siemens Aktiengesellschaft, A German Corporation | Method for the amplification of at least one nucleic acid |
HK1129808A2 (en) | 2007-10-03 | 2009-12-04 | Diagcor Bioscience Inc Ltd | Reversed flow through platform for rapid analysis of target analytes with increased sensitivity and specificity and the device thereof |
US8741815B2 (en) | 2008-02-19 | 2014-06-03 | Intelligent Bio Systems, Inc. | Methods and devices for amplification of nucleic acid |
US20090227476A1 (en) * | 2008-03-07 | 2009-09-10 | Applied Microarrays, Inc. | Amplification and microarray detection apparatus and methods of making |
EP2143491A1 (en) | 2008-07-10 | 2010-01-13 | Carpegen GmbH | Device for analysing a chemical or biological sample |
GB0912509D0 (en) * | 2009-07-17 | 2009-08-26 | Norchip As | A microfabricated device for metering an analyte |
US9493822B2 (en) * | 2009-09-01 | 2016-11-15 | Koninklijke Philips Electronics N.V. | Devices and methods for microarray selection |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
DE102011015184B4 (de) | 2010-06-02 | 2013-11-21 | Thinxxs Microtechnology Ag | Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil |
DE102010030962B4 (de) * | 2010-07-06 | 2023-04-20 | Robert Bosch Gmbh | Verfahren zur aktiven Hybridisierung in Microarrays mit Denaturierungsfunktion |
US10078075B2 (en) | 2011-12-09 | 2018-09-18 | Vanderbilt University | Integrated organ-on-chip systems and applications of the same |
EP3644058A1 (en) | 2010-10-14 | 2020-04-29 | Meso Scale Technologies, LLC | Reagent storage in an assay device |
WO2012094459A2 (en) | 2011-01-06 | 2012-07-12 | Glezer Eli N | Assay cartridges and methods of using the same |
US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
US8614087B2 (en) | 2011-05-02 | 2013-12-24 | Ibis Biosciences, Inc. | Multiple-analyte assay device and system |
US9857332B2 (en) | 2011-07-22 | 2018-01-02 | Tecan Trading Ag | System for manipulating samples in liquid droplets |
US20130067525A1 (en) | 2011-09-09 | 2013-03-14 | Pct International, Inc. | Service provisioning device with integrated cable modem |
US20130203057A1 (en) | 2012-01-20 | 2013-08-08 | Biohelix Corporation | Step-wise detection of multiple target sequences in isothermal nucleic acid amplification reactions |
WO2013161964A1 (ja) | 2012-04-27 | 2013-10-31 | キリンホールディングス株式会社 | リガンドを高感度に検出する核酸分子並びに該核酸分子のスクリーニング方法および該核酸分子の感度の最適化方法 |
US9217179B2 (en) | 2012-05-24 | 2015-12-22 | The Governing Council Of The University Of Toronto | Systems and methods for multiplexed electrochemical detection |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
US9624532B2 (en) | 2013-02-05 | 2017-04-18 | Neil Gordon | Ultra-sensitive detection of extremely low level biological analytes using electrochemical signal amplification and biosensor |
US20140329720A1 (en) * | 2013-05-01 | 2014-11-06 | Triune Ip Llc | Electronic-based biosensor |
WO2015054546A1 (en) | 2013-10-10 | 2015-04-16 | Song Diagnostic Research Llc. | Improved lateral flow assays |
GB201320071D0 (en) | 2013-11-13 | 2013-12-25 | Univ Leuven Kath | Monitoring multiplex DNA amplification |
DE102014200483B4 (de) | 2014-01-14 | 2024-05-08 | Robert Bosch Gmbh | Verfahren zum Betreiben eines mikrofluidischen Chips und mikrofluidischer Chip |
CN106660048B (zh) * | 2014-06-19 | 2019-07-05 | 阿科尼生物系统公司 | 分子分析系统及其应用 |
ES2875790T3 (es) * | 2016-10-07 | 2021-11-11 | Boehringer Ingelheim Vetmedica Gmbh | Método y sistema de análisis para probar una muestra |
-
2017
- 2017-10-05 US US15/725,323 patent/US10953403B2/en active Active
- 2017-10-05 WO PCT/EP2017/025279 patent/WO2018065102A1/en unknown
- 2017-10-05 KR KR1020197012883A patent/KR20190066619A/ko not_active Application Discontinuation
- 2017-10-05 EP EP17800388.5A patent/EP3523046B1/en not_active Not-in-force
- 2017-10-05 CA CA3035141A patent/CA3035141A1/en not_active Abandoned
- 2017-10-05 CN CN201780061046.6A patent/CN109789409A/zh active Pending
- 2017-10-05 JP JP2019518515A patent/JP2019537706A/ja not_active Ceased
- 2017-10-05 BR BR112019006655A patent/BR112019006655A2/pt active Search and Examination
-
2021
- 2021-03-04 US US17/191,809 patent/US20210187509A1/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110114145B (zh) | 用于检测样品的分析系统及方法 | |
CN109789412B (zh) | 用于检测样品的分析系统及方法 | |
JP6987133B2 (ja) | サンプルを検査するための方法及び分析システム | |
JP2019537705A5 (pt) | ||
KR20190064617A (ko) | 샘플을 테스트하기 위한 분석 시스템 | |
US20210187509A1 (en) | Method and analysis system for testing a sample | |
US11268134B2 (en) | Sensor apparatus and method for testing a sample | |
JPWO2018065102A5 (pt) | ||
EP3673083B1 (en) | Analysis system with cartridge and method for testing a sample | |
WO2022128917A1 (en) | Analysis system and method for testing a sample | |
NZ752616B2 (en) | Analysis system and method for testing a sample |