JPWO2018065102A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2018065102A5 JPWO2018065102A5 JP2019518515A JP2019518515A JPWO2018065102A5 JP WO2018065102 A5 JPWO2018065102 A5 JP WO2018065102A5 JP 2019518515 A JP2019518515 A JP 2019518515A JP 2019518515 A JP2019518515 A JP 2019518515A JP WO2018065102 A5 JPWO2018065102 A5 JP WO2018065102A5
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- amplification product
- group
- sensor
- sensor device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003321 amplification Effects 0.000 claims description 217
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 217
- 238000006243 chemical reaction Methods 0.000 claims description 131
- 238000009396 hybridization Methods 0.000 claims description 100
- 239000000523 sample Substances 0.000 claims description 94
- 239000012491 analyte Substances 0.000 claims description 82
- 239000012530 fluid Substances 0.000 claims description 70
- 238000000034 method Methods 0.000 claims description 62
- 238000001514 detection method Methods 0.000 claims description 28
- 150000007523 nucleic acids Chemical class 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 239000012472 biological sample Substances 0.000 claims description 8
- 239000000047 product Substances 0.000 description 202
- 238000004458 analytical method Methods 0.000 description 67
- 239000003153 chemical reaction reagent Substances 0.000 description 48
- 239000007788 liquid Substances 0.000 description 35
- 238000005259 measurement Methods 0.000 description 20
- 238000002844 melting Methods 0.000 description 20
- 230000008018 melting Effects 0.000 description 20
- 238000007689 inspection Methods 0.000 description 18
- 238000003860 storage Methods 0.000 description 17
- 108020004414 DNA Proteins 0.000 description 15
- 239000000126 substance Substances 0.000 description 14
- 239000002299 complementary DNA Substances 0.000 description 13
- 238000002156 mixing Methods 0.000 description 13
- 238000010438 heat treatment Methods 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 238000005086 pumping Methods 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 10
- 238000001035 drying Methods 0.000 description 10
- 238000003752 polymerase chain reaction Methods 0.000 description 8
- 238000005303 weighing Methods 0.000 description 8
- 239000000872 buffer Substances 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000011144 upstream manufacturing Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 244000052769 pathogen Species 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 239000011534 wash buffer Substances 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 108010090804 Streptavidin Proteins 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000006479 redox reaction Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000835 electrochemical detection Methods 0.000 description 2
- 238000002848 electrochemical method Methods 0.000 description 2
- 238000003891 environmental analysis Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- ZYPZVOKVDNSKLP-UHFFFAOYSA-N tris(4-aminophenyl) phosphate Chemical compound C1=CC(N)=CC=C1OP(=O)(OC=1C=CC(N)=CC=1)OC1=CC=C(N)C=C1 ZYPZVOKVDNSKLP-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 241000269800 Percidae Species 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000004638 bioanalytical method Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 125000003396 thiol group Chemical class [H]S* 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16020371 | 2016-10-07 | ||
| EP16020371.7 | 2016-10-07 | ||
| PCT/EP2017/025279 WO2018065102A1 (en) | 2016-10-07 | 2017-10-05 | Method and analysis system for testing a sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537706A JP2019537706A (ja) | 2019-12-26 |
| JP2019537706A5 JP2019537706A5 (enExample) | 2022-01-11 |
| JPWO2018065102A5 true JPWO2018065102A5 (enExample) | 2022-07-20 |
Family
ID=57132952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518515A Ceased JP2019537706A (ja) | 2016-10-07 | 2017-10-05 | サンプルを検査するための方法及び分析システム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10953403B2 (enExample) |
| EP (1) | EP3523046B1 (enExample) |
| JP (1) | JP2019537706A (enExample) |
| KR (1) | KR20190066619A (enExample) |
| CN (1) | CN109789409A (enExample) |
| BR (1) | BR112019006655A2 (enExample) |
| CA (1) | CA3035141A1 (enExample) |
| WO (1) | WO2018065102A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201917832D0 (en) * | 2019-12-05 | 2020-01-22 | Oxford Nanopore Tech Ltd | Microfluidic device for preparing and analysing a test liquid |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096669A (en) | 1988-09-15 | 1992-03-17 | I-Stat Corporation | Disposable sensing device for real time fluid analysis |
| DE4438785C2 (de) | 1994-10-24 | 1996-11-07 | Wita Gmbh Wittmann Inst Of Tec | Mikrochemische Reaktions- und Analyseeinheit |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| AU7066996A (en) | 1995-11-15 | 1997-05-22 | Arkray, Inc. | Liquid detection method and device therefor |
| US6054277A (en) | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system |
| DE19648441A1 (de) | 1996-11-22 | 1998-05-28 | Abb Patent Gmbh | Analysegerät |
| DE19648695C2 (de) | 1996-11-25 | 1999-07-22 | Abb Patent Gmbh | Vorrichtung zur automatischen und kontinuierlichen Analyse von Flüssigkeitsproben |
| US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
| EP1042061A1 (en) | 1997-12-24 | 2000-10-11 | Cepheid | Integrated fluid manipulation cartridge |
| GB9804483D0 (en) | 1998-03-02 | 1998-04-29 | Central Research Lab Ltd | Apparatus for and method of controlling the rate of flow of fluid along a pathway |
| WO1999046045A1 (de) | 1998-03-11 | 1999-09-16 | MICROPARTS GESELLSCHAFT FüR MIKROSTRUKTURTECHNIK MBH | Probenträger |
| DE19846466A1 (de) | 1998-10-08 | 2000-04-27 | Ghs Gesundheits Service Ag | Analyseverfahren zur simultanen Bestimmung von Parametern aus unterschiedlichen Medien |
| US6300141B1 (en) | 1999-03-02 | 2001-10-09 | Helix Biopharma Corporation | Card-based biosensor device |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| DE60014676T2 (de) | 1999-05-28 | 2005-11-17 | Cepheid, Sunnyvale | Vorrichtung und verfahren zur analyse flüssiger proben |
| DE19928410C2 (de) | 1999-06-22 | 2002-11-28 | Agilent Technologies Inc | Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips |
| DE60035199T2 (de) | 1999-08-11 | 2008-02-14 | Asahi Kasei Kabushiki Kaisha | Analysenkassette und flüssigkeitsförderkontroller |
| US6495104B1 (en) | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
| AU3537001A (en) | 1999-12-23 | 2001-07-09 | Gyros Ab | Integrated microfluidic disc |
| FR2808089B1 (fr) | 2000-04-25 | 2002-07-05 | Sebia Sa | Dispositif perfectionne d'analyse d'echantillons par electrophorese multicapillaire a thermo-regulation solide/solide |
| AU2002249481A1 (en) | 2000-10-25 | 2002-08-12 | Exiqon A/S | Open substrate platforms suitable for analysis of biomolecules |
| DE10058394C1 (de) | 2000-11-24 | 2002-07-11 | Siemens Ag | Verfahren für die biochemische Analytik und zugehörige Anordnung |
| AT410444B (de) * | 2001-03-02 | 2003-04-25 | Oesterr Forsch Seibersdorf | Verfahren zur detektion von nukleinsäuremolekülen |
| DE10111458B4 (de) | 2001-03-09 | 2008-09-11 | Siemens Ag | Analyseeinrichtung |
| DE10111457B4 (de) | 2001-03-09 | 2006-12-14 | Siemens Ag | Diagnoseeinrichtung |
| US7192557B2 (en) | 2001-03-28 | 2007-03-20 | Handylab, Inc. | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids |
| WO2002081729A2 (en) | 2001-04-06 | 2002-10-17 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| US6896778B2 (en) | 2001-06-04 | 2005-05-24 | Epocal Inc. | Electrode module |
| US6845327B2 (en) | 2001-06-08 | 2005-01-18 | Epocal Inc. | Point-of-care in-vitro blood analysis system |
| US20030064507A1 (en) | 2001-07-26 | 2003-04-03 | Sean Gallagher | System and methods for mixing within a microfluidic device |
| US20030087292A1 (en) | 2001-10-04 | 2003-05-08 | Shiping Chen | Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays |
| US7344894B2 (en) | 2001-10-16 | 2008-03-18 | Agilent Technologies, Inc. | Thermal regulation of fluidic samples within a diagnostic cartridge |
| EP1460130B1 (en) * | 2001-12-19 | 2007-03-21 | Hitachi High-Technologies Corporation | Potentiometric dna microarray, process for producing the same and method of analyzing nucleic acid |
| DE10258840A1 (de) | 2002-01-28 | 2003-08-07 | Eppendorf Ag | Stapelanordnung von Reaktionsgefäßen |
| US7485128B2 (en) | 2002-04-19 | 2009-02-03 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7744816B2 (en) | 2002-05-01 | 2010-06-29 | Intel Corporation | Methods and device for biomolecule characterization |
| US7217542B2 (en) | 2002-10-31 | 2007-05-15 | Hewlett-Packard Development Company, L.P. | Microfluidic system for analyzing nucleic acids |
| US20040115794A1 (en) * | 2002-12-12 | 2004-06-17 | Affymetrix, Inc. | Methods for detecting transcriptional factor binding sites |
| CA3171720C (en) | 2002-12-26 | 2024-01-09 | Meso Scale Technologies, Llc. | Methods for conducting electrochemiluminescence measurements |
| US7122153B2 (en) | 2003-01-08 | 2006-10-17 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| US20040223874A1 (en) | 2003-03-31 | 2004-11-11 | Canon Kabushiki Kaisha | Biochemical reaction cartridge |
| US20040224339A1 (en) | 2003-03-31 | 2004-11-11 | Canon Kabushiki Kaisha | Biochemical reaction cartridge |
| DE502004003698D1 (de) | 2003-05-13 | 2007-06-14 | Siemens Ag | Schaltkreisanordnung zur potentialkonstanthaltung an einem biosensor und zur digitalisierung des messstroms |
| DE10352887A1 (de) | 2003-11-10 | 2005-04-21 | Infineon Technologies Ag | Vorrichtung zur Vervielfältigung und Charakterisierung von Nukleinsäure-Proben mit flexiblem Speicherelement zur Speicherung von probenspezifischen Daten |
| KR20050055349A (ko) | 2003-12-08 | 2005-06-13 | 삼성전자주식회사 | 스페이서용 감광제 및 이를 이용한 액정 표시 장치의 제조방법 |
| US20050176135A1 (en) | 2004-02-06 | 2005-08-11 | Brian Jones | Cassette for isolation, amplification and identification of DNA or protein and method of use |
| JP4127679B2 (ja) | 2004-03-18 | 2008-07-30 | 株式会社東芝 | 核酸検出カセット及び核酸検出装置 |
| US20090130658A1 (en) | 2004-10-15 | 2009-05-21 | Heike Barlag | Arrangement for integrated and automated dna or protein analysis in a single-use cartridge, method for producing such a cartridge and operating method for dna or protein analysis using such a cartridge |
| JP4185904B2 (ja) | 2004-10-27 | 2008-11-26 | 株式会社日立ハイテクノロジーズ | 液体搬送基板、分析システム、分析方法 |
| CN101218032A (zh) | 2005-05-25 | 2008-07-09 | 西门子公司 | 综合和自动化的dna或蛋白质分析系统及其运行方法 |
| EP1715348B2 (en) | 2005-07-15 | 2019-05-08 | Agilent Technologies, Inc. | Handling unit for microfluidic devices with clamping means |
| DE102005059535B4 (de) | 2005-12-13 | 2010-01-14 | Siemens Ag | Vorrichtung und Verfahren zur Durchführung eines Nukleinsäure-Tests, sowie Verfahren zur Herstellung einer solchen Vorrichtung |
| EP1987358A4 (en) | 2006-01-26 | 2013-12-04 | California Inst Of Techn | MECHANICALLY INTRODUCED TRAPPING OF MOLECULAR INTERACTIONS |
| GB2436616A (en) | 2006-03-29 | 2007-10-03 | Inverness Medical Switzerland | Assay device and method |
| US8900828B2 (en) | 2006-05-01 | 2014-12-02 | Cepheid | Methods and apparatus for sequential amplification reactions |
| WO2008147382A1 (en) * | 2006-09-27 | 2008-12-04 | Micronics, Inc. | Integrated microfluidic assay devices and methods |
| JP2009034052A (ja) * | 2007-08-02 | 2009-02-19 | Canon Inc | ハイブリダイゼーション方法および装置 |
| EP1947197A1 (en) | 2007-08-24 | 2008-07-23 | Siemens Aktiengesellschaft, A German Corporation | Method for the amplification of at least one nucleic acid |
| HK1129808A2 (zh) | 2007-10-03 | 2009-12-04 | 达雅高生物科技有限公司 | 能快速分析目标组分并有增强的敏感度和特异度的反向流固平台和有关设备 |
| US8741815B2 (en) | 2008-02-19 | 2014-06-03 | Intelligent Bio Systems, Inc. | Methods and devices for amplification of nucleic acid |
| US20090227476A1 (en) | 2008-03-07 | 2009-09-10 | Applied Microarrays, Inc. | Amplification and microarray detection apparatus and methods of making |
| EP2143491A1 (en) | 2008-07-10 | 2010-01-13 | Carpegen GmbH | Device for analysing a chemical or biological sample |
| GB0912509D0 (en) * | 2009-07-17 | 2009-08-26 | Norchip As | A microfabricated device for metering an analyte |
| US9493822B2 (en) * | 2009-09-01 | 2016-11-15 | Koninklijke Philips Electronics N.V. | Devices and methods for microarray selection |
| US10022696B2 (en) | 2009-11-23 | 2018-07-17 | Cyvek, Inc. | Microfluidic assay systems employing micro-particles and methods of manufacture |
| DE102011015184B4 (de) | 2010-06-02 | 2013-11-21 | Thinxxs Microtechnology Ag | Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil |
| DE102010030962B4 (de) * | 2010-07-06 | 2023-04-20 | Robert Bosch Gmbh | Verfahren zur aktiven Hybridisierung in Microarrays mit Denaturierungsfunktion |
| US10078075B2 (en) | 2011-12-09 | 2018-09-18 | Vanderbilt University | Integrated organ-on-chip systems and applications of the same |
| WO2012051386A2 (en) | 2010-10-14 | 2012-04-19 | Meso Scale Technologies, Llc | Reagent storage in an assay device |
| CA3177188A1 (en) | 2011-01-06 | 2012-07-12 | Meso Scale Technologies, Llc. | Assay cartridges for pcr analysis and methods of use thereof |
| US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| WO2012151307A1 (en) | 2011-05-02 | 2012-11-08 | Ibis Biosciences, Inc. | Multiple- analyte assay device and system |
| US9857332B2 (en) | 2011-07-22 | 2018-01-02 | Tecan Trading Ag | System for manipulating samples in liquid droplets |
| US20130067525A1 (en) | 2011-09-09 | 2013-03-14 | Pct International, Inc. | Service provisioning device with integrated cable modem |
| US20130203057A1 (en) | 2012-01-20 | 2013-08-08 | Biohelix Corporation | Step-wise detection of multiple target sequences in isothermal nucleic acid amplification reactions |
| WO2013161964A1 (ja) | 2012-04-27 | 2013-10-31 | キリンホールディングス株式会社 | リガンドを高感度に検出する核酸分子並びに該核酸分子のスクリーニング方法および該核酸分子の感度の最適化方法 |
| EP2859340B1 (en) | 2012-05-24 | 2017-05-03 | The Governing Council Of The University Of Toronto | Systems and methods for multiplexed electrochemical detection |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| US9624532B2 (en) | 2013-02-05 | 2017-04-18 | Neil Gordon | Ultra-sensitive detection of extremely low level biological analytes using electrochemical signal amplification and biosensor |
| US20140329720A1 (en) * | 2013-05-01 | 2014-11-06 | Triune Ip Llc | Electronic-based biosensor |
| US20160223536A1 (en) | 2013-10-10 | 2016-08-04 | Song Diagnostic Research Llc | Improved Lateral Flow Assays |
| GB201320071D0 (en) | 2013-11-13 | 2013-12-25 | Univ Leuven Kath | Monitoring multiplex DNA amplification |
| DE102014200483B4 (de) | 2014-01-14 | 2024-05-08 | Robert Bosch Gmbh | Verfahren zum Betreiben eines mikrofluidischen Chips und mikrofluidischer Chip |
| CN106660048B (zh) * | 2014-06-19 | 2019-07-05 | 阿科尼生物系统公司 | 分子分析系统及其应用 |
| JP6987133B2 (ja) * | 2016-10-07 | 2021-12-22 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH | サンプルを検査するための方法及び分析システム |
-
2017
- 2017-10-05 BR BR112019006655A patent/BR112019006655A2/pt active Search and Examination
- 2017-10-05 JP JP2019518515A patent/JP2019537706A/ja not_active Ceased
- 2017-10-05 CN CN201780061046.6A patent/CN109789409A/zh active Pending
- 2017-10-05 US US15/725,323 patent/US10953403B2/en not_active Expired - Fee Related
- 2017-10-05 EP EP17800388.5A patent/EP3523046B1/en not_active Not-in-force
- 2017-10-05 KR KR1020197012883A patent/KR20190066619A/ko not_active Ceased
- 2017-10-05 WO PCT/EP2017/025279 patent/WO2018065102A1/en not_active Ceased
- 2017-10-05 CA CA3035141A patent/CA3035141A1/en not_active Abandoned
-
2021
- 2021-03-04 US US17/191,809 patent/US20210187509A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110114145B (zh) | 用于检测样品的分析系统及方法 | |
| CN109789412B (zh) | 用于检测样品的分析系统及方法 | |
| JP2019537705A5 (enExample) | ||
| JP6987133B2 (ja) | サンプルを検査するための方法及び分析システム | |
| KR20190064617A (ko) | 샘플을 테스트하기 위한 분석 시스템 | |
| US20210187509A1 (en) | Method and analysis system for testing a sample | |
| JPWO2018065102A5 (enExample) | ||
| US11268134B2 (en) | Sensor apparatus and method for testing a sample | |
| EP3673083B1 (en) | Analysis system with cartridge and method for testing a sample | |
| WO2022128917A1 (en) | Analysis system and method for testing a sample | |
| NZ752616B2 (en) | Analysis system and method for testing a sample |