JPWO2017079384A5 - - Google Patents
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- Publication number
- JPWO2017079384A5 JPWO2017079384A5 JP2018543033A JP2018543033A JPWO2017079384A5 JP WO2017079384 A5 JPWO2017079384 A5 JP WO2017079384A5 JP 2018543033 A JP2018543033 A JP 2018543033A JP 2018543033 A JP2018543033 A JP 2018543033A JP WO2017079384 A5 JPWO2017079384 A5 JP WO2017079384A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- gpc
- gamma
- gpe
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000090 biomarker Substances 0.000 claims description 33
- 235000020828 fasting Nutrition 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims 84
- 239000000523 sample Substances 0.000 claims 55
- -1 1-pentadecanoyl glycerophosphocholine Chemical compound 0.000 claims 52
- 238000004458 analytical method Methods 0.000 claims 33
- 239000012472 biological sample Substances 0.000 claims 29
- 150000003384 small molecules Chemical class 0.000 claims 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 27
- 230000002503 metabolic Effects 0.000 claims 26
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 21
- 229960004203 Carnitine Drugs 0.000 claims 21
- 229960001518 levocarnitine Drugs 0.000 claims 21
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- 229960004956 Glycerylphosphorylcholine Drugs 0.000 claims 13
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 12
- MPCAJMNYNOGXPB-SLPGGIOYSA-N 1,5-anhydro-D-glucitol Chemical compound OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O MPCAJMNYNOGXPB-SLPGGIOYSA-N 0.000 claims 11
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- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims 9
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- WNLRTRBMVRJNCN-UHFFFAOYSA-N Adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 8
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 8
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- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 8
- GUBGYTABKSRVRQ-YOLKTULGSA-N Maltose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@H]1CO)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 GUBGYTABKSRVRQ-YOLKTULGSA-N 0.000 claims 8
- NPOAOTPXWNWTSH-UHFFFAOYSA-N Meglutol Chemical compound OC(=O)CC(O)(C)CC(O)=O NPOAOTPXWNWTSH-UHFFFAOYSA-N 0.000 claims 8
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- 229960002477 Riboflavin Drugs 0.000 claims 8
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 8
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- KWIUHFFTVRNATP-UHFFFAOYSA-N Trimethylglycine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 8
- NWCHELUCVWSRRS-UHFFFAOYSA-N atrolactic acid Chemical compound OC(=O)C(O)(C)C1=CC=CC=C1 NWCHELUCVWSRRS-UHFFFAOYSA-N 0.000 claims 8
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 8
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 8
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims 8
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- 235000003969 glutathione Nutrition 0.000 claims 8
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- 229950001574 riboflavin phosphate Drugs 0.000 claims 8
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 claims 8
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine zwitterion Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 8
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- KPGXRSRHYNQIFN-UHFFFAOYSA-N α-Ketoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 8
- UCMIRNVEIXFBKS-UHFFFAOYSA-N β-Alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 8
- WHBMMWSBFZVSSR-UHFFFAOYSA-N β-Hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims 8
- HEBKCHPVOIAQTA-QWWZWVQMSA-N Arabitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims 7
- 108010024636 Glutathione Proteins 0.000 claims 7
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- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 7
- FBUKVWPVBMHYJY-UHFFFAOYSA-N Nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims 7
- 235000021314 Palmitic acid Nutrition 0.000 claims 7
- ZJUKTBDSGOFHSH-WFMPWKQPSA-N S-Adenosylhomocysteine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSCC[C@H](N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZJUKTBDSGOFHSH-WFMPWKQPSA-N 0.000 claims 7
- WWUZIQQURGPMPG-KRWOKUGFSA-N Sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 claims 7
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- INAPMGSXUVUWAF-UOTPTPDRSA-N 1D-myo-inositol 1-phosphate Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-UOTPTPDRSA-N 0.000 claims 6
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- XOMRRQXKHMYMOC-UHFFFAOYSA-N Palmitoylcarnitine Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC([O-])=O)C[N+](C)(C)C XOMRRQXKHMYMOC-UHFFFAOYSA-N 0.000 claims 6
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| CA2371385A1 (en) * | 1999-04-26 | 2000-11-02 | Surromed, Inc. | Phenotype and biological marker identification system |
| US20040248106A1 (en) * | 2003-06-06 | 2004-12-09 | Leonard Leslie A. | Clinical array assays that include a sample quality evaluation step and compositions for use in practicing the same |
| US7869033B2 (en) * | 2003-12-24 | 2011-01-11 | Vadivel Masilamani | Cancer detection by optical analysis of body fluids |
| US7949475B2 (en) | 2005-08-08 | 2011-05-24 | Metabolon Inc. | System and method for analyzing metabolomic data |
| US7561975B2 (en) | 2006-03-21 | 2009-07-14 | Metabolon, Inc. | System, method, and computer program product for analyzing spectrometry data to identify and quantify individual components in a sample |
| US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| US7884318B2 (en) | 2008-01-16 | 2011-02-08 | Metabolon, Inc. | Systems, methods, and computer-readable medium for determining composition of chemical constituents in a complex mixture |
| KR20110097889A (ko) * | 2008-12-23 | 2011-08-31 | 에프. 호프만-라 로슈 아게 | 수집 디바이스 상에서 구동하는 구조화된 수집 절차의 구현, 실행, 데이터 수집, 및 데이터 분석을 위한 관리 방법 및 시스템 |
| EP2488659B1 (en) * | 2009-10-15 | 2019-12-11 | Crescendo Bioscience, Inc. | Biomarkers and methods for measuring and monitoring inflammatory disease activity |
| EP2678448A4 (en) * | 2011-02-22 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | CIRCULATING BIOMARKERS |
| CN103958662A (zh) * | 2011-10-24 | 2014-07-30 | 私募蛋白质体公司 | 用于疾病生物标记鉴定和样品质量评价的优选样品处理和加工方案的选择 |
| SG11201505515XA (en) * | 2012-01-27 | 2015-09-29 | Univ Leland Stanford Junior | Methods for profiling and quantitating cell-free rna |
| US20130286038A1 (en) * | 2012-04-30 | 2013-10-31 | General Electric Company | Systems and methods for selection and display of multiplexed images of biological tissue |
| EP2845137B1 (en) * | 2012-04-30 | 2021-01-20 | Global Life Sciences Solutions Usa Llc | Systems and methods for performing quality review scoring of biomarkers and image analysis methods for biological tissue |
| US9036888B2 (en) * | 2012-04-30 | 2015-05-19 | General Electric Company | Systems and methods for performing quality review scoring of biomarkers and image analysis methods for biological tissue |
| CN105120852A (zh) * | 2013-02-14 | 2015-12-02 | 梅坦诺米克斯保健有限公司 | 评估生物样品质量的工具和方法 |
| BR112016021929A2 (pt) * | 2014-03-26 | 2017-08-15 | Metanomics Health Gmbh | Método, dispositivo e conjunto para a avaliação da qualidade de uma amostra de produto, conjunto de dados, meio de armazenamento de dados, uso dos rotuladores e método para o fornecimento de uma coleção de produtos |
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2016
- 2016-11-03 CN CN201680073731.6A patent/CN108369612A/zh active Pending
- 2016-11-03 EP EP16862931.9A patent/EP3371730A4/en active Pending
- 2016-11-03 JP JP2018543033A patent/JP7026625B2/ja active Active
- 2016-11-03 US US15/772,834 patent/US10890592B2/en active Active
- 2016-11-03 CA CA3003742A patent/CA3003742C/en active Active
- 2016-11-03 WO PCT/US2016/060245 patent/WO2017079384A1/en active Application Filing
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2020
- 2020-11-13 US US17/097,491 patent/US20210088539A1/en active Pending
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2021
- 2021-09-14 JP JP2021149614A patent/JP2022008397A/ja not_active Abandoned
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