JPWO2016103544A1 - Dietary fiber-containing food and drink - Google Patents
Dietary fiber-containing food and drink Download PDFInfo
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- JPWO2016103544A1 JPWO2016103544A1 JP2016565866A JP2016565866A JPWO2016103544A1 JP WO2016103544 A1 JPWO2016103544 A1 JP WO2016103544A1 JP 2016565866 A JP2016565866 A JP 2016565866A JP 2016565866 A JP2016565866 A JP 2016565866A JP WO2016103544 A1 JPWO2016103544 A1 JP WO2016103544A1
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- Prior art keywords
- food
- dietary fiber
- fiber component
- drink
- alanine
- Prior art date
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- Granted
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- 235000013305 food Nutrition 0.000 title claims abstract description 66
- 235000013325 dietary fiber Nutrition 0.000 title claims abstract description 59
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract description 42
- 235000004279 alanine Nutrition 0.000 claims abstract description 42
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- 210000004369 blood Anatomy 0.000 claims abstract description 37
- 235000013361 beverage Nutrition 0.000 claims abstract description 30
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- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims abstract description 8
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- 229920002907 Guar gum Polymers 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
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- 229920002752 Konjac Polymers 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 241000790234 Sphingomonas elodea Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
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- 239000003112 inhibitor Substances 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
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- 229920001277 pectin Polymers 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/723—Xanthans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Jellies, Jams, And Syrups (AREA)
- Non-Alcoholic Beverages (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
【課題】血中アルコール濃度を低減可能である新規な飲食品を提供する。【解決手段】 キサンタンガム、グルコマンナンおよびゲランガムからなる群から1種または2種以上選ばれる食物繊維成分を含有する飲食品であって、食物繊維成分を少なくとも0.3 g/100mlの割合で含有し、且つアラニンを少なくとも3.0g/100mlの割合で含有する飲料、または食物繊維成分を少なくとも0.3 g含有し、且つアラニンを少なくとも3.0g含有する固形または半固形の食品である飲食品。【選択図】 なしThe present invention provides a novel food or drink that can reduce blood alcohol concentration. A food or drink containing a dietary fiber component selected from the group consisting of xanthan gum, glucomannan and gellan gum, comprising the dietary fiber component in a ratio of at least 0.3 g / 100 ml, and A beverage containing at least 3.0 g / 100 ml of alanine, or a food or drink that is a solid or semi-solid food containing at least 0.3 g of a dietary fiber component and containing at least 3.0 g of alanine. [Selection figure] None
Description
本発明は、食物繊維を含有する飲食品に関し、特に、当該飲食品を摂取することにより、飲酒後の血中アルコール濃度を低下させることが可能である飲食品に関する。 The present invention relates to a food or drink containing dietary fiber, and in particular, to a food or drink that can reduce blood alcohol concentration after drinking by ingesting the food or drink.
飲酒により体内に摂取されたアルコールは、肝細胞内のミトコンドリアにより代謝され、肝毒性の強いアセトアルデヒドに分解され、次いでアセトアルデヒドは速やかに酢酸に分解される。酢酸は、肝臓から血中に放出され、末梢組織のエネルギー源としてTCA回路に入り、最終的には、二酸化炭素と水に分解される。 Alcohol taken into the body by drinking is metabolized by mitochondria in hepatocytes and decomposed into acetaldehyde having strong hepatotoxicity, and then acetaldehyde is rapidly decomposed into acetic acid. Acetic acid is released from the liver into the blood, enters the TCA circuit as a source of energy for peripheral tissues, and is eventually broken down into carbon dioxide and water.
アルコールが吸収されることによる生体への影響（酒酔い）に対して、これまでに軽減効果が期待される物質が多数報告されている。特許文献1には、デキストリン類を有効成分とする血中アルコール濃度抑制剤が開示されている。 Many substances that have been expected to have a mitigating effect on the influence on the living body (drunkenness) due to the absorption of alcohol have been reported so far. Patent Document 1 discloses a blood alcohol concentration inhibitor containing dextrins as an active ingredient.
特許文献2には、アラニンとグルタミンとを1:0.001以上のモル濃度比で併用する抗アルコール症組成物が記載されている。ラットを用いた実験において、アラニン及びグルタミンを摂取させることにより、アルコールに起因する行動抑制、血糖値上昇が改善されている。 Patent Document 2 describes an anti-alcoholic composition in which alanine and glutamine are used in combination at a molar concentration ratio of 1: 0.001 or more. In the experiment using rats, the behavioral suppression caused by alcohol and the increase in blood glucose level are improved by ingesting alanine and glutamine.
非特許文献1には、トマトジュースとアルコールを同時に摂取すると、酔いの回りが緩やかになり、飲酒後の酔い覚めも早まる可能性があること、及びその原因として、トマトの水溶性成分には、生体内でアルコール及びアセトアルデヒドを代謝する酵素の活性を高める傾向が見られ、特に、肝臓中のLDHの活性が有意に高まることが記載されている。 In Non-Patent Document 1, when tomato juice and alcohol are ingested at the same time, the effect of intoxication is moderated and the intoxication after drinking may be accelerated, and as a cause thereof, There is a tendency to increase the activity of enzymes that metabolize alcohol and acetaldehyde in vivo, and in particular, it is described that the activity of LDH in the liver is significantly increased.
また、出願人も、トマト、ニンジン、および各種フルーツに含まれる非水溶性成分を摂取することにより飲酒後の血中アルコール濃度が低減されるなど酒酔いの症状が軽減されること、及びこれら非水溶性成分にアラニンを加えることでさらに血中アルコール濃度低減作用が高まることを見出した。そして、当該トマト、ニンジン、および各種フルーツ由来の非水溶性成分を含有する飲食品を提案している（特許文献３〜７）。 In addition, the applicant can reduce the symptoms of drunkness by reducing the alcohol concentration in blood after drinking by ingesting water-insoluble components contained in tomatoes, carrots, and various fruits. It has been found that the action of reducing blood alcohol concentration is further increased by adding alanine to the water-soluble component. And the food / beverage products containing the water-insoluble component derived from the said tomato, carrot, and various fruits are proposed (patent documents 3-7).
以上のような血中アルコール濃度を低下させることについての報告がこれまでにある一方で、血中アルコール濃度低下作用を有する飲食品等についてのさらなる要求が存在する。 While there have been reports on reducing the blood alcohol concentration as described above, there is a further demand for foods and drinks having a blood alcohol concentration lowering action.
本発明は、血中アルコール濃度を低減可能である新規な飲食品を提供することを目的とする。 An object of this invention is to provide the novel food-drinks which can reduce blood alcohol concentration.
上述のとおり、血中アルコール濃度低下作用を有する食品等についてのさらなる要求が存在する。ここで、血中アルコール濃度低下作用を示す成分については、実用性などの観点から、身近で食品等として利用されているものに由来することがより好ましい。一方で、アルコール摂取後の血中アルコール濃度を低下する効果が期待できるとされる食品素材・成分がこれまでに多数報告されているが、身近な食素材ではないものや効果が限定的なものが多く、実用的に用いられているものはほとんどない。
本願発明者は酩酊状態を誘発するような多量のアルコールを摂取した場合においても効果を発揮できるような材料および方法を探求した。その結果、血中アルコール濃度低下について、日常的に加工食品等に利用されている素材である各種食物繊維素材のうち、キサンタンガム、グルコマンナン、ゲランガム（ジェランガム）に血中アルコール濃度低下作用が認められること、およびこれらのうち少なくともいずれかとともにアラニンを摂取することで相乗的に効果が高まることを見出し、本発明に至った。As described above, there is a further demand for foods having a blood alcohol concentration lowering effect. Here, about the component which shows the blood alcohol concentration reduction effect | action, it is more preferable that it originates in what is utilized as food etc. near from the viewpoint of practicality. On the other hand, many food ingredients / components that have been expected to have an effect of lowering blood alcohol concentration after alcohol intake have been reported so far, but those that are not familiar food ingredients or have limited effects There are many, and there is almost no thing used practically.
The inventor of the present application sought materials and methods capable of exerting an effect even when a large amount of alcohol that induces a manic state is ingested. As a result, blood alcohol concentration lowering effect is observed in xanthan gum, glucomannan, gellan gum (gellan gum) among various dietary fiber materials that are used in processed foods etc. on a daily basis. And by ingesting alanine together with at least one of them, the inventors have found that the effect is synergistically increased, and have led to the present invention.
本発明の要旨は以下のとおりである。
[1] キサンタンガム、グルコマンナンおよびゲランガムからなる群から１種または２種以上選ばれる食物繊維成分を含有する飲食品であって、
前記食物繊維成分を少なくとも0.3 g/100mlの割合で含有し、且つアラニンを少なくとも3.0g/100mlの割合で含有する飲料、または前記食物繊維成分を少なくとも0.3 g含有し、且つアラニンを少なくとも3.0g含有する固形または半固形の食品である飲食品。
[2] 前記食物繊維成分としてキサンタンガムを少なくとも0.3 g/100mlの割合で含有する飲料である[1]に記載の飲食品。
[3] 前記食物繊維成分としてキサンタンガムを少なくとも3.0g含有する固形または半固形の食品である[1]に記載の飲食品。
[4] [1]から[3]のいずれか１つに記載の飲食品を含む血中アルコール濃度低減剤。
[5] [1]から[3]のいずれか１つに記載の飲食品を含む酒酔い軽減剤。The gist of the present invention is as follows.
[1] A food or drink containing a dietary fiber component selected from one or more selected from the group consisting of xanthan gum, glucomannan and gellan gum,
A beverage containing at least 0.3 g / 100 ml of the dietary fiber component and containing at least 3.0 g / 100 ml of alanine, or containing at least 0.3 g of the dietary fiber component and containing at least 3.0 g of alanine A food or drink that is a solid or semi-solid food.
[2] The food or drink according to [1], which is a beverage containing xanthan gum at a rate of at least 0.3 g / 100 ml as the dietary fiber component.
[3] The food or drink according to [1], which is a solid or semi-solid food containing at least 3.0 g of xanthan gum as the dietary fiber component.
[4] A blood alcohol concentration reducing agent comprising the food or drink according to any one of [1] to [3].
[5] A drunk reducing agent comprising the food or drink according to any one of [1] to [3].
本発明によれば、血中アルコール濃度を低減可能である新規な飲食品を提供できる。 ADVANTAGE OF THE INVENTION According to this invention, the novel food-drinks which can reduce blood alcohol concentration can be provided.
以下、本発明の1つの実施形態について詳述する。
本実施形態の飲食品は、それを摂取することにより血中アルコール濃度を低減可能である飲食品であって、キサンタンガム、グルコマンナン、ゲランガム（ジェランガム）からなる群から１種または２種以上選択される食物繊維成分（以下、これら食物繊維成分を総じて、本実施形態に係る食物繊維成分とも称す）を含有する。Hereinafter, one embodiment of the present invention will be described in detail.
The food / beverage product of this embodiment is a food / beverage product which can reduce blood alcohol concentration by ingesting it, and is selected from the group consisting of xanthan gum, glucomannan and gellan gum (gellan gum). Dietary fiber components (hereinafter, these dietary fiber components are collectively referred to as dietary fiber components according to the present embodiment).
キサンタンガムは、微生物（Xanthomonas campestris）により産出される水溶性多糖類であり、マンノース、グルコース、グルクロン酸で構成されている。
グルコマンナンは、コンニャクイモに含まれる水溶性多糖類であり、グルコースとマンノースから構成されている。
また、ゲランガム（ジェランガム）は、微生物（Pseudomonas elodea）により産出される水溶性多糖類であり、直鎖状のヘテロ多糖類で、グルコース、グルクロン酸、グルコース、ラムノースの４つの糖の繰り返し単位から構成されている。
これら食物繊維成分は増粘剤や安定剤等の用途で広く使用されており、本実施形態においても例えば市販されているものを用いることができる。また、ゲランガムには1−3結合したグルコースに存在するアセチル基とグリセリル基の有無によって脱アシル型ゲランガムとネイティブ型ゲランガムの2種類があり、本実施形態においてはこれらいずれか、または両方が用いられてもよく、特に限定されない。
本実施形態の飲食品は例えば後述する量でこれら３種から１種または２種以上選択される食物繊維成分を含有しており、好ましくは当該食物繊維成分としてキサンタンガムを含有するようにする。Xanthan gum is a water-soluble polysaccharide produced by microorganisms (Xanthomonas campestris), and is composed of mannose, glucose, and glucuronic acid.
Glucomannan is a water-soluble polysaccharide contained in konjac potato and is composed of glucose and mannose.
Gellan gum (gellan gum) is a water-soluble polysaccharide produced by microorganisms (Pseudomonas elodea) and is a linear heteropolysaccharide composed of four sugar repeating units: glucose, glucuronic acid, glucose, and rhamnose. Has been.
These dietary fiber components are widely used in applications such as thickeners and stabilizers, and commercially available products can also be used in this embodiment. There are two types of gellan gum, deacylated gellan gum and native gellan gum, depending on the presence or absence of acetyl and glyceryl groups present in 1-3-bonded glucose. In this embodiment, either or both of these are used. There is no particular limitation.
The food / beverage products of this embodiment contain the dietary fiber component selected from these 3 types, for example in the quantity mentioned later, Preferably it contains xanthan gum as the said dietary fiber component.
本実施形態に係る飲食品は、動物、好ましくは人間が摂取する用途に使用される物品をいう。飲食品の種類としては、その一例として、シロップ、清涼飲料、アルコール飲料、ゼリー飲料などの飲料が挙げられる。また、一定の形を有する食品（固形食品）や、固形食品よりも液分を多く含有し流動性を有するが、一般に咀嚼される食品（半固形食品）であってもよい。固形食品の形状の一例としては、例えば、粉末状、顆粒状、錠剤状、カプセル状、フィルム状、板状、ブロック状などを挙げることができる。なお、以下においては、固形食品と半固形食品とを総じて固形食品等ともいう。 The food and drink according to the present embodiment refers to an article used for use by animals, preferably humans. Examples of the types of food and drink include drinks such as syrup, soft drinks, alcoholic drinks, and jelly drinks. In addition, foods having a certain shape (solid foods) and fluids containing more liquid than solid foods and fluidity may be used, but foods generally chewed (semi-solid foods) may be used. As an example of the shape of the solid food, for example, powder, granule, tablet, capsule, film, plate, block and the like can be mentioned. In the following, solid food and semi-solid food are also collectively referred to as solid food.
本実施形態の飲食品を摂取すると、含有される本実施形態に係る食物繊維成分の作用により血中アルコール濃度が低下する。
本実施形態に係る食物繊維成分を摂取することにより血中アルコール濃度が低下する機構は明確ではないが、本実施形態に係る食物繊維成分が体内におけるアルコールの吸収を抑制していることが考えられる。この点について具体的に説明すると、本実施形態に係る食物繊維成分は、生体内環境においてエタノールを吸収し、保持する能力に優れる。そのため、体内に本実施形態に係る食物繊維成分が存在すると、当該食物繊維成分が摂取されたエタノールを優先的に吸収する。その結果、体に吸収されるエタノール量が減少し、血中アルコール濃度が低減すると考えられる。If the food / beverage products of this embodiment are ingested, blood alcohol concentration will fall by the effect | action of the dietary fiber component which concerns on this embodiment contained.
Although the mechanism by which the blood alcohol concentration decreases by ingesting the dietary fiber component according to this embodiment is not clear, it is considered that the dietary fiber component according to this embodiment suppresses the absorption of alcohol in the body. . If this point is demonstrated concretely, the dietary fiber component which concerns on this embodiment is excellent in the capability to absorb and hold | maintain ethanol in the in-vivo environment. Therefore, when the dietary fiber component according to the present embodiment is present in the body, the ethanol ingested by the dietary fiber component is preferentially absorbed. As a result, it is considered that the amount of ethanol absorbed by the body decreases and the blood alcohol concentration decreases.
本実施形態に係る食物繊維成分の飲食品中における含有割合は特に限定されず適宜設定できる。例えば、本実施形態の飲食品が飲料である場合、当該飲料中に、本実施形態に係る食物繊維成分が0.3g/100ml以上の割合で含有されることが好ましく、より好ましくは0.5g/100ml以上である。さらに好ましくは0.7g/100ml以上である。飲料中に含まれる本実施形態に係る食物繊維成分の割合が0.3g/100ml未満であると、範囲内にある場合と比較して、血中アルコール濃度低下作用が不十分になる場合がある。一方、飲みやすさの観点から、本実施形態に係る食物繊維成分の割合は、1.0g/100ml以下であることが好ましい。 The content rate in the food / beverage products of the dietary fiber component which concerns on this embodiment is not specifically limited, It can set suitably. For example, when the food or drink of the present embodiment is a beverage, the dietary fiber component according to the present embodiment is preferably contained in the beverage at a ratio of 0.3 g / 100 ml or more, more preferably 0.5 g / 100 ml. That's it. More preferably, it is 0.7 g / 100 ml or more. When the proportion of the dietary fiber component according to the present embodiment contained in the beverage is less than 0.3 g / 100 ml, the blood alcohol concentration lowering action may be insufficient as compared with the case where it is within the range. On the other hand, from the viewpoint of ease of drinking, the proportion of the dietary fiber component according to this embodiment is preferably 1.0 g / 100 ml or less.
また、本実施形態の飲食品が固形食品等である場合、当該固形食品等中に、本実施形態に係る食物繊維成分が1回当たり0.3 g以上含有されることが好ましく、より好ましくは0.5 g以上、さらにより好ましくは0.7g以上である。0.3 g未満であると、範囲内にある場合と比較して、血中アルコール濃度低下作用が不十分になる場合がある。一方、健康上の観点から、本実施形態に係る食物繊維成分は、1回当たり25g以下であることが好ましい。 Further, when the food or drink of the present embodiment is a solid food or the like, it is preferable that the dietary fiber component according to the present embodiment is contained in the solid food or the like in an amount of 0.3 g or more, more preferably 0.5 g. Above, still more preferably 0.7 g or more. If it is less than 0.3 g, the effect of lowering the blood alcohol concentration may be insufficient as compared with the case of being within the range. On the other hand, from the viewpoint of health, the dietary fiber component according to this embodiment is preferably 25 g or less per time.
本実施形態の飲食品は、上述の本実施形態に係る食物繊維成分に加えて、アラニンを含有するようにしてもよい。アラニンは、たん白質を構成する中性のアミノ酸の一つである。アラニンは自然界に広く存在しており、例えば、魚介類に多く含まれている。また、アラニンは、食品衛生法（昭和22年法律第233号）第11条第3項の規定に基づき、人の健康を損なうおそれのないことが明らかであるものとして厚生労働大臣が定める物質である。そのため、アラニンは食品添加物として広く使用されている。本実施形態の飲食品に含有されてもよいアラニンは、市販されているものでよく、ラセミ体でもD体でもL体でもよい。
本実施形態に係る食物繊維成分に加えてアラニンを含有することにより、本実施形態の飲食品による血中アルコール濃度低下作用をさらに高めることができる。The food and drink of this embodiment may contain alanine in addition to the above-described dietary fiber component according to this embodiment. Alanine is one of the neutral amino acids that make up protein. Alanine is widely present in nature, and is abundant in, for example, seafood. In addition, alanine is a substance specified by the Minister of Health, Labor and Welfare based on the provisions of Article 11, Paragraph 3 of the Food Sanitation Law (Act No. 233 of 1947) that it is clear that there is no risk of harming human health. is there. Therefore, alanine is widely used as a food additive. The alanine that may be contained in the food or drink of the present embodiment may be commercially available, and may be racemic, D-form, or L-form.
By containing alanine in addition to the dietary fiber component according to this embodiment, the blood alcohol concentration lowering effect by the food or drink of this embodiment can be further enhanced.
本実施形態の飲食品中のアラニンの含有量も適宜設定でき、特に限定されない。一方で、血中のアルコール濃度低下作用向上の観点から、本実施形態の飲食品が飲料である場合、当該飲料中に、3.0g/100ml以上含有されることが好ましい。また、本実施形態の飲食品が固形食品等である場合にも、血中のアルコール濃度低下作用向上の観点から、当該固形食品等中に3.0g以上含有されることが好ましい。
なお、摂取量が１回当たり20gを超えると、アラニン自体に毒性は無いものの、アミノ酸摂取比率のバランスが崩れる可能性がある。The content of alanine in the food / beverage products of this embodiment can also be set suitably, and is not specifically limited. On the other hand, from the viewpoint of improving the action of lowering the alcohol concentration in blood, when the food or drink of this embodiment is a beverage, it is preferably contained in the beverage at 3.0 g / 100 ml or more. Moreover, also when the food / beverage products of this embodiment are solid foods etc., it is preferable that 3.0g or more is contained in the said solid foods etc. from a viewpoint of the alcohol concentration fall effect | action improvement in blood.
In addition, if the intake amount exceeds 20 g per dose, although the alanine itself is not toxic, the balance of the amino acid intake ratio may be lost.
また、血中のアルコール濃度低下作用向上の観点から、本実施形態に係る食物繊維成分およびアラニンの割合は、以下のようにすることもできる。
例えば、本実施形態の飲食品が飲料である場合、飲料中の本実施形態に係る食物繊維成分およびアラニンの割合は、本実施形態に係る食物繊維成分：0.3 g/100ml以上、アラニン：3.0g/100ml以上とすることが挙げられる。
また、本実施形態の飲食品が固形食品等である場合には、固形食品等中の本実施形態に係る食物繊維成分およびアラニンの割合は、本実施形態に係る食物繊維成分：0.3 g以上、アラニン：3.0g以上とすることが挙げられる。Moreover, the ratio of the dietary fiber component and alanine which concerns on this embodiment can also be made into the following from a viewpoint of the alcohol concentration reduction effect | action improvement in blood.
For example, when the food and drink of this embodiment is a beverage, the ratio of dietary fiber component and alanine according to this embodiment in the beverage is as follows: dietary fiber component according to this embodiment: 0.3 g / 100 ml or more, alanine: 3.0 g / 100ml or more.
In addition, when the food or drink of this embodiment is a solid food or the like, the ratio of the dietary fiber component and alanine according to this embodiment in the solid food or the like is the dietary fiber component according to this embodiment: 0.3 g or more, Alanine: It is mentioned to be 3.0g or more.
また、特に限定されないが、飲料中のアラニン溶解性の観点から、本実施形態の飲食品が飲料である場合のアラニンは、3.0〜30g/100mlの割合で含有されることが好ましい。
本実施形態の飲食品が飲料である場合における本実施形態に係る食物繊維成分、アラニン含有量の割合の一例としては、食物繊維成分：0.3〜1.0g/100ml、アラニン：3.0〜30 g/100ml、好ましくは食物繊維成分：0.5〜1.0g/100ml、アラニン：3.0〜30 g/100ml、より好ましくは食物繊維成分：0.7〜1.0g/100ml、アラニン：3.0〜30 g/100mlとすることを挙げることができる。また、食物繊維成分としてキサンタンガムが含有されることが好ましい。
本実施形態の飲食品が固形食品等である場合における本実施形態に係る食物繊維成分、アラニン含有量の割合の一例としては、食物繊維成分：0.3〜25g、アラニン：3.0〜5.0g、好ましくは食物繊維成分：0.5〜25g、アラニン：3.0〜5.0g、より好ましくは食物繊維成分：0.7〜25g、アラニン：3.0〜5.0gとすることを挙げることができる。また、食物繊維成分としてキサンタンガムが含有されることが好ましい。Moreover, although it does not specifically limit, it is preferable that alanine in the case where the food / beverage products of this embodiment are a drink from a viewpoint of the alanine solubility in a drink in the ratio of 3.0-30 g / 100ml.
As an example of the ratio of dietary fiber component and alanine content according to the present embodiment when the food or drink of the present embodiment is a beverage, dietary fiber component: 0.3 to 1.0 g / 100 ml, alanine: 3.0 to 30 g / 100 ml , Preferably dietary fiber component: 0.5-1.0 g / 100 ml, alanine: 3.0-30 g / 100 ml, more preferably dietary fiber component: 0.7-1.0 g / 100 ml, alanine: 3.0-30 g / 100 ml be able to. Moreover, it is preferable that xanthan gum is contained as a dietary fiber component.
As an example of the ratio of the dietary fiber component and alanine content according to this embodiment in the case where the food or drink of the present embodiment is a solid food or the like, dietary fiber component: 0.3 to 25 g, alanine: 3.0 to 5.0 g, preferably Dietary fiber component: 0.5 to 25 g, alanine: 3.0 to 5.0 g, more preferably dietary fiber component: 0.7 to 25 g, alanine: 3.0 to 5.0 g. Moreover, it is preferable that xanthan gum is contained as a dietary fiber component.
その他、本実施形態の飲食品は、本実施形態に係る食物繊維成分、含有されてもよいアラニンに加えて、他の成分を含有していてもよい。当該他の成分は、飲食品の種類などに応じて適宜選択され、特に限定されない。例えば、本実施形態の飲食品が飲料である場合などは、水、アルコールなどのほか、甘味料、香料、ビタミン及び着色料等の添加物が含有されるようにすることができる。 In addition, in addition to the dietary fiber component which concerns on this embodiment, and the alanine which may be contained, the food / beverage products of this embodiment may contain the other component. The other components are appropriately selected according to the type of food and drink, and are not particularly limited. For example, when the food or drink of the present embodiment is a beverage, additives such as sweeteners, fragrances, vitamins, and coloring agents can be contained in addition to water and alcohol.
続いて、本実施形態の飲食品の製造方法について説明する。
本実施形態の飲食品は、本実施形態に係る食物繊維成分を用いて例えば通常知られる飲食品の形態を構成することにより製造でき、特に限定されない。また本実施形態に係る食物繊維成分とともに含有されていてもよいアラニンの添加方法についても特に限定されず、当業者が適宜設定することができる。Then, the manufacturing method of the food / beverage products of this embodiment is demonstrated.
The food / beverage products of this embodiment can be manufactured by comprising the form of the food / beverage products normally known, for example using the dietary fiber component which concerns on this embodiment, and are not specifically limited. Moreover, it does not specifically limit about the addition method of the alanine which may be contained with the dietary fiber component which concerns on this embodiment, Those skilled in the art can set suitably.
例えば、本実施形態の飲食品が飲料である場合は、本実施形態に係る食物繊維成分を飲用水等のその他原料と混合するなどして製造することができる。 For example, when the food / beverage products of this embodiment are drinks, it can be manufactured by mixing the dietary fiber component according to this embodiment with other raw materials such as drinking water.
また、例えば、本実施形態の飲食品が顆粒状の形態を有している食品として調製される場合は、本実施形態に係る食物繊維成分と賦形剤等の他の成分とを混合し、造粒、および整粒するなどして製造することができる。また、錠剤状の形態を有している食品についても造粒、整粒工程等を経た混合物を打錠するなどして製造することができる。 In addition, for example, when the food or drink of the present embodiment is prepared as a food having a granular form, the dietary fiber component according to the present embodiment and other components such as excipients are mixed, It can be produced by granulation and sizing. In addition, foods having a tablet-like form can also be produced by tableting a mixture that has undergone granulation, sizing process, and the like.
以上、本実施形態によれば、飲酒後の血中アルコール濃度低下作用を有する新規な飲食品を提供することができる。
本実施形態の飲食品は、飲酒後の血中アルコール濃度低減剤、又は酒酔い防止剤として使用することができる。本実施形態の飲食品をヒトに摂取させる場合、摂取量は目的に応じて適量を決定すればよい。例えば、飲料の場合は、摂取される際に100ml以上摂取されるようにすることができる。また、固形食品等の場合も、摂取される際に本実施形態に係る食物繊維成分が0.3g以上摂取される量以上とすることができる。
また、本実施形態の飲食品は、飲酒前、飲酒中又は飲酒後のいずれにおいて摂取してもよい。本実施形態の飲食品は血中アルコール濃度を低減する効率が高く、飲酒後に摂取した場合でも血中アルコール濃度低減効果を発揮する。As mentioned above, according to this embodiment, the novel food-drinks which have the blood alcohol concentration fall effect | action after drinking can be provided.
The food / beverage products of this embodiment can be used as a blood alcohol concentration-reducing agent after drinking, or a drunk prevention agent. When a human being ingests the food or drink of the present embodiment, the intake amount may be determined as appropriate according to the purpose. For example, in the case of a drink, 100 ml or more can be taken when taken. Moreover, also in the case of a solid food etc., when it is ingested, it can be more than the quantity which the dietary fiber component which concerns on this embodiment is ingested 0.3g or more.
Moreover, you may ingest the food-drinks of this embodiment before drinking, during drinking, or after drinking. The food / beverage products of this embodiment are highly efficient in reducing the blood alcohol concentration, and exhibit the blood alcohol concentration reducing effect even when ingested after drinking.
以下の実施例により本発明を更に具体的に説明するが、本発明はこれらに限定されない。 The following examples further illustrate the present invention, but the present invention is not limited thereto.
［ラットを用いての試験］
6週齢以上の雄性F344ラットに、食物繊維素材14種類（キサンタンガム、カラギーナン、ペクチン、ジェランガム、タマリンド種子多糖類、グアーガム、ローカストビーンガム、グルコマンナン、キトサン、イヌリン、セルロース、寒天、難消化性デキストリン、ポリデキストロース）をそれぞれ水に0.3〜1.25%（w/v）になるよう溶解あるいは懸濁させ、20ml/kg体重で強制胃内投与した。その30分後と1時間後にアルコールを2.0g/kg体重でそれぞれ投与した（トータルでのアルコール投与量は4.0g/kg体重）。その4時間後に尾静脈から50μl採血し、血中アルコール濃度（mg/ml）をヘッドスペースGC-MSにて測定した。なお、有意差検定はStudent’s t-testにより行った（有意水準：5%）。[Test using rats]
Male F344 rats over 6 weeks old with 14 dietary fiber materials (xanthan gum, carrageenan, pectin, gellan gum, tamarind seed polysaccharide, guar gum, locust bean gum, glucomannan, chitosan, inulin, cellulose, agar, indigestible dextrin , Polydextrose) were dissolved or suspended in water to a concentration of 0.3 to 1.25% (w / v), respectively, and were forcibly administered intragastrically at 20 ml / kg body weight. Thirty minutes and one hour later, alcohol was administered at 2.0 g / kg body weight (total alcohol dosage was 4.0 g / kg body weight). Four hours later, 50 μl of blood was collected from the tail vein, and blood alcohol concentration (mg / ml) was measured by headspace GC-MS. The significance test was performed by Student's t-test (significance level: 5%).
１４種類の食物繊維素材のうち、キサンタンガム、グルコマンナン、ゲランガム（ジェランガム）、カラギーナンに抗アルコール作用（血中アルコール低下作用）があることを発見した。その効果は0.3%（w/v）以上、好ましくは0.7%（w/v）以上の場合において発揮され、濃度を高めるとその効果は強くなった。さらに、これらにアラニンを加えると、カラギーナンを除く３種いずれも効果が増強されることを見出した。その増強効果はアラニン3.0%（w/v）以上で発揮されることが分かった。また、キサンタンガムについて、特に高い血中アルコール低下作用が確認できた。
なお、同様の方法でアラニン単独での投与を行ったところ、その割合が3.0%（w/v）であってもアルコール濃度低下作用は認められなかった。また、表１から理解できるように、アラニンの添加量を減らして2.0%添加にした場合は血中アルコール濃度が低下傾向にあるものの有意な増強効果は得られなかった。Among the 14 types of dietary fiber materials, it was discovered that xanthan gum, glucomannan, gellan gum (gellan gum), and carrageenan have anti-alcohol action (blood alcohol lowering action). The effect was exhibited in the case of 0.3% (w / v) or more, preferably 0.7% (w / v) or more, and the effect became stronger as the concentration was increased. Furthermore, when alanine was added to these, it discovered that all three types except carrageenan enhanced an effect. It was found that the enhancing effect is exhibited at alanine of 3.0% (w / v) or more. Moreover, particularly high blood alcohol lowering action was confirmed for xanthan gum.
In addition, when alanine alone was administered by the same method, even if the ratio was 3.0% (w / v), the effect of reducing the alcohol concentration was not observed. As can be seen from Table 1, when the amount of alanine added was reduced to 2.0%, the blood alcohol concentration tended to decrease, but no significant enhancement effect was obtained.
[ヒトにおける試験]
試験はクロスオーバー法に従い実施した。被験者を無作為に２群に分け、いずれかの被験食品（１００ｇ）を摂取し、その30分後に12.5度の甲類焼酎（0.32g/kg体重のアルコール量）を５分以内に摂取した。飲み終えた時間を0分とし、経時的に呼気アルコール濃度を測定した。[Human studies]
The test was performed according to the crossover method. The subjects were randomly divided into two groups, and one of the test foods (100 g) was ingested, and 30 minutes later, 12.5 degrees crustacean shochu (0.32 g / kg body weight of alcohol) was ingested within 5 minutes. The expiration time was 0 minutes, and the breath alcohol concentration was measured over time.
対照は、キサンタンガムの代わりにグアーガム、アラニンの代わりにデキストリンをそれぞれ同量混合摂取した。キサンタンガム＋アラニンはいずれの摂取量においても対照に比べて有意に呼気アルコール濃度が低下し、キサンタンガム量が多い試験IIでより強い効果を示した。ＡＵＣ（呼気アルコール濃度下面積）はみかけのアルコール吸収量を表すパラメータであり、有意に低下した。また、時間当たりのアルコール分解能力が高まり、体内からアルコールが消失する時間が早くなった。 For the control, guar gum instead of xanthan gum and dextrin instead of alanine were mixed in the same amount. Xanthan gum + alanine significantly decreased the breath alcohol concentration compared to the control at any intake, and showed a stronger effect in Test II with a high amount of xanthan gum. AUC (area under the breath alcohol concentration) is a parameter representing the apparent amount of alcohol absorbed and was significantly reduced. In addition, the ability to decompose alcohol per hour increased, and the time for alcohol to disappear from the body was accelerated.
Claims (5)
前記食物繊維成分を少なくとも0.3 g/100mlの割合で含有し、且つアラニンを少なくとも3.0g/100mlの割合で含有する飲料、または前記食物繊維成分を少なくとも0.3 g含有し、且つアラニンを少なくとも3.0g含有する固形または半固形の食品である飲食品。A food or drink containing a dietary fiber component selected from one or more of the group consisting of xanthan gum, glucomannan and gellan gum,
A beverage containing at least 0.3 g / 100 ml of the dietary fiber component and containing at least 3.0 g / 100 ml of alanine, or containing at least 0.3 g of the dietary fiber component and containing at least 3.0 g of alanine A food or drink that is a solid or semi-solid food.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6354320A (en) * | 1986-08-26 | 1988-03-08 | Ajinomoto Co Inc | Anti-alcoholic disease composition |
| JPH01256352A (en) * | 1988-04-01 | 1989-10-12 | Terumo Corp | Food for preventing aftereffect of night's drink and production thereof |
| JPH01256351A (en) * | 1988-04-01 | 1989-10-12 | Terumo Corp | Food using silk protein and production thereof |
| JP2009106217A (en) * | 2007-10-31 | 2009-05-21 | Ajinomoto Co Inc | Food composition containing thickener and amino acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6354320A (en) * | 1986-08-26 | 1988-03-08 | Ajinomoto Co Inc | Anti-alcoholic disease composition |
| JPH01256352A (en) * | 1988-04-01 | 1989-10-12 | Terumo Corp | Food for preventing aftereffect of night's drink and production thereof |
| JPH01256351A (en) * | 1988-04-01 | 1989-10-12 | Terumo Corp | Food using silk protein and production thereof |
| JP2009106217A (en) * | 2007-10-31 | 2009-05-21 | Ajinomoto Co Inc | Food composition containing thickener and amino acid |
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