JP6569642B2 - Internal liquid - Google Patents

Description

  The present invention relates to an internal solution containing liver hydrolyzate and turmeric extract.

  Turmeric extract contains curcumin, the yellow pigment of turmeric, and has the action to prevent hangover and hangover, anti-inflammatory action, anti-tumor action, antioxidant action, etc., so it is formulated in functional foods and health drinks. (Patent Documents 1 and 2). On the other hand, liver hydrolyzate has a nutritional tonic effect, liver function improving effect, and the like, and is therefore blended in pharmaceuticals, functional foods, and health drinks (Patent Document 3 and the like). An internal solution containing a turmeric extract and a liver extract has been developed and is commercially available.

JP2012-031080A JP 2011-250709 A JP 2013-95670 A

However, with regard to the internal solution containing liver hydrolyzate and turmeric extract, when the pH is adjusted to 3.5 or less in order to improve the taste of the internal solution, precipitation that greatly impairs the product value due to storage occurs. It has been found that a problem arises that the turbid state cannot be maintained.
Accordingly, an object of the present invention is to provide an internal preparation having a good taste and excellent storage stability, which contains liver hydrolyzate and turmeric extract.

  Therefore, the present inventors have made various studies aiming to achieve both the storage stability and taste of the internal liquid preparation containing liver hydrolyzate and turmeric extract, and as a result, the pH of the internal liquid preparation is 3.5 or less, and xanthan gum, When a component selected from pectin, chondroitin sulfate or a salt thereof, alginic acid or a salt thereof and carrageenan is added, the stability is significantly improved and the taste is improved as compared with the case where other various polysaccharides are added. As a result, the present invention has been completed. In addition, by adding microcrystalline cellulose to this, it was found that the slightly generated precipitate was fixed to the bottom of the container, and by adding carbon dioxide, the taste was further improved and it became easier to drink.

  That is, the present invention provides the following [1] to [5].

[1] containing one or more selected from (A) liver hydrolyzate, (B) turmeric extract and (C) xanthan gum, pectin, chondroitin sulfate or salt thereof, alginic acid or salt thereof, and carrageenan, A liquid for internal use having a pH of 3.5 or less.
[2] The internal solution according to [1], wherein the content of the component (C) is 0.02 to 0.2 w / v%. [3] The content of component (A) is 0.001 to 1.0 w / v%, and the content of component (B) is 0.005 to 0.1 w / v% as curcumin [1] or [ 2] The liquid for internal use as described.
[4] The internal liquid preparation according to any one of [1] to [3], further containing microcrystalline cellulose. [5] The internal liquid preparation according to any one of [1] to [4], further containing carbon dioxide.

  The liquid preparation for internal use of the present invention contains a liver hydrolyzate and a turmeric extract, prevents the occurrence of precipitation due to storage, and maintains a suspended state, so that it is excellent in dosing and has a good flavor. Moreover, when microcrystalline cellulose is mix | blended, the adhesion | attachment to the container bottom part of the precipitation which generate | occur | produces slightly will be prevented, and if carbon dioxide is mix | blended, a flavor will improve further.

  The internal use liquid preparation of the present invention is one or two selected from (A) liver hydrolyzate, (B) turmeric extract and (C) xanthan gum, pectin, chondroitin sulfate or salt thereof, alginic acid or salt thereof, and carrageenan. It contains the above, It is characterized by pH being 3.5 or less.

  (A) Liver hydrolyzate is also called liver hydrolyzate, liver extract, liver decomposed extract, liver hydrolyzate, and is obtained by hydrolyzing the liver with digestive enzymes, etc., and used as a liver function improving drug It is what has been. As a raw material, fresh non-human animal livers such as cows, pigs and skipjack are used.

  (A) The content of the liver hydrolyzate is preferably 0.001 to 1.0 w / v% in the internal liquid preparation of the present invention from the viewpoint of effectiveness, storage stability and taste, and is preferably 0.01 to 0.00%. 6 w / v% is more preferable, and 0.05 to 0.5 w / v% is more preferable.

  (B) In the present invention, the turmeric extract is a rhizome extract of Ginger family turmeric, and preferably contains a turmeric pigment. Here, the turmeric pigment is obtained, for example, by extraction from a dried product of turmeric rhizomes with hot ethanol, hot oil or propylene glycol, or room temperature to hot hexane or acetone. Examples of the pigment include curcumin. In addition to the turmeric pigment, other turmeric extracts (eg, turmeric water, hot water, or an extract of a mixed solvent of water and a hydrophilic organic solvent (eg, ethanol)) may be included. The mixing ratio of the mixed solvent of water and the hydrophilic organic solvent is not particularly limited. For example, the weight ratio is preferably in the range of 10:90 to 90:10, and more preferably in the range of 50:50 to 80:20.

  In the present invention, the turmeric extract is preferably a turmeric extract that is finely divided to improve dispersibility and oral absorbability. The micronized turmeric extract refers to a product prepared by subjecting the turmeric pigment or the turmeric extract other than the turmeric pigment to a micronization treatment (grinding treatment) by a known method, for example, the following method.

The physical properties of the micronized turmeric extract preferably comprise at least one of the following characteristics, more preferably both.
(1) The center particle diameter (median diameter: d50) is 5 μm or less, preferably 2 μm or less, more preferably 1 μm or less. Although the minimum of the said center particle diameter is not specifically limited, 0.5 micrometer or more is preferable.

  As the fine particle treatment method, a known method can be used as a fine particle treatment method for a poorly water-soluble substance. For example, a method in which a solution in which a turmeric pigment is dissolved in a hydrophilic organic solvent such as ethanol is dispersed in an aqueous solvent to form fine particles, or a mixture of a turmeric pigment and an emulsifier is pulverized, or And a method of pulverizing a dispersion obtained by dispersing a turmeric pigment in an aqueous solvent containing an emulsifier, a polysaccharide and the like. The finely divided turmeric extract obtained by pulverizing a dispersion obtained by dispersing a turmeric pigment in an aqueous solvent containing an emulsifier, or by pulverizing a mixture of turmeric pigment and an emulsifier is the present invention. Are particularly preferably used.

Examples of the fine particle treatment method include the following methods.
(1) A method of producing an emulsified preparation of a turmeric pigment by pulverizing a turmeric pigment, a polyhydric alcohol, and an emulsifier with a homomixer or the like (Japanese Patent Laid-Open No. 2004-208555).

(2) A method in which an alcohol (ethanol) solution in which a turmeric pigment is dissolved is dispersed in water to form a dispersion in which the turmeric pigment is finely divided in an aqueous system, and an emulsifier is added thereto to bind to the fine particles and stabilize ( JP, 2005-328839, A).

(3) The turmeric pigment is micronized in the presence of an aqueous solvent in which an emulsifier is dissolved or dispersed, and the emulsifier is selected from polyglycerin fatty acid ester, sucrose fatty acid ester, and modified lecithin having an HLB value of 9 or more 1 type or 2 types or more are used, and 1 type, or 2 or more types selected from water and glycerin is used as an aqueous solvent (Japanese Patent Laid-Open No. 2009-201371).

  Turmeric extracts other than turmeric pigments can also be microparticulated by the method described above.

  (B) The content of the turmeric extract in the liquid for internal use of the present invention is preferably 0.005 to 0.1 w / v% as curcumin from the viewpoint of effectiveness, storage stability and taste, and 0.01 to 0.1 w. / V% is more preferable, and 0.02 to 0.1 w / v% is more preferable.

  In the internal use liquid preparation of the present invention, blending one or two or more selected from xanthan gum, pectin, chondroitin sulfate or a salt thereof, alginic acid or a salt thereof and carrageenan prevents the occurrence of precipitation after storage and is good. This is important in maintaining dispersibility. Polysaccharides other than component (C), such as locust bean gum, soybean dietary fiber, guar gum, tamarind seed gum, succinoglycan, methylcellulose, hydroxypropylmethylcellulose, polydextrose, agar, and dextrin are replaced with the polysaccharide of the present invention. However, it has been confirmed that precipitation after storage cannot be prevented.

  (C) Xanthan gum is a natural polysaccharide obtained by fermenting starch with Xanthomonas campestris, and is composed of glucose, mannose and glucuronic acid.

  Pectin is a complex polysaccharide contained in plant cell walls and middle leaves, and is mainly composed of polygalacturonic acid. There are HM pectin having a degree of esterification of galacturonic acid of 50% or more and LM pectin having a degree of esterification of less than 50%, both of which can be used in the present invention.

  Chondroitin sulfate is a kind of proteoglycan present in animal tissues and the like, and is a polysaccharide having a structure in which a sulfate group is bonded to a sugar chain in which N-acetyl-D-galactosamine and D-glucuronic acid are repeatedly bonded. In the present invention, it is preferably used in the form of a salt such as sodium chondroitin sulfate.

  Alginic acid is a kind of polysaccharide mainly contained in brown algae. It has a structure in which α-L-guluronic acid and β-D-mannuronic acid are linked by a 1,4-glycoside bond in a pyranose type. Alginic acid is preferably used in the form of a salt such as sodium alginate.

  Carrageenan is a kind of linear sulfur-containing polysaccharide extracted mainly from red algae, and is a polymer compound composed of D-galactose (or 3,6-anhydro-D-galactose) and sulfuric acid.

  In the present invention, one or more of these components (C) can be used. Of these components (C), xanthan gum is more preferable because of its particularly good storage stability. When xanthan gum is adopted as the component (C), another component (C) may be blended.

  The content of the component (C) in the liquid preparation for internal use of the present invention is preferably 0.02 to 0.2 w / v% from the viewpoint of storage stability and taste, and preferably 0.02 to 0.1 w / v. % Is more preferable, 0.02 to 0.08 w / v% is more preferable, and 0.02 to 0.05 w / v% is most preferable.

  The pH of the internal solution of the present invention is 3.5 or less in order to improve the taste. When the pH is higher than 3.5, the taste becomes worse. The lower limit of the pH is not particularly limited, but is preferably 2.5 or more and more preferably 2.8 or more from the viewpoint of stably storing the internal solution for a long period of time.

Moreover, it is preferable to mix | blend microcrystalline cellulose with the liquid medicine for internal use of this invention, in order to prevent the precipitation which generate | occur | produces slightly after a preservation | save to the container bottom part. Microcrystalline cellulose is obtained by partially depolymerizing and purifying α-cellulose obtained from a fibrous plant with an acid, and is widely used as a pharmaceutical additive.
The content of microcrystalline cellulose is preferably 0.003 to 0.1 w / v% in the liquid for internal use of the present invention, from the viewpoints of preventing precipitation after storage and preventing the precipitation from adhering to the bottom of the container. 0.006 to 0.05 w / v% is more preferable.

Moreover, it is preferable that the liquid for internal use of this invention contains a carbon dioxide from the point of flavor improvement. If carbon dioxide is contained, it becomes a carbonated beverage and the feeling of dosing is improved.
The amount of carbon dioxide enclosed in the internal liquid preparation of the present invention is preferably 1.2 to 4.0 in terms of gas volume [the amount of carbon dioxide dissolved in the internal liquid (v / v)]. 5-3.0 is more preferable. The gas volume in the present invention is obtained by dividing the volume of carbon dioxide dissolved in the internal solution at 1 atm 15.6 ° C. by the volume of the internal solution.

  In addition to the above components, the internal use liquid preparation of the present invention includes other active ingredients, flavoring agents, sweeteners, stabilizers, solubilizers, pH adjusters, colorants, flavors, water, ethanol, propylene glycol, Glycerin etc. can be mix | blended. Other active ingredients include vitamin B1, vitamin B2, vitamin B6, niacin, pantothenic acid, vitamin B12, vitamin C, taurine and the like. Of these, vitamin B1 is preferably contained in an amount of 0.001 to 0.03 w / v%, vitamin B2 is preferably contained in an amount of 0.001 to 0.03 w / v%, and vitamin B6 is contained in an amount of 0.001 to 0.03. It is preferable to contain 1 w / v%, and it is preferable to contain niacin 0.001-0.1 w / v%.

  The liquid for internal use of this invention can be used as a pharmaceutical, a functional food, a health drink, a carbonated drink, and a soft drink. In particular, it can be taken for the purpose of prevention of hangover, prevention of hangover, improvement of liver function, nutrition and tonic, nutritional supplement, etc., and 50 to 200 mL is preferable as a single dose.

  EXAMPLES Next, an Example is given and this invention is demonstrated still in detail.

Example 1
1 g of liver extract, 2.7 g of micronized turmeric extract, 3 g of citric acid, 0.65 g of sodium citrate, 0.5 g of xanthan gum, 90 g of fructose-glucose liquid sugar, an appropriate amount of fragrance are dissolved in an appropriate amount of purified water or hot water, and then purified water The total volume was 1000 mL. The micronized turmeric extract is a turmeric extract micronized by wet pulverization containing 23 parts by weight of a dried product of ethanol extracted from turmeric, the curcumin content is 20 parts by weight, and the center particle size is 0.8 μm. Met.

Example 2
1 g of liver extract, 2.7 g of micronized turmeric extract, 3 g of citric acid, 0.65 g of sodium citrate, 0.5 g of xanthan gum, 0.07 g of microcrystalline cellulose, 90 g of fructose-glucose liquid sugar, appropriate amount of fragrance and purified water or hot water After being dissolved in the solution, an aqueous solution having a total volume of 1000 mL was made with purified water, and carbon dioxide was sealed therein so that the gas volume was 2 to obtain an internal solution.

Examples 17-21 and Comparative Examples 1-12
In the same manner as in Example 1, internal liquid preparations shown in Tables 1 to 3 were obtained.

Examples 3-16
In the same manner as in Example 2, liquid preparations for internal use shown in Tables 1 and 2 were obtained.

(Test and evaluation)
(1) Stability over time After the obtained internal preparation was stored at 60 ° C. for 1 week, the precipitation amount, suspension state, and redispersibility of the precipitate were evaluated.
(Precipitation amount)
Very many: ×
Many: △
Slightly less: ○
Less: ◎
(Suspended state)
Changing: ×
Somewhat changed: △
Almost no change: ○
No change: ◎
(Redispersibility of precipitation)
Difficult to redisperse: ×
Slightly difficult to redisperse: △
Easy to redisperse: ○
Very easy to re-disperse: ◎

(2) Ingestion feeling A special panelist took the obtained liquid for internal use and evaluated the ingestion feeling.
Difficult to take ： ×
Slightly difficult to take: △
Slightly easy to take: ○
Easy to take ： ◎
Very easy to take: ◎◎

  The results are shown in Tables 1 to 3.

1 to 3 selected from (C) xanthan gum, pectin, chondroitin sulfate or a salt thereof, alginic acid or a salt thereof, and carrageenan from Tables 1 to 3 as (A) liver hydrolyzate and (B) a turmeric extract. If seeds or two or more kinds were blended and the pH was 3.5 or less, the occurrence of precipitation could be prevented even after storage, and the feeling of dosing was good. In addition, when microcrystalline cellulose was added to this, precipitation was prevented from sticking to the bottom of the container. Moreover, if carbon dioxide was blended, the flavor was further improved.
On the other hand, when the component (C) is not blended (Comparative Example 1), when the pH is higher than 3.5 (Comparative Example 2), when a polysaccharide other than the component (C) is blended (Comparative Example 3) ~ 12) were poor in storage stability and flavor.

Claims (4)

  (A) One or more selected from (C) xanthan gum, pectin, chondroitin sulfate or a salt thereof, alginic acid or a salt thereof, and carrageenan in an internal solution containing a liver hydrolyzate and (B) a turmeric extract A method for preventing precipitation of an internal liquid preparation, characterized in that the pH is 3.5 or less. In the final internal solution, the content of component (A) is 0.001 to 1.0 w / v%, the content of component (B) is 0.005 to 0.1 w / v% as curcumin, component (C ) Content of 0.02 to 0.2 w / v% . Furthermore, the precipitation prevention method of Claim 1 or 2 which mix | blends microcrystalline cellulose. Furthermore, the precipitation prevention method of any one of Claims 1-3 which mix | blends a carbon dioxide.