JPWO2014171538A1 - Support for patch and patch using the same - Google Patents

Abstract

To provide a support for a patch and a patch using the same, which are excellent in handleability, usability and adhesion to the skin when used in a patch, and hardly cause back stain when used in a patch. . A patch support comprising a knitted fabric made of fibers having a crimp rate of 45% or more and a denier number of 55 or less.

Description

  The present invention relates to a patch support and a patch using the same.

  In Japan, which has been facing an aging society for a long time, many elderly people have joint pain, low back pain, and neuralgia in the knees, elbows, ankles, and hips. As a means of treating these chronic diseases, internal medicines and patches are applied, but internal medicines are formulated with anti-inflammatory analgesics such as NSAIDs and can induce gastrointestinal disorders as side effects. is there.

  On the other hand, the above-mentioned side effects can be avoided by applying a patch, particularly a locally active preparation. Such a patch is required to have less discomfort during use and to follow the movement of the joint when applied to the joint or its vicinity.

JP-A-5-309128 JP 7-53357 A JP-A-7-69870 Japanese Patent Laid-Open No. 7-126155 JP 2005-281202 A

Supports for various patches have been developed to satisfy the above requirements (Patent Documents 1 to 5), but patches using conventional supports are difficult to take out from the storage bag and have poor handleability. There are problems such as uncomfortable interference and friction with clothes such as shirts, inferior feeling of use, corners easily peeling off and insufficient adhesion, etc., and satisfying these handling characteristics, feeling of use and adhesion at the same time Was difficult.
In addition, when a knitted fabric made using a fiber having a small denier number is used as a support for a patch, a back stain of a component contained in the adhesive base layer occurs between the fibers. .
Accordingly, an object of the present invention is to provide a support for a patch and a support for the patch that are excellent in handleability when used in a patch, a feeling of use and adhesion to the skin, and hardly cause back stains when used in a patch. It is to provide a patch used.

  Therefore, as a result of intensive studies, the inventor of the present invention uses a fiber having a crimp rate of 45% or more and a denier number of 55 or less, so that the handleability, feeling of use, and skin when used in a patch are used. The present invention has been completed by finding that a support for patch can be obtained which is excellent in adhesiveness and hardly causes back stain when used in a patch.

  That is, the present invention provides a patch support comprising a knitted fabric made of fibers having a crimp rate of 45% or more and a denier number of 55 or less.

  The present invention also provides a patch in which an adhesive base layer is laminated on the support.

The support for a patch of the present invention is excellent in handleability when used in a patch, a feeling of use and adhesion to the skin, and is less likely to cause back stain when used in a patch.
Therefore, the patch of the present invention is excellent in handleability, usability and adhesion to the skin, and hardly causes back stain.

<Support for patch>
The fibers used for the patch support of the present invention have a crimp rate of 45% or more and a denier number of 55 or less. By using such a fiber, the handleability, the feeling of use, and the adhesion to the skin when used in a patch are improved, and the back stain is less likely to occur when used in a patch. In addition, excellent stretchability and anchoring property of the adhesive base are also provided.

The crimp rate is preferably 45 to 80%, more preferably 45 to 70%, still more preferably 45 to 65%, from the viewpoints of prevention of back stain, stretchability, and anchoring property of the adhesive base. And particularly preferably 45 to 60%.
In the present invention, the crimp ratio means a percentage of the difference between the length when the fiber crimp is stretched and the original length to the length when stretched.

The denier number is preferably 5 or more, more preferably 10 or more, and still more preferably, from the viewpoints of feeling when used in a patch and adhesion to the skin, prevention of back stain, and reduction of the burden on the skin. 15 or more, particularly preferably 20 or more, and preferably 55 or less, and particularly preferably 53 or less from the viewpoint of adhesion.
In the present invention, the denier number means the weight (g) of fibers per 9000 m length. For example, the denier number of 1 g of fiber per 9000 m length is 1.

The material of the fiber used for the patch support of the present invention is not particularly limited as long as it is used as the patch support, but synthesis of nylon, polyester, acrylic, polyurethane, polypropylene, vinylon, polyethylene, etc. Examples thereof include filaments of natural materials derived from animals and plants such as fibers and silk. Among these, synthetic fibers are preferable from the viewpoint of stable supply and price, and polyester is preferable from the viewpoints of drug migration from the adhesive base layer to the skin, dimensional stability, and dyeability.
Specific examples of the synthetic fiber include nylon 6, nylon 6,6, ethyl cellulose, cellulose acetate, polyethylene terephthalate, and the like. From the viewpoint of drug migration from the adhesive base layer to the skin, dimensional stability and dyeability. Therefore, polyethylene terephthalate is preferable.

In addition, as a knitted fabric constituting the support for a patch of the present invention, 50% elongation stress and wale (course) in the course direction are used from the viewpoint of suppressing the uncomfortable feeling of the skin of the patch and the ability to follow the skin. The absolute value of the difference from the stress at 50% elongation in the direction of wall is preferably 0 to 500 gf, more preferably 0 to 400 gf, and still more preferably 0 to 300 gf.
Moreover, it is preferable that the 50% elongation stress in the course direction and the 50% elongation stress in the wale direction are both 200 to 900 gf, more preferably 300 to 700 gf. By setting these stresses in the above-mentioned range, it is difficult to cause inversion of the adhesive base layer and the support during the manufacture of the patch and shrinkage after lamination, and the adhesive when used in the patch. The anchorage of the base is improved.
The 50% elongation stress can be measured in the same manner as in the examples described later, and serves as an index of extensibility.

  The ratio of the stress at 50% elongation in the course direction to the stress at 50% elongation in the wale direction [course direction / wale direction] is preferably 0.4 or more from the viewpoint of followability to the skin. More preferably, it is 0.4-1.6, Most preferably, it is 0.6-1.4.

Further, the knitted fabric constituting the patch support of the present invention is preferably one in which only one of the number of courses or the number of wales is 55 or more per inch, more preferably, from the viewpoint of preventing back stain. Only one of them is 55 to 80 per inch, more preferably only one is 55 to 70 per inch, and particularly preferably only one is 55 to 65 per inch.
The other number of courses or wales is preferably 30 to 54 per inch, more preferably 35 to 53 per inch, and particularly preferably 40 to 52 per inch from the same viewpoint as described above.

  Moreover, as thickness of the knitted fabric which comprises the support body for patch of this invention, from a viewpoint of suppressing the thickness of a patch, 0.6 mm or less is preferable and 0.2-0.6 mm is more preferable.

In addition, the knitted fabric constituting the patch support of the present invention preferably has a static friction coefficient and a dynamic friction coefficient of 0.32 or less from the viewpoint of usability and adhesion, and both are 0.1 to 0.32. Are more preferred, and those that are both 0.15 to 0.32 are particularly preferred.
In addition, the static friction coefficient and the dynamic friction coefficient can be set to such ranges by setting the above-described crimp ratio and the denier number to the above ranges.

  The knitted fabric may be manufactured according to a conventional method, and may be either warp knitted or weft knitted. Examples of warp knitting include atlas knitting, chain knitting, cord knitting, and denby knitting, and examples of weft knitting include rubber knitting, pearl knitting, and flat knitting.

  The support for a patch of the present invention is excellent in handleability, usability and adhesion to the skin when used in a patch, and hardly causes back stain when used in a patch. Moreover, since it is thin, flexible, and excellent in stretchability, when used in a patch, it can follow the stretch of the skin, and can suppress the uncomfortable feeling at the time of sticking due to insufficient follow-up. Furthermore, since the adhesive base is excellent in anchoring property to the support, it can be thinned as a patch, has excellent breathability, has excellent therapeutic effects, and has little skin irritation.

<Patch>
The patch of the present invention is one in which an adhesive base layer is laminated on the support.
The pressure-sensitive adhesive base contained in the pressure-sensitive adhesive base layer is roughly classified into two types, a pressure-sensitive pressure-sensitive adhesive base and a poultice base. The pressure-sensitive adhesive base is used for the tape agent, and the poultice base is used for the poultice.

  The pressure-sensitive adhesive base is not particularly limited, and examples thereof include (meth) acrylic adhesives, synthetic rubber adhesives, natural rubber adhesives, and the like. These may be used alone or in combination of two or more. can do. These may be emulsified.

Examples of the (meth) acrylic adhesive include (meth) acrylic acid and (meth) acrylic acid such as sodium (meth) acrylate or salts thereof; (meth) acrylic acid methyl ester, (meth) acrylic acid ethyl Ester, (meth) acrylic acid butyl ester, (meth) acrylic acid octyl ester, (meth) acrylic acid isononyl ester, (meth) acrylic acid 2-ethylhexyl ester, (meth) acrylic acid hydroxyethyl ester, (meth) acrylic Polymers using (meth) acrylic acid alkyl esters as monomers, such as acid dodecyl esters, and copolymers of two or more thereof; (meth) acrylic acid alkyl esters and vinyl acetate, vinyl propionate, styrene, N- Copolymers with vinyl compounds such as vinyl-2-pyrrolidone ((meth) a Acrylic acid alkyl ester - vinyl compound copolymer) and the like. These can be used alone or in combination of two or more.
Specifically, acrylic acid / octyl acrylate ester copolymer, acrylic ester / vinyl acetate copolymer, 2-ethylhexyl acrylate / vinyl pyrrolidone copolymer solution, 2-ethylhexyl acrylate / 2-ethylhexyl methacrylate -Dodecyl methacrylate copolymer solution, ethyl acrylate-methyl methacrylate copolymer dispersion, methyl acrylate-2-ethylhexyl acrylate copolymer resin emulsion, acrylic resin alkanolamine solution, methacrylic acid-n-butyl acrylate copolymer , Silk fibroin acrylate copolymer resin, starch acrylate 300, starch acrylate 1000, butyl acrylate / methacrylic acid 2-ethylhexyl / diacetone acrylamide copolymer, butyl acrylate / methacrylate 2-Hydroxyethyl diacetone acrylamide copolymer, butyl acrylate / ethyl acrylate / methacrylic acid 2-hydroxyethyl / diacetone acrylamide copolymer, butyl acrylate / 2-ethylhexyl acrylate / methacrylic acid 2- Hydroxyethyl / diacetone acrylamide copolymer, isononyl acrylate / methacrylic acid 2-hydroxyethyl / diacetone acrylamide copolymer, 2-ethylhexyl acrylate / methacrylic acid 2-hydroxyethyl / diacetone acrylamide copolymer, acrylic acid Butyl / ethyl acrylate / methacrylic acid 3-hydroxypropyl / methacrylic acid 2-hydroxyethyl / diacetone acrylamide copolymer, butyl acrylate / ethyl acrylate / methacrylic acid 3-hydride Kishipuropiru-diacetone acrylamide copolymer, and the like.

  Examples of the synthetic rubber-based adhesive include cis-isoprene rubber, styrene-isoprene rubber, cis-polyisoprene rubber, high-cis-polyisoprene rubber, styrene-butadiene rubber, styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block. Examples thereof include a copolymer, polyisoprene, polyisobutylene, chloroprene rubber, polybutene, natural rubber latex, and SBR synthetic latex. These can be used alone or in combination of two or more.

  On the other hand, the poultice base is not particularly limited. For example, polyacrylic acid, sodium polyacrylate, partially neutralized polyacrylic acid, N-vinylacetamide / sodium acrylate copolymer, polyvinyl alcohol , Polyvinylpyrrolidone, hydroxymethylcellulose, sodium carboxymethylcellulose, alginic acid, sodium alginate, gelatin, gum arabic and the like, and those crosslinked with a metal salt such as aluminum, zinc, magnesium, calcium and the like. These can be used alone or in combination of two or more.

When the patch of the present invention is a tape, the content of the pressure sensitive adhesive is preferably 10 to 70 mass%, more preferably 15 to 55 mass%, more preferably 15 to 40 mass% in the pressure sensitive adhesive layer. % Is particularly preferred.
On the other hand, when the patch of the present invention is a patch, the content of the patch base is preferably 1 to 60% by weight, more preferably 1 to 40% by weight in the patch base layer. 20% by mass is particularly preferred.

  The adhesive base layer contains a drug. The drug is not particularly limited, for example, actarit, acemetacin, ampiroxicam, ampenac sodium hydrate, ibuprofen, indomethacin, indomethacin farnesyl, etodolac, ketoprofen, zaltoprofen, diclofenac sodium, sulindac, celecoxib, thiaprofenic acid, tenoxicam, naproxen, Anti-inflammatory analgesics such as piroxicam, felbinac, pranoprofen, flurbiprofen, flurbiprofen axetil, mefenamic acid, medicoxib, meloxicam, mofezolac, lefecoxib, loxoprofen sodium hydrate, lobenzarit disodium, lornoxicam; Alzheimer type treatment for dementia such as salt and memantine hydrochloride; Asthma such as tulobuterol療剤; isosorbide ischemic heart disease therapeutic agent such as a nitrate; scabies therapeutic agent such as crotamiton and the like.

  Content of the said drug is 0.01-20 mass% normally in an adhesive base layer, Preferably it is 0.1-10 mass%.

  In addition to the above components, the adhesive base layer contains a plasticizer, a tackifier resin, a filler, a water-soluble / water-swellable polymer, a transdermal absorption accelerator, an ultraviolet absorber, and the like. May be.

Examples of the plasticizer include liquid paraffin, light liquid paraffin, cetyl octanoate, hexyl laurate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, myristyl lactate, dioctyl adipate, diethyl sebacate , Diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dioctyl succinate, octyldodecanol, hexyldecanol, almond oil, olive oil, camellia oil, castor oil, peanut oil, mint oil, l-menthol, diethylene glycol, propylene glycol, di- Propylene glycol, polyethylene glycol, polypropylene glycol, triacetin, triethyl citrate, glycerin, etc., and these Alone or in combination of two or more can be used.
Content of the said plasticizer is 0.5-60 mass% normally in an adhesive base layer, Preferably it is 1-50 mass%.

Examples of the tackifying resin include rosin, hydrogenated rosin glycerin ester, ester gum, maleated rosin glycerin ester, terpene resin, petroleum resin, alicyclic saturated hydrocarbon resin, aliphatic hydrocarbon resin, and the like. These can be used alone or in combination of two or more.
When it contains the said tackifying resin, the content is 1-60 mass% normally in an adhesive base layer, Preferably it is 1-50 mass%.

Examples of the filler include zinc oxide, aluminum oxide, titanium oxide, magnesium oxide, iron oxide, zinc stearate, calcium carbonate, kaolin, silica, dihydroxyaluminum aminoacetate, and talc. Two or more kinds can be used in combination.
When it contains the said filler, the content is 0.1-20 mass% normally in an adhesive base layer, Preferably it is 0.2-10 mass%.

Examples of water-soluble and water-swellable polymers include polyvinyl alcohol, povidone, hypromellose, hydroxypropylcellulose, carboxyvinyl polymer, methylcellulose, hydroxyethylcellulose, carboxymethylethylcellulose, carmellose, carmellose potassium, carmellose calcium, carmellose sodium. , Sodium alginate, propylene glycol alginate, sodium carboxymethyl starch, xanthan gum, dextran, dextrin, gelatin and the like, and these can be used alone or in combination of two or more.
When the water-soluble / water-swellable polymer is contained, the content is usually 1 to 20% by mass, preferably 1 to 10% by mass in the adhesive base layer.

Examples of the percutaneous absorption accelerator include polyoxyethylene (2) 2-ethylhexyl ether, polyoxyethylene (4) 2-ethylhexyl ether, polyoxyethylene (3) decyl ether, polyoxyethylene (3.5) isoform. Decyl ether, polyoxyethylene (2) lauryl ether, polyoxyethylene (2.2) lauryl ether, polyoxyethylene (3) lauryl ether, polyoxyethylene (3) tridecyl ether, polyoxyethylene (3) myristyl ether , Polyoxyethylene (2) cetyl ether, polyoxyethylene (2) stearyl ether, polyoxyethylene (3.3) stearyl ether, polyoxyethylene (4) stearyl ether, polyoxyethylene (4) isostearyl ether, Polyoxyalkylene alkyl ethers such as reoxyethylene (2) oleyl ether, polyoxyethylene (4) oleyl ether, polyoxyethylene (3) octylphenyl ether, polyoxyethylene (1) polyoxypropylene (1) cetyl ether; Terpenes such as camphor, geraniol, citronellal, terpineol, borneol, menthol, limonene; ylang ylang oil, fennel oil, orange oil, chamomile oil, cinnamon oil, perilla oil, citronella oil, ginger oil, camphor oil, peppermint oil, Geranium oil, clove oil, turpentine oil, spruce oil, neroli oil, mint oil, palmarosa oil, bergamot oil, eucalyptus oil, lavender oil, linaloe oil, lemon oil, rose oil, rosemary oil, roman chamomile oil, etc. Essential oils containing rupenes; higher alcohols such as octyl alcohol, nonyl alcohol, decyl alcohol, isodecyl alcohol, undecyl alcohol, lauryl alcohol, tridecyl alcohol, isostearyl alcohol, oleyl alcohol, linoleyl alcohol, etc. Or two or more types can be used in combination.
When it contains the said transdermal absorption promoter, the content is 0.01-20 mass% normally in an adhesive base layer, Preferably it is 0.05-10 mass%.

  When the patch of the present invention is a cataplasm, the cataplasm base layer further contains water and the like in addition to the above components.

As a specific example of the patch of the present invention, the support, the adhesive base layer and a release liner (release paper) are provided, and the adhesive base layer is laminated on the support, and the adhesive base layer is peeled off. Examples include those in which a liner (release paper) is laminated.
As such a tape agent, the support, the pressure-sensitive adhesive layer, and a release liner (release paper) are provided, and the pressure-sensitive adhesive layer is laminated on the support, and the release liner ( And a laminate of release paper). The ratio of the pressure-sensitive adhesive layer in this case is not particularly limited, but is preferably 1 to 70% by mass, more preferably 10 to 60% by mass, and still more preferably 25 to 50% by mass with respect to the total amount of the tape agent.
Further, as the above poultice, the support, the cataplasm base layer and the release liner (release paper) are provided, and the cataplasm base layer is laminated on the support, and the cataplasm base layer Examples include a laminate of a release liner (release paper). The ratio of the poultice base layer in this case is not particularly limited, but is preferably 50 to 99 mass%, more preferably 60 to 99 mass%, and particularly preferably 70 to 95 mass% with respect to the total amount of the poultice.

  The release liner is not particularly limited, and examples thereof include films of polyester, polyethylene terephthalate separator, polyethylene, polypropylene, ethylene / vinyl acetate copolymer, cellophane, and the like.

  The shape and size of the patch of the present invention may be appropriately adjusted according to the affected area, but is preferably rectangular or substantially rectangular, and these may have R at the corners. Specific examples include rectangular or substantially rectangular shapes such as 14 cm × 10 cm, 10 cm × 7 cm, 7 cm × 5 cm, 1.6 cm × 1.6 cm, 2.25 cm × 2.25 cm, 3.2 cm × 3.2 cm, and the like. It is done.

The patch of the present invention can be produced based on a known method such as the 16th revised Japanese Pharmacopoeia General Rules for Preparations.
For example, the tape agent may be manufactured based on a known method (solvent method, hot melt method, emulsion method, etc.). For example, appropriate additives such as drugs and pressure-sensitive adhesives are immersed in an appropriate organic solvent as necessary, and stirred to disperse evenly to produce a pressure-sensitive adhesive layer, which is supported by the present invention. It can be manufactured by spreading on a body or a release liner, volatilizing and drying the solvent, and bonding the release liner or the support of the present invention together. Moreover, after a pressure-sensitive adhesive layer is spread and applied to the support or release liner of the present invention with a spreader, it can be produced by laminating the release liner or the support of the present invention.
In addition, the poultice is prepared by spreading a cataplasm base layer prepared by adding a drug and an appropriate additive as necessary based on a known method on the support or release liner of the present invention. It can manufacture by bonding together the support body of this invention.

  The patch of the present invention is excellent in handleability, usability and adhesion to the skin, and hardly causes back stain.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these Examples.

The measurement conditions and evaluation methods in this example are as shown below.
〔Measurement condition〕
<50% elongation stress of support>
A support (length before stretching: 50 mm) is fixed to a tensile tester (texture analyzer, Eihiro Seiki Co., Ltd.), and stretched by 25 mm at a speed of 1 mm / sec (length after stretching: 75 mm). Was measured as the stress at 50% elongation of the support.
<Static friction coefficient and dynamic friction coefficient of support>
The static friction coefficient and the dynamic friction coefficient of the support were measured according to JIS K 7125 (countermaterial: glass plate).

〔Evaluation method〕
<Evaluation of the thickness of the patch>
A patch with a thickness of 0.8 mm or less was evaluated as having little discomfort during use (evaluation: ◯), and a patch with a thickness exceeding 0.8 mm was evaluated as having discomfort during use (evaluation: x).

<Usage feeling of the patch>
The sleeves of the paneler's clothes were rolled up, the patch was applied to the arms, and the sleeves were put back. Thereafter, the usability of the patch for 10 minutes was evaluated according to the following criteria.
(Usage evaluation criteria)
○: Uncomfortable interference between the worn clothing and the patch does not occur, and the feeling is smooth. ×: Feels unpleasant interference between the worn clothing and the patch, Not a smooth impression

<Difficult to peel off the corners of patches>
After applying the patch to the arm for 10 minutes and tracing the skin to the patch with 10 fingers, ask the panelists to test whether the corner (R part) of the patch is peeled off. Evaluated according to.
(Evaluation criteria for difficulty in peeling off corners)
○: Number of people who did not peel 9 people △: Number of people who did not peel 5-8 people ×: Number of people who did not peel 0-4 people

<There is no stain on the back of the patch>
It was visually evaluated whether or not the component contained in the adhesive base layer of the patch stains the support, and the non-back stain was evaluated as ◯, and the back stain was evaluated as x.

<Ease of taking out the patch>
After stacking 7 patches and storing them in a 15.5 cm × 13 cm (14 cm wide outlet) aluminum bag, the fourth patch located in the center was taken out, ○ which was easy to take out, was difficult to take out Things were evaluated as x.

Example 1 Cataplasm 1 part by weight of indomethacin, 2 parts by weight of crotamiton, 3.5 parts by weight of polyacrylic acid partial neutralized product, 3 parts by weight of carmellose sodium, 22 parts by weight of concentrated glycerin, 3 parts by weight of kaolin, 1 part by weight of gelatin Then, 0.30 parts by mass of dihydroxyaluminum aminoacetate and 1.25 parts by mass of lactic acid were mixed with 35 parts by mass of purified water. To this, 10 parts by mass of ester gum dissolved in 2.50 parts by mass of light liquid paraffin and 2 parts by mass of dextrin palmitate were added.
Next, purified water was added thereto to make the total amount 100 parts by mass, and the mixture was stirred with a stirrer until it became uniform to obtain a poultice base layer. The obtained patch base layer was spread coated on a polyester release liner, and the surface coated with the patch base layer was coated with the support 1 shown in Table 1, and then 10 cm × 7 cm per sheet. To obtain a poultice.

Example 2 Tape agent A polymer solution in which 20 parts by mass of a styrene / isoprene / styrene block copolymer and 40 parts by mass of an alicyclic saturated hydrocarbon resin were dissolved in 30 parts by mass of liquid paraffin at 120 ° C. was obtained.
On the other hand, 1 part by mass of indomethacin is added to 5 parts by mass of polyethylene glycol 400 and dissolved at room temperature, 3 parts by mass of oleyl alcohol and 1 part by mass of l-menthol are added, and a polymer solution is added thereto and mixed well at 90 ° C. An adhesive base layer was obtained.
The obtained adhesive base layer was spread-coated on a release liner made of polyethylene terephthalate separator, and the surface coated with the adhesive base layer was coated with the support 1 shown in Table 1, and then 10 cm × 7 cm per sheet. To obtain a tape preparation.

Example 3 Tape agent A tape agent was obtained in the same manner as in Example 2 except that the support 1 was replaced with the support 2 shown in Table 1.

Example 4 Tape agent A tape agent was obtained in the same manner as in Example 2 except that the support 1 was replaced with the support 3 shown in Table 1.

Example 5 Cataplasm A cataplasm is obtained in the same manner as in Example 1 except that the substrate 1 is changed to the substrate 11 shown in Table 1.

Example 6 A poultice is obtained in the same manner as in Example 1 except that the support 1 is replaced with the support 12 shown in Table 1.

Example 7 Cataplasm A cataplasm is obtained in the same manner as in Example 1 except that the substrate 1 is replaced with the substrate 13 shown in Table 1.

Comparative Example 1 A poultice was obtained in the same manner as in Example 1 except that the support 1 was replaced with the support 4 shown in Table 1.

Comparative Example 2 A poultice was obtained in the same manner as in Example 1 except that the support 1 was replaced with the support 5 shown in Table 1.

Comparative Example 3 A poultice was obtained in the same manner as in Example 1 except that the support 1 was replaced with the support 6 shown in Table 1.

Comparative Example 4 Cataplasm A cataplasm was obtained in the same manner as in Example 1 except that the substrate 1 was replaced with the substrate 7 shown in Table 1.

Comparative Example 5 Tape Agent A tape agent was obtained in the same manner as in Example 2 except that the support 1 was replaced with the support 8 shown in Table 1.

Comparative Example 6 Tape Agent A tape agent was obtained in the same manner as in Example 2 except that the support 1 was replaced with the support 9 shown in Table 1.

Comparative Example 7 Tape Agent A tape agent was obtained in the same manner as in Example 2 except that the support 1 was replaced with the support 10 shown in Table 1.

  Tables 1 to 3 show the measurement results and evaluation results for each support, cataplasm and tape agent.

  As shown in Tables 1 to 3, the patches of Examples 1 to 4 using the supports 1 to 3 are excellent in feeling of use and ease of taking out, the corners are not easily peeled off, and the back stain is difficult to occur.

Claims (6)

  A patch support comprising a knitted fabric made of fibers having a crimp rate of 45% or more and a denier number of 55 or less.   The support according to claim 1, wherein the absolute value of the difference between the stress at 50% elongation in the course direction and the stress at 50% elongation in the wale direction is 500 gf or less.   3. The support according to claim 1, wherein a ratio of the 50% elongation stress in the course direction to the 50% elongation stress in the wale direction (course direction / wale direction) is 0.4 or more.   The support according to any one of claims 1 to 3, wherein only one of the number of courses and the number of wales is 55 or more per inch.   The support according to any one of claims 1 to 4, wherein both the static friction coefficient and the dynamic friction coefficient are 0.32 or less.   A patch comprising an adhesive base layer laminated on the support according to any one of claims 1 to 5.